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The map label for this gene is degP [H]

Identifier: 21674268

GI number: 21674268

Start: 1357805

End: 1359322

Strand: Reverse

Name: degP [H]

Synonym: CT1447

Alternate gene names: 21674268

Gene position: 1359322-1357805 (Counterclockwise)

Preceding gene: 21674269

Following gene: 21674267

Centisome position: 63.08

GC content: 56.32

Gene sequence:

>1518_bases
ATGAAAAAGAAACTGACTATGCTCAAATCGGCAGCGCTGGTATCTGTGGGGATCACCGCTGGGGCGCTCGCTTTTTCCAA
TCTCGATTTTTCGTTTAACGGAGGCGGCAATAACGGGTTTATGGTTTCCAGTCACCCCAACTCGAGTATTGCGGCTGAAA
CCCTTCGCAACCATCCGATACGGACGCTCAACGATCTCAATGATGCTTTCGTGGATATCGCTGAGTCAGCTACCCCTTCG
GTGGTGACGATTTATACTGAAACCGAAGTGGATCGCCGGATTATGACCCCCTTCGATTTTTTCGGCAAATCGTTTGGAGA
GATGTTTGACTTTCCTTTACCCGAAGAACCGAACGTTCGCAAGGAGGTGATCCATGGACTGGGATCGGGTGTGATCGTCA
GCCAGGATGGCTACATTCTGACCAACAACCATGTGATCGACCAGGCGGGCTCCATTGCGGTTATGACCTCTGATAACCGG
AAATTCAAGGCCAAGATCGTCGGCACCGATCCCCGCACCGACCTGGCTGTGCTGAAGATTTCCGGTTCCGGTCTCAAGCC
GATCGCTTTCGGCGACAGCGACAAGCTGCGGGTCGGGGAGTGGGTGCTCGCCATCGGCAGTCCACTCGGCGAAAACCTCG
CCCGCACCGTGACGCAGGGTATCGTTAGCGCCAAGGGCCGTGTCAATGTCGGGGTGGCCGATTACGAGAATTTTATCCAG
ACTGATGCAGCCATCAATCCAGGAAACTCTGGCGGCCCATTGGTCAATATCGGTGGCGAGCTGGTAGGCATCAATACGGC
GATAGCCAGCCGCACTGGTGGGTTTGAAGGTATCGGCTTTGCCGTGCCGTCGAACATGGCATATCGGGTCTATACTTCGC
TGGTTAAAAACGGCAAGGTCGAGCGCGGCTACCTCGGCGTTACGATTCAGGATATCGATGAGAATATCGCCAAGGGGCTG
CAACTCAAATCTCCCGAAGGGGTTCTGGTCGGCACGGTGATGCAGGGTGGCCCTGCGGCCAGGGCCGGCCTGAAGAGCGG
GGATGTGATCCTTGAATTCAACGGACGGAAGGTGAACAGCGCGGCGGAGCTGCGCAACCGGATCGCGGCGATGGCTCCCG
GCAGCAGCGCCGCCATCAGGATCAATCGCGACGGCGCGATTCTCACCTTGAACGCACGCCTCGAATCGCTTCCAGACAAC
GCGACCGCCTCGGCTCGAAGCACCGAATCGAAGAACGAATTGCTCGGCTTCTCGGTTGCGCCATTGACCCCCGAACTGGC
CGGGCGGCTGAATCTGAAAGCCGACTCGCGCCGGATCGTGGTGACATCAGTCAGCAAATCGAGCAGGGCCTTCTCGGTTG
GCCTTCGTCCGGGCGATGTGGTCATATCGGTCGACAAAAAGCCGGTGGATTCGGTTGCGGCATTCAATGCAATCGTCAAA
AACAAGAAAAGGGGCGATCTGCTCTTCCTGTTGGTTGAGCGCGGATGGAGTCGGATGTATTTTGCGTTTAATCTGTAA

Upstream 100 bases:

>100_bases
ATTTGAATACGAAGAGACCATGAACAAGATGAGAGCAGGCCTGACGGCTCTTGAAAGTATTGAGACCTTTGTCTGATAAA
CTTTTAAACCGAAGACAGCT

Downstream 100 bases:

>100_bases
TGCCCTTTGCTCGCAGGATAAAGTTTTCTAAATTCTTTTAACAGAAGTAAAGTCAGCCAGGCTGCTGACTTTACTTTTTT
TGTTTGCCAAACCATTGTTG

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MKKKLTMLKSAALVSVGITAGALAFSNLDFSFNGGGNNGFMVSSHPNSSIAAETLRNHPIRTLNDLNDAFVDIAESATPS
VVTIYTETEVDRRIMTPFDFFGKSFGEMFDFPLPEEPNVRKEVIHGLGSGVIVSQDGYILTNNHVIDQAGSIAVMTSDNR
KFKAKIVGTDPRTDLAVLKISGSGLKPIAFGDSDKLRVGEWVLAIGSPLGENLARTVTQGIVSAKGRVNVGVADYENFIQ
TDAAINPGNSGGPLVNIGGELVGINTAIASRTGGFEGIGFAVPSNMAYRVYTSLVKNGKVERGYLGVTIQDIDENIAKGL
QLKSPEGVLVGTVMQGGPAARAGLKSGDVILEFNGRKVNSAAELRNRIAAMAPGSSAAIRINRDGAILTLNARLESLPDN
ATASARSTESKNELLGFSVAPLTPELAGRLNLKADSRRIVVTSVSKSSRAFSVGLRPGDVVISVDKKPVDSVAAFNAIVK
NKKRGDLLFLLVERGWSRMYFAFNL

Sequences:

>Translated_505_residues
MKKKLTMLKSAALVSVGITAGALAFSNLDFSFNGGGNNGFMVSSHPNSSIAAETLRNHPIRTLNDLNDAFVDIAESATPS
VVTIYTETEVDRRIMTPFDFFGKSFGEMFDFPLPEEPNVRKEVIHGLGSGVIVSQDGYILTNNHVIDQAGSIAVMTSDNR
KFKAKIVGTDPRTDLAVLKISGSGLKPIAFGDSDKLRVGEWVLAIGSPLGENLARTVTQGIVSAKGRVNVGVADYENFIQ
TDAAINPGNSGGPLVNIGGELVGINTAIASRTGGFEGIGFAVPSNMAYRVYTSLVKNGKVERGYLGVTIQDIDENIAKGL
QLKSPEGVLVGTVMQGGPAARAGLKSGDVILEFNGRKVNSAAELRNRIAAMAPGSSAAIRINRDGAILTLNARLESLPDN
ATASARSTESKNELLGFSVAPLTPELAGRLNLKADSRRIVVTSVSKSSRAFSVGLRPGDVVISVDKKPVDSVAAFNAIVK
NKKRGDLLFLLVERGWSRMYFAFNL
>Mature_505_residues
MKKKLTMLKSAALVSVGITAGALAFSNLDFSFNGGGNNGFMVSSHPNSSIAAETLRNHPIRTLNDLNDAFVDIAESATPS
VVTIYTETEVDRRIMTPFDFFGKSFGEMFDFPLPEEPNVRKEVIHGLGSGVIVSQDGYILTNNHVIDQAGSIAVMTSDNR
KFKAKIVGTDPRTDLAVLKISGSGLKPIAFGDSDKLRVGEWVLAIGSPLGENLARTVTQGIVSAKGRVNVGVADYENFIQ
TDAAINPGNSGGPLVNIGGELVGINTAIASRTGGFEGIGFAVPSNMAYRVYTSLVKNGKVERGYLGVTIQDIDENIAKGL
QLKSPEGVLVGTVMQGGPAARAGLKSGDVILEFNGRKVNSAAELRNRIAAMAPGSSAAIRINRDGAILTLNARLESLPDN
ATASARSTESKNELLGFSVAPLTPELAGRLNLKADSRRIVVTSVSKSSRAFSVGLRPGDVVISVDKKPVDSVAAFNAIVK
NKKRGDLLFLLVERGWSRMYFAFNL

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=267, Percent_Identity=37.8277153558052, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI7019477, Length=297, Percent_Identity=36.3636363636364, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI24308541, Length=279, Percent_Identity=34.7670250896057, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI22129776, Length=266, Percent_Identity=35.3383458646617, Blast_Score=139, Evalue=7e-33,
Organism=Escherichia coli, GI1789629, Length=505, Percent_Identity=37.8217821782178, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI1786356, Length=475, Percent_Identity=38.1052631578947, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1789630, Length=279, Percent_Identity=43.010752688172, Blast_Score=203, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24646839, Length=263, Percent_Identity=36.5019011406844, Blast_Score=146, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 53529; Mature: 53529

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKLTMLKSAALVSVGITAGALAFSNLDFSFNGGGNNGFMVSSHPNSSIAAETLRNHPI
CCCHHHHHHHHHEEEECCHHCEEEEECCCEEECCCCCCCEEEECCCCCCHHHHHHHCCCC
RTLNDLNDAFVDIAESATPSVVTIYTETEVDRRIMTPFDFFGKSFGEMFDFPLPEEPNVR
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEECCCHHHHHHHHHHHCCCCCCCCCCHH
KEVIHGLGSGVIVSQDGYILTNNHVIDQAGSIAVMTSDNRKFKAKIVGTDPRTDLAVLKI
HHHHHHCCCCEEEECCCEEEECCEEECCCCCEEEEECCCCEEEEEEECCCCCCCEEEEEE
SGSGLKPIAFGDSDKLRVGEWVLAIGSPLGENLARTVTQGIVSAKGRVNVGVADYENFIQ
CCCCCCEEEECCCCCEEECEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHH
TDAAINPGNSGGPLVNIGGELVGINTAIASRTGGFEGIGFAVPSNMAYRVYTSLVKNGKV
HCCCCCCCCCCCCEEEECCEEEEEEHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCC
ERGYLGVTIQDIDENIAKGLQLKSPEGVLVGTVMQGGPAARAGLKSGDVILEFNGRKVNS
CCCEEEEEEEHHHHHHHCCCEECCCCCEEEEEEECCCCHHHCCCCCCCEEEEECCCEECH
AAELRNRIAAMAPGSSAAIRINRDGAILTLNARLESLPDNATASARSTESKNELLGFSVA
HHHHHHHHEEECCCCCEEEEEECCCEEEEEECCHHCCCCCCCCCCCCCCCCCCEEEEEEC
PLTPELAGRLNLKADSRRIVVTSVSKSSRAFSVGLRPGDVVISVDKKPVDSVAAFNAIVK
CCCHHHHCEEEEECCCCEEEEEECCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHC
NKKRGDLLFLLVERGWSRMYFAFNL
CCCCCCEEEEEEECCCCEEEEEEEC
>Mature Secondary Structure
MKKKLTMLKSAALVSVGITAGALAFSNLDFSFNGGGNNGFMVSSHPNSSIAAETLRNHPI
CCCHHHHHHHHHEEEECCHHCEEEEECCCEEECCCCCCCEEEECCCCCCHHHHHHHCCCC
RTLNDLNDAFVDIAESATPSVVTIYTETEVDRRIMTPFDFFGKSFGEMFDFPLPEEPNVR
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEECCCHHHHHHHHHHHCCCCCCCCCCHH
KEVIHGLGSGVIVSQDGYILTNNHVIDQAGSIAVMTSDNRKFKAKIVGTDPRTDLAVLKI
HHHHHHCCCCEEEECCCEEEECCEEECCCCCEEEEECCCCEEEEEEECCCCCCCEEEEEE
SGSGLKPIAFGDSDKLRVGEWVLAIGSPLGENLARTVTQGIVSAKGRVNVGVADYENFIQ
CCCCCCEEEECCCCCEEECEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHH
TDAAINPGNSGGPLVNIGGELVGINTAIASRTGGFEGIGFAVPSNMAYRVYTSLVKNGKV
HCCCCCCCCCCCCEEEECCEEEEEEHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCC
ERGYLGVTIQDIDENIAKGLQLKSPEGVLVGTVMQGGPAARAGLKSGDVILEFNGRKVNS
CCCEEEEEEEHHHHHHHCCCEECCCCCEEEEEEECCCCHHHCCCCCCCEEEEECCCEECH
AAELRNRIAAMAPGSSAAIRINRDGAILTLNARLESLPDNATASARSTESKNELLGFSVA
HHHHHHHHEEECCCCCEEEEEECCCEEEEEECCHHCCCCCCCCCCCCCCCCCCEEEEEEC
PLTPELAGRLNLKADSRRIVVTSVSKSSRAFSVGLRPGDVVISVDKKPVDSVAAFNAIVK
CCCHHHHCEEEEECCCCEEEEEECCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHC
NKKRGDLLFLLVERGWSRMYFAFNL
CCCCCCEEEEEEECCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]