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The map label for this gene is gpo [H]

Identifier: 16125974

GI number: 16125974

Start: 1902250

End: 1902732

Strand: Direct

Name: gpo [H]

Synonym: CC_1730

Alternate gene names: 16125974

Gene position: 1902250-1902732 (Clockwise)

Preceding gene: 16125973

Following gene: 16125975

Centisome position: 47.36

GC content: 62.11

Gene sequence:

>483_bases
ATGGCCATGTCGATCTACGACTATTCCGCCAAGACGCTGGACGGCCAGGACGTGAGCCTGGCCGACTATCGCGGCCAAGT
GCTGCTGATCGTGAACACCGCCAGCAAGTGCGGGTTCACGCCGCAGTACGAGGGCCTGGAAGCGCTCTACAAGGCGCACA
AGGACCGTGGCTTCACGGTCCTGGCCTTCCCCTGCAATCAGTTCGGCGCTCAGGAGCCGGGTAACGCCGAGGAAATCGCG
AACTTCTGCTCGCTGACCTACGACGTGAGCTTCCCGGTCATGAGCAAGATCGACGTCAACGGCGCCGACGCCCACCCGCT
CTACAAGTTCCTCAAGAAGGAACAGAAGGGCGTCTTGGGCACCGAGGCGATCAAGTGGAACTTCACCAAGTTCCTGATCG
GCAAGGACGGCCAGGTCGTCGATCGGTTCGCGCCGACCGTGAAGCCCGAAGACCTGAAGGTCGCGGTCGAGGCGCTGCTC
TAG

Upstream 100 bases:

>100_bases
CGTGGTCGACGGCTCGGTCGGCGCCAAGTTCCTGGCGGCCTTCAGGCCGCTGATTGAAGAGCCGCTGACCCTGATCGTCT
GATCAGGGCGCGGGGAAGGT

Downstream 100 bases:

>100_bases
TTTCTCCCAGACCGGTTTGCAGACTGGTCGATCGGCGCCGCGCGCTCCCTCGTGCGATCGCCAAAGTCAGGGTTAGAAGA
TCATGTCCACGGAATTCGAT

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MAMSIYDYSAKTLDGQDVSLADYRGQVLLIVNTASKCGFTPQYEGLEALYKAHKDRGFTVLAFPCNQFGAQEPGNAEEIA
NFCSLTYDVSFPVMSKIDVNGADAHPLYKFLKKEQKGVLGTEAIKWNFTKFLIGKDGQVVDRFAPTVKPEDLKVAVEALL

Sequences:

>Translated_160_residues
MAMSIYDYSAKTLDGQDVSLADYRGQVLLIVNTASKCGFTPQYEGLEALYKAHKDRGFTVLAFPCNQFGAQEPGNAEEIA
NFCSLTYDVSFPVMSKIDVNGADAHPLYKFLKKEQKGVLGTEAIKWNFTKFLIGKDGQVVDRFAPTVKPEDLKVAVEALL
>Mature_159_residues
AMSIYDYSAKTLDGQDVSLADYRGQVLLIVNTASKCGFTPQYEGLEALYKAHKDRGFTVLAFPCNQFGAQEPGNAEEIAN
FCSLTYDVSFPVMSKIDVNGADAHPLYKFLKKEQKGVLGTEAIKWNFTKFLIGKDGQVVDRFAPTVKPEDLKVAVEALL

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI90903240, Length=151, Percent_Identity=50.9933774834437, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI75709200, Length=151, Percent_Identity=50.9933774834437, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI15618997, Length=156, Percent_Identity=47.4358974358974, Blast_Score=140, Evalue=3e-34,
Organism=Homo sapiens, GI90903238, Length=133, Percent_Identity=51.1278195488722, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI192455698, Length=158, Percent_Identity=38.6075949367089, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI41406084, Length=184, Percent_Identity=38.5869565217391, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI4557629, Length=177, Percent_Identity=37.8531073446328, Blast_Score=103, Evalue=9e-23,
Organism=Homo sapiens, GI6006001, Length=176, Percent_Identity=34.6590909090909, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI33186887, Length=156, Percent_Identity=38.4615384615385, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI32967607, Length=184, Percent_Identity=33.1521739130435, Blast_Score=93, Evalue=1e-19,
Organism=Escherichia coli, GI1788003, Length=170, Percent_Identity=48.8235294117647, Blast_Score=162, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17535473, Length=158, Percent_Identity=48.7341772151899, Blast_Score=157, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17506887, Length=158, Percent_Identity=47.4683544303797, Blast_Score=155, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71993584, Length=158, Percent_Identity=44.3037974683544, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI193210707, Length=162, Percent_Identity=43.8271604938272, Blast_Score=129, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI193209493, Length=166, Percent_Identity=37.3493975903614, Blast_Score=116, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17550320, Length=166, Percent_Identity=37.3493975903614, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71993573, Length=95, Percent_Identity=40, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17507603, Length=108, Percent_Identity=38.8888888888889, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71999642, Length=78, Percent_Identity=39.7435897435897, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193210709, Length=72, Percent_Identity=48.6111111111111, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322228, Length=146, Percent_Identity=58.2191780821918, Blast_Score=190, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6319721, Length=160, Percent_Identity=51.875, Blast_Score=189, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6322826, Length=155, Percent_Identity=44.5161290322581, Blast_Score=145, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24656772, Length=163, Percent_Identity=49.079754601227, Blast_Score=150, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24656767, Length=163, Percent_Identity=49.079754601227, Blast_Score=150, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24656777, Length=163, Percent_Identity=49.079754601227, Blast_Score=149, Evalue=5e-37,
Organism=Drosophila melanogaster, GI85726443, Length=160, Percent_Identity=38.75, Blast_Score=112, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 17653; Mature: 17522

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1 ; PS00763 GLUTATHIONE_PEROXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMSIYDYSAKTLDGQDVSLADYRGQVLLIVNTASKCGFTPQYEGLEALYKAHKDRGFTV
CCEEEECCCCCCCCCCCCEEECCCCEEEEEEECCHHCCCCCCCHHHHHHHHHHCCCCCEE
LAFPCNQFGAQEPGNAEEIANFCSLTYDVSFPVMSKIDVNGADAHPLYKFLKKEQKGVLG
EEECCHHCCCCCCCCHHHHHHHHHEEEECCCCCEEEECCCCCCCHHHHHHHHHHHCCCCC
TEAIKWNFTKFLIGKDGQVVDRFAPTVKPEDLKVAVEALL
CCEEEEEEEEEEECCCCCCHHHHCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
AMSIYDYSAKTLDGQDVSLADYRGQVLLIVNTASKCGFTPQYEGLEALYKAHKDRGFTV
CEEEECCCCCCCCCCCCEEECCCCEEEEEEECCHHCCCCCCCHHHHHHHHHHCCCCCEE
LAFPCNQFGAQEPGNAEEIANFCSLTYDVSFPVMSKIDVNGADAHPLYKFLKKEQKGVLG
EEECCHHCCCCCCCCHHHHHHHHHEEEECCCCCEEEECCCCCCCHHHHHHHHHHHCCCCC
TEAIKWNFTKFLIGKDGQVVDRFAPTVKPEDLKVAVEALL
CCEEEEEEEEEEECCCCCCHHHHCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]