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The map label for this gene is pdhC [H]

Identifier: 15898356

GI number: 15898356

Start: 1380370

End: 1381005

Strand: Direct

Name: pdhC [H]

Synonym: SSO1529

Alternate gene names: 15898356

Gene position: 1380370-1381005 (Clockwise)

Preceding gene: 15898355

Following gene: 15898357

Centisome position: 46.13

GC content: 38.52

Gene sequence:

>636_bases
ATGGGCAAAGAAGTATTAATGCCTAAGTTAGGCTTAACCATGACAAAAGGGAAAATAGTTCAATGGAAGAAAAAGGAAGG
TGACAGAGTTCAAGAAGGAGAGGACTTAGTAATAATAGAAACTGAGAAAATAACAACTACAGTAAAATCACCAGTTAGTG
GTATCCTACTTAAGATTTACGCTAAGGAAGGTGAAGAGGTACCCGTTGGTCAAATAATAGCGTACATAGGCGAAATTGGA
GAACAACCTCCACCCTCACCTACTAAACCCGCTTTAGCTACTCAACAACAACAAGCGCAACCAATTCGAACCGAAGAGGT
AAAGGTAATAGGCGAAGTAAGAGCTTCACCTAGGGCTAGAAGACTTGCCAAAGAAAAAGGAATAGATCTAAGTAAAATTA
GGGGGACAGGACCAGGCGGTATGATAACGGAAGATGATGTAATTAGAGAGCTGGAAAATATCGAAAAAGGAATGAAATTC
ACCGCAACTGGTCTTAGGGTTAAAGAAGTGATACCAATGAGTGTAATAAGACAAGAAATAAGTAGAAGAATGGTTCAGAG
CCTTCAGACAATGGCCCAAGTAACACTAAGTATTGAGATTAATGCAAATTCGTTAGTTAAAATGAAAATGAAATAG

Upstream 100 bases:

>100_bases
CAATGGTTAGAATTGATAGAGATGGTCCTCTCTTAGTTAGTATACCTAAGTCTTTAAATTATATAAATAGTTATTATAGA
GAGGAGATGGGTGAACTAAG

Downstream 100 bases:

>100_bases
AGTCTAAGTATAGCATGAAAATTACCTATACAGATATTCTAGTTAAGGTAGTAGCTAAACTCCTCAGGGACCATCCATAT
TTAAACGCAACATTAGAGGG

Product: dihydrolipoamide S-acetyltransferase, amino-end (pdhC)

Products: NA

Alternate protein names: Acetoin dehydrogenase E2 component; Dihydrolipoamide acetyltransferase component of acetoin cleaving system [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MGKEVLMPKLGLTMTKGKIVQWKKKEGDRVQEGEDLVIIETEKITTTVKSPVSGILLKIYAKEGEEVPVGQIIAYIGEIG
EQPPPSPTKPALATQQQQAQPIRTEEVKVIGEVRASPRARRLAKEKGIDLSKIRGTGPGGMITEDDVIRELENIEKGMKF
TATGLRVKEVIPMSVIRQEISRRMVQSLQTMAQVTLSIEINANSLVKMKMK

Sequences:

>Translated_211_residues
MGKEVLMPKLGLTMTKGKIVQWKKKEGDRVQEGEDLVIIETEKITTTVKSPVSGILLKIYAKEGEEVPVGQIIAYIGEIG
EQPPPSPTKPALATQQQQAQPIRTEEVKVIGEVRASPRARRLAKEKGIDLSKIRGTGPGGMITEDDVIRELENIEKGMKF
TATGLRVKEVIPMSVIRQEISRRMVQSLQTMAQVTLSIEINANSLVKMKMK
>Mature_210_residues
GKEVLMPKLGLTMTKGKIVQWKKKEGDRVQEGEDLVIIETEKITTTVKSPVSGILLKIYAKEGEEVPVGQIIAYIGEIGE
QPPPSPTKPALATQQQQAQPIRTEEVKVIGEVRASPRARRLAKEKGIDLSKIRGTGPGGMITEDDVIRELENIEKGMKFT
ATGLRVKEVIPMSVIRQEISRRMVQSLQTMAQVTLSIEINANSLVKMKMK

Specific function: The 2-Oxoglutarate Dehydrogenase Complex Catalyzes The Overall Conversion Of 2-Oxoglutarate To Succinyl-CoA And Co(2). It Contains Multiple Copies Of Three Enzymatic Components: 2- Oxoglutarate Dehydrogenase (E1), Dihydrolipoamide Succinyltransferase (E2)

COG id: COG0508

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI31711992, Length=247, Percent_Identity=32.3886639676113, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI203098753, Length=161, Percent_Identity=34.7826086956522, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI203098816, Length=161, Percent_Identity=34.7826086956522, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1786946, Length=219, Percent_Identity=27.8538812785388, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560088, Length=239, Percent_Identity=32.2175732217573, Blast_Score=90, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17537937, Length=225, Percent_Identity=24.4444444444444, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324258, Length=254, Percent_Identity=29.5275590551181, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20129315, Length=71, Percent_Identity=46.4788732394366, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3096 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001078
- InterPro:   IPR000089
- InterPro:   IPR023213
- InterPro:   IPR004167
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 23328; Mature: 23197

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKEVLMPKLGLTMTKGKIVQWKKKEGDRVQEGEDLVIIETEKITTTVKSPVSGILLKIY
CCCCCCCCCCCCEECCCCEEEEECCCCCCCCCCCCEEEEECCHHHHHHHCCHHHEEEEEE
AKEGEEVPVGQIIAYIGEIGEQPPPSPTKPALATQQQQAQPIRTEEVKVIGEVRASPRAR
ECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHCCCCCHHHHHHHHHHHCCHHHH
RLAKEKGIDLSKIRGTGPGGMITEDDVIRELENIEKGMKFTATGLRVKEVIPMSVIRQEI
HHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHH
SRRMVQSLQTMAQVTLSIEINANSLVKMKMK
HHHHHHHHHHHHHEEEEEEECCCEEEEEECC
>Mature Secondary Structure 
GKEVLMPKLGLTMTKGKIVQWKKKEGDRVQEGEDLVIIETEKITTTVKSPVSGILLKIY
CCCCCCCCCCCEECCCCEEEEECCCCCCCCCCCCEEEEECCHHHHHHHCCHHHEEEEEE
AKEGEEVPVGQIIAYIGEIGEQPPPSPTKPALATQQQQAQPIRTEEVKVIGEVRASPRAR
ECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHCCCCCHHHHHHHHHHHCCHHHH
RLAKEKGIDLSKIRGTGPGGMITEDDVIRELENIEKGMKFTATGLRVKEVIPMSVIRQEI
HHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHH
SRRMVQSLQTMAQVTLSIEINANSLVKMKMK
HHHHHHHHHHHHHEEEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969503; 9384377 [H]