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The map label for this gene is lldD [H]

Identifier: 13475754

GI number: 13475754

Start: 5683206

End: 5684342

Strand: Reverse

Name: lldD [H]

Synonym: mll6909

Alternate gene names: 13475754

Gene position: 5684342-5683206 (Counterclockwise)

Preceding gene: 13475755

Following gene: 13475753

Centisome position: 80.79

GC content: 62.71

Gene sequence:

>1137_bases
ATGAGCGACATTCTCACCATCGCGGACCTCAAGGATCTCGCCCGCCGGCGCGTGCCCAAGATGTTTTTCGACTATGCCGA
TTCAGGCGCCTGGACCGAGAGCACCTATCGGGCCAACGAGGAAGATTTCCAGAAGATCAAGTTCCGCCAGCGCGTGATGG
TCGACATGAGCAACCGGTCGCTGGAATCGACCATGATCGGCCAGAAAGTGTCGATGCCGGTGGCGCTGGCGCCGACCGGC
CTGACCGGCATGCAGCACGCCGATGGCGAGATGCTGGCGGCGAAGGCGGCGGAGGAATTCGGCGTGCCTTTCACCCTGTC
GACGATGAGCATCTGCTCGATCGAGGATGTCGCCTCGGCGACGACGAAACCGTTCTGGTTCCAGCTCTATGTGCTGCGCG
ACAAGGATTTCGTGCTCGATTTGATCGACCGCGCCAAGGCGGCGAAATGCTCGGCGCTGGTCCTGACGCTCGATCTGCAG
ATCCTTGGCCAGCGCCACAAGGATGTGCGCAACGGGCTTTCGGCGCCGCCCAAGATGACGCTGGCCAACATCATCGACCT
GGCCAGCAAGCCACGCTGGTGCCTGGGTATCGCCGGCACCAAGCGCCGTACCTTCCGCAACATCGTCGGCCACGCCAAGG
GTGTCGGCGACGTGTCTTCGCTGTCGTCCTGGACAAACGAGCAGTTCGACCCGCAGCTGTCGTGGAAGGATGTCGCCTGG
ATCAAGGAACGCTGGGGCGGCAAGCTGATCCTGAAAGGCATCCTCGACAAGGAGGACGCGCTGATGGCGGCCAAGACCGG
CGCCGACGCGATCGTGGTTTCCAACCATGGCGGGCGCCAGCTCGATGGCGCATCGTCCTCGATCATGGTGCTCGAAGAAA
TCGCGGACACGGTCGGCGACAGAATAGAGGTGCATATGGACGGCGGCATCCGCTCCGGCCAGGACGTCCTGAAGGCGCTC
TGCCTCGGCGCCAAGGGCACCTATATCGGCCGGCCGTTCCTTTACGGCCTCGGTGCGCTCGGCAAGGAAGGGGTTACCAA
AGCGTTGGAAATCATCCGCAAGGAGATGGACATCACGCTGGCTCTGTGCGGAAAGCGTCTAGTCACCGACATGGGCAAGG
ACCAGCTCCGGCGCTAG

Upstream 100 bases:

>100_bases
GCAACGCGTGTCACGGCTGCGGCTGCGGCAGCGTTCGGAAGCCGGCGACACCGAACCGGCGCGCAGACGCTCCTAGTAGT
ACGATCAAGCGGGAACCATC

Downstream 100 bases:

>100_bases
GGTCCGGTGACAGCCTGACCACGGAGACCACGACGCGTTGGCGGAACCCGGCATCCATTTTCTCGACGCTCATGGGCCGG
AGGGTGTGCGTCTTTACGCA

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MSDILTIADLKDLARRRVPKMFFDYADSGAWTESTYRANEEDFQKIKFRQRVMVDMSNRSLESTMIGQKVSMPVALAPTG
LTGMQHADGEMLAAKAAEEFGVPFTLSTMSICSIEDVASATTKPFWFQLYVLRDKDFVLDLIDRAKAAKCSALVLTLDLQ
ILGQRHKDVRNGLSAPPKMTLANIIDLASKPRWCLGIAGTKRRTFRNIVGHAKGVGDVSSLSSWTNEQFDPQLSWKDVAW
IKERWGGKLILKGILDKEDALMAAKTGADAIVVSNHGGRQLDGASSSIMVLEEIADTVGDRIEVHMDGGIRSGQDVLKAL
CLGAKGTYIGRPFLYGLGALGKEGVTKALEIIRKEMDITLALCGKRLVTDMGKDQLRR

Sequences:

>Translated_378_residues
MSDILTIADLKDLARRRVPKMFFDYADSGAWTESTYRANEEDFQKIKFRQRVMVDMSNRSLESTMIGQKVSMPVALAPTG
LTGMQHADGEMLAAKAAEEFGVPFTLSTMSICSIEDVASATTKPFWFQLYVLRDKDFVLDLIDRAKAAKCSALVLTLDLQ
ILGQRHKDVRNGLSAPPKMTLANIIDLASKPRWCLGIAGTKRRTFRNIVGHAKGVGDVSSLSSWTNEQFDPQLSWKDVAW
IKERWGGKLILKGILDKEDALMAAKTGADAIVVSNHGGRQLDGASSSIMVLEEIADTVGDRIEVHMDGGIRSGQDVLKAL
CLGAKGTYIGRPFLYGLGALGKEGVTKALEIIRKEMDITLALCGKRLVTDMGKDQLRR
>Mature_377_residues
SDILTIADLKDLARRRVPKMFFDYADSGAWTESTYRANEEDFQKIKFRQRVMVDMSNRSLESTMIGQKVSMPVALAPTGL
TGMQHADGEMLAAKAAEEFGVPFTLSTMSICSIEDVASATTKPFWFQLYVLRDKDFVLDLIDRAKAAKCSALVLTLDLQI
LGQRHKDVRNGLSAPPKMTLANIIDLASKPRWCLGIAGTKRRTFRNIVGHAKGVGDVSSLSSWTNEQFDPQLSWKDVAWI
KERWGGKLILKGILDKEDALMAAKTGADAIVVSNHGGRQLDGASSSIMVLEEIADTVGDRIEVHMDGGIRSGQDVLKALC
LGAKGTYIGRPFLYGLGALGKEGVTKALEIIRKEMDITLALCGKRLVTDMGKDQLRR

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=376, Percent_Identity=35.1063829787234, Blast_Score=244, Evalue=7e-65,
Organism=Homo sapiens, GI54234014, Length=372, Percent_Identity=36.0215053763441, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI7705393, Length=372, Percent_Identity=36.0215053763441, Blast_Score=227, Evalue=1e-59,
Organism=Escherichia coli, GI1790033, Length=375, Percent_Identity=44.2666666666667, Blast_Score=333, Evalue=8e-93,
Organism=Caenorhabditis elegans, GI193208036, Length=383, Percent_Identity=35.2480417754569, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI32566217, Length=298, Percent_Identity=32.8859060402685, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6323587, Length=387, Percent_Identity=33.0749354005168, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI281363140, Length=373, Percent_Identity=36.7292225201072, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI78707190, Length=373, Percent_Identity=36.7292225201072, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI78707188, Length=373, Percent_Identity=36.7292225201072, Blast_Score=246, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41543; Mature: 41411

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILTIADLKDLARRRVPKMFFDYADSGAWTESTYRANEEDFQKIKFRQRVMVDMSNRS
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHHCCCCCC
LESTMIGQKVSMPVALAPTGLTGMQHADGEMLAAKAAEEFGVPFTLSTMSICSIEDVASA
HHHHHCCHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCHHHHCHHHHHHC
TTKPFWFQLYVLRDKDFVLDLIDRAKAAKCSALVLTLDLQILGQRHKDVRNGLSAPPKMT
CCCCEEEEEEEEECCHHHHHHHHHHHHHHHEEEEEEEEHHHHHHHHHHHHCCCCCCCCHH
LANIIDLASKPRWCLGIAGTKRRTFRNIVGHAKGVGDVSSLSSWTNEQFDPQLSWKDVAW
HHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHH
IKERWGGKLILKGILDKEDALMAAKTGADAIVVSNHGGRQLDGASSSIMVLEEIADTVGD
HHHHCCCEEEEEHHCCCCHHHEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCC
RIEVHMDGGIRSGQDVLKALCLGAKGTYIGRPFLYGLGALGKEGVTKALEIIRKEMDITL
EEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ALCGKRLVTDMGKDQLRR
HHHHHHHHHHCCHHHHCC
>Mature Secondary Structure 
SDILTIADLKDLARRRVPKMFFDYADSGAWTESTYRANEEDFQKIKFRQRVMVDMSNRS
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHHCCCCCC
LESTMIGQKVSMPVALAPTGLTGMQHADGEMLAAKAAEEFGVPFTLSTMSICSIEDVASA
HHHHHCCHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCHHHHCHHHHHHC
TTKPFWFQLYVLRDKDFVLDLIDRAKAAKCSALVLTLDLQILGQRHKDVRNGLSAPPKMT
CCCCEEEEEEEEECCHHHHHHHHHHHHHHHEEEEEEEEHHHHHHHHHHHHCCCCCCCCHH
LANIIDLASKPRWCLGIAGTKRRTFRNIVGHAKGVGDVSSLSSWTNEQFDPQLSWKDVAW
HHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHH
IKERWGGKLILKGILDKEDALMAAKTGADAIVVSNHGGRQLDGASSSIMVLEEIADTVGD
HHHHCCCEEEEEHHCCCCHHHEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCC
RIEVHMDGGIRSGQDVLKALCLGAKGTYIGRPFLYGLGALGKEGVTKALEIIRKEMDITL
EEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ALCGKRLVTDMGKDQLRR
HHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA