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The map label for this gene is rnd [H]

Identifier: 16125948

GI number: 16125948

Start: 1876022

End: 1877191

Strand: Direct

Name: rnd [H]

Synonym: CC_1704

Alternate gene names: 16125948

Gene position: 1876022-1877191 (Clockwise)

Preceding gene: 16125944

Following gene: 16125949

Centisome position: 46.7

GC content: 67.26

Gene sequence:

>1170_bases
ATGAAGCTGATCACCACCACCGCCGAGTTGGCGGCGTTCTGTAATGGCCTTGCGGGCGAGCCTTTCGTCGCCGTGGACAC
CGAGTTCATGCGCGAGACGACCTACTGGCCCAAGCTGTGCCTGATCCAGGTCGCGTCCCCCACCCAGGAAGCGGTCATCG
ACCCGCTCGCCGATAATATCGATCTTGAGCCGCTGCTGGTCGTGATGCGTGACGAGCGCATCCTCAAGGTGTTCCACGCC
GCCCGGCAGGACGTCGAGATCTTCAACAATCTGAAGGCGATGCCCAAGCCGCTGTTCGACACGCAGGTCGCAGGCATGGC
CGCCGGCTTCGGCGAGCAGATCGCCTATGACGCCCTGGTGCGTCAGATGCTGCGGATCGAGATCGACAAGTCCAGCCGCT
TCACCGACTGGGCCCGACGTCCGCTCACCGACGCGCAGCTCAGCTACGCCCTGGCCGACGTGACCCACCTGGCCAAGCTG
TTCCCGATCCTGCGCGAGCGCCTGGAAACCTCGGGCCGTCTGGCCTGGGTCGAGGAGGAGATGACCGCCATCTCCGACCC
GGCCGCCTATGATGTCGACCCGGAAAAGGCCTGGCGTCGCCTGCGTCCGCGCAAGACCGCGCCGAAGTATCTGGCCGTGT
TCAAGGCCGTCGCCGCCTGGCGCGAGCGCACCGCCCAGAACCGCGACCAGCCGCGCGGCCGGATCCTGAAGGACGAGGCC
ATCGACGAGCTGGCCACCCAGACGCCCGGCAATCTCGAGGCGCTGAACAATCTGCGAGGCGTGCCCAAGGGCTTTGGCGG
CAGCAAGTTCGGTCCCGACCTGCTGGCGGCGATCAAGGACGCTCTGGCCGATCCGGAAGGCTACGCGCCCGTCGTCGACA
AGCCCGGCCCGCCGCCGCCTCAGAACGCCGGCGCCGTCGTCGAGCTCCTCAAGGTGCTGCTGAAGGCGCGTGCGGAAGAG
GCCGGTGTGGCCTCCAAGCTGATCGCCACGGTCTCCGACCTTGAGAAGATCGCCGCCGATGACAACGCCACGACGCCCGC
CCTTACGGGCTGGCGACGCGAAGCGTTCGGTTCCGATGCGCTCAAGATCAAGCGCGGCGAACTGGCGCTGGTGCTGGACG
GCGCCCGTGTGCGGGTGGTCGAGGTGCGTCGCGCCCCCAAGAACGATTGA

Upstream 100 bases:

>100_bases
CGACGACGCCGTCCGAACTCGCGGAAAATTTGCTTCCCGGCCATGCTTGGCGCGTCTTGACGCTTGCAGACTCGGGGGTG
CGCGAGGCTATTAGCAGCGG

Downstream 100 bases:

>100_bases
TCGTCCTTGTTTAAGGCTCAAATTCGCGGTCTTGGCGTCCCGCTGGCGCCTCGATCGCGGGTTTCAGGCGCCTGAACTGG
CCTCACGCGCGATGCTGGCG

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKLITTTAELAAFCNGLAGEPFVAVDTEFMRETTYWPKLCLIQVASPTQEAVIDPLADNIDLEPLLVVMRDERILKVFHA
ARQDVEIFNNLKAMPKPLFDTQVAGMAAGFGEQIAYDALVRQMLRIEIDKSSRFTDWARRPLTDAQLSYALADVTHLAKL
FPILRERLETSGRLAWVEEEMTAISDPAAYDVDPEKAWRRLRPRKTAPKYLAVFKAVAAWRERTAQNRDQPRGRILKDEA
IDELATQTPGNLEALNNLRGVPKGFGGSKFGPDLLAAIKDALADPEGYAPVVDKPGPPPPQNAGAVVELLKVLLKARAEE
AGVASKLIATVSDLEKIAADDNATTPALTGWRREAFGSDALKIKRGELALVLDGARVRVVEVRRAPKND

Sequences:

>Translated_389_residues
MKLITTTAELAAFCNGLAGEPFVAVDTEFMRETTYWPKLCLIQVASPTQEAVIDPLADNIDLEPLLVVMRDERILKVFHA
ARQDVEIFNNLKAMPKPLFDTQVAGMAAGFGEQIAYDALVRQMLRIEIDKSSRFTDWARRPLTDAQLSYALADVTHLAKL
FPILRERLETSGRLAWVEEEMTAISDPAAYDVDPEKAWRRLRPRKTAPKYLAVFKAVAAWRERTAQNRDQPRGRILKDEA
IDELATQTPGNLEALNNLRGVPKGFGGSKFGPDLLAAIKDALADPEGYAPVVDKPGPPPPQNAGAVVELLKVLLKARAEE
AGVASKLIATVSDLEKIAADDNATTPALTGWRREAFGSDALKIKRGELALVLDGARVRVVEVRRAPKND
>Mature_389_residues
MKLITTTAELAAFCNGLAGEPFVAVDTEFMRETTYWPKLCLIQVASPTQEAVIDPLADNIDLEPLLVVMRDERILKVFHA
ARQDVEIFNNLKAMPKPLFDTQVAGMAAGFGEQIAYDALVRQMLRIEIDKSSRFTDWARRPLTDAQLSYALADVTHLAKL
FPILRERLETSGRLAWVEEEMTAISDPAAYDVDPEKAWRRLRPRKTAPKYLAVFKAVAAWRERTAQNRDQPRGRILKDEA
IDELATQTPGNLEALNNLRGVPKGFGGSKFGPDLLAAIKDALADPEGYAPVVDKPGPPPPQNAGAVVELLKVLLKARAEE
AGVASKLIATVSDLEKIAADDNATTPALTGWRREAFGSDALKIKRGELALVLDGARVRVVEVRRAPKND

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=258, Percent_Identity=24.4186046511628, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI50301240, Length=258, Percent_Identity=24.4186046511628, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1788105, Length=374, Percent_Identity=31.8181818181818, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17531757, Length=174, Percent_Identity=31.0344827586207, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324574, Length=267, Percent_Identity=25.0936329588015, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI161078302, Length=267, Percent_Identity=24.7191011235955, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42826; Mature: 42826

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLITTTAELAAFCNGLAGEPFVAVDTEFMRETTYWPKLCLIQVASPTQEAVIDPLADNI
CCEEEHHHHHHHHHCCCCCCCEEEECHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCC
DLEPLLVVMRDERILKVFHAARQDVEIFNNLKAMPKPLFDTQVAGMAAGFGEQIAYDALV
CCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHH
RQMLRIEIDKSSRFTDWARRPLTDAQLSYALADVTHLAKLFPILRERLETSGRLAWVEEE
HHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHH
MTAISDPAAYDVDPEKAWRRLRPRKTAPKYLAVFKAVAAWRERTAQNRDQPRGRILKDEA
HHHHCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHH
IDELATQTPGNLEALNNLRGVPKGFGGSKFGPDLLAAIKDALADPEGYAPVVDKPGPPPP
HHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
QNAGAVVELLKVLLKARAEEAGVASKLIATVSDLEKIAADDNATTPALTGWRREAFGSDA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCHHHHHCCCCC
LKIKRGELALVLDGARVRVVEVRRAPKND
EEEECCCEEEEECCCEEEEEEECCCCCCC
>Mature Secondary Structure
MKLITTTAELAAFCNGLAGEPFVAVDTEFMRETTYWPKLCLIQVASPTQEAVIDPLADNI
CCEEEHHHHHHHHHCCCCCCCEEEECHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCC
DLEPLLVVMRDERILKVFHAARQDVEIFNNLKAMPKPLFDTQVAGMAAGFGEQIAYDALV
CCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHH
RQMLRIEIDKSSRFTDWARRPLTDAQLSYALADVTHLAKLFPILRERLETSGRLAWVEEE
HHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHH
MTAISDPAAYDVDPEKAWRRLRPRKTAPKYLAVFKAVAAWRERTAQNRDQPRGRILKDEA
HHHHCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHH
IDELATQTPGNLEALNNLRGVPKGFGGSKFGPDLLAAIKDALADPEGYAPVVDKPGPPPP
HHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
QNAGAVVELLKVLLKARAEEAGVASKLIATVSDLEKIAADDNATTPALTGWRREAFGSDA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCHHHHHCCCCC
LKIKRGELALVLDGARVRVVEVRRAPKND
EEEECCCEEEEECCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]