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The map label for this gene is sahH [H]

Identifier: 21673551

GI number: 21673551

Start: 703037

End: 704452

Strand: Reverse

Name: sahH [H]

Synonym: CT0721

Alternate gene names: 21673551

Gene position: 704452-703037 (Counterclockwise)

Preceding gene: 161485728

Following gene: 21673548

Centisome position: 32.69

GC content: 59.18

Gene sequence:

>1416_bases
ATGACAACAGAAGCAGCAGTGCTCGACTACAAGGTGGCCGATATTTCGCTTGCCGAATGGGGCCGCAAAGAGATCGAAAT
CGCTGAAAAAGAGATGCCGGGCCTGATGGCTACGCGCAAGAAATACGAAGGCAAGAAGCCACTGGCAGGCGCCCGCATCG
CTGGCTCCCTGCACATGACCATCCAGACTGCCGTCCTGATCGAAACGCTCGTCGAACTCGGCGCGGACGTGCGCTGGGCG
AGCTGTAACATCTTCTCGACGCAGGATCACGCCGCAGCGGCTATCGCTGCCGCCGGTGTGCCGGTGTTCGCCTGGAAGGG
CGAGACCCTCGACGAGTACTGGTGGTGCACCCGTCAGATTCTTGAGTTTGAAGGCGGCCTCGGCCCGAACCTCATCGTCG
ATGACGGCGGCGACGCAACCCTGATGATCCACTTCGGCTACAAGATCGAGAATGATCCTTCGATGCTCGACAAAACCCCG
GGCAACGCCGAAGAGAAAGCGCTCCTCCAGCAGCTCAAGGCTGTCTTCGCCGAAGACAACCAGCGCTGGCACAAGGTTGC
CGCCGGCATGAAGGGTGTCTCCGAAGAGACCACCACCGGCGTGCATCGCCTCTACCAGATGATGGAAAAGGGCGAACTGC
TTTTCCCGGCCATCAACGTCAACGACTCGGTCACCAAGTCGAAGTTCGACAACCTTTACGGCTGCAGAGAGTCGCTCGCT
GACGGCATCAAGCGCGCCACGGACGTCATGATCGCCGGCAAGGTGGTCGTTGTGCTTGGCTACGGCGACGTCGGCAAAGG
CTGCGCCCACTCGATGCGCTCCTACGGTGCTCGCGTGATCGTCACCGAGATCGACCCGATCTGCGCATTGCAGGCCGCCA
TGGAGGGTTTTGAAGTCACCACCATGGAAGAGGCTGTCAAGGAAGGCAACATCTTCGTCACCGCCACCGGTAACAAGGAT
GTGATCACCCTCGACCACATCAAGCAGATGCGCGACGAAGCGATTGTCTGCAACATCGGCCACTTCGACAACGAAATCCA
GGTCGATGCGCTCAACAACTTCAAGGGCGCGACCAGAATCAACATCAAGCCGCAGGTTGACAAGTATGTCTTCGAAAACG
GCAACTGCATTTACCTGCTCGCCGAAGGCCGCCTGGTGAACCTCGGCTGCGCCACTGGCCACCCGTCGTTCGTGATGAGC
AACTCCTTCACCAACCAGACGCTCGCCCAGATCGAACTCTGGCAGAACGACTACAAAGTTGGTGTCTATCGCCTGCCGAA
GAAGCTTGACGAAGAGGTTGCGCGGCTGCACCTCGGCCAGATTGGCGCCAAGCTGACCACGCTCACCAAAGAGCAGGCCG
ACTACATCGGTGTACCGGTCGAAGGCCCCTACAAGCCCGAACACTACCGCTACTGA

Upstream 100 bases:

>100_bases
CCGCTTTGGGCCTCTGATCAAAAACCCTCTGAAAGCCTCTGCGGACTTGCGTCCCGGAGGCTTTCCCTTATTCTGAAAAA
ACTGAAAACACGCTGACATC

Downstream 100 bases:

>100_bases
TCTGCGGTTCACCGCTGGATCAACGCCAAAAAAGCCGCCCGAAAAAGGGCGGCTTTTTTTGTTTAAAAATCGGACAGATC
AGACGAATCAGTCAGATCCA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTTEAAVLDYKVADISLAEWGRKEIEIAEKEMPGLMATRKKYEGKKPLAGARIAGSLHMTIQTAVLIETLVELGADVRWA
SCNIFSTQDHAAAAIAAAGVPVFAWKGETLDEYWWCTRQILEFEGGLGPNLIVDDGGDATLMIHFGYKIENDPSMLDKTP
GNAEEKALLQQLKAVFAEDNQRWHKVAAGMKGVSEETTTGVHRLYQMMEKGELLFPAINVNDSVTKSKFDNLYGCRESLA
DGIKRATDVMIAGKVVVVLGYGDVGKGCAHSMRSYGARVIVTEIDPICALQAAMEGFEVTTMEEAVKEGNIFVTATGNKD
VITLDHIKQMRDEAIVCNIGHFDNEIQVDALNNFKGATRINIKPQVDKYVFENGNCIYLLAEGRLVNLGCATGHPSFVMS
NSFTNQTLAQIELWQNDYKVGVYRLPKKLDEEVARLHLGQIGAKLTTLTKEQADYIGVPVEGPYKPEHYRY

Sequences:

>Translated_471_residues
MTTEAAVLDYKVADISLAEWGRKEIEIAEKEMPGLMATRKKYEGKKPLAGARIAGSLHMTIQTAVLIETLVELGADVRWA
SCNIFSTQDHAAAAIAAAGVPVFAWKGETLDEYWWCTRQILEFEGGLGPNLIVDDGGDATLMIHFGYKIENDPSMLDKTP
GNAEEKALLQQLKAVFAEDNQRWHKVAAGMKGVSEETTTGVHRLYQMMEKGELLFPAINVNDSVTKSKFDNLYGCRESLA
DGIKRATDVMIAGKVVVVLGYGDVGKGCAHSMRSYGARVIVTEIDPICALQAAMEGFEVTTMEEAVKEGNIFVTATGNKD
VITLDHIKQMRDEAIVCNIGHFDNEIQVDALNNFKGATRINIKPQVDKYVFENGNCIYLLAEGRLVNLGCATGHPSFVMS
NSFTNQTLAQIELWQNDYKVGVYRLPKKLDEEVARLHLGQIGAKLTTLTKEQADYIGVPVEGPYKPEHYRY
>Mature_470_residues
TTEAAVLDYKVADISLAEWGRKEIEIAEKEMPGLMATRKKYEGKKPLAGARIAGSLHMTIQTAVLIETLVELGADVRWAS
CNIFSTQDHAAAAIAAAGVPVFAWKGETLDEYWWCTRQILEFEGGLGPNLIVDDGGDATLMIHFGYKIENDPSMLDKTPG
NAEEKALLQQLKAVFAEDNQRWHKVAAGMKGVSEETTTGVHRLYQMMEKGELLFPAINVNDSVTKSKFDNLYGCRESLAD
GIKRATDVMIAGKVVVVLGYGDVGKGCAHSMRSYGARVIVTEIDPICALQAAMEGFEVTTMEEAVKEGNIFVTATGNKDV
ITLDHIKQMRDEAIVCNIGHFDNEIQVDALNNFKGATRINIKPQVDKYVFENGNCIYLLAEGRLVNLGCATGHPSFVMSN
SFTNQTLAQIELWQNDYKVGVYRLPKKLDEEVARLHLGQIGAKLTTLTKEQADYIGVPVEGPYKPEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=466, Percent_Identity=64.3776824034335, Blast_Score=581, Evalue=1e-166,
Organism=Homo sapiens, GI239937451, Length=442, Percent_Identity=64.027149321267, Blast_Score=547, Evalue=1e-156,
Organism=Homo sapiens, GI24308043, Length=466, Percent_Identity=50.6437768240343, Blast_Score=463, Evalue=1e-130,
Organism=Homo sapiens, GI195539337, Length=466, Percent_Identity=50.6437768240343, Blast_Score=463, Evalue=1e-130,
Organism=Homo sapiens, GI298286489, Length=466, Percent_Identity=50.6437768240343, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI195539349, Length=466, Percent_Identity=50.6437768240343, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI21361647, Length=466, Percent_Identity=48.9270386266094, Blast_Score=435, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17506425, Length=467, Percent_Identity=63.169164882227, Blast_Score=584, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6320882, Length=484, Percent_Identity=59.0909090909091, Blast_Score=541, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24642172, Length=464, Percent_Identity=65.948275862069, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24656245, Length=455, Percent_Identity=50.3296703296703, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45553387, Length=465, Percent_Identity=49.8924731182796, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI45553385, Length=464, Percent_Identity=49.7844827586207, Blast_Score=427, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51950; Mature: 51819

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEAAVLDYKVADISLAEWGRKEIEIAEKEMPGLMATRKKYEGKKPLAGARIAGSLHMT
CCCCCEEEEEEEEEEEHHHCCCHHEEHHHHHCCCHHHHHHHCCCCCCCCCCEEECEEEEH
IQTAVLIETLVELGADVRWASCNIFSTQDHAAAAIAAAGVPVFAWKGETLDEYWWCTRQI
HHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
LEFEGGLGPNLIVDDGGDATLMIHFGYKIENDPSMLDKTPGNAEEKALLQQLKAVFAEDN
HHHCCCCCCCEEEECCCCEEEEEEECEEECCCCHHHCCCCCCHHHHHHHHHHHHHHHCCC
QRWHKVAAGMKGVSEETTTGVHRLYQMMEKGELLFPAINVNDSVTKSKFDNLYGCRESLA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
DGIKRATDVMIAGKVVVVLGYGDVGKGCAHSMRSYGARVIVTEIDPICALQAAMEGFEVT
HHHHHHHHEEEECEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCEEE
TMEEAVKEGNIFVTATGNKDVITLDHIKQMRDEAIVCNIGHFDNEIQVDALNNFKGATRI
HHHHHHHCCCEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCEEE
NIKPQVDKYVFENGNCIYLLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELWQNDYKV
ECCCCCCHHEEECCCEEEEEECCEEEEEEECCCCCCEEEECCCCCCHHEEEEEECCCCEE
GVYRLPKKLDEEVARLHLGQIGAKLTTLTKEQADYIGVPVEGPYKPEHYRY
EHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTEAAVLDYKVADISLAEWGRKEIEIAEKEMPGLMATRKKYEGKKPLAGARIAGSLHMT
CCCCEEEEEEEEEEEHHHCCCHHEEHHHHHCCCHHHHHHHCCCCCCCCCCEEECEEEEH
IQTAVLIETLVELGADVRWASCNIFSTQDHAAAAIAAAGVPVFAWKGETLDEYWWCTRQI
HHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
LEFEGGLGPNLIVDDGGDATLMIHFGYKIENDPSMLDKTPGNAEEKALLQQLKAVFAEDN
HHHCCCCCCCEEEECCCCEEEEEEECEEECCCCHHHCCCCCCHHHHHHHHHHHHHHHCCC
QRWHKVAAGMKGVSEETTTGVHRLYQMMEKGELLFPAINVNDSVTKSKFDNLYGCRESLA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
DGIKRATDVMIAGKVVVVLGYGDVGKGCAHSMRSYGARVIVTEIDPICALQAAMEGFEVT
HHHHHHHHEEEECEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCEEE
TMEEAVKEGNIFVTATGNKDVITLDHIKQMRDEAIVCNIGHFDNEIQVDALNNFKGATRI
HHHHHHHCCCEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCEEE
NIKPQVDKYVFENGNCIYLLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELWQNDYKV
ECCCCCCHHEEECCCEEEEEECCEEEEEEECCCCCCEEEECCCCCCHHEEEEEECCCCEE
GVYRLPKKLDEEVARLHLGQIGAKLTTLTKEQADYIGVPVEGPYKPEHYRY
EHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA