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The map label for this gene is trpF

Identifier: 21673548

GI number: 21673548

Start: 700418

End: 701083

Strand: Reverse

Name: trpF

Synonym: CT0718

Alternate gene names: 21673548

Gene position: 701083-700418 (Counterclockwise)

Preceding gene: 21673551

Following gene: 21673544

Centisome position: 32.53

GC content: 60.81

Gene sequence:

>666_bases
ATGACGAAAATCAAGATCTGCGGCATCACCCGCGCGCAAGATGCCCTGGAAGCAGCGCTCGCTGGTGCCGACGCCCTCGG
CTTCAACTTCAGCCGCAAAAGCCCCCGCAGGATTGATGCCGAAACGGCCCGAAGCATTATCGCCGGATTGCCTCCGCTGG
TCACGCCGGTCGGTGTCTTCGTTGAGCAGTCGCCCGAGGAGATCAACGACATCTGCCGCCACTGCGGCTTGCTGGTCGCG
CAACTCCATTCGGATGACTACGATGCTGAAAAGACTTTGCAGATCAAGGGCGTTCGGGTGATCCGGGTGTTCCGGCCAAG
TCCGGGTTTTGAGGTTTCGCAGGTGAGAAAGTTCACTGAAAAAACGGGATGCAGGAGCTTTCTGTTCGACGCTTACAGCC
CGGCGATGGCTGGCGGCACCGGCCAGAGCATCGAGGCACAAACAGCGGGGTCGCTGTTTGATGAAACTCGTGATTTCAGC
TGGGCGCTGCTCGCGGGCGGACTGAAGCCGGAGAACGTCGGTGACGCCGTGACGCTGATAAGGCCCTGGGGCGTCGATAC
GGCCAGCGGCGTCGAGTCGGGACCAGGCATCAAGGATGCGCTGAAGATCAGGCAGTTCGTCGAAGCAGTGCGCAAGGCCG
ACCGGTCGCTCACGAATTGCTGCTGA

Upstream 100 bases:

>100_bases
TAGCTTAAAACACAAAATGAAGCCCGAATGAGCGCGAAAAAGAGAGCGGGCTTTTTTACCTTTCTATTCAGCTTTCTGTA
ACATACATTCCGGCTCGCTC

Downstream 100 bases:

>100_bases
TGTGCTGAAGCACAATCTCCGCAGCAGTTTGTGGAAGCTCCAGCGTGATGAGATGGCCGCAATCCGGCACGCAGAGATAG
CTGCCTGATGGGGTCATTTC

Product: N-(5'-phosphoribosyl)-anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MTKIKICGITRAQDALEAALAGADALGFNFSRKSPRRIDAETARSIIAGLPPLVTPVGVFVEQSPEEINDICRHCGLLVA
QLHSDDYDAEKTLQIKGVRVIRVFRPSPGFEVSQVRKFTEKTGCRSFLFDAYSPAMAGGTGQSIEAQTAGSLFDETRDFS
WALLAGGLKPENVGDAVTLIRPWGVDTASGVESGPGIKDALKIRQFVEAVRKADRSLTNCC

Sequences:

>Translated_221_residues
MTKIKICGITRAQDALEAALAGADALGFNFSRKSPRRIDAETARSIIAGLPPLVTPVGVFVEQSPEEINDICRHCGLLVA
QLHSDDYDAEKTLQIKGVRVIRVFRPSPGFEVSQVRKFTEKTGCRSFLFDAYSPAMAGGTGQSIEAQTAGSLFDETRDFS
WALLAGGLKPENVGDAVTLIRPWGVDTASGVESGPGIKDALKIRQFVEAVRKADRSLTNCC
>Mature_220_residues
TKIKICGITRAQDALEAALAGADALGFNFSRKSPRRIDAETARSIIAGLPPLVTPVGVFVEQSPEEINDICRHCGLLVAQ
LHSDDYDAEKTLQIKGVRVIRVFRPSPGFEVSQVRKFTEKTGCRSFLFDAYSPAMAGGTGQSIEAQTAGSLFDETRDFSW
ALLAGGLKPENVGDAVTLIRPWGVDTASGVESGPGIKDALKIRQFVEAVRKADRSLTNCC

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=218, Percent_Identity=30.7339449541284, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320210, Length=223, Percent_Identity=33.1838565022422, Blast_Score=75, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_CHLTE (Q8KEH1)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661613.1
- ProteinModelPortal:   Q8KEH1
- SMR:   Q8KEH1
- GeneID:   1006346
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0718
- NMPDR:   fig|194439.1.peg.707
- TIGR:   CT0718
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- ProtClustDB:   CLSK637437
- BioCyc:   CTEP194439:CT_0718-MONOMER
- BRENDA:   5.3.1.24
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 23801; Mature: 23670

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIKICGITRAQDALEAALAGADALGFNFSRKSPRRIDAETARSIIAGLPPLVTPVGVF
CCEEEEECCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
VEQSPEEINDICRHCGLLVAQLHSDDYDAEKTLQIKGVRVIRVFRPSPGFEVSQVRKFTE
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEEEEEECCCCCCCHHHHHHHHH
KTGCRSFLFDAYSPAMAGGTGQSIEAQTAGSLFDETRDFSWALLAGGLKPENVGDAVTLI
HHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEEEE
RPWGVDTASGVESGPGIKDALKIRQFVEAVRKADRSLTNCC
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKIKICGITRAQDALEAALAGADALGFNFSRKSPRRIDAETARSIIAGLPPLVTPVGVF
CEEEEECCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
VEQSPEEINDICRHCGLLVAQLHSDDYDAEKTLQIKGVRVIRVFRPSPGFEVSQVRKFTE
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEEEEEECCCCCCCHHHHHHHHH
KTGCRSFLFDAYSPAMAGGTGQSIEAQTAGSLFDETRDFSWALLAGGLKPENVGDAVTLI
HHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEEEE
RPWGVDTASGVESGPGIKDALKIRQFVEAVRKADRSLTNCC
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901