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The map label for this gene is rmlA1 [H]

Identifier: 13476271

GI number: 13476271

Start: 6232050

End: 6232931

Strand: Direct

Name: rmlA1 [H]

Synonym: mlr7550

Alternate gene names: 13476271

Gene position: 6232050-6232931 (Clockwise)

Preceding gene: 13476270

Following gene: 13476272

Centisome position: 88.57

GC content: 58.05

Gene sequence:

>882_bases
TTGAAAGGAATTATCCTTGCTGGAGGCAGTGGAACGCGTCTTTATCCACTGACATTAGCGGTCTCTAAGCAAATCCTTCC
GATATACGACAAGCCGATGATTTATTATCCGCTGAGCGTACTGATGCTCGCGGGAATCCGCGAGATTCTGATTGTCTCGA
CACCGCGTGATCTGCCGGCTTTTCGTGATTTACTCGGCGACGGATCGGAGTTCGGGCTGGCGTTCTCCTACGCCGAGCAA
CCGCATCCCAATGGTCTTGCGGAAGCTTTCATTATCGGCCGGGATTTCATCGGCAAAGATAGCGTCTCGATGATCCTTGG
CGACAACATCTATTTCGGTGATGGCCTGTCGCAGCTTTGCCGCGCCGCCGCTGCGCGCGACGCGGGTGCTTCGGTGTTCG
CCTATCATGTCGAGGATCCCGAGCGCTATGGCGTCGTGTCCTTCGACAAGGCAACCGGGACCGCGCTGACGATTGAGGAA
AAACCGCAGAAACCGAAGTCGAACTGGGCTGTCACCGGTCTCTATTTCTACGACAATGAGGTGGTCGACATCGCCCCGAC
GATCCGCCCCTCGGCGCGTGGCGAGCTCGAGATCACGGCGGTCAACAATGTCTATCTCGAGCGCGGCAAGCTGCATGTGC
ACCGTTTGGGCCGTGGCTATGCCTGGCTCGACACCGGCACGCATGACAGTTTGCACGAAGCCTCTTCTTTCGTGCGCACG
ATCGAACATCGCCAGGGTATCAAGGTTGCCTGCCCTGAGGAGATCGCCTTCGAGCAGGGCTGGCTGACGGCGGAGCAAGT
GCTGCAACGCGCAACCCGGTTGGGCAAAAATGAATATGCCGCCTATCTGCGGCGGCGCGTCGCCGATCTGTTGGAGGGCT
AA

Upstream 100 bases:

>100_bases
AGACCCCTTCTGTGTCGCGTGCCGCATTGACAAGCCATTGAATGAAACCTAAGCACGGGCGGTCAGGGCCGGGGGGCTTC
GGCATGTCAAGGAGAGCTTC

Downstream 100 bases:

>100_bases
GCTTTGGAGATCAGGTCCCTCGGCATCGATGGCGTGCTGGAAATCGTTCCCAAGCGACATGGCGATGCACGCGGCTTCTT
CATGGAAACCTACAATGCCG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKGIILAGGSGTRLYPLTLAVSKQILPIYDKPMIYYPLSVLMLAGIREILIVSTPRDLPAFRDLLGDGSEFGLAFSYAEQ
PHPNGLAEAFIIGRDFIGKDSVSMILGDNIYFGDGLSQLCRAAAARDAGASVFAYHVEDPERYGVVSFDKATGTALTIEE
KPQKPKSNWAVTGLYFYDNEVVDIAPTIRPSARGELEITAVNNVYLERGKLHVHRLGRGYAWLDTGTHDSLHEASSFVRT
IEHRQGIKVACPEEIAFEQGWLTAEQVLQRATRLGKNEYAAYLRRRVADLLEG

Sequences:

>Translated_293_residues
MKGIILAGGSGTRLYPLTLAVSKQILPIYDKPMIYYPLSVLMLAGIREILIVSTPRDLPAFRDLLGDGSEFGLAFSYAEQ
PHPNGLAEAFIIGRDFIGKDSVSMILGDNIYFGDGLSQLCRAAAARDAGASVFAYHVEDPERYGVVSFDKATGTALTIEE
KPQKPKSNWAVTGLYFYDNEVVDIAPTIRPSARGELEITAVNNVYLERGKLHVHRLGRGYAWLDTGTHDSLHEASSFVRT
IEHRQGIKVACPEEIAFEQGWLTAEQVLQRATRLGKNEYAAYLRRRVADLLEG
>Mature_293_residues
MKGIILAGGSGTRLYPLTLAVSKQILPIYDKPMIYYPLSVLMLAGIREILIVSTPRDLPAFRDLLGDGSEFGLAFSYAEQ
PHPNGLAEAFIIGRDFIGKDSVSMILGDNIYFGDGLSQLCRAAAARDAGASVFAYHVEDPERYGVVSFDKATGTALTIEE
KPQKPKSNWAVTGLYFYDNEVVDIAPTIRPSARGELEITAVNNVYLERGKLHVHRLGRGYAWLDTGTHDSLHEASSFVRT
IEHRQGIKVACPEEIAFEQGWLTAEQVLQRATRLGKNEYAAYLRRRVADLLEG

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=283, Percent_Identity=23.6749116607774, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI11761621, Length=283, Percent_Identity=23.6749116607774, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=65.9722222222222, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1790224, Length=283, Percent_Identity=64.6643109540636, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1787488, Length=294, Percent_Identity=27.5510204081633, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=207, Percent_Identity=26.0869565217391, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320148, Length=257, Percent_Identity=28.0155642023346, Blast_Score=92, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21355443, Length=252, Percent_Identity=24.2063492063492, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24644084, Length=252, Percent_Identity=24.2063492063492, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32349; Mature: 32349

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPLTLAVSKQILPIYDKPMIYYPLSVLMLAGIREILIVSTPRDLPA
CCCEEEECCCCCEEEEEEEEECCCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECCCCCHH
FRDLLGDGSEFGLAFSYAEQPHPNGLAEAFIIGRDFIGKDSVSMILGDNIYFGDGLSQLC
HHHHHCCCCCCCEEEECCCCCCCCCCHHEEEECCCCCCCCCEEEEECCCEEECCCHHHHH
RAAAARDAGASVFAYHVEDPERYGVVSFDKATGTALTIEEKPQKPKSNWAVTGLYFYDNE
HHHHCCCCCCEEEEEECCCCCCCCEEEECCCCCCEEEECCCCCCCCCCEEEEEEEEECCC
VVDIAPTIRPSARGELEITAVNNVYLERGKLHVHRLGRGYAWLDTGTHDSLHEASSFVRT
EEEECCCCCCCCCCCEEEEEECEEEEECCCEEEEECCCCEEEEECCCCHHHHHHHHHHHH
IEHRQGIKVACPEEIAFEQGWLTAEQVLQRATRLGKNEYAAYLRRRVADLLEG
HHHHCCCEEECCHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKGIILAGGSGTRLYPLTLAVSKQILPIYDKPMIYYPLSVLMLAGIREILIVSTPRDLPA
CCCEEEECCCCCEEEEEEEEECCCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECCCCCHH
FRDLLGDGSEFGLAFSYAEQPHPNGLAEAFIIGRDFIGKDSVSMILGDNIYFGDGLSQLC
HHHHHCCCCCCCEEEECCCCCCCCCCHHEEEECCCCCCCCCEEEEECCCEEECCCHHHHH
RAAAARDAGASVFAYHVEDPERYGVVSFDKATGTALTIEEKPQKPKSNWAVTGLYFYDNE
HHHHCCCCCCEEEEEECCCCCCCCEEEECCCCCCEEEECCCCCCCCCCEEEEEEEEECCC
VVDIAPTIRPSARGELEITAVNNVYLERGKLHVHRLGRGYAWLDTGTHDSLHEASSFVRT
EEEECCCCCCCCCCCEEEEEECEEEEECCCEEEEECCCCEEEEECCCCHHHHHHHHHHHH
IEHRQGIKVACPEEIAFEQGWLTAEQVLQRATRLGKNEYAAYLRRRVADLLEG
HHHHCCCEEECCHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]