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The map label for this gene is lepB [H]

Identifier: 21674271

GI number: 21674271

Start: 1361436

End: 1362278

Strand: Reverse

Name: lepB [H]

Synonym: CT1450

Alternate gene names: 21674271

Gene position: 1362278-1361436 (Counterclockwise)

Preceding gene: 21674272

Following gene: 21674269

Centisome position: 63.22

GC content: 52.43

Gene sequence:

>843_bases
GTGAAAAAACAGAACACGACCCCCAACGGAAAAAACGGCAAGACGCAATCGCGTGAATGGTTCGAGGCTCTTGTCATTGC
CGCCCTGGTGGCGGCAATTCTCAGGATGTTTGTTATAGAATCATACAGAATTCCGACGGGTTCGATGGAAAAAACGCTGC
TTGCCGGCGATTTCCTTTTTGTCAACAAGTTTGTCTATGGTGCCAAGGTGCCTTTTACTGACATCTCTCTGCCCAAAGTT
CATGATGTCAGACGAGGTGATATCATCGTCTTCAAGTTTCCCCGCGATCGGAGCCTGAACTACATCAAGCGCTGTATCGC
CTTGCCGGGAGACAATCTTGAAATCCGGAACCAGCAGGTTTACATCAATGGCAAAGGGATGCAGTTACCGCCTCACGCTC
AGTTCATTGGCACAAAAATGCCGGCAGGCGTGCCCGAGTTCCAGATTTTCCCGAGCATGTCCGATTACAACAAGGACAAT
TACGGCCCTATCCATATTCCGCGCAGTGGCGATGTGATCACGCTCACCTCAGCGACGCTTCCGCTCTATCGCGACCTGAT
CGCCTATGAGGGGCATACGGTCAGCCTGGTCGGCGATCAGGTGTTTCTCGATGGCCAGGCGGCAAATCGCTACACCGTGA
GCCGCAACTACTATTTCGCTATGGGCGATAACCGTGACAACAGCCTCGACAGCCGTTACTGGGGTTTTCTGCCGGAAAAC
GATATTGTGGGCCAGGCCATGATGGTGTACTGGTCATGGGATCCCGATCTGCCGCTGCTGTTCGATCCGGTTGAAAAGAT
TGCCTCTATTCGGTGGAATCGCATCGGTTTGGCTGTTCACTGA

Upstream 100 bases:

>100_bases
CCGTTTAATCAGCATGGCTGCGCTGGATACCACTCATCTTGACGTCTTACAGATGGTGCGTACGATTGAGCATTCCAGCA
ACGTCTAAAAAAAGCACAGT

Downstream 100 bases:

>100_bases
ACGCTGTTCAAAAGAATGACTCGACTGACTTTGCGCAGGGTAAGCAGTTCGTCTGCCGGTTTGAAGGGGAAAAGGCTGAG
GTCGGCGCATTCGATACGAA

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKKQNTTPNGKNGKTQSREWFEALVIAALVAAILRMFVIESYRIPTGSMEKTLLAGDFLFVNKFVYGAKVPFTDISLPKV
HDVRRGDIIVFKFPRDRSLNYIKRCIALPGDNLEIRNQQVYINGKGMQLPPHAQFIGTKMPAGVPEFQIFPSMSDYNKDN
YGPIHIPRSGDVITLTSATLPLYRDLIAYEGHTVSLVGDQVFLDGQAANRYTVSRNYYFAMGDNRDNSLDSRYWGFLPEN
DIVGQAMMVYWSWDPDLPLLFDPVEKIASIRWNRIGLAVH

Sequences:

>Translated_280_residues
MKKQNTTPNGKNGKTQSREWFEALVIAALVAAILRMFVIESYRIPTGSMEKTLLAGDFLFVNKFVYGAKVPFTDISLPKV
HDVRRGDIIVFKFPRDRSLNYIKRCIALPGDNLEIRNQQVYINGKGMQLPPHAQFIGTKMPAGVPEFQIFPSMSDYNKDN
YGPIHIPRSGDVITLTSATLPLYRDLIAYEGHTVSLVGDQVFLDGQAANRYTVSRNYYFAMGDNRDNSLDSRYWGFLPEN
DIVGQAMMVYWSWDPDLPLLFDPVEKIASIRWNRIGLAVH
>Mature_280_residues
MKKQNTTPNGKNGKTQSREWFEALVIAALVAAILRMFVIESYRIPTGSMEKTLLAGDFLFVNKFVYGAKVPFTDISLPKV
HDVRRGDIIVFKFPRDRSLNYIKRCIALPGDNLEIRNQQVYINGKGMQLPPHAQFIGTKMPAGVPEFQIFPSMSDYNKDN
YGPIHIPRSGDVITLTSATLPLYRDLIAYEGHTVSLVGDQVFLDGQAANRYTVSRNYYFAMGDNRDNSLDSRYWGFLPEN
DIVGQAMMVYWSWDPDLPLLFDPVEKIASIRWNRIGLAVH

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=254, Percent_Identity=35.0393700787402, Blast_Score=130, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 31803; Mature: 31803

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQNTTPNGKNGKTQSREWFEALVIAALVAAILRMFVIESYRIPTGSMEKTLLAGDFLF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEECCHHE
VNKFVYGAKVPFTDISLPKVHDVRRGDIIVFKFPRDRSLNYIKRCIALPGDNLEIRNQQV
EHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEECCEE
YINGKGMQLPPHAQFIGTKMPAGVPEFQIFPSMSDYNKDNYGPIHIPRSGDVITLTSATL
EECCCCCCCCCCHHHHCCCCCCCCCCEEEECCHHHCCCCCCCCEEECCCCCEEEEECCCH
PLYRDLIAYEGHTVSLVGDQVFLDGQAANRYTVSRNYYFAMGDNRDNSLDSRYWGFLPEN
HHHHHHHHHCCCEEEEECCEEEECCCCCCEEEEECCEEEEECCCCCCCCCCCEECCCCCC
DIVGQAMMVYWSWDPDLPLLFDPVEKIASIRWNRIGLAVH
CCCCEEEEEEEECCCCCCEEECHHHHHHHCCCCEEEEEEC
>Mature Secondary Structure
MKKQNTTPNGKNGKTQSREWFEALVIAALVAAILRMFVIESYRIPTGSMEKTLLAGDFLF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEECCHHE
VNKFVYGAKVPFTDISLPKVHDVRRGDIIVFKFPRDRSLNYIKRCIALPGDNLEIRNQQV
EHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEECCEE
YINGKGMQLPPHAQFIGTKMPAGVPEFQIFPSMSDYNKDNYGPIHIPRSGDVITLTSATL
EECCCCCCCCCCHHHHCCCCCCCCCCEEEECCHHHCCCCCCCCEEECCCCCEEEEECCCH
PLYRDLIAYEGHTVSLVGDQVFLDGQAANRYTVSRNYYFAMGDNRDNSLDSRYWGFLPEN
HHHHHHHHHCCCEEEEECCEEEECCCCCCEEEEECCEEEEECCCCCCCCCCCEECCCCCC
DIVGQAMMVYWSWDPDLPLLFDPVEKIASIRWNRIGLAVH
CCCCEEEEEEEECCCCCCEEECHHHHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]