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The map label for this gene is lpd [H]

Identifier: 16125975

GI number: 16125975

Start: 1902815

End: 1904215

Strand: Direct

Name: lpd [H]

Synonym: CC_1731

Alternate gene names: 16125975

Gene position: 1902815-1904215 (Clockwise)

Preceding gene: 16125974

Following gene: 16125976

Centisome position: 47.37

GC content: 66.02

Gene sequence:

>1401_bases
ATGTCCACGGAATTCGATGTCGTCGTCATCGGCGCCGGTCCTGGCGGCTATGTGGCCGCGATCCGCGCCAGCCAGCTGGG
CCTGAATACGGCCATCATCGAGCGTGAGAATCTGGGCGGCATCTGCCTGAACTGGGGCTGCATCCCGACCAAGGCGCTGC
TGAAGTCCGGCGAGGTCTACGAGCAGCTGTCGCATCTGGGCGGTTACGGTCTGTCGGTCGAGAAGGCCTCGTTCGACTTC
GGCAAGATCATCGAGCGCTCGCGCGGCGTGGCCAAGAACATGTCGGGCGGCATCGCCTTCCTGATGAAGAAGCACAAGAT
CGAGGTGATCGAGGGCGAGGCCAAGCTTGAGAAGGGCGCGCCGGCTCCGAAGGTCGTTGTCGCCTTGAAGGCCGGCGGCA
GCCGCACGGTGCAGGCCAAGAACGTGATCCTGGCCAGCGGCGCCCGCGCCCGCGAGATCCCGGCCATCGGCGCGGTCTCG
GACGGCGACAAGATCTGGACCTACCGCGACGCCCTGGCGCCCAAGTCTATGCCCAAGTCGCTGGTCGTGATCGGCTCGGG
CGCCATCGGCATCGAGTTCGCCAGCTTCTACCGTGCGCTGGGCGCCGAAGTGACCGTCGTCGAAGCCATTGACCGCATCA
TGCCGGTCGAGGACGAGGAAGTTTCCAAGGCCGCCCAGAAGGCGTTCGAGAAGCGCGGTATCAAGTTCCGTGTCGGCGCG
AAGGTCAGCAAGATCGAGAAGACCAAGGACGGCGTCGCCGTCACCGTCGAAGCCGGTGGCAAGATCGAGCAGCTGACCGC
CGAGAAGTGCATCGTCGCCGTCGGCATCGCGCCCAACAATGACGGCCTGGAAGCGCTGGGCGTGAGCCTGGATCGTGGTC
ACGTCGTGACCGACAAGCACTGCCGCACCAACGTGCCCGGCCTTTACGCCATCGGCGACATCGCCGGCGCGCCGTGGCTC
GCCCACAAGGCCAGCCACGAGGGCATCCACGCGGCCGAGGCGATCGCCGGCTACAAGACGCCCAACGTCCTTTCGCCGAT
CCCGGGCTGCACCTACGCCAATCCGCAAGTGGCCTCGGTGGGCTACACCGAAGCCGGCGCCAAGGCGGCGGGTATCGAGG
TCAAGGCCGGCCGCTTCCCATTCCGCGTCAACGGCAAGGCCGTGGCGTCGGGCGAGACCGAAGGCTTCGTCAAGACCGTG
TTCGACGCCAAGACGGGCGCCTTGATCGGCGCTCACATGATCGGCCACGAAGTGACCGAGATGATCCAGGGCTTCGTCAC
CGCCATCACCCTGGAAGCGACCGAGGAAGACCTGCACGGCGTCGTCTACGCCCACCCGACCATGTCGGAAGCGATGCACG
AAGCCGCTCTGGACGCCTACGGACGCGTGCTGCACATCTAG

Upstream 100 bases:

>100_bases
GTCGAGGCGCTGCTCTAGTTTCTCCCAGACCGGTTTGCAGACTGGTCGATCGGCGCCGCGCGCTCCCTCGTGCGATCGCC
AAAGTCAGGGTTAGAAGATC

Downstream 100 bases:

>100_bases
GGCAGCTTAGGGAGTCTGGATGGCGCGCAAGGCCGCCGCGACAGCGGGTGAAAAGCCGAAGGTGCGGAAGGGGTCGAAGA
CGACCCTTTCCGAAGCCAAT

Product: pyruvate dehydrogenase complex, E3 component, lipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSTEFDVVVIGAGPGGYVAAIRASQLGLNTAIIERENLGGICLNWGCIPTKALLKSGEVYEQLSHLGGYGLSVEKASFDF
GKIIERSRGVAKNMSGGIAFLMKKHKIEVIEGEAKLEKGAPAPKVVVALKAGGSRTVQAKNVILASGARAREIPAIGAVS
DGDKIWTYRDALAPKSMPKSLVVIGSGAIGIEFASFYRALGAEVTVVEAIDRIMPVEDEEVSKAAQKAFEKRGIKFRVGA
KVSKIEKTKDGVAVTVEAGGKIEQLTAEKCIVAVGIAPNNDGLEALGVSLDRGHVVTDKHCRTNVPGLYAIGDIAGAPWL
AHKASHEGIHAAEAIAGYKTPNVLSPIPGCTYANPQVASVGYTEAGAKAAGIEVKAGRFPFRVNGKAVASGETEGFVKTV
FDAKTGALIGAHMIGHEVTEMIQGFVTAITLEATEEDLHGVVYAHPTMSEAMHEAALDAYGRVLHI

Sequences:

>Translated_466_residues
MSTEFDVVVIGAGPGGYVAAIRASQLGLNTAIIERENLGGICLNWGCIPTKALLKSGEVYEQLSHLGGYGLSVEKASFDF
GKIIERSRGVAKNMSGGIAFLMKKHKIEVIEGEAKLEKGAPAPKVVVALKAGGSRTVQAKNVILASGARAREIPAIGAVS
DGDKIWTYRDALAPKSMPKSLVVIGSGAIGIEFASFYRALGAEVTVVEAIDRIMPVEDEEVSKAAQKAFEKRGIKFRVGA
KVSKIEKTKDGVAVTVEAGGKIEQLTAEKCIVAVGIAPNNDGLEALGVSLDRGHVVTDKHCRTNVPGLYAIGDIAGAPWL
AHKASHEGIHAAEAIAGYKTPNVLSPIPGCTYANPQVASVGYTEAGAKAAGIEVKAGRFPFRVNGKAVASGETEGFVKTV
FDAKTGALIGAHMIGHEVTEMIQGFVTAITLEATEEDLHGVVYAHPTMSEAMHEAALDAYGRVLHI
>Mature_465_residues
STEFDVVVIGAGPGGYVAAIRASQLGLNTAIIERENLGGICLNWGCIPTKALLKSGEVYEQLSHLGGYGLSVEKASFDFG
KIIERSRGVAKNMSGGIAFLMKKHKIEVIEGEAKLEKGAPAPKVVVALKAGGSRTVQAKNVILASGARAREIPAIGAVSD
GDKIWTYRDALAPKSMPKSLVVIGSGAIGIEFASFYRALGAEVTVVEAIDRIMPVEDEEVSKAAQKAFEKRGIKFRVGAK
VSKIEKTKDGVAVTVEAGGKIEQLTAEKCIVAVGIAPNNDGLEALGVSLDRGHVVTDKHCRTNVPGLYAIGDIAGAPWLA
HKASHEGIHAAEAIAGYKTPNVLSPIPGCTYANPQVASVGYTEAGAKAAGIEVKAGRFPFRVNGKAVASGETEGFVKTVF
DAKTGALIGAHMIGHEVTEMIQGFVTAITLEATEEDLHGVVYAHPTMSEAMHEAALDAYGRVLHI

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=474, Percent_Identity=39.662447257384, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI50301238, Length=468, Percent_Identity=29.0598290598291, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI22035672, Length=462, Percent_Identity=26.1904761904762, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI33519430, Length=450, Percent_Identity=25.5555555555556, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI33519428, Length=450, Percent_Identity=25.5555555555556, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI33519426, Length=450, Percent_Identity=25.5555555555556, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI148277071, Length=450, Percent_Identity=25.5555555555556, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI148277065, Length=450, Percent_Identity=25.5555555555556, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI291045266, Length=465, Percent_Identity=22.1505376344086, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI291045268, Length=457, Percent_Identity=22.1006564551422, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI226437568, Length=145, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI65787454, Length=145, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI21389617, Length=145, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786307, Length=466, Percent_Identity=39.0557939914163, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI87082354, Length=471, Percent_Identity=28.0254777070064, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=27.7904328018223, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI87081717, Length=460, Percent_Identity=24.1304347826087, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI32565766, Length=471, Percent_Identity=39.2781316348195, Blast_Score=292, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI71983419, Length=462, Percent_Identity=28.5714285714286, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI71983429, Length=462, Percent_Identity=28.5714285714286, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17557007, Length=483, Percent_Identity=26.2939958592132, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17559934, Length=238, Percent_Identity=28.9915966386555, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71982272, Length=493, Percent_Identity=21.9066937119675, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=482, Percent_Identity=40.0414937759336, Blast_Score=282, Evalue=8e-77,
Organism=Saccharomyces cerevisiae, GI6325240, Length=476, Percent_Identity=29.4117647058824, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6325166, Length=474, Percent_Identity=26.1603375527426, Blast_Score=150, Evalue=3e-37,
Organism=Drosophila melanogaster, GI21358499, Length=475, Percent_Identity=40.4210526315789, Blast_Score=305, Evalue=3e-83,
Organism=Drosophila melanogaster, GI24640553, Length=483, Percent_Identity=28.3643892339545, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24640549, Length=483, Percent_Identity=28.1573498964803, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24640551, Length=483, Percent_Identity=28.1573498964803, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17737741, Length=478, Percent_Identity=26.7782426778243, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 48773; Mature: 48641

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEFDVVVIGAGPGGYVAAIRASQLGLNTAIIERENLGGICLNWGCIPTKALLKSGEVY
CCCCEEEEEEECCCCCEEEEEEHHHCCCEEEEEEECCCCCEEEECCCCCHHHHHCCCHHH
EQLSHLGGYGLSVEKASFDFGKIIERSRGVAKNMSGGIAFLMKKHKIEVIEGEAKLEKGA
HHHHHCCCCCCEEECCCCCHHHHHHHHCCCHHCCCCCEEEEEECCEEEEEECCHHHCCCC
PAPKVVVALKAGGSRTVQAKNVILASGARAREIPAIGAVSDGDKIWTYRDALAPKSMPKS
CCCEEEEEEECCCCCEEEECEEEEECCCCCCCCCEEEEECCCCEEEEEHHHCCCCCCCCE
LVVIGSGAIGIEFASFYRALGAEVTVVEAIDRIMPVEDEEVSKAAQKAFEKRGIKFRVGA
EEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECC
KVSKIEKTKDGVAVTVEAGGKIEQLTAEKCIVAVGIAPNNDGLEALGVSLDRGHVVTDKH
CHHHHHHCCCCEEEEEECCCCCHHCCCCCEEEEEEECCCCCCHHHHEEEECCCCEEECCC
CRTNVPGLYAIGDIAGAPWLAHKASHEGIHAAEAIAGYKTPNVLSPIPGCTYANPQVASV
CCCCCCCEEEECCCCCCCHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEC
GYTEAGAKAAGIEVKAGRFPFRVNGKAVASGETEGFVKTVFDAKTGALIGAHMIGHEVTE
CCCCCCCCCCCEEEECCCCCEEECCEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHH
MIQGFVTAITLEATEEDLHGVVYAHPTMSEAMHEAALDAYGRVLHI
HHHHHHHEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCEECC
>Mature Secondary Structure 
STEFDVVVIGAGPGGYVAAIRASQLGLNTAIIERENLGGICLNWGCIPTKALLKSGEVY
CCCEEEEEEECCCCCEEEEEEHHHCCCEEEEEEECCCCCEEEECCCCCHHHHHCCCHHH
EQLSHLGGYGLSVEKASFDFGKIIERSRGVAKNMSGGIAFLMKKHKIEVIEGEAKLEKGA
HHHHHCCCCCCEEECCCCCHHHHHHHHCCCHHCCCCCEEEEEECCEEEEEECCHHHCCCC
PAPKVVVALKAGGSRTVQAKNVILASGARAREIPAIGAVSDGDKIWTYRDALAPKSMPKS
CCCEEEEEEECCCCCEEEECEEEEECCCCCCCCCEEEEECCCCEEEEEHHHCCCCCCCCE
LVVIGSGAIGIEFASFYRALGAEVTVVEAIDRIMPVEDEEVSKAAQKAFEKRGIKFRVGA
EEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECC
KVSKIEKTKDGVAVTVEAGGKIEQLTAEKCIVAVGIAPNNDGLEALGVSLDRGHVVTDKH
CHHHHHHCCCCEEEEEECCCCCHHCCCCCEEEEEEECCCCCCHHHHEEEECCCCEEECCC
CRTNVPGLYAIGDIAGAPWLAHKASHEGIHAAEAIAGYKTPNVLSPIPGCTYANPQVASV
CCCCCCCEEEECCCCCCCHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEC
GYTEAGAKAAGIEVKAGRFPFRVNGKAVASGETEGFVKTVFDAKTGALIGAHMIGHEVTE
CCCCCCCCCCCEEEECCCCCEEECCEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHH
MIQGFVTAITLEATEEDLHGVVYAHPTMSEAMHEAALDAYGRVLHI
HHHHHHHEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]