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The map label for this gene is bioA [H]

Identifier: 13488066

GI number: 13488066

Start: 76178

End: 77455

Strand: Reverse

Name: bioA [H]

Synonym: mll9097

Alternate gene names: 13488066

Gene position: 77455-76178 (Counterclockwise)

Preceding gene: 13488067

Following gene: 13488065

Centisome position: 22.01

GC content: 64.63

Gene sequence:

>1278_bases
GTGTCCGGGAGATCACTGATGTCCCCCGTCTGGCATCCCTTCACCCAGCACGCGCTCGAGCTCGCCATCCCTGAAATCGC
CCGGACGGAAGGCGCCTACCTCCACAAGGCCGACGGCACGCGCATCCTGGATGCCATCTCCTCCTGGTGGGTCGTTACCC
ACTGCCACCGCCATCCCCGCATCATCAAGGCCATCGAGACGACCGCGGCGAGCCTCGACCAGATCATCTTCGCCGGCTTC
ACGCACGAGCCGGCGGAACGTCTGGCCAGGGCACTTGTCGGCCTTGCTCCCGCCGGCCTTGACTGGGTGTTCTATTCAGA
CAGCGGCTCGACCTCCGTCGAGGTCGCGCTGAAGATGGCGCTCGGCTATTTCCGCAACATCGGCGCGCCGCGCTCGCGCA
TCGTCGTCATGGAGCACAGCTATCATGGCGACACCATCGGCACGATGAGCGTCGGCGCCCGCGGTGTGTTCAACGCCGCC
TACGAACCCTTGCTGTTCGAGGTCGACACCATCCCCTTCCCTGCCGCCGGGCAAGAGCAGGAGACGCTGGATCGGTTCGA
GGCAGTCTCCCGCGACCGGCGTGCCGCCGCGCTGATCGTCGAGCCGCTCGTGCTTGGCGCCGGAGGCATGCAGATGTATC
CGGCCTGGGTTCTGGCCGAATTGAAGAAAATCACTGAGGCCTCTGGCACGTTGCTGATCACCGACGAGGTGATGACCGGC
TGGGGGCGCACCGGAACCATGTTCGCCTGCGAGCAGGCATCGATTTCTCCAGATATCCTGTGCACCTCGAAAGGCTTGAC
CGGCGGCACCATCCCGCTGGCCGCAACGCTTGCCACCGATGCGATCTTCCAGGCTCATTATTCCGAGGACCGGAAGAAGA
CATTTTTCCACTCGAGTTCCTACACCGCCAATCCGATTGCCTGCGGGGCAGCACTTGCCAATGTCGAGATCTGGCGGGAC
GAGCCGGTGGCCGAGCGGATCGCGGCGTTGAGTGCGATGCAGGCCGCCGGGCTTCGGCGCTTTGGCGACAACCCTCGCTT
CACCGACAGCCGGGTTACCGGCACGATCGCAGCCCTCGATCTGCGCACGAGCTCCGCCGGCTATCTGGCCGACATCGGGC
CGAAGCTGCGCGCTTTTTTCCTTGAGCGCGGACTGCTCGTGCGTCCGCTCGGCAACGTGCTCGATCTCATGCCGCCCTAT
TGCATCACCGGCGACGAACTCGACGGACTCTATGACGCCATCGAGGAGGCCGCCGAACGCTTCGGGTCTAGGCCATGA

Upstream 100 bases:

>100_bases
AAATGGGTGGGGTACCGCAGCTTGGCAGGTTGCCCTATCTCGATCCGCTGACGGACAAAACGTTAAGAGCGGCAATGATT
GCCGGATTTGCCTTCGCCTC

Downstream 100 bases:

>100_bases
GCAAGTCGTCGCGCATTCTCGGGTTCGGCCATCATGCGCCCGGGCGCAAAGTGGAGAATGCCGAGATCGAGAACAATCTC
GGCCTCGAGCCGGGCTGGAT

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSGRSLMSPVWHPFTQHALELAIPEIARTEGAYLHKADGTRILDAISSWWVVTHCHRHPRIIKAIETTAASLDQIIFAGF
THEPAERLARALVGLAPAGLDWVFYSDSGSTSVEVALKMALGYFRNIGAPRSRIVVMEHSYHGDTIGTMSVGARGVFNAA
YEPLLFEVDTIPFPAAGQEQETLDRFEAVSRDRRAAALIVEPLVLGAGGMQMYPAWVLAELKKITEASGTLLITDEVMTG
WGRTGTMFACEQASISPDILCTSKGLTGGTIPLAATLATDAIFQAHYSEDRKKTFFHSSSYTANPIACGAALANVEIWRD
EPVAERIAALSAMQAAGLRRFGDNPRFTDSRVTGTIAALDLRTSSAGYLADIGPKLRAFFLERGLLVRPLGNVLDLMPPY
CITGDELDGLYDAIEEAAERFGSRP

Sequences:

>Translated_425_residues
MSGRSLMSPVWHPFTQHALELAIPEIARTEGAYLHKADGTRILDAISSWWVVTHCHRHPRIIKAIETTAASLDQIIFAGF
THEPAERLARALVGLAPAGLDWVFYSDSGSTSVEVALKMALGYFRNIGAPRSRIVVMEHSYHGDTIGTMSVGARGVFNAA
YEPLLFEVDTIPFPAAGQEQETLDRFEAVSRDRRAAALIVEPLVLGAGGMQMYPAWVLAELKKITEASGTLLITDEVMTG
WGRTGTMFACEQASISPDILCTSKGLTGGTIPLAATLATDAIFQAHYSEDRKKTFFHSSSYTANPIACGAALANVEIWRD
EPVAERIAALSAMQAAGLRRFGDNPRFTDSRVTGTIAALDLRTSSAGYLADIGPKLRAFFLERGLLVRPLGNVLDLMPPY
CITGDELDGLYDAIEEAAERFGSRP
>Mature_424_residues
SGRSLMSPVWHPFTQHALELAIPEIARTEGAYLHKADGTRILDAISSWWVVTHCHRHPRIIKAIETTAASLDQIIFAGFT
HEPAERLARALVGLAPAGLDWVFYSDSGSTSVEVALKMALGYFRNIGAPRSRIVVMEHSYHGDTIGTMSVGARGVFNAAY
EPLLFEVDTIPFPAAGQEQETLDRFEAVSRDRRAAALIVEPLVLGAGGMQMYPAWVLAELKKITEASGTLLITDEVMTGW
GRTGTMFACEQASISPDILCTSKGLTGGTIPLAATLATDAIFQAHYSEDRKKTFFHSSSYTANPIACGAALANVEIWRDE
PVAERIAALSAMQAAGLRRFGDNPRFTDSRVTGTIAALDLRTSSAGYLADIGPKLRAFFLERGLLVRPLGNVLDLMPPYC
ITGDELDGLYDAIEEAAERFGSRP

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=398, Percent_Identity=25.8793969849246, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI13994255, Length=415, Percent_Identity=24.578313253012, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI284507298, Length=305, Percent_Identity=26.8852459016393, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI24119277, Length=425, Percent_Identity=23.5294117647059, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1786991, Length=419, Percent_Identity=37.708830548926, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI145693181, Length=387, Percent_Identity=29.4573643410853, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1789759, Length=402, Percent_Identity=28.6069651741293, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788044, Length=410, Percent_Identity=27.3170731707317, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1787560, Length=402, Percent_Identity=26.1194029850746, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1789016, Length=394, Percent_Identity=26.6497461928934, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1786349, Length=323, Percent_Identity=26.0061919504644, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI25144271, Length=406, Percent_Identity=23.8916256157635, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI32564660, Length=437, Percent_Identity=26.0869565217391, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25144274, Length=292, Percent_Identity=26.3698630136986, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17541228, Length=439, Percent_Identity=22.5512528473804, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324386, Length=466, Percent_Identity=28.5407725321888, Blast_Score=185, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6323470, Length=393, Percent_Identity=26.4631043256997, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6324432, Length=324, Percent_Identity=26.8518518518519, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357415, Length=400, Percent_Identity=24.5, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI161085790, Length=432, Percent_Identity=26.6203703703704, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI28574759, Length=418, Percent_Identity=27.2727272727273, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 46089; Mature: 45958

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGRSLMSPVWHPFTQHALELAIPEIARTEGAYLHKADGTRILDAISSWWVVTHCHRHPR
CCCCCCCCHHCCHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCH
IIKAIETTAASLDQIIFAGFTHEPAERLARALVGLAPAGLDWVFYSDSGSTSVEVALKMA
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHH
LGYFRNIGAPRSRIVVMEHSYHGDTIGTMSVGARGVFNAAYEPLLFEVDTIPFPAAGQEQ
HHHHHHCCCCCCEEEEEEECCCCCCCEEHHCCCCHHHHHCCCCEEEEEECCCCCCCCCHH
ETLDRFEAVSRDRRAAALIVEPLVLGAGGMQMYPAWVLAELKKITEASGTLLITDEVMTG
HHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHC
WGRTGTMFACEQASISPDILCTSKGLTGGTIPLAATLATDAIFQAHYSEDRKKTFFHSSS
CCCCCCEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHEEECCC
YTANPIACGAALANVEIWRDEPVAERIAALSAMQAAGLRRFGDNPRFTDSRVTGTIAALD
CCCCCHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEE
LRTSSAGYLADIGPKLRAFFLERGLLVRPLGNVLDLMPPYCITGDELDGLYDAIEEAAER
EECCCCCCHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHH
FGSRP
HCCCC
>Mature Secondary Structure 
SGRSLMSPVWHPFTQHALELAIPEIARTEGAYLHKADGTRILDAISSWWVVTHCHRHPR
CCCCCCCHHCCHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCH
IIKAIETTAASLDQIIFAGFTHEPAERLARALVGLAPAGLDWVFYSDSGSTSVEVALKMA
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHH
LGYFRNIGAPRSRIVVMEHSYHGDTIGTMSVGARGVFNAAYEPLLFEVDTIPFPAAGQEQ
HHHHHHCCCCCCEEEEEEECCCCCCCEEHHCCCCHHHHHCCCCEEEEEECCCCCCCCCHH
ETLDRFEAVSRDRRAAALIVEPLVLGAGGMQMYPAWVLAELKKITEASGTLLITDEVMTG
HHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHC
WGRTGTMFACEQASISPDILCTSKGLTGGTIPLAATLATDAIFQAHYSEDRKKTFFHSSS
CCCCCCEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHEEECCC
YTANPIACGAALANVEIWRDEPVAERIAALSAMQAAGLRRFGDNPRFTDSRVTGTIAALD
CCCCCHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEE
LRTSSAGYLADIGPKLRAFFLERGLLVRPLGNVLDLMPPYCITGDELDGLYDAIEEAAER
EECCCCCCHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHH
FGSRP
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]