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The map label for this gene is hmgA

Identifier: 15897456

GI number: 15897456

Start: 460955

End: 462184

Strand: Reverse

Name: hmgA

Synonym: SSO0531

Alternate gene names: 15897456

Gene position: 462184-460955 (Counterclockwise)

Preceding gene: 15897457

Following gene: 15897455

Centisome position: 15.45

GC content: 39.11

Gene sequence:

>1230_bases
ATGAAAATTGATGAAGTGGTTGAAAAGTTAGTAAAGGGAGAAATTTCTTTTCATGAAGTTGACAATTTATTAGAAGCAAA
TGCTGCAATGGTTGCGAGGAGGCTTGCATTAGAGAAGATTGTAGGAGTCGGTCTTCCCTCAATTGGTTCTACAGTTATTG
ATTATAGTGAGATAAAAAATAAAAATGCCGAAAATGTGATTGGAGCAATACAAATACCATTAGGTATAGTGGGGCCAATT
AGAGTCAATGGTGATTACGCAAAGGGCGATTTCTATGTACCTATGGCGACGACAGAAGGAGCGCTAATAGCCAGTGTAAA
TAGGGGTATCAAGGCTGTTACACTAAGTGGGGGAGTTAGGGCTAAGGTTTTAAAGGATGAAATGACGAGAGCCCCCGTTT
TTAAGTTTGATTCAATAGAACAGATACCGAATTTTCTAAAGTTCATAGAGGAGAATCTTGAGAAGATAAGGAATATAGCC
AATTCTACCTCTCATCATGGTAAATTAAAATCCATTACACCTTTCGTACTAGGCAATAATGTTTGGCTTAGATTTTCCTT
TGAAACTGGTGATGCTATGGGGATGAACATGGTTACGATAGCAGTTGAAAAAGTATGTGAGTTTATAGAGGAAAACTTCC
CATCAGCTGATTGTTTAGCTGTAAGCGGAAATATGTGTAGTGATAAGAAACAGACCAATGTCAATAGCCTCTTCGGTAGA
GGTAAAACTGTAGTGGCTGAGGCTCTCATCAAGAAGGATGTTATAAGGAATATATTACACTCTAATGCTCAACTAATTCA
TGATATAAATCTACGGAAGAATTGGCTCGGGACAGCAAGAGCAGGATCCTTATCTCAATTTAATGCTCATTTCGCAAACA
TAGTCACAGCAATCTTTATAGCTACTGGCCAAGATGTAGCTCAAATAGTTGAGAGTAGTTCTGGATATACATGGACTGAA
GTAAGAGGAGAGGACTTATATATATCAGTTACACTGCCCTCGTTAGAAGTAGGAACTGTAGGAGGAGGTACAAGGTTACC
TACCCAGAAAGAAGCCCTATCCATTATGGGAGTTTACGGCAGTGGAAATCCACCTGGCTCTAATGCTAAGAAATTAGCTG
AGATCATAGCTTCTACTGTACTATCTGGGGAACTTAATCTCCTAGCTGCTTTATCCAACAAGGAGTTAGGTAAGGCTCAC
GCTAAACTTGGAAGAGCTATGAAAGTCTAA

Upstream 100 bases:

>100_bases
TAAAAGAAGGAGTTAAGGTAGAAGCTACATTAAGGAGAGTTTATACGGACTCATATAATGGTTTAATACAGTATGGGATA
AAGTTTAGGGTAGCTGAAGG

Downstream 100 bases:

>100_bases
TCTTTTTATCAAAGTTTAAATATTCTGTAACTACTTTACTCTTATGTCACTTCCTAAAGAATTAGAAAAAGTTCTTGAAA
TTACTAAGGCACAGAACGTA

Product: 3 hydroxy 3 methylglutaryl coenzyme a reductase

Products: NA

Alternate protein names: HMG-CoA reductase

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MKIDEVVEKLVKGEISFHEVDNLLEANAAMVARRLALEKIVGVGLPSIGSTVIDYSEIKNKNAENVIGAIQIPLGIVGPI
RVNGDYAKGDFYVPMATTEGALIASVNRGIKAVTLSGGVRAKVLKDEMTRAPVFKFDSIEQIPNFLKFIEENLEKIRNIA
NSTSHHGKLKSITPFVLGNNVWLRFSFETGDAMGMNMVTIAVEKVCEFIEENFPSADCLAVSGNMCSDKKQTNVNSLFGR
GKTVVAEALIKKDVIRNILHSNAQLIHDINLRKNWLGTARAGSLSQFNAHFANIVTAIFIATGQDVAQIVESSSGYTWTE
VRGEDLYISVTLPSLEVGTVGGGTRLPTQKEALSIMGVYGSGNPPGSNAKKLAEIIASTVLSGELNLLAALSNKELGKAH
AKLGRAMKV

Sequences:

>Translated_409_residues
MKIDEVVEKLVKGEISFHEVDNLLEANAAMVARRLALEKIVGVGLPSIGSTVIDYSEIKNKNAENVIGAIQIPLGIVGPI
RVNGDYAKGDFYVPMATTEGALIASVNRGIKAVTLSGGVRAKVLKDEMTRAPVFKFDSIEQIPNFLKFIEENLEKIRNIA
NSTSHHGKLKSITPFVLGNNVWLRFSFETGDAMGMNMVTIAVEKVCEFIEENFPSADCLAVSGNMCSDKKQTNVNSLFGR
GKTVVAEALIKKDVIRNILHSNAQLIHDINLRKNWLGTARAGSLSQFNAHFANIVTAIFIATGQDVAQIVESSSGYTWTE
VRGEDLYISVTLPSLEVGTVGGGTRLPTQKEALSIMGVYGSGNPPGSNAKKLAEIIASTVLSGELNLLAALSNKELGKAH
AKLGRAMKV
>Mature_409_residues
MKIDEVVEKLVKGEISFHEVDNLLEANAAMVARRLALEKIVGVGLPSIGSTVIDYSEIKNKNAENVIGAIQIPLGIVGPI
RVNGDYAKGDFYVPMATTEGALIASVNRGIKAVTLSGGVRAKVLKDEMTRAPVFKFDSIEQIPNFLKFIEENLEKIRNIA
NSTSHHGKLKSITPFVLGNNVWLRFSFETGDAMGMNMVTIAVEKVCEFIEENFPSADCLAVSGNMCSDKKQTNVNSLFGR
GKTVVAEALIKKDVIRNILHSNAQLIHDINLRKNWLGTARAGSLSQFNAHFANIVTAIFIATGQDVAQIVESSSGYTWTE
VRGEDLYISVTLPSLEVGTVGGGTRLPTQKEALSIMGVYGSGNPPGSNAKKLAEIIASTVLSGELNLLAALSNKELGKAH
AKLGRAMKV

Specific function: Converts HMG-CoA to mevalonate

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family

Homologues:

Organism=Homo sapiens, GI4557643, Length=407, Percent_Identity=42.2604422604423, Blast_Score=302, Evalue=4e-82,
Organism=Homo sapiens, GI196049380, Length=294, Percent_Identity=45.578231292517, Blast_Score=244, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI25144592, Length=408, Percent_Identity=43.8725490196078, Blast_Score=316, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6323565, Length=416, Percent_Identity=40.1442307692308, Blast_Score=283, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6323483, Length=417, Percent_Identity=40.7673860911271, Blast_Score=280, Evalue=3e-76,
Organism=Drosophila melanogaster, GI281362379, Length=360, Percent_Identity=45.8333333333333, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI45553469, Length=360, Percent_Identity=45.8333333333333, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24649399, Length=360, Percent_Identity=45.8333333333333, Blast_Score=279, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HMDH_SULSO (O08424)

Other databases:

- EMBL:   U95360
- EMBL:   Y18930
- EMBL:   AE006641
- PIR:   D90199
- PIR:   T51306
- RefSeq:   NP_342061.1
- ProteinModelPortal:   O08424
- SMR:   O08424
- GeneID:   1454818
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0531
- NMPDR:   fig|273057.1.peg.484
- HOGENOM:   HBG604528
- OMA:   AHFANII
- ProtClustDB:   CLSK865250
- BioCyc:   MetaCyc:MONOMER-14624
- BioCyc:   SSOL273057:SSO0531-MONOMER
- BRENDA:   1.1.1.34
- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029
- Gene3D:   G3DSA:3.90.770.10
- PANTHER:   PTHR10572
- PRINTS:   PR00071
- TIGRFAMs:   TIGR00533

Pfam domain/function: PF00368 HMG-CoA_red; SSF55035 HMG_CoA_NAD_bind; SSF56542 HMG_CoA_sub_bind

EC number: =1.1.1.34

Molecular weight: Translated: 44009; Mature: 44009

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00066 HMG_COA_REDUCTASE_1; PS00318 HMG_COA_REDUCTASE_2; PS01192 HMG_COA_REDUCTASE_3; PS50065 HMG_COA_REDUCTASE_4

Important sites: ACT_SITE 99-99 ACT_SITE 305-305 ACT_SITE 400-400

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIDEVVEKLVKGEISFHEVDNLLEANAAMVARRLALEKIVGVGLPSIGSTVIDYSEIKN
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCC
KNAENVIGAIQIPLGIVGPIRVNGDYAKGDFYVPMATTEGALIASVNRGIKAVTLSGGVR
CCHHHEEEEEEECCCEECEEEECCCCCCCCEEEEEECCCCCEEEECCCCEEEEEECCCCE
AKVLKDEMTRAPVFKFDSIEQIPNFLKFIEENLEKIRNIANSTSHHGKLKSITPFVLGNN
EHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCC
VWLRFSFETGDAMGMNMVTIAVEKVCEFIEENFPSADCLAVSGNMCSDKKQTNVNSLFGR
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHCCHHHHHCC
GKTVVAEALIKKDVIRNILHSNAQLIHDINLRKNWLGTARAGSLSQFNAHFANIVTAIFI
CHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
ATGQDVAQIVESSSGYTWTEVRGEDLYISVTLPSLEVGTVGGGTRLPTQKEALSIMGVYG
HCCHHHHHHHHCCCCCEEEEECCCEEEEEEEECCEEEECCCCCCCCCCHHHHEEEEEEEC
SGNPPGSNAKKLAEIIASTVLSGELNLLAALSNKELGKAHAKLGRAMKV
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIDEVVEKLVKGEISFHEVDNLLEANAAMVARRLALEKIVGVGLPSIGSTVIDYSEIKN
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCC
KNAENVIGAIQIPLGIVGPIRVNGDYAKGDFYVPMATTEGALIASVNRGIKAVTLSGGVR
CCHHHEEEEEEECCCEECEEEECCCCCCCCEEEEEECCCCCEEEECCCCEEEEEECCCCE
AKVLKDEMTRAPVFKFDSIEQIPNFLKFIEENLEKIRNIANSTSHHGKLKSITPFVLGNN
EHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCC
VWLRFSFETGDAMGMNMVTIAVEKVCEFIEENFPSADCLAVSGNMCSDKKQTNVNSLFGR
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHCCHHHHHCC
GKTVVAEALIKKDVIRNILHSNAQLIHDINLRKNWLGTARAGSLSQFNAHFANIVTAIFI
CHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
ATGQDVAQIVESSSGYTWTEVRGEDLYISVTLPSLEVGTVGGGTRLPTQKEALSIMGVYG
HCCHHHHHHHHCCCCCEEEEECCCEEEEEEEECCEEEECCCCCCCCCCHHHHEEEEEEEC
SGNPPGSNAKKLAEIIASTVLSGELNLLAALSNKELGKAHAKLGRAMKV
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9171410; 10701121; 11427726