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The map label for this gene is folD2

Identifier: 13475761

GI number: 13475761

Start: 5691462

End: 5692382

Strand: Reverse

Name: folD2

Synonym: mll6921

Alternate gene names: 13475761

Gene position: 5692382-5691462 (Counterclockwise)

Preceding gene: 13475763

Following gene: 13475755

Centisome position: 80.9

GC content: 65.69

Gene sequence:

>921_bases
ATGTCCCTGCCCGACGACAGCCGCTATCTCAAGGGCGGCCCGGTTGCCCAGCGCATCATCGCCGCCGTGCGCGAGGACGC
GGCGATTGCCAAGGCCGAGGGTTTTCCGCCCAAGCTGATCTCGATCACCGTCGGCGATACCGATGCCGTGGATGTCTATG
TGCGCAACCAGCGCGCCAAGGCGCAGCTTGCCGGCATCGATTTCGAGGAACGGCGTTTTCCCGCCACCATCACCTCGGGC
GAATTGGAAGCGGCCATCCACGGGCTGAACGCCGATCCGCGTGTCACCGGCATCATCATCCAGCGGCCGGTGCCCGCGCA
TATTTCGGTCAAGACGCTGCAGGCGGCAGTGCATCCGCTCAAGGATGTCGAAGGCATGCACCCGGCCTCGATCGGCAACA
TCGTCTACAACCAGCTTGATCTGGCGCCCTGCACGGCGGCTGCCTCCGTCGAACTGCTCAAGGAGACCGGCCTCGACCTC
AAGGGGCTGGAAGTGGTCGTCGTCGGCCATTCGGAAATCGTCGGCAAGCCGATCGCTTTCTTGCTGATGAGCGAAGGCGC
GACGGTCACGGTCTGCCACCACTTGACGCGATCGGTCGCCGCGCATGCGCGCCGCGCCGATGCGCTGTTCGTCGCCGTGG
GCAAGCCGCGGCTGATCAAGGCCGACATGGTCAAGCCAGGGGCTGCCGTCATCGATATCGGCATCAATTCCGAGATCGGG
CCCGATGGGACGAGCCGTATCGTCGGCGACGTCGACACCGACAGTGTGAAAGACGTGGCCTCCTGGATCACGCCGGTGCC
GGGCGGCGTCGGCCCGATCACGGTGGCGATCCTGCTGCGTAACACGATGGTGGCGCTCAGCCGGCAGCGCGCGCTTTACG
AGGCAACCTACGGCACGGCGGACAGGCTCGCGGCGGAGTAA

Upstream 100 bases:

>100_bases
TCGTTGCGTCGCGCAGAAGGCATGGCGCTTCGCTTTCATGCTGCCATTTTCGGCGGTCTTTTGTTATGTCGGCGCCAACG
CGAGAAAAGAGTCCACCTCC

Downstream 100 bases:

>100_bases
GCGCCGATCCCTACTCCGCAGCGATCAGGCTCTCGTCTCGGACACCCTCCGGCTTCGGTCCGCCATAAGCCCAGTCGAGC
AGCTTGATGGTGTGCACCAC

Product: methylenetetrahydrofolate dehydrogenase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MSLPDDSRYLKGGPVAQRIIAAVREDAAIAKAEGFPPKLISITVGDTDAVDVYVRNQRAKAQLAGIDFEERRFPATITSG
ELEAAIHGLNADPRVTGIIIQRPVPAHISVKTLQAAVHPLKDVEGMHPASIGNIVYNQLDLAPCTAAASVELLKETGLDL
KGLEVVVVGHSEIVGKPIAFLLMSEGATVTVCHHLTRSVAAHARRADALFVAVGKPRLIKADMVKPGAAVIDIGINSEIG
PDGTSRIVGDVDTDSVKDVASWITPVPGGVGPITVAILLRNTMVALSRQRALYEATYGTADRLAAE

Sequences:

>Translated_306_residues
MSLPDDSRYLKGGPVAQRIIAAVREDAAIAKAEGFPPKLISITVGDTDAVDVYVRNQRAKAQLAGIDFEERRFPATITSG
ELEAAIHGLNADPRVTGIIIQRPVPAHISVKTLQAAVHPLKDVEGMHPASIGNIVYNQLDLAPCTAAASVELLKETGLDL
KGLEVVVVGHSEIVGKPIAFLLMSEGATVTVCHHLTRSVAAHARRADALFVAVGKPRLIKADMVKPGAAVIDIGINSEIG
PDGTSRIVGDVDTDSVKDVASWITPVPGGVGPITVAILLRNTMVALSRQRALYEATYGTADRLAAE
>Mature_305_residues
SLPDDSRYLKGGPVAQRIIAAVREDAAIAKAEGFPPKLISITVGDTDAVDVYVRNQRAKAQLAGIDFEERRFPATITSGE
LEAAIHGLNADPRVTGIIIQRPVPAHISVKTLQAAVHPLKDVEGMHPASIGNIVYNQLDLAPCTAAASVELLKETGLDLK
GLEVVVVGHSEIVGKPIAFLLMSEGATVTVCHHLTRSVAAHARRADALFVAVGKPRLIKADMVKPGAAVIDIGINSEIGP
DGTSRIVGDVDTDSVKDVASWITPVPGGVGPITVAILLRNTMVALSRQRALYEATYGTADRLAAE

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222418558, Length=263, Percent_Identity=45.2471482889734, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI222136639, Length=288, Percent_Identity=37.8472222222222, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI94721354, Length=302, Percent_Identity=40.0662251655629, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI36796743, Length=206, Percent_Identity=25.7281553398058, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786741, Length=282, Percent_Identity=40.4255319148936, Blast_Score=188, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17568735, Length=264, Percent_Identity=41.6666666666667, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6319558, Length=291, Percent_Identity=40.5498281786942, Blast_Score=193, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6321643, Length=270, Percent_Identity=38.1481481481481, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6322933, Length=308, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17136818, Length=295, Percent_Identity=41.6949152542373, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI17136816, Length=295, Percent_Identity=41.6949152542373, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24645718, Length=291, Percent_Identity=39.5189003436426, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17137370, Length=291, Percent_Identity=39.5189003436426, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI62472483, Length=291, Percent_Identity=39.5189003436426, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI45551871, Length=291, Percent_Identity=39.5189003436426, Blast_Score=186, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD2_RHILO (Q987T6)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107328.1
- HSSP:   P11586
- ProteinModelPortal:   Q987T6
- SMR:   Q987T6
- GeneID:   1229983
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll6921
- NMPDR:   fig|266835.1.peg.5429
- HOGENOM:   HBG328751
- OMA:   DEEIFPP
- ProtClustDB:   CLSK506682
- BRENDA:   1.5.1.5
- BRENDA:   3.5.4.9
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 32229; Mature: 32097

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPDDSRYLKGGPVAQRIIAAVREDAAIAKAEGFPPKLISITVGDTDAVDVYVRNQRAK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEECCCCE
AQLAGIDFEERRFPATITSGELEAAIHGLNADPRVTGIIIQRPVPAHISVKTLQAAVHPL
EEEECCCHHHCCCCEEEECCCCEEHEECCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHH
KDVEGMHPASIGNIVYNQLDLAPCTAAASVELLKETGLDLKGLEVVVVGHSEIVGKPIAF
HHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCHHHHCCCEEE
LLMSEGATVTVCHHLTRSVAAHARRADALFVAVGKPRLIKADMVKPGAAVIDIGINSEIG
EEECCCCEEEHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCCCCEEEEECCCCCCC
PDGTSRIVGDVDTDSVKDVASWITPVPGGVGPITVAILLRNTMVALSRQRALYEATYGTA
CCCCCCEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DRLAAE
HHHCCC
>Mature Secondary Structure 
SLPDDSRYLKGGPVAQRIIAAVREDAAIAKAEGFPPKLISITVGDTDAVDVYVRNQRAK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEECCCCE
AQLAGIDFEERRFPATITSGELEAAIHGLNADPRVTGIIIQRPVPAHISVKTLQAAVHPL
EEEECCCHHHCCCCEEEECCCCEEHEECCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHH
KDVEGMHPASIGNIVYNQLDLAPCTAAASVELLKETGLDLKGLEVVVVGHSEIVGKPIAF
HHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCHHHHCCCEEE
LLMSEGATVTVCHHLTRSVAAHARRADALFVAVGKPRLIKADMVKPGAAVIDIGINSEIG
EEECCCCEEEHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCCCCEEEEECCCCCCC
PDGTSRIVGDVDTDSVKDVASWITPVPGGVGPITVAILLRNTMVALSRQRALYEATYGTA
CCCCCCEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DRLAAE
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968