Click here to switch to the map view.

The map label for this gene is glyA [H]

Identifier: 15897455

GI number: 15897455

Start: 459610

End: 460911

Strand: Reverse

Name: glyA [H]

Synonym: SSO0530

Alternate gene names: 15897455

Gene position: 460911-459610 (Counterclockwise)

Preceding gene: 15897456

Following gene: 15897447

Centisome position: 15.4

GC content: 37.25

Gene sequence:

>1302_bases
ATGTCACTTCCTAAAGAATTAGAAAAAGTTCTTGAAATTACTAAGGCACAGAACGTATGGAGAAGGACGCAGACTTTGAA
CCTTATTGCATCTGAAAACGTAATGAGTCCACTAGCTGAAAGTGTGTATATGAGTGACTTCATGTCCAGATATGCAGAAG
GTAAACCATACAAGAGATACTATCAAGGGACCAAGTATACTGATGAAATCGAGACTCTTACTATGGAGTTGATGAATGAG
ATAACAAACTCAAAGGATTGTGATCTAAGACCTACTAGCGGTACCATAGCAAATGCGGCTGTGTTTAGAGTTTTAGCTGA
GCCTGGAGATAAGGCATTAATAGCACCAGTCCAAGCTGGTGCCCATGTCAGTCATACCAAATTTGGAACATTGGGAGCTT
TGGGTATTCAACATATTGAAATGCCATTTGATGAGGAAAACATTAACGTAGATGTAGATAAAGCAATAAAGATGATAGAA
GAAGTTAAACCAAAATTCGTAGTGCTAGGAGGCAGTCTTTACCTATTTCCTCATCCTACTAAGGAATTAGCTCAACACGT
TCACGCTGTAGGAGCTAAATTGGTTTACGATGCTGCACATGTTTATGGGTTGATAGAGGGTAAAGTTTGGAGTAACCCAC
TAAAAGATGGAGCGGATATTATGACTGTCTCTACGCATAAGACTTTTCCTGGTCCTCAAGGAGGAGCGATTTTCTCTGAT
GGTTCAGAAGTTTTTAAACAAGTCTCAAAGACAATATTCCCATGGTTTGTTAGTAATCATCATTTGCATAGATTACCAGC
TACTGCAGTAACTGCCATTGAGATGAAATATTTTGGCGAAAGTTATGCTAATCAAATACTAAGGAATTCGAAGGCTCTAG
CAGAGGCTTTAGCTGAAAGAGGATTTAAGGTAATTGGAGAAAATTTAGGTTATACTAAGAGTCATCAAGTAGCGGTAGAT
GTTAGACAATTCGGTGGGGGAAATAAGATAGCTAAGCTATTAGAGGACGCAAATATCATAGTAAATAAAAATCTATTGCC
CTATGATAAGCCAGAAGATGTTTCCGATCCAAGTGGCTTAAGAATAGGGGTACAAGAGATGACAAGATATGGGATGAAAG
AAGGTGAAATGGAGGAGATAGCTGAGCTATTTAAGAAAGTTATTATAGACAAAAAAGATGTTAACGAAGTTAAAAAAGAG
GTAATTGAGATGAGAAGGAATTTCTTGGAGGTTAAGTATACATTCGATGATATGAAAGATTTAGAAAAGTACTCGTCAAA
ATCATTAAAATTGATCATCTAA

Upstream 100 bases:

>100_bases
TCCAACAAGGAGTTAGGTAAGGCTCACGCTAAACTTGGAAGAGCTATGAAAGTCTAATCTTTTTATCAAAGTTTAAATAT
TCTGTAACTACTTTACTCTT

Downstream 100 bases:

>100_bases
CTAATATCACAGATACTGGAGCGTTTATCGATATTGCTAACGCTGTAGAGCCTATATTTATATCGCTATTTAGTGAAGTT
CCTCTTGCACCCATTATTAT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MSLPKELEKVLEITKAQNVWRRTQTLNLIASENVMSPLAESVYMSDFMSRYAEGKPYKRYYQGTKYTDEIETLTMELMNE
ITNSKDCDLRPTSGTIANAAVFRVLAEPGDKALIAPVQAGAHVSHTKFGTLGALGIQHIEMPFDEENINVDVDKAIKMIE
EVKPKFVVLGGSLYLFPHPTKELAQHVHAVGAKLVYDAAHVYGLIEGKVWSNPLKDGADIMTVSTHKTFPGPQGGAIFSD
GSEVFKQVSKTIFPWFVSNHHLHRLPATAVTAIEMKYFGESYANQILRNSKALAEALAERGFKVIGENLGYTKSHQVAVD
VRQFGGGNKIAKLLEDANIIVNKNLLPYDKPEDVSDPSGLRIGVQEMTRYGMKEGEMEEIAELFKKVIIDKKDVNEVKKE
VIEMRRNFLEVKYTFDDMKDLEKYSSKSLKLII

Sequences:

>Translated_433_residues
MSLPKELEKVLEITKAQNVWRRTQTLNLIASENVMSPLAESVYMSDFMSRYAEGKPYKRYYQGTKYTDEIETLTMELMNE
ITNSKDCDLRPTSGTIANAAVFRVLAEPGDKALIAPVQAGAHVSHTKFGTLGALGIQHIEMPFDEENINVDVDKAIKMIE
EVKPKFVVLGGSLYLFPHPTKELAQHVHAVGAKLVYDAAHVYGLIEGKVWSNPLKDGADIMTVSTHKTFPGPQGGAIFSD
GSEVFKQVSKTIFPWFVSNHHLHRLPATAVTAIEMKYFGESYANQILRNSKALAEALAERGFKVIGENLGYTKSHQVAVD
VRQFGGGNKIAKLLEDANIIVNKNLLPYDKPEDVSDPSGLRIGVQEMTRYGMKEGEMEEIAELFKKVIIDKKDVNEVKKE
VIEMRRNFLEVKYTFDDMKDLEKYSSKSLKLII
>Mature_432_residues
SLPKELEKVLEITKAQNVWRRTQTLNLIASENVMSPLAESVYMSDFMSRYAEGKPYKRYYQGTKYTDEIETLTMELMNEI
TNSKDCDLRPTSGTIANAAVFRVLAEPGDKALIAPVQAGAHVSHTKFGTLGALGIQHIEMPFDEENINVDVDKAIKMIEE
VKPKFVVLGGSLYLFPHPTKELAQHVHAVGAKLVYDAAHVYGLIEGKVWSNPLKDGADIMTVSTHKTFPGPQGGAIFSDG
SEVFKQVSKTIFPWFVSNHHLHRLPATAVTAIEMKYFGESYANQILRNSKALAEALAERGFKVIGENLGYTKSHQVAVDV
RQFGGGNKIAKLLEDANIIVNKNLLPYDKPEDVSDPSGLRIGVQEMTRYGMKEGEMEEIAELFKKVIIDKKDVNEVKKEV
IEMRRNFLEVKYTFDDMKDLEKYSSKSLKLII

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=389, Percent_Identity=30.5912596401028, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI261862352, Length=389, Percent_Identity=30.5912596401028, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI261862350, Length=389, Percent_Identity=30.5912596401028, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI261862348, Length=389, Percent_Identity=30.5912596401028, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI261862346, Length=387, Percent_Identity=30.749354005168, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI22547186, Length=395, Percent_Identity=29.3670886075949, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI22547189, Length=378, Percent_Identity=28.8359788359788, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1788902, Length=398, Percent_Identity=32.9145728643216, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25144732, Length=450, Percent_Identity=25.7777777777778, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI25144729, Length=452, Percent_Identity=26.1061946902655, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323087, Length=394, Percent_Identity=29.4416243654822, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319739, Length=396, Percent_Identity=29.5454545454545, Blast_Score=143, Evalue=4e-35,
Organism=Drosophila melanogaster, GI221329721, Length=385, Percent_Identity=32.2077922077922, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24640005, Length=385, Percent_Identity=32.2077922077922, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 48509; Mature: 48378

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPKELEKVLEITKAQNVWRRTQTLNLIASENVMSPLAESVYMSDFMSRYAEGKPYKRY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
YQGTKYTDEIETLTMELMNEITNSKDCDLRPTSGTIANAAVFRVLAEPGDKALIAPVQAG
HCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCC
AHVSHTKFGTLGALGIQHIEMPFDEENINVDVDKAIKMIEEVKPKFVVLGGSLYLFPHPT
CCCCCCCCCHHHHHCHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCEEEECCCCH
KELAQHVHAVGAKLVYDAAHVYGLIEGKVWSNPLKDGADIMTVSTHKTFPGPQGGAIFSD
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEECC
GSEVFKQVSKTIFPWFVSNHHLHRLPATAVTAIEMKYFGESYANQILRNSKALAEALAER
HHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GFKVIGENLGYTKSHQVAVDVRQFGGGNKIAKLLEDANIIVNKNLLPYDKPEDVSDPSGL
CHHHHHCCCCCCCCCEEEEEHHHCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCC
RIGVQEMTRYGMKEGEMEEIAELFKKVIIDKKDVNEVKKEVIEMRRNFLEVKYTFDDMKD
EECHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEECHHHHHH
LEKYSSKSLKLII
HHHHCCCCEEEEC
>Mature Secondary Structure 
SLPKELEKVLEITKAQNVWRRTQTLNLIASENVMSPLAESVYMSDFMSRYAEGKPYKRY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
YQGTKYTDEIETLTMELMNEITNSKDCDLRPTSGTIANAAVFRVLAEPGDKALIAPVQAG
HCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCC
AHVSHTKFGTLGALGIQHIEMPFDEENINVDVDKAIKMIEEVKPKFVVLGGSLYLFPHPT
CCCCCCCCCHHHHHCHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCEEEECCCCH
KELAQHVHAVGAKLVYDAAHVYGLIEGKVWSNPLKDGADIMTVSTHKTFPGPQGGAIFSD
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEECC
GSEVFKQVSKTIFPWFVSNHHLHRLPATAVTAIEMKYFGESYANQILRNSKALAEALAER
HHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GFKVIGENLGYTKSHQVAVDVRQFGGGNKIAKLLEDANIIVNKNLLPYDKPEDVSDPSGL
CHHHHHCCCCCCCCCEEEEEHHHCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCC
RIGVQEMTRYGMKEGEMEEIAELFKKVIIDKKDVNEVKKEVIEMRRNFLEVKYTFDDMKD
EECHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEECHHHHHH
LEKYSSKSLKLII
HHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA