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The map label for this gene is ppiA [H]

Identifier: 21674627

GI number: 21674627

Start: 1717739

End: 1718227

Strand: Direct

Name: ppiA [H]

Synonym: CT1813

Alternate gene names: 21674627

Gene position: 1717739-1718227 (Clockwise)

Preceding gene: 21674626

Following gene: 21674628

Centisome position: 79.71

GC content: 59.1

Gene sequence:

>489_bases
ATGCCAGAAAAATTCATCATCAAGACCAGCATGGGTGATATTTCCATCGCCCTGTATGACGACACTCCCCGGCACCGCGA
TAACTTCGTCAAGCTCGTCGGCGAAGGCTACTACGACGGCATCCGTTTTCACAGGGTGATCGAAGGCTTCATGATCCAGT
CCGGCGATCCGCTTTCGCGCTTCGACGAGAAGCGCATGATGCACGGCACCGGCGGCCCCGACTACCGTGTTCCGGCTGAA
ATCAAGCACCCGAACAAAAAGGGCACGATTGCCGCCGCGCGTGACAACAACCCGCAGAAGGCCTCGTCCGGCAGCCAGTT
CTACATCAACCAGGCCGACAACGGCTTCCTCGACGGCGAATATACCGTGTTCGGCGTTGTCGAATCGGGCATCGACGTGG
TTGACGCCATCGCCGCCGTCGAGACCGACATGCGCGACAACCCGCTCAAGCCGGTGACCATCGAAACCATCACTCCTGCA
ACCGCCTGA

Upstream 100 bases:

>100_bases
CAGCGGGAATGGCCCAGCGCGCGCTCTTGCGCCTTGCCGGCGCAGGCGTGCAGATACCGCAAATCTGACCGATTGTTTTT
CGACACTCAACCACATTACC

Downstream 100 bases:

>100_bases
TCGCCGAAAACATGGAAAGCATCTCATCGAACCTCACCGCCGTCAGGGAACAGATCGCCGAGGCCTGCCGCAAGGCGGGC
CGCCGCGAGGATGAGGTAAC

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MPEKFIIKTSMGDISIALYDDTPRHRDNFVKLVGEGYYDGIRFHRVIEGFMIQSGDPLSRFDEKRMMHGTGGPDYRVPAE
IKHPNKKGTIAAARDNNPQKASSGSQFYINQADNGFLDGEYTVFGVVESGIDVVDAIAAVETDMRDNPLKPVTIETITPA
TA

Sequences:

>Translated_162_residues
MPEKFIIKTSMGDISIALYDDTPRHRDNFVKLVGEGYYDGIRFHRVIEGFMIQSGDPLSRFDEKRMMHGTGGPDYRVPAE
IKHPNKKGTIAAARDNNPQKASSGSQFYINQADNGFLDGEYTVFGVVESGIDVVDAIAAVETDMRDNPLKPVTIETITPA
TA
>Mature_161_residues
PEKFIIKTSMGDISIALYDDTPRHRDNFVKLVGEGYYDGIRFHRVIEGFMIQSGDPLSRFDEKRMMHGTGGPDYRVPAEI
KHPNKKGTIAAARDNNPQKASSGSQFYINQADNGFLDGEYTVFGVVESGIDVVDAIAAVETDMRDNPLKPVTIETITPAT
A

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=163, Percent_Identity=36.8098159509202, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI24308049, Length=155, Percent_Identity=36.7741935483871, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI19557636, Length=154, Percent_Identity=35.0649350649351, Blast_Score=83, Evalue=9e-17,
Organism=Homo sapiens, GI4758950, Length=155, Percent_Identity=40, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI22547212, Length=154, Percent_Identity=34.4155844155844, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI7657473, Length=154, Percent_Identity=34.4155844155844, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI22547215, Length=154, Percent_Identity=34.4155844155844, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI64276486, Length=166, Percent_Identity=33.1325301204819, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI20911035, Length=158, Percent_Identity=34.1772151898734, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1789763, Length=159, Percent_Identity=40.251572327044, Blast_Score=89, Evalue=1e-19,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=39.2638036809816, Blast_Score=84, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=153, Percent_Identity=37.2549019607843, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71980590, Length=144, Percent_Identity=38.1944444444444, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17539496, Length=156, Percent_Identity=35.2564102564103, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17506311, Length=156, Percent_Identity=37.8205128205128, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17552780, Length=151, Percent_Identity=37.7483443708609, Blast_Score=76, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71997782, Length=166, Percent_Identity=33.1325301204819, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17551284, Length=161, Percent_Identity=34.1614906832298, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17551282, Length=161, Percent_Identity=34.1614906832298, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17506307, Length=151, Percent_Identity=37.0860927152318, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=157, Percent_Identity=37.5796178343949, Blast_Score=72, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321848, Length=162, Percent_Identity=35.1851851851852, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323562, Length=152, Percent_Identity=35.5263157894737, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17986117, Length=154, Percent_Identity=37.012987012987, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI19922376, Length=151, Percent_Identity=32.4503311258278, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20130249, Length=154, Percent_Identity=39.6103896103896, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19922912, Length=157, Percent_Identity=34.3949044585987, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24652460, Length=132, Percent_Identity=34.8484848484849, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136360, Length=154, Percent_Identity=33.1168831168831, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357249, Length=132, Percent_Identity=34.0909090909091, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586038, Length=156, Percent_Identity=33.974358974359, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17897; Mature: 17766

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEKFIIKTSMGDISIALYDDTPRHRDNFVKLVGEGYYDGIRFHRVIEGFMIQSGDPLSR
CCCCEEEEECCCCEEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHEECCCCCHHH
FDEKRMMHGTGGPDYRVPAEIKHPNKKGTIAAARDNNPQKASSGSQFYINQADNGFLDGE
HHHHHHCCCCCCCCEECCCCEECCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCEECCC
YTVFGVVESGIDVVDAIAAVETDMRDNPLKPVTIETITPATA
EEEEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
PEKFIIKTSMGDISIALYDDTPRHRDNFVKLVGEGYYDGIRFHRVIEGFMIQSGDPLSR
CCCEEEEECCCCEEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHEECCCCCHHH
FDEKRMMHGTGGPDYRVPAEIKHPNKKGTIAAARDNNPQKASSGSQFYINQADNGFLDGE
HHHHHHCCCCCCCCEECCCCEECCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCEECCC
YTVFGVVESGIDVVDAIAAVETDMRDNPLKPVTIETITPATA
EEEEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA