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The map label for this gene is mutS2 [H]

Identifier: 21673173

GI number: 21673173

Start: 349441

End: 351837

Strand: Direct

Name: mutS2 [H]

Synonym: CT0334

Alternate gene names: 21673173

Gene position: 349441-351837 (Clockwise)

Preceding gene: 21673172

Following gene: 21673174

Centisome position: 16.22

GC content: 62.41

Gene sequence:

>2397_bases
ATGGACGAAACGACAGTGACAGAATCGGTCTCCCTCTTCAGAAAGCTTGAGTTTGACAAGGTGGCCCGTCATGCGGCGGG
GTTCTGCATTTCGGCGATGGGGAGCGATTTGCTGATGGAGATGGGGCTTCCCGACGAGTGCGAGCGGGAACTGGTGCGGG
TGCTTGAGCTGAAGAACTTTCTGCTCGAAGGCGAGCCGCTGCCGTTTTCGCGCCTGCCCGACACGCGCTTTCTGCTCAGC
AAGCTCGAAGTGCTCGACAGCTGGCTCAATGCCGCCGAGCTGCTCGATATTTTCTACCTGCTGCAAAGCTCCGCGCAGCT
TCGCAAGTTCATGTTTACCAGCCGCGAGCGATTCCCGGCACTGAACGAATTCACCATCCGCATCTGGCTCGAAAAGAGCA
TCCAGTATTCGATTTCGCAGGCCATCGACGAGCGGGCTGTGGTGCGCGATACGGCAAGCGACGCGCTCTACGAAATCCGC
AAAAAACTCGGCGAGGCGCGCGACGGATTGCGCCGCAAAATGGAGCGCATCCTGCGCCGCTGCCAGAACGAAGGGTGGCT
GATGGAGGAGACCGTGGCGCTGAAAAACGGTCGGCAGGTGCTGCCGCTTCGGGTCGAGAACAAGCACCGGCTGCCCGGCT
ACATCCAGGACTACTCACAGACCGGCCAGACGGTGTTCGTCGAACCCGCCGAAACGCTCGAAATCAGCAATCGCATCCAG
GAACTCGAAATCGCCGAGCGGCGCGAGATCGAGCGCATTCTCAAGGCGCTCTCCGACGGCGTGCGGCAGGAGCTGGAGAA
TGTGCGCCATAACGAGCGAATCATGGCGGCGTTCGACTCGCTTTACGCACGGGCGCGGCTCGCCGTCGAGACCGGTTCGA
TGCTGCCGAAAATCTCGGCGGGGCGGCGGCTGAAGATCGTCAAGGGCTACCATCCGTGGCTCTTCATTTCGCACGGTTTC
TCGAAGGAGAAAGTCTTTCCGCTCGACATGGAGCTTGACGAAAACGAACAGGTGCTGGTGATTTCGGGGCCGAACGCGGG
CGGCAAGTCGGTGGCGATGAAGACCGTCGGGCTGCTGGTCTGCATGTTGCGCCACGGCTATCTCGTGCCGTGCAGCGAGA
GTTCGGAGTTCCCGCTTTTCAACAGCATCTTCATCGAAATCGGCGACGAGCAGTCGATCGAAAACGATCTCTCGACCTTC
AGCTCGCACCTCTCGGCGATCCGCGACATCCTTGACCACGCGCAGCCCGACAGCCTCGTTTTGATCGACGAACTCTGCTC
CGGCACCGACGTCGAGGAGGGGAGCGCCATCGCCCGCGCGGTGATTGAGGAGCTGCTTGAACGCGGCGTCAAGACCATCG
TCACCACCCATCTCGGCGAGCTGAAGCTTTACGCCCACCGGCGCGAAGGGGTCGTCAACGGCGCGATGGAGTTCGACCGG
CACGGCCTCGCGCCGACCTTTCGCTTCCTTAAAGGCGTGCCGGGCAACAGCTTCGCCTTTGCGATGATGCGGCGCATGGG
CTTTTCGGATGAGATCGTCAACCGCGCAACAGGCTTTTTGACGACCGGTCATACCGGCTTGGAGGAGATGATCGAGGATT
TCCGGAAGTCTGCGGCGAGCAACCGCGAGCTGGAGAGGGAGCTGAGGCGCGAGCGGCTCGAAGCCGAATCGATTCGCTCG
GCCTTGACCTTGCAGCGGGCCGAACTGCGCAAAAAAATGCAGGAGCTGAAGAGCAGGGGGTATCGCGATCTCGACCGCCA
GCTCGAACAGGCGCGCAAGGAGATTCGCGATCTCGTGCGCGAGGTGAAGGAACATCCCGGCGACGATGCGACGCTGCACA
AGGCGCGGACGAAGCTGGCCGGAATGAAGCGCGAGTTGGCGGTGAAGGGGGAGCAGGTCGAGCGCGAGGTCGCGCCGCAG
GCCGACCTGAGCATCCGCCCCGGCGACACGGTTCGGATTGGCGACACCAACACCACCGGCGAGGTGGAGTCGATCCAGGG
CGACTCGGCGGTGGTGCAATGCGGCAACTTCCGGCTTACCACGGCGTTGCGCGGGCTGAAGAAGATTTCCCGTGCCGGTG
CGAAGAAGCTGCAAAAAGAGGCGGCGACGGGCGCGGCGGCGGGCAAGAGCTGGTCGGTCAAATCGTCAACGCTCGAATCG
ACGCGGCTCGACCTGCGCGGCCTCACTGGTGACGAAGCGATTGCCGAGATCGGGCGTTTCATCGACGCGCTGGCGGTGCA
CCGGATGCCCTTCGGAACCATTGTTCACGGCAAAGGTTCCGGCGCGTTGCGGCTGCGTACGGCAGAGTTTCTCAAGCAGC
ACTCGCGCGTCAAAAGCTTCCGCCTTGGCGACTGGCAGGAGGGCGGTGCGGGCGTGACCGTGGTCGAGATGCGCTGA

Upstream 100 bases:

>100_bases
CATCCCCCCAACAAAATCTCTCATTCTCAGCTTTTTCGGGATTATCTTTTATCTTGGCGGCCTGAAGCGTGAACGAAGTG
ACAACAGTGTTATGGTGAAT

Downstream 100 bases:

>100_bases
GTGCGATCAACTCATTCGCCCGGCGTATTTCAGTCAGCTTTGACAAAATGTGCAGGATGAAGTATCTTTTGCCCTTGCGA
ACGTTCGGATTGAGGAGGCA

Product: DNA mismatch binding protein MutS2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 798; Mature: 798

Protein sequence:

>798_residues
MDETTVTESVSLFRKLEFDKVARHAAGFCISAMGSDLLMEMGLPDECERELVRVLELKNFLLEGEPLPFSRLPDTRFLLS
KLEVLDSWLNAAELLDIFYLLQSSAQLRKFMFTSRERFPALNEFTIRIWLEKSIQYSISQAIDERAVVRDTASDALYEIR
KKLGEARDGLRRKMERILRRCQNEGWLMEETVALKNGRQVLPLRVENKHRLPGYIQDYSQTGQTVFVEPAETLEISNRIQ
ELEIAERREIERILKALSDGVRQELENVRHNERIMAAFDSLYARARLAVETGSMLPKISAGRRLKIVKGYHPWLFISHGF
SKEKVFPLDMELDENEQVLVISGPNAGGKSVAMKTVGLLVCMLRHGYLVPCSESSEFPLFNSIFIEIGDEQSIENDLSTF
SSHLSAIRDILDHAQPDSLVLIDELCSGTDVEEGSAIARAVIEELLERGVKTIVTTHLGELKLYAHRREGVVNGAMEFDR
HGLAPTFRFLKGVPGNSFAFAMMRRMGFSDEIVNRATGFLTTGHTGLEEMIEDFRKSAASNRELERELRRERLEAESIRS
ALTLQRAELRKKMQELKSRGYRDLDRQLEQARKEIRDLVREVKEHPGDDATLHKARTKLAGMKRELAVKGEQVEREVAPQ
ADLSIRPGDTVRIGDTNTTGEVESIQGDSAVVQCGNFRLTTALRGLKKISRAGAKKLQKEAATGAAAGKSWSVKSSTLES
TRLDLRGLTGDEAIAEIGRFIDALAVHRMPFGTIVHGKGSGALRLRTAEFLKQHSRVKSFRLGDWQEGGAGVTVVEMR

Sequences:

>Translated_798_residues
MDETTVTESVSLFRKLEFDKVARHAAGFCISAMGSDLLMEMGLPDECERELVRVLELKNFLLEGEPLPFSRLPDTRFLLS
KLEVLDSWLNAAELLDIFYLLQSSAQLRKFMFTSRERFPALNEFTIRIWLEKSIQYSISQAIDERAVVRDTASDALYEIR
KKLGEARDGLRRKMERILRRCQNEGWLMEETVALKNGRQVLPLRVENKHRLPGYIQDYSQTGQTVFVEPAETLEISNRIQ
ELEIAERREIERILKALSDGVRQELENVRHNERIMAAFDSLYARARLAVETGSMLPKISAGRRLKIVKGYHPWLFISHGF
SKEKVFPLDMELDENEQVLVISGPNAGGKSVAMKTVGLLVCMLRHGYLVPCSESSEFPLFNSIFIEIGDEQSIENDLSTF
SSHLSAIRDILDHAQPDSLVLIDELCSGTDVEEGSAIARAVIEELLERGVKTIVTTHLGELKLYAHRREGVVNGAMEFDR
HGLAPTFRFLKGVPGNSFAFAMMRRMGFSDEIVNRATGFLTTGHTGLEEMIEDFRKSAASNRELERELRRERLEAESIRS
ALTLQRAELRKKMQELKSRGYRDLDRQLEQARKEIRDLVREVKEHPGDDATLHKARTKLAGMKRELAVKGEQVEREVAPQ
ADLSIRPGDTVRIGDTNTTGEVESIQGDSAVVQCGNFRLTTALRGLKKISRAGAKKLQKEAATGAAAGKSWSVKSSTLES
TRLDLRGLTGDEAIAEIGRFIDALAVHRMPFGTIVHGKGSGALRLRTAEFLKQHSRVKSFRLGDWQEGGAGVTVVEMR
>Mature_798_residues
MDETTVTESVSLFRKLEFDKVARHAAGFCISAMGSDLLMEMGLPDECERELVRVLELKNFLLEGEPLPFSRLPDTRFLLS
KLEVLDSWLNAAELLDIFYLLQSSAQLRKFMFTSRERFPALNEFTIRIWLEKSIQYSISQAIDERAVVRDTASDALYEIR
KKLGEARDGLRRKMERILRRCQNEGWLMEETVALKNGRQVLPLRVENKHRLPGYIQDYSQTGQTVFVEPAETLEISNRIQ
ELEIAERREIERILKALSDGVRQELENVRHNERIMAAFDSLYARARLAVETGSMLPKISAGRRLKIVKGYHPWLFISHGF
SKEKVFPLDMELDENEQVLVISGPNAGGKSVAMKTVGLLVCMLRHGYLVPCSESSEFPLFNSIFIEIGDEQSIENDLSTF
SSHLSAIRDILDHAQPDSLVLIDELCSGTDVEEGSAIARAVIEELLERGVKTIVTTHLGELKLYAHRREGVVNGAMEFDR
HGLAPTFRFLKGVPGNSFAFAMMRRMGFSDEIVNRATGFLTTGHTGLEEMIEDFRKSAASNRELERELRRERLEAESIRS
ALTLQRAELRKKMQELKSRGYRDLDRQLEQARKEIRDLVREVKEHPGDDATLHKARTKLAGMKRELAVKGEQVEREVAPQ
ADLSIRPGDTVRIGDTNTTGEVESIQGDSAVVQCGNFRLTTALRGLKKISRAGAKKLQKEAATGAAAGKSWSVKSSTLES
TRLDLRGLTGDEAIAEIGRFIDALAVHRMPFGTIVHGKGSGALRLRTAEFLKQHSRVKSFRLGDWQEGGAGVTVVEMR

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=265, Percent_Identity=29.0566037735849, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI36949366, Length=158, Percent_Identity=39.2405063291139, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI4504191, Length=272, Percent_Identity=30.5147058823529, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI4557761, Length=149, Percent_Identity=34.2281879194631, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI26638666, Length=248, Percent_Identity=30.6451612903226, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI4505253, Length=248, Percent_Identity=30.6451612903226, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI26638664, Length=249, Percent_Identity=30.5220883534137, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI262231786, Length=175, Percent_Identity=34.2857142857143, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789089, Length=271, Percent_Identity=27.3062730627306, Blast_Score=96, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17508445, Length=348, Percent_Identity=23.5632183908046, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17534743, Length=246, Percent_Identity=28.0487804878049, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17539736, Length=259, Percent_Identity=24.3243243243243, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17508447, Length=121, Percent_Identity=34.7107438016529, Blast_Score=67, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321912, Length=197, Percent_Identity=31.4720812182741, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324482, Length=347, Percent_Identity=23.342939481268, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319935, Length=317, Percent_Identity=26.1829652996845, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320302, Length=224, Percent_Identity=27.2321428571429, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664545, Length=227, Percent_Identity=29.9559471365639, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24584320, Length=256, Percent_Identity=30.078125, Blast_Score=87, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 89898; Mature: 89898

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDETTVTESVSLFRKLEFDKVARHAAGFCISAMGSDLLMEMGLPDECERELVRVLELKNF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHH
LLEGEPLPFSRLPDTRFLLSKLEVLDSWLNAAELLDIFYLLQSSAQLRKFMFTSRERFPA
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LNEFTIRIWLEKSIQYSISQAIDERAVVRDTASDALYEIRKKLGEARDGLRRKMERILRR
CCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CQNEGWLMEETVALKNGRQVLPLRVENKHRLPGYIQDYSQTGQTVFVEPAETLEISNRIQ
HCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHCCCCEEEECCHHHHHHHHHHH
ELEIAERREIERILKALSDGVRQELENVRHNERIMAAFDSLYARARLAVETGSMLPKISA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GRRLKIVKGYHPWLFISHGFSKEKVFPLDMELDENEQVLVISGPNAGGKSVAMKTVGLLV
CCEEEEEECCCCEEEEECCCCCCCEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
CMLRHGYLVPCSESSEFPLFNSIFIEIGDEQSIENDLSTFSSHLSAIRDILDHAQPDSLV
HHHHCCEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LIDELCSGTDVEEGSAIARAVIEELLERGVKTIVTTHLGELKLYAHRREGVVNGAMEFDR
EHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
HGLAPTFRFLKGVPGNSFAFAMMRRMGFSDEIVNRATGFLTTGHTGLEEMIEDFRKSAAS
CCCCHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHCCEECCCCCHHHHHHHHHHHHCC
NRELERELRRERLEAESIRSALTLQRAELRKKMQELKSRGYRDLDRQLEQARKEIRDLVR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
EVKEHPGDDATLHKARTKLAGMKRELAVKGEQVEREVAPQADLSIRPGDTVRIGDTNTTG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEECCCCEEEECCCCCCC
EVESIQGDSAVVQCGNFRLTTALRGLKKISRAGAKKLQKEAATGAAAGKSWSVKSSTLES
CHHHCCCCCCEEEECCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
TRLDLRGLTGDEAIAEIGRFIDALAVHRMPFGTIVHGKGSGALRLRTAEFLKQHSRVKSF
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEHHHHHHHHHHHHHHC
RLGDWQEGGAGVTVVEMR
CCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MDETTVTESVSLFRKLEFDKVARHAAGFCISAMGSDLLMEMGLPDECERELVRVLELKNF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHH
LLEGEPLPFSRLPDTRFLLSKLEVLDSWLNAAELLDIFYLLQSSAQLRKFMFTSRERFPA
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LNEFTIRIWLEKSIQYSISQAIDERAVVRDTASDALYEIRKKLGEARDGLRRKMERILRR
CCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CQNEGWLMEETVALKNGRQVLPLRVENKHRLPGYIQDYSQTGQTVFVEPAETLEISNRIQ
HCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHCCCCEEEECCHHHHHHHHHHH
ELEIAERREIERILKALSDGVRQELENVRHNERIMAAFDSLYARARLAVETGSMLPKISA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GRRLKIVKGYHPWLFISHGFSKEKVFPLDMELDENEQVLVISGPNAGGKSVAMKTVGLLV
CCEEEEEECCCCEEEEECCCCCCCEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
CMLRHGYLVPCSESSEFPLFNSIFIEIGDEQSIENDLSTFSSHLSAIRDILDHAQPDSLV
HHHHCCEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LIDELCSGTDVEEGSAIARAVIEELLERGVKTIVTTHLGELKLYAHRREGVVNGAMEFDR
EHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
HGLAPTFRFLKGVPGNSFAFAMMRRMGFSDEIVNRATGFLTTGHTGLEEMIEDFRKSAAS
CCCCHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHCCEECCCCCHHHHHHHHHHHHCC
NRELERELRRERLEAESIRSALTLQRAELRKKMQELKSRGYRDLDRQLEQARKEIRDLVR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
EVKEHPGDDATLHKARTKLAGMKRELAVKGEQVEREVAPQADLSIRPGDTVRIGDTNTTG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEECCCCEEEECCCCCCC
EVESIQGDSAVVQCGNFRLTTALRGLKKISRAGAKKLQKEAATGAAAGKSWSVKSSTLES
CHHHCCCCCCEEEECCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
TRLDLRGLTGDEAIAEIGRFIDALAVHRMPFGTIVHGKGSGALRLRTAEFLKQHSRVKSF
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEHHHHHHHHHHHHHHC
RLGDWQEGGAGVTVVEMR
CCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA