Click here to switch to the map view.

The map label for this gene is gltA [H]

Identifier: 16126149

GI number: 16126149

Start: 2102858

End: 2104138

Strand: Direct

Name: gltA [H]

Synonym: CC_1906

Alternate gene names: 16126149

Gene position: 2102858-2104138 (Clockwise)

Preceding gene: 16126148

Following gene: 16126167

Centisome position: 52.35

GC content: 63.08

Gene sequence:

>1281_bases
ATGACCGATAAAGCCACGCTGACGATCGGCGACAAGAGCTATGAGCTGCCGATCCTCAAGGGCAGCACGGGTCCGGACGT
CATCGACGTTCGGAAGATCTACGGTGAAAGCGATCACTTCACGTTCGATCCAGGCTTCACCTCCACCGCCTCGTGCGAGA
GCAAGATCACCTATATCGACGGCGACGCGGGCATCCTGCTGCACCGCGGCTATCCGATCGACCAGCTGGCCGAGAAGTCC
TCGTTCCTCGAGGTCTGCTACCTGCTGCTGAACGGCGAACTGCCCAAGGCCGACGAGTTCGCCAAGTTCGAGCACAACAT
CACCTACCACACGATGTTGCACGCTCAGTTCGACCGCTTCTTCGAGGGCTTCCGCCGCGACGCTCACCCGATGGCGGTCA
TGACCGGCGCCGTCGGCGCTCTGTCGGCCTTCTATTCGGACAGCATCAATGTCGACGACGCCCGTGAGCGCGAGATCAGC
GCCCATCGCCTGATCGCGAAGATGCCGACGATCGCCGCCCGCGCCTACAAGTACACGGTCGGCCAGCCGTTCGTGTCGCC
GCGCAACGACCTGTCGTATTCGGAAAACTTCCTGCGCATGTGCTTCGCCGTGCCGGCCGAGGACTGGAAGCCGAACCCGG
TGCTGACCCGCGCCATGGACCGGATCTTCATCCTGCACGCCGATCACGAGCAGAACGCCTCGACCTCGACCGTCCGTCTG
GCCGGTTCGTCGGGCGCGCACCCGTTCGCCTGTATCGCCGCCGGCATCGCCTGCCTGTGGGGCCCGTCGCACGGCGGCGC
CAACCAGGAAGCGCTTGAGATGCTGGAGACCATCGGTTCGGTCGACAACATCAAGGACTACGTCCAGGGCGTGAAGGACC
GGAAGTACAAGCTGATGGGCTTCGGCCACCGCGTGTACAAGAACTTCGACCCGCGCGCGAAGGTCATGCAAAAGACCGCG
CACGAGGTTCTGGCCGAGCTGGGCCATAACAACGATCCGCTGCTGCAGGTCGCCCAGGAGCTGGAAAAGGTCGCCCTGAA
CGACCCGTACTTCGTCGATCGCAAGCTGTACCCGAACATCGATTTCTATTCGGGCATCACCCTGCGCGCGATGGGCTTCC
CGACCAACATGTTCACCGTGCTGTTCGCCCTGGCCCGCACCGTGGGCTGGATCAGCCAGTGGAAGGAAATGTTCGAGGAC
CCCACCCGCAAGATCGGTCGTCCCCGTCAGCTCTACACGGGCGCCACGCATCGCGACTACGTCACGCTCGACAAGCGCTA
A

Upstream 100 bases:

>100_bases
CGTCTTGACGACGCGCTAGCGCCTCGCGCATGAGGCGCTATAACGCACCCGCGAAAAGCGAAAATTGGACTGCCCGTCCC
AATAATGAAGGGGTCTACGG

Downstream 100 bases:

>100_bases
AGCGCTTACAGTCCGGCGCTATGGATCAGGCCCCGCTCCGGCGGGGCCTTTTTCGTTTCAGCGCTTGAGCAGGAAGCTCA
ACACCTCGGCGACCGCGCGG

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTDKATLTIGDKSYELPILKGSTGPDVIDVRKIYGESDHFTFDPGFTSTASCESKITYIDGDAGILLHRGYPIDQLAEKS
SFLEVCYLLLNGELPKADEFAKFEHNITYHTMLHAQFDRFFEGFRRDAHPMAVMTGAVGALSAFYSDSINVDDAREREIS
AHRLIAKMPTIAARAYKYTVGQPFVSPRNDLSYSENFLRMCFAVPAEDWKPNPVLTRAMDRIFILHADHEQNASTSTVRL
AGSSGAHPFACIAAGIACLWGPSHGGANQEALEMLETIGSVDNIKDYVQGVKDRKYKLMGFGHRVYKNFDPRAKVMQKTA
HEVLAELGHNNDPLLQVAQELEKVALNDPYFVDRKLYPNIDFYSGITLRAMGFPTNMFTVLFALARTVGWISQWKEMFED
PTRKIGRPRQLYTGATHRDYVTLDKR

Sequences:

>Translated_426_residues
MTDKATLTIGDKSYELPILKGSTGPDVIDVRKIYGESDHFTFDPGFTSTASCESKITYIDGDAGILLHRGYPIDQLAEKS
SFLEVCYLLLNGELPKADEFAKFEHNITYHTMLHAQFDRFFEGFRRDAHPMAVMTGAVGALSAFYSDSINVDDAREREIS
AHRLIAKMPTIAARAYKYTVGQPFVSPRNDLSYSENFLRMCFAVPAEDWKPNPVLTRAMDRIFILHADHEQNASTSTVRL
AGSSGAHPFACIAAGIACLWGPSHGGANQEALEMLETIGSVDNIKDYVQGVKDRKYKLMGFGHRVYKNFDPRAKVMQKTA
HEVLAELGHNNDPLLQVAQELEKVALNDPYFVDRKLYPNIDFYSGITLRAMGFPTNMFTVLFALARTVGWISQWKEMFED
PTRKIGRPRQLYTGATHRDYVTLDKR
>Mature_425_residues
TDKATLTIGDKSYELPILKGSTGPDVIDVRKIYGESDHFTFDPGFTSTASCESKITYIDGDAGILLHRGYPIDQLAEKSS
FLEVCYLLLNGELPKADEFAKFEHNITYHTMLHAQFDRFFEGFRRDAHPMAVMTGAVGALSAFYSDSINVDDAREREISA
HRLIAKMPTIAARAYKYTVGQPFVSPRNDLSYSENFLRMCFAVPAEDWKPNPVLTRAMDRIFILHADHEQNASTSTVRLA
GSSGAHPFACIAAGIACLWGPSHGGANQEALEMLETIGSVDNIKDYVQGVKDRKYKLMGFGHRVYKNFDPRAKVMQKTAH
EVLAELGHNNDPLLQVAQELEKVALNDPYFVDRKLYPNIDFYSGITLRAMGFPTNMFTVLFALARTVGWISQWKEMFEDP
TRKIGRPRQLYTGATHRDYVTLDKR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=396, Percent_Identity=27.020202020202, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786939, Length=426, Percent_Identity=65.2582159624413, Blast_Score=584, Evalue=1e-168,
Organism=Escherichia coli, GI1786527, Length=369, Percent_Identity=33.3333333333333, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17555174, Length=407, Percent_Identity=27.5184275184275, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319850, Length=333, Percent_Identity=28.2282282282282, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324328, Length=327, Percent_Identity=26.9113149847095, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325257, Length=362, Percent_Identity=25.6906077348066, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24640126, Length=351, Percent_Identity=29.6296296296296, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24640124, Length=351, Percent_Identity=29.6296296296296, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21356863, Length=355, Percent_Identity=27.3239436619718, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 47919; Mature: 47788

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKATLTIGDKSYELPILKGSTGPDVIDVRKIYGESDHFTFDPGFTSTASCESKITYID
CCCCEEEEECCCCEEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCEEEEEE
GDAGILLHRGYPIDQLAEKSSFLEVCYLLLNGELPKADEFAKFEHNITYHTMLHAQFDRF
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHH
FEGFRRDAHPMAVMTGAVGALSAFYSDSINVDDAREREISAHRLIAKMPTIAARAYKYTV
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHEEEEC
GQPFVSPRNDLSYSENFLRMCFAVPAEDWKPNPVLTRAMDRIFILHADHEQNASTSTVRL
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCEEEEEECCCCCCCCCCEEEE
AGSSGAHPFACIAAGIACLWGPSHGGANQEALEMLETIGSVDNIKDYVQGVKDRKYKLMG
ECCCCCCHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEE
FGHRVYKNFDPRAKVMQKTAHEVLAELGHNNDPLLQVAQELEKVALNDPYFVDRKLYPNI
CCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCC
DFYSGITLRAMGFPTNMFTVLFALARTVGWISQWKEMFEDPTRKIGRPRQLYTGATHRDY
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHEECCCCCCCE
VTLDKR
EEECCC
>Mature Secondary Structure 
TDKATLTIGDKSYELPILKGSTGPDVIDVRKIYGESDHFTFDPGFTSTASCESKITYID
CCCEEEEECCCCEEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCEEEEEE
GDAGILLHRGYPIDQLAEKSSFLEVCYLLLNGELPKADEFAKFEHNITYHTMLHAQFDRF
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHH
FEGFRRDAHPMAVMTGAVGALSAFYSDSINVDDAREREISAHRLIAKMPTIAARAYKYTV
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHEEEEC
GQPFVSPRNDLSYSENFLRMCFAVPAEDWKPNPVLTRAMDRIFILHADHEQNASTSTVRL
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCEEEEEECCCCCCCCCCEEEE
AGSSGAHPFACIAAGIACLWGPSHGGANQEALEMLETIGSVDNIKDYVQGVKDRKYKLMG
ECCCCCCHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEE
FGHRVYKNFDPRAKVMQKTAHEVLAELGHNNDPLLQVAQELEKVALNDPYFVDRKLYPNI
CCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCC
DFYSGITLRAMGFPTNMFTVLFALARTVGWISQWKEMFEDPTRKIGRPRQLYTGATHRDY
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHEECCCCCCCE
VTLDKR
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]