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The map label for this gene is trpE [H]

Identifier: 21674269

GI number: 21674269

Start: 1359347

End: 1360861

Strand: Reverse

Name: trpE [H]

Synonym: CT1448

Alternate gene names: 21674269

Gene position: 1360861-1359347 (Counterclockwise)

Preceding gene: 21674271

Following gene: 21674268

Centisome position: 63.15

GC content: 59.14

Gene sequence:

>1515_bases
ATGATCAGATCTTTTTCGGACAATACGGCCGACCCGGCAAAGGAGCCGTCTTTTATTCTGACCCCTCTGGTCAGAACCTT
TCAGGCTGATACGGAAACCCCGGTGTCGGTGTACCTCAAACTCCAGCGCCCTTACTCCTGCCTGCTCGAGTCGGTCGAAG
GGGAGGAGCGTATGGCCCGTTATTCCTATATCGCCGTCGATCCGGTAGCCGTACTCAAGGGGACGGTTGGCGGAGAGATT
TTGCTTGACGTTCGTGACGAGCGTTTCCGCCAGTTGTCTGCCATTGTTGAACAGGAGCGTGACCTTCGCGCCGTCGTGGA
TCGCTGCATGGCGATGTTCTCCTCCGAAAAGCTGCCTCGCCACAAGAGCGGTTCGCAGCAGATGAGCACCTCCGGTGTGT
TCGGTTATTTCGGTTACGACACCATGCACCTCATCGAAAAGATTCCCGCCGCCGAGCAGCCCGATCCGGCAGGGATGCCA
GACCTTTGCTTGCTTTTCTGCGACACGCTCGTCATCTTTGACAACGTGATGCGCAAGCTCTTTCTCGTGACCAACTATCT
CGACGCCGCCGACCGCACGCGCGCCGACCGCAAAATCGACGAGCTTGCCGCACTGTTGCAGAAGCCGCTCGTGCCTGCTC
TCGTGCCGTTTCAGCCCGAGAAACCGGAGCCGGTCATCTCGAACACCACGCGTGACGAGTATTACGCCAAGGTGCTCAAG
GCCAAGGAGTACATTCTGAGCGGTGACATCTTCCAGGTGCAGATTTCGCAGCGCCTGAAGCGCAAGCTGCACACCCGTCC
GTTCGACGTCTATCGCGCGCTCCGGACGATCAACCCTTCGCCTTACCTCTACTTCTTTGACTTCGAGGATTTTCATGTCG
TCGGCTCATCGCCCGAGCTGCTGGTCAAGGTAGAGCGCGACCACACCGGACGCCGCATGGTCGATACCCGGCCTATCGCC
GGAACGCGACGGCGCGGCGAGAGCTTCGAGGAGGACGAGCGCAACGCCAAGGAGCTGATCTCCGACGAAAAGGAGCGGGC
CGAGCACCTGATGCTCATCGACCTAAGCCGCAACGACATCGGGCGCATCGCCAAGATCGGCACGGTCGAGACCAACGAGA
TGATGGTGATCGAGAAGTACTCGCATGTTATGCACATCGTCAGCAACGTCCGGGGTGAATTGCAGGACGGTCTGACGGCG
ATGGACGCCTTCTGGTCGTGCTTCCCGGCGGGAACGCTGACCGGCGCGCCGAAGGTTCGCGCCATGGAGATCATCTACGA
GCTGGAGAAAGAGAAGCGCGGCCTTTACGGCGGCGCGGTGGGCTACCTCGATTTCCGGGGGCAGCTCAACACTGCCATCG
CTATCCGCACGATGGTGATCCGCGACGGCGTTATCTACTTCCAGGCGGCGGGCGGCATCGTGGCCGATTCGACGCCAGAA
TTTGAATACGAAGAGACCATGAACAAGATGAGAGCAGGCCTGACGGCTCTTGAAAGTATTGAGACCTTTGTCTGA

Upstream 100 bases:

>100_bases
CCTGAGTACTACGCTGTGTTCATAAGTGTAGCAATATAGAAACAGCGAAGGTGTGATACTATGAATTTTTTACCTTATCG
TACGTAGCATCTACTCATTC

Downstream 100 bases:

>100_bases
TAAACTTTTAAACCGAAGACAGCTATGAAAAAGAAACTGACTATGCTCAAATCGGCAGCGCTGGTATCTGTGGGGATCAC
CGCTGGGGCGCTCGCTTTTT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MIRSFSDNTADPAKEPSFILTPLVRTFQADTETPVSVYLKLQRPYSCLLESVEGEERMARYSYIAVDPVAVLKGTVGGEI
LLDVRDERFRQLSAIVEQERDLRAVVDRCMAMFSSEKLPRHKSGSQQMSTSGVFGYFGYDTMHLIEKIPAAEQPDPAGMP
DLCLLFCDTLVIFDNVMRKLFLVTNYLDAADRTRADRKIDELAALLQKPLVPALVPFQPEKPEPVISNTTRDEYYAKVLK
AKEYILSGDIFQVQISQRLKRKLHTRPFDVYRALRTINPSPYLYFFDFEDFHVVGSSPELLVKVERDHTGRRMVDTRPIA
GTRRRGESFEEDERNAKELISDEKERAEHLMLIDLSRNDIGRIAKIGTVETNEMMVIEKYSHVMHIVSNVRGELQDGLTA
MDAFWSCFPAGTLTGAPKVRAMEIIYELEKEKRGLYGGAVGYLDFRGQLNTAIAIRTMVIRDGVIYFQAAGGIVADSTPE
FEYEETMNKMRAGLTALESIETFV

Sequences:

>Translated_504_residues
MIRSFSDNTADPAKEPSFILTPLVRTFQADTETPVSVYLKLQRPYSCLLESVEGEERMARYSYIAVDPVAVLKGTVGGEI
LLDVRDERFRQLSAIVEQERDLRAVVDRCMAMFSSEKLPRHKSGSQQMSTSGVFGYFGYDTMHLIEKIPAAEQPDPAGMP
DLCLLFCDTLVIFDNVMRKLFLVTNYLDAADRTRADRKIDELAALLQKPLVPALVPFQPEKPEPVISNTTRDEYYAKVLK
AKEYILSGDIFQVQISQRLKRKLHTRPFDVYRALRTINPSPYLYFFDFEDFHVVGSSPELLVKVERDHTGRRMVDTRPIA
GTRRRGESFEEDERNAKELISDEKERAEHLMLIDLSRNDIGRIAKIGTVETNEMMVIEKYSHVMHIVSNVRGELQDGLTA
MDAFWSCFPAGTLTGAPKVRAMEIIYELEKEKRGLYGGAVGYLDFRGQLNTAIAIRTMVIRDGVIYFQAAGGIVADSTPE
FEYEETMNKMRAGLTALESIETFV
>Mature_504_residues
MIRSFSDNTADPAKEPSFILTPLVRTFQADTETPVSVYLKLQRPYSCLLESVEGEERMARYSYIAVDPVAVLKGTVGGEI
LLDVRDERFRQLSAIVEQERDLRAVVDRCMAMFSSEKLPRHKSGSQQMSTSGVFGYFGYDTMHLIEKIPAAEQPDPAGMP
DLCLLFCDTLVIFDNVMRKLFLVTNYLDAADRTRADRKIDELAALLQKPLVPALVPFQPEKPEPVISNTTRDEYYAKVLK
AKEYILSGDIFQVQISQRLKRKLHTRPFDVYRALRTINPSPYLYFFDFEDFHVVGSSPELLVKVERDHTGRRMVDTRPIA
GTRRRGESFEEDERNAKELISDEKERAEHLMLIDLSRNDIGRIAKIGTVETNEMMVIEKYSHVMHIVSNVRGELQDGLTA
MDAFWSCFPAGTLTGAPKVRAMEIIYELEKEKRGLYGGAVGYLDFRGQLNTAIAIRTMVIRDGVIYFQAAGGIVADSTPE
FEYEETMNKMRAGLTALESIETFV

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=460, Percent_Identity=32.1739130434783, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1787518, Length=387, Percent_Identity=37.984496124031, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1786809, Length=219, Percent_Identity=27.3972602739726, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87082077, Length=232, Percent_Identity=26.2931034482759, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320935, Length=487, Percent_Identity=39.0143737166324, Blast_Score=306, Evalue=6e-84,
Organism=Saccharomyces cerevisiae, GI6324361, Length=398, Percent_Identity=24.3718592964824, Blast_Score=112, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 57183; Mature: 57183

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRSFSDNTADPAKEPSFILTPLVRTFQADTETPVSVYLKLQRPYSCLLESVEGEERMAR
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHCCCHHHHHH
YSYIAVDPVAVLKGTVGGEILLDVRDERFRQLSAIVEQERDLRAVVDRCMAMFSSEKLPR
HHEEEECHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
HKSGSQQMSTSGVFGYFGYDTMHLIEKIPAAEQPDPAGMPDLCLLFCDTLVIFDNVMRKL
CCCCCCHHHCCCEEEECCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FLVTNYLDAADRTRADRKIDELAALLQKPLVPALVPFQPEKPEPVISNTTRDEYYAKVLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
AKEYILSGDIFQVQISQRLKRKLHTRPFDVYRALRTINPSPYLYFFDFEDFHVVGSSPEL
HHHHHHCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCE
LVKVERDHTGRRMVDTRPIAGTRRRGESFEEDERNAKELISDEKERAEHLMLIDLSRNDI
EEEEECCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHCCEEEEEEECCCCC
GRIAKIGTVETNEMMVIEKYSHVMHIVSNVRGELQDGLTAMDAFWSCFPAGTLTGAPKVR
CHHHEECEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
AMEIIYELEKEKRGLYGGAVGYLDFRGQLNTAIAIRTMVIRDGVIYFQAAGGIVADSTPE
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCEEEEEECCCEEECCCCC
FEYEETMNKMRAGLTALESIETFV
CCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIRSFSDNTADPAKEPSFILTPLVRTFQADTETPVSVYLKLQRPYSCLLESVEGEERMAR
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHCCCHHHHHH
YSYIAVDPVAVLKGTVGGEILLDVRDERFRQLSAIVEQERDLRAVVDRCMAMFSSEKLPR
HHEEEECHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
HKSGSQQMSTSGVFGYFGYDTMHLIEKIPAAEQPDPAGMPDLCLLFCDTLVIFDNVMRKL
CCCCCCHHHCCCEEEECCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FLVTNYLDAADRTRADRKIDELAALLQKPLVPALVPFQPEKPEPVISNTTRDEYYAKVLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
AKEYILSGDIFQVQISQRLKRKLHTRPFDVYRALRTINPSPYLYFFDFEDFHVVGSSPEL
HHHHHHCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCE
LVKVERDHTGRRMVDTRPIAGTRRRGESFEEDERNAKELISDEKERAEHLMLIDLSRNDI
EEEEECCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHCCEEEEEEECCCCC
GRIAKIGTVETNEMMVIEKYSHVMHIVSNVRGELQDGLTAMDAFWSCFPAGTLTGAPKVR
CHHHEECEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
AMEIIYELEKEKRGLYGGAVGYLDFRGQLNTAIAIRTMVIRDGVIYFQAAGGIVADSTPE
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCEEEEEECCCEEECCCCC
FEYEETMNKMRAGLTALESIETFV
CCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1987141 [H]