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The map label for this gene is czcD [H]

Identifier: 21674638

GI number: 21674638

Start: 1728333

End: 1729256

Strand: Reverse

Name: czcD [H]

Synonym: CT1824

Alternate gene names: 21674638

Gene position: 1729256-1728333 (Counterclockwise)

Preceding gene: 21674639

Following gene: 21674637

Centisome position: 80.25

GC content: 60.17

Gene sequence:

>924_bases
ATGAGCGAGCACCATCACGACCATAGTCACGATCACGGTCACGCCGGGCATCAGTACCACGCAGTCGGGAGCATCCAGAT
CGCATTTTTCATGAACTTCGGCTTCACGATCCTCGAAGCCATCGGCGGCGTCATGACCAACAGCACGGCGATTCTCGCCA
ACGCCGTGCACGACTTTGGCGACTCTATCGCCGTCGGTCAGGCTTGGTATTTCGAAAAGCTTTCGGGCCGCACGGGCGAC
AAGCGCTACTCCTATGGCTACCAGCGCTTCTCGATCTTTGGTGCGCTCGTCAGCGCACTCATGATGCTCGCCAGCTCCTT
CCTCGTGCTGGTCGAGGCGGTGCCGCGCCTGCTTCATCCAGAGCATCCGAATGCCAAAGGTATGGTTGCTTTCGCGCTGG
TTGGCGTGGCCGTCAACGCGCTCGCTATGCTGCGCCTCAAGGGGCAGGCCGGCATGAACGCCCGCGTCATTGCGCTGCAC
CTGCTCGAAGACGTGCTCGGCTGGCTCTCGGTTTTGCTGGTTTCTGTGGTGTTGCTTTTCACCTCTTTGCCGATACTCGA
CCCGCTGCTCGCCATCGTCATCACGCTCTACATCCTCACCGGCGTGGTGAAGAATCTCCGCGCAATGGTTCCCGTCTTCC
TGCAAGCCGTGCCAAGCGAGCTCAGCCTCGACAAGGTTGTCGCCGACATTCAGCAGACCGAGCACGTCACCGGCGTTCAC
CACGCCCATCTCTGGTCGCTCGACGGCCAGCGCACAGTCTTCACCGCTCACCTCGAAATCGGCTGCGATGTCAACCCTGC
CGAATACGCCAGCATCAAAGAGGAGATTCGCAAGCTCGTCGCCCGCCACGGTATTTACCACTCCACCGTAGAGCTCGAAT
ACCCCGGCGAAGTGTGCCGCAACGAGTCGCATAAAGACGGGTAG

Upstream 100 bases:

>100_bases
ACCGTCGTGTTCGACTGAGCTGATCCGTCCGGCGGGAATTTCCCGGGCCGCTCGAACAGTTCCTGTAAGACGAAGTATTG
TTTGTCAGATCGGAATCCGA

Downstream 100 bases:

>100_bases
GGGGAGGACATCCGGAACTTTGAGGCGGGGATTTTGTTGTTCCTGAAAAAAACGGGAGAACACCGATGAAAAAACTCTTT
TTGCCTATGCTGCTTTGGAT

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSEHHHDHSHDHGHAGHQYHAVGSIQIAFFMNFGFTILEAIGGVMTNSTAILANAVHDFGDSIAVGQAWYFEKLSGRTGD
KRYSYGYQRFSIFGALVSALMMLASSFLVLVEAVPRLLHPEHPNAKGMVAFALVGVAVNALAMLRLKGQAGMNARVIALH
LLEDVLGWLSVLLVSVVLLFTSLPILDPLLAIVITLYILTGVVKNLRAMVPVFLQAVPSELSLDKVVADIQQTEHVTGVH
HAHLWSLDGQRTVFTAHLEIGCDVNPAEYASIKEEIRKLVARHGIYHSTVELEYPGEVCRNESHKDG

Sequences:

>Translated_307_residues
MSEHHHDHSHDHGHAGHQYHAVGSIQIAFFMNFGFTILEAIGGVMTNSTAILANAVHDFGDSIAVGQAWYFEKLSGRTGD
KRYSYGYQRFSIFGALVSALMMLASSFLVLVEAVPRLLHPEHPNAKGMVAFALVGVAVNALAMLRLKGQAGMNARVIALH
LLEDVLGWLSVLLVSVVLLFTSLPILDPLLAIVITLYILTGVVKNLRAMVPVFLQAVPSELSLDKVVADIQQTEHVTGVH
HAHLWSLDGQRTVFTAHLEIGCDVNPAEYASIKEEIRKLVARHGIYHSTVELEYPGEVCRNESHKDG
>Mature_306_residues
SEHHHDHSHDHGHAGHQYHAVGSIQIAFFMNFGFTILEAIGGVMTNSTAILANAVHDFGDSIAVGQAWYFEKLSGRTGDK
RYSYGYQRFSIFGALVSALMMLASSFLVLVEAVPRLLHPEHPNAKGMVAFALVGVAVNALAMLRLKGQAGMNARVIALHL
LEDVLGWLSVLLVSVVLLFTSLPILDPLLAIVITLYILTGVVKNLRAMVPVFLQAVPSELSLDKVVADIQQTEHVTGVHH
AHLWSLDGQRTVFTAHLEIGCDVNPAEYASIKEEIRKLVARHGIYHSTVELEYPGEVCRNESHKDG

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI64762489, Length=306, Percent_Identity=25.1633986928105, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI289803013, Length=306, Percent_Identity=25.1633986928105, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI289803009, Length=306, Percent_Identity=25.1633986928105, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI289803007, Length=306, Percent_Identity=25.1633986928105, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI289803003, Length=306, Percent_Identity=25.1633986928105, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI52352805, Length=309, Percent_Identity=23.9482200647249, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI52352803, Length=216, Percent_Identity=25, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1786966, Length=272, Percent_Identity=27.5735294117647, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI193210990, Length=317, Percent_Identity=25.2365930599369, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17555794, Length=314, Percent_Identity=25.796178343949, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17555796, Length=281, Percent_Identity=26.6903914590747, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32564488, Length=299, Percent_Identity=23.4113712374582, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=196, Percent_Identity=27.0408163265306, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323899, Length=153, Percent_Identity=28.1045751633987, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24583858, Length=319, Percent_Identity=23.1974921630094, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24656728, Length=147, Percent_Identity=31.9727891156463, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24656724, Length=147, Percent_Identity=31.9727891156463, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24656720, Length=147, Percent_Identity=31.9727891156463, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24656715, Length=147, Percent_Identity=31.9727891156463, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357035, Length=147, Percent_Identity=31.9727891156463, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33621; Mature: 33490

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHHHDHSHDHGHAGHQYHAVGSIQIAFFMNFGFTILEAIGGVMTNSTAILANAVHDFG
CCCCCCCCCCCCCCCCCEEEEECCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
DSIAVGQAWYFEKLSGRTGDKRYSYGYQRFSIFGALVSALMMLASSFLVLVEAVPRLLHP
CCEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EHPNAKGMVAFALVGVAVNALAMLRLKGQAGMNARVIALHLLEDVLGWLSVLLVSVVLLF
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSLPILDPLLAIVITLYILTGVVKNLRAMVPVFLQAVPSELSLDKVVADIQQTEHVTGVH
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCH
HAHLWSLDGQRTVFTAHLEIGCDVNPAEYASIKEEIRKLVARHGIYHSTVELEYPGEVCR
HHHEEECCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEECEEEEECCHHHHC
NESHKDG
CCCCCCC
>Mature Secondary Structure 
SEHHHDHSHDHGHAGHQYHAVGSIQIAFFMNFGFTILEAIGGVMTNSTAILANAVHDFG
CCCCCCCCCCCCCCCCEEEEECCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
DSIAVGQAWYFEKLSGRTGDKRYSYGYQRFSIFGALVSALMMLASSFLVLVEAVPRLLHP
CCEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EHPNAKGMVAFALVGVAVNALAMLRLKGQAGMNARVIALHLLEDVLGWLSVLLVSVVLLF
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSLPILDPLLAIVITLYILTGVVKNLRAMVPVFLQAVPSELSLDKVVADIQQTEHVTGVH
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCH
HAHLWSLDGQRTVFTAHLEIGCDVNPAEYASIKEEIRKLVARHGIYHSTVELEYPGEVCR
HHHEEECCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEECEEEEECCHHHHC
NESHKDG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA