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The map label for this gene is gltX

Identifier: 16126148

GI number: 16126148

Start: 2101378

End: 2102790

Strand: Direct

Name: gltX

Synonym: CC_1905

Alternate gene names: 16126148

Gene position: 2101378-2102790 (Clockwise)

Preceding gene: 16126145

Following gene: 16126149

Centisome position: 52.31

GC content: 66.24

Gene sequence:

>1413_bases
ATGTCGAACCCCACCCCTACCGGCGTCGTCACGCGCTTCGCCCCCTCGCCCACCGGTTTCCTGCATATCGGCGGCGCTCG
TACGGCGCTGTTCAACTGGTTATATGCACGCCATACGGGAGGGAAGTTCCTTATTCGCGTCGAGGACACCGATCGCGAGC
GCTCTACCGAAGCGGCCGTCGCCGCGATCTTCGAAGGGCTGGACTGGCTGGGCCTGAAATCCGACGACGAGGTGATCTTC
CAGCACACCCGCGCGCCGCGTCACGTGGAGGTGGTGCATGAGCTGCTGGCCAAGGGCCGCGCCTATCGCTGCTGGATGAG
CATCGAGGAGCTGGAGGTCGCCCGCGAAAAGGCCCGCGCCGAGGGCCGCGCGATCCGTTCGCCGTGGCGCGACGCGCCTG
AAGGCGACCTCTCCGCGCCCCACGTGATCCGCTTCAAGGGACCGCTGGACGGCGAGACCCTGGTCAACGACCTGGTCAAG
GGGCCTGTCACTTTCAAGAACATCGAGTTGGACGATCTTGTCCTGCTGCGCGCAGACGGCGCCCCCACGTACAATCTCGC
GGTCGTGGTGGATGATCACGACATGGGCGTGACCCACGTGATCCGAGGCGACGATCACCTGAACAACGCCGCCCGCCAGA
CCCTGATCTATCAGGCCATGGACTGGGCGGTGCCGGCCTTCGCCCACATCCCGCTGATTCACGGCCCGGACGGCGCCAAG
CTCTCCAAGCGCCACGGCGCCCAGGCCGTCGGCGAATTCGCTGACCTTGGCTACATCCCCGAAGGCATGCGCAACTATCT
GGCCCGCCTGGGCTGGGGTCATGGCGACGACGAAGTCTTCACCGACGAGCAGGCGATCAGCTGGTTCGACGTCGCCGATG
TCGTCAAAGCCCCCGCGCGCCTGGACTGGGCCAAGCTCAATCACATCAACGCCCAGCACCTGCGCAAGGCCGACGACGCG
CGTCTGACGGCCCTAGCCTTGGCGGCGGCGGAAACGCGCGGCGAGCCCCTGCCCGCCGACGCGGCCGAGCGCATCGCCCG
CACGGTTCCCGAGGTCAAGGAAGGCGCCAAGACGATCCTCGAACTGGTCGATCACTGCGCATTCGCGCTGAAGACCCGCC
CATTGGCGCTGGAAGAGAAAACCCAAAAACAGCTTACCGAAGAGACGGTCGAGCGGCTGAAGCGTCTGCGCGACCAACTG
GCCGCCGCGCCCGACTTCGACGCTGCAACCCTGGAAACCGTGTTGAAATCATTCGCGGAATCCGAAGGCGTCGGCTTTGG
CAAGTTCGGTCCCGCGCTGCGCGGAGTCCTCACGGGCGGGGCGCAGGCTCCCGACTTGAACAAGACCATGGCGGCCCTCT
CCCGCGATGAGGCGATTGGCCGTCTTGACGACGCGCTAGCGCCTCGCGCATGA

Upstream 100 bases:

>100_bases
CCCGGCGTTGAGCCGCATGCTAAGACGCCTCGCCCGCGTCGCTTCGCGGCGAACGTTTCCCAGCGCCGCTCCGGCGCCCT
GTCCTGCAGCCTTGAAGTCC

Downstream 100 bases:

>100_bases
GGCGCTATAACGCACCCGCGAAAAGCGAAAATTGGACTGCCCGTCCCAATAATGAAGGGGTCTACGGATGACCGATAAAG
CCACGCTGACGATCGGCGAC

Product: glutamyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamate--tRNA ligase; GluRS

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSNPTPTGVVTRFAPSPTGFLHIGGARTALFNWLYARHTGGKFLIRVEDTDRERSTEAAVAAIFEGLDWLGLKSDDEVIF
QHTRAPRHVEVVHELLAKGRAYRCWMSIEELEVAREKARAEGRAIRSPWRDAPEGDLSAPHVIRFKGPLDGETLVNDLVK
GPVTFKNIELDDLVLLRADGAPTYNLAVVVDDHDMGVTHVIRGDDHLNNAARQTLIYQAMDWAVPAFAHIPLIHGPDGAK
LSKRHGAQAVGEFADLGYIPEGMRNYLARLGWGHGDDEVFTDEQAISWFDVADVVKAPARLDWAKLNHINAQHLRKADDA
RLTALALAAAETRGEPLPADAAERIARTVPEVKEGAKTILELVDHCAFALKTRPLALEEKTQKQLTEETVERLKRLRDQL
AAAPDFDAATLETVLKSFAESEGVGFGKFGPALRGVLTGGAQAPDLNKTMAALSRDEAIGRLDDALAPRA

Sequences:

>Translated_470_residues
MSNPTPTGVVTRFAPSPTGFLHIGGARTALFNWLYARHTGGKFLIRVEDTDRERSTEAAVAAIFEGLDWLGLKSDDEVIF
QHTRAPRHVEVVHELLAKGRAYRCWMSIEELEVAREKARAEGRAIRSPWRDAPEGDLSAPHVIRFKGPLDGETLVNDLVK
GPVTFKNIELDDLVLLRADGAPTYNLAVVVDDHDMGVTHVIRGDDHLNNAARQTLIYQAMDWAVPAFAHIPLIHGPDGAK
LSKRHGAQAVGEFADLGYIPEGMRNYLARLGWGHGDDEVFTDEQAISWFDVADVVKAPARLDWAKLNHINAQHLRKADDA
RLTALALAAAETRGEPLPADAAERIARTVPEVKEGAKTILELVDHCAFALKTRPLALEEKTQKQLTEETVERLKRLRDQL
AAAPDFDAATLETVLKSFAESEGVGFGKFGPALRGVLTGGAQAPDLNKTMAALSRDEAIGRLDDALAPRA
>Mature_469_residues
SNPTPTGVVTRFAPSPTGFLHIGGARTALFNWLYARHTGGKFLIRVEDTDRERSTEAAVAAIFEGLDWLGLKSDDEVIFQ
HTRAPRHVEVVHELLAKGRAYRCWMSIEELEVAREKARAEGRAIRSPWRDAPEGDLSAPHVIRFKGPLDGETLVNDLVKG
PVTFKNIELDDLVLLRADGAPTYNLAVVVDDHDMGVTHVIRGDDHLNNAARQTLIYQAMDWAVPAFAHIPLIHGPDGAKL
SKRHGAQAVGEFADLGYIPEGMRNYLARLGWGHGDDEVFTDEQAISWFDVADVVKAPARLDWAKLNHINAQHLRKADDAR
LTALALAAAETRGEPLPADAAERIARTVPEVKEGAKTILELVDHCAFALKTRPLALEEKTQKQLTEETVERLKRLRDQLA
AAPDFDAATLETVLKSFAESEGVGFGKFGPALRGVLTGGAQAPDLNKTMAALSRDEAIGRLDDALAPRA

Specific function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI134288884, Length=500, Percent_Identity=31.4, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI62241042, Length=225, Percent_Identity=25.7777777777778, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788743, Length=466, Percent_Identity=40.7725321888412, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI226510925, Length=247, Percent_Identity=35.6275303643725, Blast_Score=135, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI71993394, Length=335, Percent_Identity=34.9253731343284, Blast_Score=179, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324540, Length=330, Percent_Identity=38.7878787878788, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6321192, Length=226, Percent_Identity=28.7610619469027, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24665321, Length=493, Percent_Identity=32.657200811359, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI17864488, Length=129, Percent_Identity=35.6589147286822, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: 1,800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYE_CAUCR (Q9A721)

Other databases:

- EMBL:   AE005673
- PIR:   D87485
- RefSeq:   NP_420712.1
- ProteinModelPortal:   Q9A721
- SMR:   Q9A721
- GeneID:   942561
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_1905
- NMPDR:   fig|190650.1.peg.1892
- TIGR:   CC_1905
- HOGENOM:   HBG628189
- OMA:   LPYVMGQ
- ProtClustDB:   PRK01406
- BRENDA:   6.1.1.17
- GO:   GO:0005737
- HAMAP:   MF_00022_B
- InterPro:   IPR008925
- InterPro:   IPR020751
- InterPro:   IPR001412
- InterPro:   IPR004527
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR014729
- Gene3D:   G3DSA:1.10.1160.10
- Gene3D:   G3DSA:3.40.50.620
- Gene3D:   G3DSA:1.10.10.350
- PANTHER:   PTHR10119
- PRINTS:   PR00987
- TIGRFAMs:   TIGR00464

Pfam domain/function: PF00749 tRNA-synt_1c; SSF48163 tRNA-synt_bind

EC number: =6.1.1.17

Molecular weight: Translated: 51465; Mature: 51334

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 243-243

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPTPTGVVTRFAPSPTGFLHIGGARTALFNWLYARHTGGKFLIRVEDTDRERSTEAAV
CCCCCCCCEEEECCCCCCCEEEECCHHHHHHHHHHHEECCCEEEEEEECCCCHHHHHHHH
AAIFEGLDWLGLKSDDEVIFQHTRAPRHVEVVHELLAKGRAYRCWMSIEELEVAREKARA
HHHHHCCHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHH
EGRAIRSPWRDAPEGDLSAPHVIRFKGPLDGETLVNDLVKGPVTFKNIELDDLVLLRADG
CCHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEECCCCCCEEEEEECC
APTYNLAVVVDDHDMGVTHVIRGDDHLNNAARQTLIYQAMDWAVPAFAHIPLIHGPDGAK
CCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCC
LSKRHGAQAVGEFADLGYIPEGMRNYLARLGWGHGDDEVFTDEQAISWFDVADVVKAPAR
HHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
LDWAKLNHINAQHLRKADDARLTALALAAAETRGEPLPADAAERIARTVPEVKEGAKTIL
CCHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ELVDHCAFALKTRPLALEEKTQKQLTEETVERLKRLRDQLAAAPDFDAATLETVLKSFAE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
SEGVGFGKFGPALRGVLTGGAQAPDLNKTMAALSRDEAIGRLDDALAPRA
HCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SNPTPTGVVTRFAPSPTGFLHIGGARTALFNWLYARHTGGKFLIRVEDTDRERSTEAAV
CCCCCCCEEEECCCCCCCEEEECCHHHHHHHHHHHEECCCEEEEEEECCCCHHHHHHHH
AAIFEGLDWLGLKSDDEVIFQHTRAPRHVEVVHELLAKGRAYRCWMSIEELEVAREKARA
HHHHHCCHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHH
EGRAIRSPWRDAPEGDLSAPHVIRFKGPLDGETLVNDLVKGPVTFKNIELDDLVLLRADG
CCHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEECCCCCCEEEEEECC
APTYNLAVVVDDHDMGVTHVIRGDDHLNNAARQTLIYQAMDWAVPAFAHIPLIHGPDGAK
CCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCC
LSKRHGAQAVGEFADLGYIPEGMRNYLARLGWGHGDDEVFTDEQAISWFDVADVVKAPAR
HHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
LDWAKLNHINAQHLRKADDARLTALALAAAETRGEPLPADAAERIARTVPEVKEGAKTIL
CCHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ELVDHCAFALKTRPLALEEKTQKQLTEETVERLKRLRDQLAAAPDFDAATLETVLKSFAE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
SEGVGFGKFGPALRGVLTGGAQAPDLNKTMAALSRDEAIGRLDDALAPRA
HCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647