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The map label for this gene is appB [H]

Identifier: 21674449

GI number: 21674449

Start: 1540818

End: 1541783

Strand: Reverse

Name: appB [H]

Synonym: CT1631

Alternate gene names: 21674449

Gene position: 1541783-1540818 (Counterclockwise)

Preceding gene: 21674450

Following gene: 21674448

Centisome position: 71.55

GC content: 59.94

Gene sequence:

>966_bases
ATGCTCAGGTATATCTTCAAACGGCTCTTGATTGCCGTGCCGCTCATCTTCGGGGTGCTGACCCTGACCTTCTTCATCAT
CCGGCTCGCGCCGGGCGACCCCGCGGCGTTCTTCATCCAGCCGGGCATCAGTCCCAACGTGGCCGAGCAGATCCGCCAGC
AGTATGGGCTGAACGATCCGCTGCCGGTGCAGTACATCAAGTGGCTCGGCAACGTGCTGCACGGTGATTTCGGACGCAGT
TTCAGCCGCGCGCAGCAGCCGGTGTTCGACGTGATTGCCGAGGCGTTGCCGGTAACGATGACCATCGCCGTGCTGACGCT
CATCGCGAACTTCGTCTTCGGTATCATCATCGGCGTGATTTCGGCGGTCAAACAGAACAGCTTTCTTGACCGCTTCCTGA
CGGTTACGGCGCTCTTCTTCTATTCGATGCCGGAGTTCTGGCTCGCCCTGATGATGATTATCCTTTTTGCCCTGAAGTGG
CCGCTTTTCCCGGTTTCAGGCCTGAACGAAATCGGCGCGGAGAGCTACGGGACGTTCGGCTTCATCATGGACAGGATCTG
GCACCTCGCCTTGCCAGTAACGGTGCTCAGCATCAACGGCTCCGCCGGCATCGCCCGCTACGTGCGGGGCAGTATGCTTG
AGGTGATCCGGCAGGACTACGTCCGCACGGCTCGGGCCAAGGGGCTCAGCGAGCGGGTGGTGATTCTCAAACACGCCTTG
CGCAATGCGCTCTTGCCGGTGGTCACGCTGATGGGCAGCTCGCTGCCGTTCATCTTCAGCGGGGCGCTCTTTATCGAGGT
GATCTTTGCTTTTCCCGGCATGGGGCGCGTCACGGTCGAGGCGATCTTTGCACGCGACTATCCGCTGATTATCGCCAATA
CCTTCGTCTCCGGCACGATGATCGTCTTCGGTAACCTCTTGGCCGACGTGCTCTACGCGGTGGTCGATCCGAGGATCAAA
CTGTGA

Upstream 100 bases:

>100_bases
GGGTTCAGCAAGCGTATTCAGGGCGCGAAGCTCAATATTTCCGGTACTTTCTACAACATCGACGACTGGACGCTGAAACC
GTCAATCGCGCCGTAACGAC

Downstream 100 bases:

>100_bases
ATGCAAAACGAGAGCTTGAGTGAGGATTGAAGCCCTGAATACCGCACCCGACGCGACGGAAGCCCGGTTCGAGGAGCAGA
TACGGCCGCAAAAGATGGGC

Product: peptide ABC transporter, permease protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MLRYIFKRLLIAVPLIFGVLTLTFFIIRLAPGDPAAFFIQPGISPNVAEQIRQQYGLNDPLPVQYIKWLGNVLHGDFGRS
FSRAQQPVFDVIAEALPVTMTIAVLTLIANFVFGIIIGVISAVKQNSFLDRFLTVTALFFYSMPEFWLALMMIILFALKW
PLFPVSGLNEIGAESYGTFGFIMDRIWHLALPVTVLSINGSAGIARYVRGSMLEVIRQDYVRTARAKGLSERVVILKHAL
RNALLPVVTLMGSSLPFIFSGALFIEVIFAFPGMGRVTVEAIFARDYPLIIANTFVSGTMIVFGNLLADVLYAVVDPRIK
L

Sequences:

>Translated_321_residues
MLRYIFKRLLIAVPLIFGVLTLTFFIIRLAPGDPAAFFIQPGISPNVAEQIRQQYGLNDPLPVQYIKWLGNVLHGDFGRS
FSRAQQPVFDVIAEALPVTMTIAVLTLIANFVFGIIIGVISAVKQNSFLDRFLTVTALFFYSMPEFWLALMMIILFALKW
PLFPVSGLNEIGAESYGTFGFIMDRIWHLALPVTVLSINGSAGIARYVRGSMLEVIRQDYVRTARAKGLSERVVILKHAL
RNALLPVVTLMGSSLPFIFSGALFIEVIFAFPGMGRVTVEAIFARDYPLIIANTFVSGTMIVFGNLLADVLYAVVDPRIK
L
>Mature_321_residues
MLRYIFKRLLIAVPLIFGVLTLTFFIIRLAPGDPAAFFIQPGISPNVAEQIRQQYGLNDPLPVQYIKWLGNVLHGDFGRS
FSRAQQPVFDVIAEALPVTMTIAVLTLIANFVFGIIIGVISAVKQNSFLDRFLTVTALFFYSMPEFWLALMMIILFALKW
PLFPVSGLNEIGAESYGTFGFIMDRIWHLALPVTVLSINGSAGIARYVRGSMLEVIRQDYVRTARAKGLSERVVILKHAL
RNALLPVVTLMGSSLPFIFSGALFIEVIFAFPGMGRVTVEAIFARDYPLIIANTFVSGTMIVFGNLLADVLYAVVDPRIK
L

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG0601

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789965, Length=337, Percent_Identity=39.1691394658754, Blast_Score=234, Evalue=6e-63,
Organism=Escherichia coli, GI1787497, Length=320, Percent_Identity=37.8125, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1787053, Length=320, Percent_Identity=37.1875, Blast_Score=215, Evalue=3e-57,
Organism=Escherichia coli, GI1789888, Length=323, Percent_Identity=35.2941176470588, Blast_Score=188, Evalue=4e-49,
Organism=Escherichia coli, GI1788504, Length=361, Percent_Identity=29.9168975069252, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI1787761, Length=327, Percent_Identity=35.474006116208, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1787550, Length=269, Percent_Identity=31.5985130111524, Blast_Score=149, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 35656; Mature: 35656

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLRYIFKRLLIAVPLIFGVLTLTFFIIRLAPGDPAAFFIQPGISPNVAEQIRQQYGLNDP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCC
LPVQYIKWLGNVLHGDFGRSFSRAQQPVFDVIAEALPVTMTIAVLTLIANFVFGIIIGVI
CHHHHHHHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAVKQNSFLDRFLTVTALFFYSMPEFWLALMMIILFALKWPLFPVSGLNEIGAESYGTFG
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCHHHCCHHH
FIMDRIWHLALPVTVLSINGSAGIARYVRGSMLEVIRQDYVRTARAKGLSERVVILKHAL
HHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RNALLPVVTLMGSSLPFIFSGALFIEVIFAFPGMGRVTVEAIFARDYPLIIANTFVSGTM
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEHHHHHHHH
IVFGNLLADVLYAVVDPRIKL
HHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]