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The map label for this gene is dapA [H]

Identifier: 13476428

GI number: 13476428

Start: 6416877

End: 6417794

Strand: Direct

Name: dapA [H]

Synonym: mlr7746

Alternate gene names: 13476428

Gene position: 6416877-6417794 (Clockwise)

Preceding gene: 13476425

Following gene: 13476429

Centisome position: 91.2

GC content: 63.62

Gene sequence:

>918_bases
ATGCATAAACAAACAAGTCCCAAGGAGTTGGACGACATGCTGAGAGGCTCGCTTACTGCGCTCGTGACACCGTTCGAAAA
GAGCGGGCGTTTCGACGAGAAAGCCTTTCGCGCCTTTGTCGAATGGCAGCTCGGGGAAGGCACGACGGGTCTGGTCCCGG
TGGGCACGACCGGCGAGTCGCCGACGCTGTCGCATGACGAGCACCGCCATGTCGTCAAGGTCTGCATCGAGGTGGCCAAT
GGGCGCGCTCCGGTCGTCGCCGGCGCCGGCTCCAACAACACCGCGGAAGCGGTCGGGCTTGTGCAATATGCCGAAAAGGC
CGGCGCCGATGCCGCCCTGGTCGTCACGCCCTATTACAACAAGCCGACACAGCGCGGCCTCTACGAGCATTTCGCCGCCG
TCGCCAGGGCGACCAAGCTGCCGATCATCATCTACAACATCCCGCCGCGCTCGGTGATCGACATGATGCCGGAGACGATG
GGCCGGCTGGCGCACGACTTCAAGAACATCGTCGGCGTCAAGGATGCGACCGGCAAGGTCGAGCGTGTGTCCGAGCAGCG
CATGACCTGCGGCAAGGATTTCATCCAGCTTTCCGGCGAGGATGCCTCGGCGCTCGGCTTCAACGCCCATGGCGGTGTCG
GCTGCATCTCGGTGACCTCGAACGTCGCCCCGCGGCTGTGCGCCGAATTCCAGGAAGCCACGCTGTCCGGCGACAGTGTG
AAGGCGCTGGAATTGCAGGACCGTCTCTTGCCGCTGCATAAGGCGATCTTCCTGGAGCCCGGCGTGTCCGGCGCCAAATA
CGCGCTGTCGAAGCTGGGCAAGGTCGAGAACGTGCTACGGTCGCCGTTGGTCACGGTCGAGGAGTCGACCGCGGCGAAGA
TCGATGCGGCCATGAAGCACGCCGGCTTGATCAATTAG

Upstream 100 bases:

>100_bases
GCGCCGCTTCGCTTTCAGTTAGAAGGCGCGCACGACAAACTGATCGACAAAACACCGATGCATGTCGCCCAAAGGTGGAT
ACCGGTTTTGGGACAACGAC

Downstream 100 bases:

>100_bases
CGAGCCCGTTTGGAAACTCTACTCCTGCGGCATCTGAAGGCGCCACCTGCGCTTCCGGTGCTCACGTACTATATGTACGC
TCCGCTCCGGTTTCGCGCAT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MHKQTSPKELDDMLRGSLTALVTPFEKSGRFDEKAFRAFVEWQLGEGTTGLVPVGTTGESPTLSHDEHRHVVKVCIEVAN
GRAPVVAGAGSNNTAEAVGLVQYAEKAGADAALVVTPYYNKPTQRGLYEHFAAVARATKLPIIIYNIPPRSVIDMMPETM
GRLAHDFKNIVGVKDATGKVERVSEQRMTCGKDFIQLSGEDASALGFNAHGGVGCISVTSNVAPRLCAEFQEATLSGDSV
KALELQDRLLPLHKAIFLEPGVSGAKYALSKLGKVENVLRSPLVTVEESTAAKIDAAMKHAGLIN

Sequences:

>Translated_305_residues
MHKQTSPKELDDMLRGSLTALVTPFEKSGRFDEKAFRAFVEWQLGEGTTGLVPVGTTGESPTLSHDEHRHVVKVCIEVAN
GRAPVVAGAGSNNTAEAVGLVQYAEKAGADAALVVTPYYNKPTQRGLYEHFAAVARATKLPIIIYNIPPRSVIDMMPETM
GRLAHDFKNIVGVKDATGKVERVSEQRMTCGKDFIQLSGEDASALGFNAHGGVGCISVTSNVAPRLCAEFQEATLSGDSV
KALELQDRLLPLHKAIFLEPGVSGAKYALSKLGKVENVLRSPLVTVEESTAAKIDAAMKHAGLIN
>Mature_305_residues
MHKQTSPKELDDMLRGSLTALVTPFEKSGRFDEKAFRAFVEWQLGEGTTGLVPVGTTGESPTLSHDEHRHVVKVCIEVAN
GRAPVVAGAGSNNTAEAVGLVQYAEKAGADAALVVTPYYNKPTQRGLYEHFAAVARATKLPIIIYNIPPRSVIDMMPETM
GRLAHDFKNIVGVKDATGKVERVSEQRMTCGKDFIQLSGEDASALGFNAHGGVGCISVTSNVAPRLCAEFQEATLSGDSV
KALELQDRLLPLHKAIFLEPGVSGAKYALSKLGKVENVLRSPLVTVEESTAAKIDAAMKHAGLIN

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=251, Percent_Identity=28.2868525896414, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1788823, Length=293, Percent_Identity=45.3924914675768, Blast_Score=267, Evalue=6e-73,
Organism=Escherichia coli, GI87082415, Length=296, Percent_Identity=31.4189189189189, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786463, Length=266, Percent_Identity=29.6992481203008, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1789620, Length=237, Percent_Identity=29.535864978903, Blast_Score=94, Evalue=9e-21,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32607; Mature: 32607

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKQTSPKELDDMLRGSLTALVTPFEKSGRFDEKAFRAFVEWQLGEGTTGLVPVGTTGES
CCCCCCHHHHHHHHHCCHHHEECCHHHCCCCHHHHHHHHHHEECCCCCCCEEEECCCCCC
PTLSHDEHRHVVKVCIEVANGRAPVVAGAGSNNTAEAVGLVQYAEKAGADAALVVTPYYN
CCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCC
KPTQRGLYEHFAAVARATKLPIIIYNIPPRSVIDMMPETMGRLAHDFKNIVGVKDATGKV
CCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
ERVSEQRMTCGKDFIQLSGEDASALGFNAHGGVGCISVTSNVAPRLCAEFQEATLSGDSV
HHHHHHHHHHCCHHHEECCCCCCEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCE
KALELQDRLLPLHKAIFLEPGVSGAKYALSKLGKVENVLRSPLVTVEESTAAKIDAAMKH
EEHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHH
AGLIN
CCCCC
>Mature Secondary Structure
MHKQTSPKELDDMLRGSLTALVTPFEKSGRFDEKAFRAFVEWQLGEGTTGLVPVGTTGES
CCCCCCHHHHHHHHHCCHHHEECCHHHCCCCHHHHHHHHHHEECCCCCCCEEEECCCCCC
PTLSHDEHRHVVKVCIEVANGRAPVVAGAGSNNTAEAVGLVQYAEKAGADAALVVTPYYN
CCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCC
KPTQRGLYEHFAAVARATKLPIIIYNIPPRSVIDMMPETMGRLAHDFKNIVGVKDATGKV
CCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
ERVSEQRMTCGKDFIQLSGEDASALGFNAHGGVGCISVTSNVAPRLCAEFQEATLSGDSV
HHHHHHHHHHCCHHHEECCCCCCEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCE
KALELQDRLLPLHKAIFLEPGVSGAKYALSKLGKVENVLRSPLVTVEESTAAKIDAAMKH
EEHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHH
AGLIN
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]