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The map label for this gene is hemA

Identifier: 15897131

GI number: 15897131

Start: 151633

End: 152913

Strand: Direct

Name: hemA

Synonym: SSO0180

Alternate gene names: 15897131

Gene position: 151633-152913 (Clockwise)

Preceding gene: 15897130

Following gene: 15897132

Centisome position: 5.07

GC content: 30.21

Gene sequence:

>1281_bases
ATGAGCAAGGATGAAGAGTTACTACAAAATTATTGTTCGATTTTATTTACATACAAAACTATAGGAATAAGTAACCTTCA
CTTATATTACTTTAGGGAAACGGAAATAAAATCGTTAAAACAATTAATCAATGCTGAATTTGCTATTCTACAAACTTGTA
ATAGAGTTGAAATATATCTATATTCAGATACTAATACATTAAAGGAGGTTAATAAAATAATCCAATATTTGAATAACATA
CATAATGAACCTATCGGAAATCAAGCTAGGGTACTCTGTGGTAAAGATGCTGCAAAACACTTATTTTTGGTAGCTAGTGG
AGCTGATTCACTATCTATTGGAGAATACGAAATCTTATCTCAAATAAGATCTACTATTGATATGTTTAAAAAATTAGGCT
TCAGCGGAAAATATTTACAAATATTTTTCGAAAGAGCAATTAAAGTAGGCAGAAAAGTTAGAGAAGAGACTAGTATTTCT
AAGGGGAAAGTTGGTATATATTCTCTTGCTATTGATGAGGCTAAAAAACGATTCAATGATTTTTATGATAGAAGAATATT
AGTAATAGGAGCTGGCGAAATGGCGCAGAAAATAACTAGTATGCTCCACAATGAAGGAGCCAAAGATGTTACAATAATGA
ATAGAACAATAGAAAAGGCAAAACAACTTGCACTAAAGTTCGGCTATAACTACGAAAAATTAGATTTAGACAAGTTAGGT
AACTTCGATGTCGCTTTTATATCAATTTATCATGAGAATCTTAGACTTGAGAACAAATGGAATACATTAATTGTTGATAT
AACTGTCCCGCCCCTATTTACTGGGAATAACGTAATTACACTAGAAGAATTAGAAAGAATATCAAACCTCAACTTCAAAG
CTAGAGAAGAGGAATTAGCTAAAATTAATAAATTGGTAGAGGATGGAATAAATGAATTACTATATGATTACAAAAAAGAA
ATCTATACGGAATTCATGTCAAAAATAATGAAAAGGATAGAAACTATAAGAGAAAACGAGATTCTAAGAGCGTATAAAGA
ACTTGAGAAACTTGGAATAAACGACCAACAAGCGAAGGAAATACTAGATTTGATGACTAGATCAATCATTAAAAAGTCAT
TCCAACCCCTTTTCGATAATATAAGATCACTAATATTTAACGGAGAAAATTCGATAAACTACATTAACTTTCTAATTGAT
ATTTTTAAAGATGGTAACATTTCCGGTTTTGAGACCGAGAAGATTAAGGAAAAGCAAGTTAGTGAGAGATCTAGTATCTG
A

Upstream 100 bases:

>100_bases
TATTCATTATATCATAAAATATATAATGATGAAAAATTCAAATATTATGCTACTAATGGTTTAATAAATAAAGCATTAAA
TAGAGCGGAGGAGATAATTA

Downstream 100 bases:

>100_bases
AACATCTATTTCACAAAACGATTTAGTACTTCCAGTATTTATAAAGGAAAACATAAATGAGCCAGAGCAAATTGCTTCGA
TGCCAGGTATATATAGATAT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSKDEELLQNYCSILFTYKTIGISNLHLYYFRETEIKSLKQLINAEFAILQTCNRVEIYLYSDTNTLKEVNKIIQYLNNI
HNEPIGNQARVLCGKDAAKHLFLVASGADSLSIGEYEILSQIRSTIDMFKKLGFSGKYLQIFFERAIKVGRKVREETSIS
KGKVGIYSLAIDEAKKRFNDFYDRRILVIGAGEMAQKITSMLHNEGAKDVTIMNRTIEKAKQLALKFGYNYEKLDLDKLG
NFDVAFISIYHENLRLENKWNTLIVDITVPPLFTGNNVITLEELERISNLNFKAREEELAKINKLVEDGINELLYDYKKE
IYTEFMSKIMKRIETIRENEILRAYKELEKLGINDQQAKEILDLMTRSIIKKSFQPLFDNIRSLIFNGENSINYINFLID
IFKDGNISGFETEKIKEKQVSERSSI

Sequences:

>Translated_426_residues
MSKDEELLQNYCSILFTYKTIGISNLHLYYFRETEIKSLKQLINAEFAILQTCNRVEIYLYSDTNTLKEVNKIIQYLNNI
HNEPIGNQARVLCGKDAAKHLFLVASGADSLSIGEYEILSQIRSTIDMFKKLGFSGKYLQIFFERAIKVGRKVREETSIS
KGKVGIYSLAIDEAKKRFNDFYDRRILVIGAGEMAQKITSMLHNEGAKDVTIMNRTIEKAKQLALKFGYNYEKLDLDKLG
NFDVAFISIYHENLRLENKWNTLIVDITVPPLFTGNNVITLEELERISNLNFKAREEELAKINKLVEDGINELLYDYKKE
IYTEFMSKIMKRIETIRENEILRAYKELEKLGINDQQAKEILDLMTRSIIKKSFQPLFDNIRSLIFNGENSINYINFLID
IFKDGNISGFETEKIKEKQVSERSSI
>Mature_425_residues
SKDEELLQNYCSILFTYKTIGISNLHLYYFRETEIKSLKQLINAEFAILQTCNRVEIYLYSDTNTLKEVNKIIQYLNNIH
NEPIGNQARVLCGKDAAKHLFLVASGADSLSIGEYEILSQIRSTIDMFKKLGFSGKYLQIFFERAIKVGRKVREETSISK
GKVGIYSLAIDEAKKRFNDFYDRRILVIGAGEMAQKITSMLHNEGAKDVTIMNRTIEKAKQLALKFGYNYEKLDLDKLGN
FDVAFISIYHENLRLENKWNTLIVDITVPPLFTGNNVITLEELERISNLNFKAREEELAKINKLVEDGINELLYDYKKEI
YTEFMSKIMKRIETIRENEILRAYKELEKLGINDQQAKEILDLMTRSIIKKSFQPLFDNIRSLIFNGENSINYINFLIDI
FKDGNISGFETEKIKEKQVSERSSI

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=334, Percent_Identity=26.6467065868263, Blast_Score=92, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_SULSO (Q980U7)

Other databases:

- EMBL:   AE006641
- PIR:   G90158
- RefSeq:   NP_341736.1
- ProteinModelPortal:   Q980U7
- SMR:   Q980U7
- GeneID:   1455336
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0180
- NMPDR:   fig|273057.1.peg.159
- HOGENOM:   HBG553533
- OMA:   GEDQIIG
- ProtClustDB:   PRK00045
- BioCyc:   SSOL273057:SSO0180-MONOMER
- BRENDA:   1.2.1.70
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 49423; Mature: 49291

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 53-53 BINDING 110-110 BINDING 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKDEELLQNYCSILFTYKTIGISNLHLYYFRETEIKSLKQLINAEFAILQTCNRVEIYL
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHCCHHHHHHCCCCEEEEE
YSDTNTLKEVNKIIQYLNNIHNEPIGNQARVLCGKDAAKHLFLVASGADSLSIGEYEILS
ECCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCCHHHHHH
QIRSTIDMFKKLGFSGKYLQIFFERAIKVGRKVREETSISKGKVGIYSLAIDEAKKRFND
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHH
FYDRRILVIGAGEMAQKITSMLHNEGAKDVTIMNRTIEKAKQLALKFGYNYEKLDLDKLG
HHCCEEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEECHHHCC
NFDVAFISIYHENLRLENKWNTLIVDITVPPLFTGNNVITLEELERISNLNFKAREEELA
CCCEEEEEEEHHHCEEECCCCEEEEEEEECCEECCCCEEEHHHHHHHHCCCCCHHHHHHH
KINKLVEDGINELLYDYKKEIYTEFMSKIMKRIETIRENEILRAYKELEKLGINDQQAKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ILDLMTRSIIKKSFQPLFDNIRSLIFNGENSINYINFLIDIFKDGNISGFETEKIKEKQV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
SERSSI
HHHCCC
>Mature Secondary Structure 
SKDEELLQNYCSILFTYKTIGISNLHLYYFRETEIKSLKQLINAEFAILQTCNRVEIYL
CCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHCCHHHHHHCCCCEEEEE
YSDTNTLKEVNKIIQYLNNIHNEPIGNQARVLCGKDAAKHLFLVASGADSLSIGEYEILS
ECCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCCHHHHHH
QIRSTIDMFKKLGFSGKYLQIFFERAIKVGRKVREETSISKGKVGIYSLAIDEAKKRFND
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHH
FYDRRILVIGAGEMAQKITSMLHNEGAKDVTIMNRTIEKAKQLALKFGYNYEKLDLDKLG
HHCCEEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEECHHHCC
NFDVAFISIYHENLRLENKWNTLIVDITVPPLFTGNNVITLEELERISNLNFKAREEELA
CCCEEEEEEEHHHCEEECCCCEEEEEEEECCEECCCCEEEHHHHHHHHCCCCCHHHHHHH
KINKLVEDGINELLYDYKKEIYTEFMSKIMKRIETIRENEILRAYKELEKLGINDQQAKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ILDLMTRSIIKKSFQPLFDNIRSLIFNGENSINYINFLIDIFKDGNISGFETEKIKEKQV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
SERSSI
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726