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The map label for this gene is cdc6

Identifier: 15897673

GI number: 15897673

Start: 655982

End: 657223

Strand: Reverse

Name: cdc6

Synonym: SSO0771

Alternate gene names: 15897673

Gene position: 657223-655982 (Counterclockwise)

Preceding gene: 15897674

Following gene: 15897672

Centisome position: 21.96

GC content: 32.61

Gene sequence:

>1242_bases
TTGGTTTCAGCTAAGGACATACTTTCAGATAGTTTAAGATCATCTGTATTGATAATTAAACATAAGGACAAGCTTTCACC
AGATTATGTACCGGAAAATTTACCACATAGAGAAGAGAAGATTAAGGAGTTAGGATTTATATTCAAAGATCTATTAGCTG
GAGACGCTAAAGATTCTGAAAGAGTTGTAATACTAGGTAGGACAGGTACTGGGAAAACAGCTACTGTTAGATTGTTTGGT
AAAAATTTTGAAGATATTGCGGAGAGAGAATATGGGGTTAAAGTAAAGTATGTTCATATAAATTGTTATAGACATAGAAC
GCTGTATTTAATAAGCCAAGAAATAGCTAACGCGTTAAAACTACCTATACCTTCGAGGGGACTATCGGCACAAGAAGTAT
TTAAGATGATCCATGAATATCTAGATAGAAGAAATATACATCTAATAGTTGCACTAGATGAATTTGGGCATTTTCTAAAT
ACAGCAAATACTGAGGAAATATACTTCTTAGTAAGATTGTATGATGAAATATCTGCAATAATAAAGAGAATTAGTTATAT
ATTTATAGTTAATGAGAGTCATTCAATTTATAAATTAGATAGAAGTATAAGGGATCATATAGCTAGAAGGTTAATTGAAT
TTCCTCCTTATAAGTCTATGGAACTTTACGATATTTTGAAGTATAGAGTGGATGAGGCTTTTAATGACAATGCTGTAGAC
GATGAGGTATTACAATTTATATCCAATACTTATGGTTATGATAAAGGAGGTAATGGTAATGCTAGAATTGCAATAGAGAC
TCTAAGTTTAGCTGGAGAGATAGCAGAGAAGGAGGGATCGCCAGTGGTATTGTTAGATCATGCTAAGAAGGCTAATTCTA
CAATAAATCCGGAGATTCAAGAGATTATAGATAGTTTATCGTATCTCGATTTGCATCAACTTATACTCTTAAAAGCGTTG
ATAAGAGCTTTAAATAAGACTAAAGCTGATGAGATCACAATGGGAACCTTAGAAGAGGAATACATATCATTATCAAGAGA
GTTTAATGAGGAACCTAGAAGACATACGCAAGTTTATGAGTATCTGAGAAAACTTAAGGTAATAGGGATAATTAATACAA
GACAGAGTGGAAAAGGAATGAGAGGAAGAACGACTCTCGTTTCTCTTTCTCTTCCATTAGATAAAAGATTAGACGATTAT
ATTATGCAACAAATAATGGTGAGGTTAAAATCGAGAGCTTAA

Upstream 100 bases:

>100_bases
CTGGGATATCGCTTTTGAGAAAGAATCAAGAAAAGTTTCGGGCTACTCTCTTAGATAAAATATAAGGTAATACCACTTAA
TTTAGATTGGGGTAAAAGTT

Downstream 100 bases:

>100_bases
TCTATAATCCATCTAAAATGAAAATATTGTATATATTGATAAAAAACGGTGATATGAACATCACTAAATTATATAGATTA
TCTAAAATCCACTATGATAA

Product: cell division control protein 6

Products: NA

Alternate protein names: CDC6 homolog 2

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MVSAKDILSDSLRSSVLIIKHKDKLSPDYVPENLPHREEKIKELGFIFKDLLAGDAKDSERVVILGRTGTGKTATVRLFG
KNFEDIAEREYGVKVKYVHINCYRHRTLYLISQEIANALKLPIPSRGLSAQEVFKMIHEYLDRRNIHLIVALDEFGHFLN
TANTEEIYFLVRLYDEISAIIKRISYIFIVNESHSIYKLDRSIRDHIARRLIEFPPYKSMELYDILKYRVDEAFNDNAVD
DEVLQFISNTYGYDKGGNGNARIAIETLSLAGEIAEKEGSPVVLLDHAKKANSTINPEIQEIIDSLSYLDLHQLILLKAL
IRALNKTKADEITMGTLEEEYISLSREFNEEPRRHTQVYEYLRKLKVIGIINTRQSGKGMRGRTTLVSLSLPLDKRLDDY
IMQQIMVRLKSRA

Sequences:

>Translated_413_residues
MVSAKDILSDSLRSSVLIIKHKDKLSPDYVPENLPHREEKIKELGFIFKDLLAGDAKDSERVVILGRTGTGKTATVRLFG
KNFEDIAEREYGVKVKYVHINCYRHRTLYLISQEIANALKLPIPSRGLSAQEVFKMIHEYLDRRNIHLIVALDEFGHFLN
TANTEEIYFLVRLYDEISAIIKRISYIFIVNESHSIYKLDRSIRDHIARRLIEFPPYKSMELYDILKYRVDEAFNDNAVD
DEVLQFISNTYGYDKGGNGNARIAIETLSLAGEIAEKEGSPVVLLDHAKKANSTINPEIQEIIDSLSYLDLHQLILLKAL
IRALNKTKADEITMGTLEEEYISLSREFNEEPRRHTQVYEYLRKLKVIGIINTRQSGKGMRGRTTLVSLSLPLDKRLDDY
IMQQIMVRLKSRA
>Mature_413_residues
MVSAKDILSDSLRSSVLIIKHKDKLSPDYVPENLPHREEKIKELGFIFKDLLAGDAKDSERVVILGRTGTGKTATVRLFG
KNFEDIAEREYGVKVKYVHINCYRHRTLYLISQEIANALKLPIPSRGLSAQEVFKMIHEYLDRRNIHLIVALDEFGHFLN
TANTEEIYFLVRLYDEISAIIKRISYIFIVNESHSIYKLDRSIRDHIARRLIEFPPYKSMELYDILKYRVDEAFNDNAVD
DEVLQFISNTYGYDKGGNGNARIAIETLSLAGEIAEKEGSPVVLLDHAKKANSTINPEIQEIIDSLSYLDLHQLILLKAL
IRALNKTKADEITMGTLEEEYISLSREFNEEPRRHTQVYEYLRKLKVIGIINTRQSGKGMRGRTTLVSLSLPLDKRLDDY
IMQQIMVRLKSRA

Specific function: Might be involved in the initiation of DNA replication. Binds both single-strand and double-strand DNA. Has a weak ATPase activity. Strongly inhibits the ATPase and DNA helicase activity of the MCM protein

COG id: COG1474

COG function: function code LO; Cdc6-related protein, AAA superfamily ATPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDC6/cdc18 family

Homologues:

Organism=Homo sapiens, GI4502703, Length=345, Percent_Identity=22.3188405797101, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355681, Length=347, Percent_Identity=22.1902017291066, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CDC62_SULSO (Q9UXF8)

Other databases:

- EMBL:   Y18930
- EMBL:   AE006641
- PIR:   E90226
- RefSeq:   NP_342278.1
- ProteinModelPortal:   Q9UXF8
- SMR:   Q9UXF8
- DIP:   DIP-48852N
- GeneID:   1455035
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0771
- NMPDR:   fig|273057.1.peg.701
- HOGENOM:   HBG553472
- OMA:   IPFPRRG
- ProtClustDB:   PRK00411
- BioCyc:   SSOL273057:SSO0771-MONOMER
- HAMAP:   MF_01407
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR015163
- InterPro:   IPR014277
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PANTHER:   PTHR10763:SF8
- SMART:   SM00382
- TIGRFAMs:   TIGR02928

Pfam domain/function: PF00004 AAA; PF09079 Cdc6_C

EC number: NA

Molecular weight: Translated: 47533; Mature: 47533

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSAKDILSDSLRSSVLIIKHKDKLSPDYVPENLPHREEKIKELGFIFKDLLAGDAKDSE
CCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
RVVILGRTGTGKTATVRLFGKNFEDIAEREYGVKVKYVHINCYRHRTLYLISQEIANALK
EEEEEECCCCCCEEEEEEECCCHHHHHHHHHCCEEEEEEEEEEECHHHEEHHHHHHHHHC
LPIPSRGLSAQEVFKMIHEYLDRRNIHLIVALDEFGHFLNTANTEEIYFLVRLYDEISAI
CCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IKRISYIFIVNESHSIYKLDRSIRDHIARRLIEFPPYKSMELYDILKYRVDEAFNDNAVD
HHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCC
DEVLQFISNTYGYDKGGNGNARIAIETLSLAGEIAEKEGSPVVLLDHAKKANSTINPEIQ
HHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHH
EIIDSLSYLDLHQLILLKALIRALNKTKADEITMGTLEEEYISLSREFNEEPRRHTQVYE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHCCCHHHHHHHHH
YLRKLKVIGIINTRQSGKGMRGRTTLVSLSLPLDKRLDDYIMQQIMVRLKSRA
HHHHHHHEEEEECCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVSAKDILSDSLRSSVLIIKHKDKLSPDYVPENLPHREEKIKELGFIFKDLLAGDAKDSE
CCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
RVVILGRTGTGKTATVRLFGKNFEDIAEREYGVKVKYVHINCYRHRTLYLISQEIANALK
EEEEEECCCCCCEEEEEEECCCHHHHHHHHHCCEEEEEEEEEEECHHHEEHHHHHHHHHC
LPIPSRGLSAQEVFKMIHEYLDRRNIHLIVALDEFGHFLNTANTEEIYFLVRLYDEISAI
CCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IKRISYIFIVNESHSIYKLDRSIRDHIARRLIEFPPYKSMELYDILKYRVDEAFNDNAVD
HHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCC
DEVLQFISNTYGYDKGGNGNARIAIETLSLAGEIAEKEGSPVVLLDHAKKANSTINPEIQ
HHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHH
EIIDSLSYLDLHQLILLKALIRALNKTKADEITMGTLEEEYISLSREFNEEPRRHTQVYE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHCCCHHHHHHHHH
YLRKLKVIGIINTRQSGKGMRGRTTLVSLSLPLDKRLDDYIMQQIMVRLKSRA
HHHHHHHEEEEECCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726