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The map label for this gene is lexA [H]

Identifier: 16126145

GI number: 16126145

Start: 2097435

End: 2098172

Strand: Direct

Name: lexA [H]

Synonym: CC_1902

Alternate gene names: 16126145

Gene position: 2097435-2098172 (Clockwise)

Preceding gene: 16126144

Following gene: 16126148

Centisome position: 52.21

GC content: 65.99

Gene sequence:

>738_bases
TTGCGGTTTGTTCCGCGCTCCAGCGAGGCCGACATGCTCACGCGCAAGCAGCACGAACTGCTGATGTTCATCCACGAACG
GATCAAGGAAACCGGCGTCTCGCCGTCGTTCGACGAGATGAAGGAAGCCCTCGATCTGGCGTCCAAGTCCGGCATTCACC
GCCTGATCACCGCATTGGAAGAGCGCGGCTTCATCCGCCGTCTGGCGCACCGGGCCCGAGCGCTCGAGGTCGTGAAGCTC
CCTCAGCAGGCGACGGCCGCCGCCCCTCCCAAGGGACGCGGCGCCTTCCGTCCGCAGGTCTTCGAAGGCGGCGGGGCGCC
GCCTCCGGCCGCCAGTCCTGCCGCCGCCGCCAACGACAGTCGCGAACTGCCCATCCTTGGCCGGATCGCGGCCGGTACGC
CGATCGACGCCATCCAGCACGAACGCGAACGCCTGCCGGTGCCGGAAGCGATGCTGGGGGCCGGTGAGCACTATGTCTTG
GAAGTCCAGGGTGACTCTATGATCGAGGCCGGCATCCTCGATGGCGACTACGTGATCATCAAGAAGGGCGACACCGCCAC
CTCGGGCGAGATCGTCGTCGCGTTGGTGGGCGAGGAAGCCACGCTCAAGCGTCTGCGCAAGAAGGGCGGATCCATCGCAC
TGGAAGCCGCCAACCCCAAGTATGAAACCCGGATCTTTGGCCCTGATCAGGTCGAGGTGCAGGGCAAGCTGGTCGGCCTG
ATCCGGCGCTACCACTGA

Upstream 100 bases:

>100_bases
GCCCAACCAACAGCTAACTCTCTGATTTTTCGAACCTTTCGCCCGTTAACAAAGCTCGGCTTGACTTTGCAGCGGAACAC
CAGGAGAACATTCGAAAGGT

Downstream 100 bases:

>100_bases
CGGCTTGGCGATTATCGCTGCGAAAAATGGAGCAGGCCCTGATCCCGCCAGGATCAGGGCCTCTTGTTATTCAGGCGTCG
GGTGAAATCCGCCCTTGCTC

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MRFVPRSSEADMLTRKQHELLMFIHERIKETGVSPSFDEMKEALDLASKSGIHRLITALEERGFIRRLAHRARALEVVKL
PQQATAAAPPKGRGAFRPQVFEGGGAPPPAASPAAAANDSRELPILGRIAAGTPIDAIQHERERLPVPEAMLGAGEHYVL
EVQGDSMIEAGILDGDYVIIKKGDTATSGEIVVALVGEEATLKRLRKKGGSIALEAANPKYETRIFGPDQVEVQGKLVGL
IRRYH

Sequences:

>Translated_245_residues
MRFVPRSSEADMLTRKQHELLMFIHERIKETGVSPSFDEMKEALDLASKSGIHRLITALEERGFIRRLAHRARALEVVKL
PQQATAAAPPKGRGAFRPQVFEGGGAPPPAASPAAAANDSRELPILGRIAAGTPIDAIQHERERLPVPEAMLGAGEHYVL
EVQGDSMIEAGILDGDYVIIKKGDTATSGEIVVALVGEEATLKRLRKKGGSIALEAANPKYETRIFGPDQVEVQGKLVGL
IRRYH
>Mature_245_residues
MRFVPRSSEADMLTRKQHELLMFIHERIKETGVSPSFDEMKEALDLASKSGIHRLITALEERGFIRRLAHRARALEVVKL
PQQATAAAPPKGRGAFRPQVFEGGGAPPPAASPAAAANDSRELPILGRIAAGTPIDAIQHERERLPVPEAMLGAGEHYVL
EVQGDSMIEAGILDGDYVIIKKGDTATSGEIVVALVGEEATLKRLRKKGGSIALEAANPKYETRIFGPDQVEVQGKLVGL
IRRYH

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=232, Percent_Identity=25.4310344827586, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 26606; Mature: 26606

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFVPRSSEADMLTRKQHELLMFIHERIKETGVSPSFDEMKEALDLASKSGIHRLITALE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
ERGFIRRLAHRARALEVVKLPQQATAAAPPKGRGAFRPQVFEGGGAPPPAASPAAAANDS
HCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCC
RELPILGRIAAGTPIDAIQHERERLPVPEAMLGAGEHYVLEVQGDSMIEAGILDGDYVII
CCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHCCCCEEEEEECCCCEEEEEECCCCEEEE
KKGDTATSGEIVVALVGEEATLKRLRKKGGSIALEAANPKYETRIFGPDQVEVQGKLVGL
ECCCCCCCCCEEEEEECCHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCEEHHHHHHHH
IRRYH
HHHCC
>Mature Secondary Structure
MRFVPRSSEADMLTRKQHELLMFIHERIKETGVSPSFDEMKEALDLASKSGIHRLITALE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
ERGFIRRLAHRARALEVVKLPQQATAAAPPKGRGAFRPQVFEGGGAPPPAASPAAAANDS
HCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCC
RELPILGRIAAGTPIDAIQHERERLPVPEAMLGAGEHYVLEVQGDSMIEAGILDGDYVII
CCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHCCCCEEEEEECCCCEEEEEECCCCEEEE
KKGDTATSGEIVVALVGEEATLKRLRKKGGSIALEAANPKYETRIFGPDQVEVQGKLVGL
ECCCCCCCCCEEEEEECCHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCEEHHHHHHHH
IRRYH
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA