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The map label for this gene is pdhR [H]

Identifier: 13475755

GI number: 13475755

Start: 5684367

End: 5685170

Strand: Reverse

Name: pdhR [H]

Synonym: mll6911

Alternate gene names: 13475755

Gene position: 5685170-5684367 (Counterclockwise)

Preceding gene: 13475761

Following gene: 13475754

Centisome position: 80.8

GC content: 66.42

Gene sequence:

>804_bases
TTGAGCGATATTTTTTCCAGGATCGAGCATTCGCGCACCGCCGACGAGGTGGTGCAGCAGATCGAGAGCCTCATCCTCGA
AGGCGTGCTGCGCACCGGCGACCGGTTGCCGGGCGAGCGCGAGCTGGCACGCCAGTTCGACGTATCGCGGCCGATCCTGC
GCGACGCGCTGAAGGCGCTGGAAGGGCGTGGGCTGCTGACGACCAAGGCCGGCGGCGGCACTCATGTCGCCGACATCATC
GGCCAGCTGTTCACCAAGCCGGTGGCCGACCTGATCTCGATGCATCGCAAGGCGGTGACCGATTATCTGGAATATCGCCG
CGAGATCGAAGGCATAGCCGCCGAATATGCCGCGCGGCGCGCCACCCCGGAGGATCTCGCCCTGCTCGACCGCATTATGG
CGCGCATGGACGAGGCGCACCGCACCGGCGATTTCGACGACGAGGCCGAGATCGACGTCGAGTTCCATCAAGCGATCTGC
GAATGCGCGCACAACATCCTGCTTTTGCACACGCTGCGCTCCTGCTACCGGCTTTTGTCGGAAGGCGTCTTCCAGAACCG
GCTGCTGGTCTTCACCGTGCCCGGGGCGCGCGAGGCACTGCTGGCGCAGCACAAGGCAATCCACGCCGCGGTCAAGGCCG
GCGATCCCAACGCTGCCCGGCACGCGGCAATGGACCACATGACCTATGTCGAGCGGTCGATGGCCGAAGCCGAGCGCAGC
GGCGACTGGCAACGCGTGTCACGGCTGCGGCTGCGGCAGCGTTCGGAAGCCGGCGACACCGAACCGGCGCGCAGACGCTC
CTAG

Upstream 100 bases:

>100_bases
GCGAAACCGACACGTTTCGACCAATTGGATAAATAATTTGACCAGTTGGCGACGCAGGCTTTATCCTGCGCGACACCGGT
CCAATTCCCAGGCACAGCTG

Downstream 100 bases:

>100_bases
TAGTACGATCAAGCGGGAACCATCATGAGCGACATTCTCACCATCGCGGACCTCAAGGATCTCGCCCGCCGGCGCGTGCC
CAAGATGTTTTTCGACTATG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSDIFSRIEHSRTADEVVQQIESLILEGVLRTGDRLPGERELARQFDVSRPILRDALKALEGRGLLTTKAGGGTHVADII
GQLFTKPVADLISMHRKAVTDYLEYRREIEGIAAEYAARRATPEDLALLDRIMARMDEAHRTGDFDDEAEIDVEFHQAIC
ECAHNILLLHTLRSCYRLLSEGVFQNRLLVFTVPGAREALLAQHKAIHAAVKAGDPNAARHAAMDHMTYVERSMAEAERS
GDWQRVSRLRLRQRSEAGDTEPARRRS

Sequences:

>Translated_267_residues
MSDIFSRIEHSRTADEVVQQIESLILEGVLRTGDRLPGERELARQFDVSRPILRDALKALEGRGLLTTKAGGGTHVADII
GQLFTKPVADLISMHRKAVTDYLEYRREIEGIAAEYAARRATPEDLALLDRIMARMDEAHRTGDFDDEAEIDVEFHQAIC
ECAHNILLLHTLRSCYRLLSEGVFQNRLLVFTVPGAREALLAQHKAIHAAVKAGDPNAARHAAMDHMTYVERSMAEAERS
GDWQRVSRLRLRQRSEAGDTEPARRRS
>Mature_266_residues
SDIFSRIEHSRTADEVVQQIESLILEGVLRTGDRLPGERELARQFDVSRPILRDALKALEGRGLLTTKAGGGTHVADIIG
QLFTKPVADLISMHRKAVTDYLEYRREIEGIAAEYAARRATPEDLALLDRIMARMDEAHRTGDFDDEAEIDVEFHQAICE
CAHNILLLHTLRSCYRLLSEGVFQNRLLVFTVPGAREALLAQHKAIHAAVKAGDPNAARHAAMDHMTYVERSMAEAERSG
DWQRVSRLRLRQRSEAGDTEPARRRS

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=230, Percent_Identity=42.1739130434783, Blast_Score=177, Evalue=9e-46,
Organism=Escherichia coli, GI1790032, Length=227, Percent_Identity=37.8854625550661, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1789353, Length=228, Percent_Identity=32.8947368421053, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790780, Length=234, Percent_Identity=30.7692307692308, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI87082208, Length=204, Percent_Identity=27.9411764705882, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI48994955, Length=228, Percent_Identity=26.7543859649123, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789621, Length=229, Percent_Identity=27.0742358078603, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 30045; Mature: 29913

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIFSRIEHSRTADEVVQQIESLILEGVLRTGDRLPGERELARQFDVSRPILRDALKAL
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHH
EGRGLLTTKAGGGTHVADIIGQLFTKPVADLISMHRKAVTDYLEYRREIEGIAAEYAARR
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ATPEDLALLDRIMARMDEAHRTGDFDDEAEIDVEFHQAICECAHNILLLHTLRSCYRLLS
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGVFQNRLLVFTVPGAREALLAQHKAIHAAVKAGDPNAARHAAMDHMTYVERSMAEAERS
HHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GDWQRVSRLRLRQRSEAGDTEPARRRS
CCHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SDIFSRIEHSRTADEVVQQIESLILEGVLRTGDRLPGERELARQFDVSRPILRDALKAL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHH
EGRGLLTTKAGGGTHVADIIGQLFTKPVADLISMHRKAVTDYLEYRREIEGIAAEYAARR
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ATPEDLALLDRIMARMDEAHRTGDFDDEAEIDVEFHQAICECAHNILLLHTLRSCYRLLS
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGVFQNRLLVFTVPGAREALLAQHKAIHAAVKAGDPNAARHAAMDHMTYVERSMAEAERS
HHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GDWQRVSRLRLRQRSEAGDTEPARRRS
CCHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]