Click here to switch to the map view.

The map label for this gene is pdhC [H]

Identifier: 15898357

GI number: 15898357

Start: 1381020

End: 1381553

Strand: Direct

Name: pdhC [H]

Synonym: SSO1530

Alternate gene names: 15898357

Gene position: 1381020-1381553 (Clockwise)

Preceding gene: 15898356

Following gene: 15898358

Centisome position: 46.15

GC content: 36.7

Gene sequence:

>534_bases
ATGAAAATTACCTATACAGATATTCTAGTTAAGGTAGTAGCTAAACTCCTCAGGGACCATCCATATTTAAACGCAACATT
AGAGGGAGATCAAATAAAGATAATTGAAGAGGTTAATATAGGAATAGCTGTGGCTTTGGATCAAGGATTAATAGTACCAG
TAATAAGGAACGCAGATACTAAGCCAATTACTGAAATAGCGAAAGAAAGTCATGAACTCGCTGATAAGGCCAGAGAGAAT
AAGTTAAACCCTGATGAAGTATCTGGAGGCACGTTTACGATAAGTAATTTAGGAATGTACGATATAGACTCATTTACACC
AATTATAAATCCTCCTCAAACTGCCATATTGGGAGTAGGTAGGATAAGAAGGGCACCAGTAGTAGTAGGCGATAACATCT
CAATTGGTTATATTATGTGGCTGAGTTTAACGTTCGATCATAGAGTGATGGATGGACATACTGCAGCCAAGTTCCTAAAA
GAGCTTACTGAAATATTAGAGGATGAAAACAAATTGAGAACGTTTCTAAGTTAG

Upstream 100 bases:

>100_bases
TGGTTCAGAGCCTTCAGACAATGGCCCAAGTAACACTAAGTATTGAGATTAATGCAAATTCGTTAGTTAAAATGAAAATG
AAATAGAGTCTAAGTATAGC

Downstream 100 bases:

>100_bases
GGGAGATTCAGTTATCCATTGTATATTCACTTTATTTTAAAGAAACTACGAAATTAACTAAATGAAGGCGACTGATTAGC
AGAGATACATGATTACTGAT

Product: dihydrolipoamide S-acetyltransferase, carboxy-end (pdhC)

Products: NA

Alternate protein names: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2 [H]

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MKITYTDILVKVVAKLLRDHPYLNATLEGDQIKIIEEVNIGIAVALDQGLIVPVIRNADTKPITEIAKESHELADKAREN
KLNPDEVSGGTFTISNLGMYDIDSFTPIINPPQTAILGVGRIRRAPVVVGDNISIGYIMWLSLTFDHRVMDGHTAAKFLK
ELTEILEDENKLRTFLS

Sequences:

>Translated_177_residues
MKITYTDILVKVVAKLLRDHPYLNATLEGDQIKIIEEVNIGIAVALDQGLIVPVIRNADTKPITEIAKESHELADKAREN
KLNPDEVSGGTFTISNLGMYDIDSFTPIINPPQTAILGVGRIRRAPVVVGDNISIGYIMWLSLTFDHRVMDGHTAAKFLK
ELTEILEDENKLRTFLS
>Mature_177_residues
MKITYTDILVKVVAKLLRDHPYLNATLEGDQIKIIEEVNIGIAVALDQGLIVPVIRNADTKPITEIAKESHELADKAREN
KLNPDEVSGGTFTISNLGMYDIDSFTPIINPPQTAILGVGRIRRAPVVVGDNISIGYIMWLSLTFDHRVMDGHTAAKFLK
ELTEILEDENKLRTFLS

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0508

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI19923748, Length=170, Percent_Identity=38.8235294117647, Blast_Score=131, Evalue=3e-31,
Organism=Homo sapiens, GI203098753, Length=177, Percent_Identity=38.4180790960452, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI203098816, Length=177, Percent_Identity=38.4180790960452, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI31711992, Length=169, Percent_Identity=40.2366863905325, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI260898739, Length=166, Percent_Identity=39.1566265060241, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI110671329, Length=171, Percent_Identity=32.7485380116959, Blast_Score=88, Evalue=3e-18,
Organism=Escherichia coli, GI1786946, Length=172, Percent_Identity=37.7906976744186, Blast_Score=133, Evalue=5e-33,
Organism=Escherichia coli, GI1786305, Length=174, Percent_Identity=37.3563218390805, Blast_Score=119, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI25146366, Length=168, Percent_Identity=40.4761904761905, Blast_Score=119, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17538894, Length=167, Percent_Identity=38.3233532934132, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17560088, Length=176, Percent_Identity=39.2045454545455, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17537937, Length=170, Percent_Identity=32.3529411764706, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320352, Length=171, Percent_Identity=40.9356725146199, Blast_Score=138, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6324258, Length=173, Percent_Identity=36.4161849710983, Blast_Score=117, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24645909, Length=168, Percent_Identity=40.4761904761905, Blast_Score=130, Evalue=4e-31,
Organism=Drosophila melanogaster, GI20129315, Length=175, Percent_Identity=36.5714285714286, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24582497, Length=175, Percent_Identity=36.5714285714286, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI18859875, Length=170, Percent_Identity=34.1176470588235, Blast_Score=101, Evalue=2e-22,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3096 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR001078
- InterPro:   IPR006257
- InterPro:   IPR000089
- InterPro:   IPR023213
- InterPro:   IPR004167
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 19666; Mature: 19666

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITYTDILVKVVAKLLRDHPYLNATLEGDQIKIIEEVNIGIAVALDQGLIVPVIRNADT
CEEEHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEECCCCEEEEECCCEEEEEECCCCC
KPITEIAKESHELADKARENKLNPDEVSGGTFTISNLGMYDIDSFTPIINPPQTAILGVG
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEECCCCCCCCCCCHHHHEECC
RIRRAPVVVGDNISIGYIMWLSLTFDHRVMDGHTAAKFLKELTEILEDENKLRTFLS
CCCCCCEEECCCCCEEEEEEEEEEECCEECCCHHHHHHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure
MKITYTDILVKVVAKLLRDHPYLNATLEGDQIKIIEEVNIGIAVALDQGLIVPVIRNADT
CEEEHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEECCCCEEEEECCCEEEEEECCCCC
KPITEIAKESHELADKARENKLNPDEVSGGTFTISNLGMYDIDSFTPIINPPQTAILGVG
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEECCCCCCCCCCCHHHHEECC
RIRRAPVVVGDNISIGYIMWLSLTFDHRVMDGHTAAKFLKELTEILEDENKLRTFLS
CCCCCCEEECCCCCEEEEEEEEEEECCEECCCHHHHHHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA