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The map label for this gene is edd [H]

Identifier: 13475443

GI number: 13475443

Start: 5321961

End: 5323784

Strand: Reverse

Name: edd [H]

Synonym: mll6512

Alternate gene names: 13475443

Gene position: 5323784-5321961 (Counterclockwise)

Preceding gene: 13475444

Following gene: 13475438

Centisome position: 75.66

GC content: 66.67

Gene sequence:

>1824_bases
ATGACCGCAAGACGCGATATCGAAGCCATCACCGAGCGCATTCGCCAACGTTCGAAGGCGGGCCGCGAGCGCTATCTCGG
CCGTATCGCCGAAGCGTCGAACCAGACCGCCAACCGGTCGGTATTGTCCTGCGGCAACCTCGCTCACGGCTTTGCGGTGT
GCAGCCCCTCGGAAAAGCTGGCGCTCGGTGCCGACAAGGTGCCCAATCTCGGCATCATCACCTCCTACAACGACATGCTG
TCGGCGCATCAGCCCTTCGAGACCTATCCGGCCCTGATCAAGGACGCGGCGCGCGAGGCCGGCGGCATCGCCCAGGTGGC
CGGCGGCGTGCCGGCGATGTGCGATGGCGTCACGCAGGGCCAGCCCGGCATGGAATTGTCGCTGTTTTCGCGCGACGTAA
TCGCCATGTCGGCGGCGGTCGGCCTGTCGCACAACATGTTCGACGCCGCCGTCTTTCTCGGGGTCTGCGACAAGATCGTA
CCGGGACTGGTGATCGCGGCGCTGACTTTCGGCCATCTGCCGGCGGTGTTCATTCCGGCCGGACCGATGACGACCGGGTT
GCCCAACGACGAGAAGGCCAAGGTCCGCCAGCTCTATGCCGAGGGCAAGGCGGGGCGCGCCGAACTGCTGGAAGCCGAAT
CCAAATCCTACCACGGGCCGGGCACCTGCACCTTCTACGGCACGGCGAACTCCAACCAGATGTTGATGGAGATCATGGGC
CTGCATACGCCCGGCGCCTCCTTCGTCAATCCCGGCACGCCGTTGCGTGAAGCGCTGACCCGCGAGGCGACGAAGCGGGC
GCTGGCGATCACCGCGCTCGGCAATGCCTATACGCCGGTCGGGCGGATGATCGACGAGCGGTCGATCGTCAACGGCGTCG
TCGGCCTGCATGCCACCGGCGGCTCGACCAATCATACCATCCACCTCATTGCCATGGCGGCAGCGGCCGGCATCGCACTG
ACCTGGCAGGATATTTCCGACCTTTCGGAAGCGGTGCCGCTTCTGGCTCGCGTCTATCCGAATGGCCTTGCCGACGTGAA
CCATTTCCATGCCGCCGGCGGGCTCGGCTTCCTGATCCGCGAACTGCTCGACGAAGGCGTGCTGCACGAGGATGTGCAGA
CGGTGTGGGGCGAAGGCCTGCGACCCTACGCTGTCGAGGCAAAACTCGGCGCCGATGGCTCCGTCGTGCGCGAGGCCTCG
CCGCAGGCCAGCGGCGACGAAAAGGTGCTGGCGCCGTTCCACAAGGCGTTCCAGCCGACGGGCGGCCTGAAGGTGCTGGC
GGGCAATCTCGGCCACGCCGTCATCAAGACCTCCGCCGTCAAGCCGGAACGGCGCATCATAGAGGCGCCGGCCAAGGTGT
TCGACAGCCAGCAGGGCCTGAACGATGCGTTCAAGGCGGGCACGCTCACCGGCGATTTCATCGCCGTCATCCGCTTCCAG
GGCCCGAAGGCCAACGGCATGCCGGAACTGCACAAGCTGACCACCGTGCTCGGCATCCTGCAGGATCGCGGCCAACGCGT
CGCGCTGGTCACCGATGGGCGCATGTCTGGCGCTTCCGGCAAGGTGCCGGCGGCGATCCACGTGACACCGGAAGCGGTCG
AGGACGGGCCGATCGCCCGGCTTCACGACGGCGACATCATCCGCCTCGACGCCGATGCCGGAACGCTGGAGGTGCTGGTG
CCGGGAACCGAATTCGCGCTGCGCCGCACCGCCGAAGCCGATCTCATCGGCAACGAGTTCGGCTTCGGCCGCGAGCTTTT
CGCCGGCTTCCGGCAGTTGGTGGGCCGTGCCGACCATGGCGCCAGCGCATTCGGAACGGCCTGA

Upstream 100 bases:

>100_bases
AGACCCGTAGAGGTTTTCTGGGCGCCCTGATTTTGGATTTAGTGGTCCCGGCAACGGCGGGAGGATGTTTCCGGGACCTC
GCCTGAAAGGACCGACCGCC

Downstream 100 bases:

>100_bases
TATTCCTGACTTTCAAACGAAAAGGGCGGCCTTGAGCCGCCCTTCTTTGTTTGTCCTGCCGGATGCTACTCGACTTTGAG
CTCGCTCCGCTCGCCGGCCT

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MTARRDIEAITERIRQRSKAGRERYLGRIAEASNQTANRSVLSCGNLAHGFAVCSPSEKLALGADKVPNLGIITSYNDML
SAHQPFETYPALIKDAAREAGGIAQVAGGVPAMCDGVTQGQPGMELSLFSRDVIAMSAAVGLSHNMFDAAVFLGVCDKIV
PGLVIAALTFGHLPAVFIPAGPMTTGLPNDEKAKVRQLYAEGKAGRAELLEAESKSYHGPGTCTFYGTANSNQMLMEIMG
LHTPGASFVNPGTPLREALTREATKRALAITALGNAYTPVGRMIDERSIVNGVVGLHATGGSTNHTIHLIAMAAAAGIAL
TWQDISDLSEAVPLLARVYPNGLADVNHFHAAGGLGFLIRELLDEGVLHEDVQTVWGEGLRPYAVEAKLGADGSVVREAS
PQASGDEKVLAPFHKAFQPTGGLKVLAGNLGHAVIKTSAVKPERRIIEAPAKVFDSQQGLNDAFKAGTLTGDFIAVIRFQ
GPKANGMPELHKLTTVLGILQDRGQRVALVTDGRMSGASGKVPAAIHVTPEAVEDGPIARLHDGDIIRLDADAGTLEVLV
PGTEFALRRTAEADLIGNEFGFGRELFAGFRQLVGRADHGASAFGTA

Sequences:

>Translated_607_residues
MTARRDIEAITERIRQRSKAGRERYLGRIAEASNQTANRSVLSCGNLAHGFAVCSPSEKLALGADKVPNLGIITSYNDML
SAHQPFETYPALIKDAAREAGGIAQVAGGVPAMCDGVTQGQPGMELSLFSRDVIAMSAAVGLSHNMFDAAVFLGVCDKIV
PGLVIAALTFGHLPAVFIPAGPMTTGLPNDEKAKVRQLYAEGKAGRAELLEAESKSYHGPGTCTFYGTANSNQMLMEIMG
LHTPGASFVNPGTPLREALTREATKRALAITALGNAYTPVGRMIDERSIVNGVVGLHATGGSTNHTIHLIAMAAAAGIAL
TWQDISDLSEAVPLLARVYPNGLADVNHFHAAGGLGFLIRELLDEGVLHEDVQTVWGEGLRPYAVEAKLGADGSVVREAS
PQASGDEKVLAPFHKAFQPTGGLKVLAGNLGHAVIKTSAVKPERRIIEAPAKVFDSQQGLNDAFKAGTLTGDFIAVIRFQ
GPKANGMPELHKLTTVLGILQDRGQRVALVTDGRMSGASGKVPAAIHVTPEAVEDGPIARLHDGDIIRLDADAGTLEVLV
PGTEFALRRTAEADLIGNEFGFGRELFAGFRQLVGRADHGASAFGTA
>Mature_606_residues
TARRDIEAITERIRQRSKAGRERYLGRIAEASNQTANRSVLSCGNLAHGFAVCSPSEKLALGADKVPNLGIITSYNDMLS
AHQPFETYPALIKDAAREAGGIAQVAGGVPAMCDGVTQGQPGMELSLFSRDVIAMSAAVGLSHNMFDAAVFLGVCDKIVP
GLVIAALTFGHLPAVFIPAGPMTTGLPNDEKAKVRQLYAEGKAGRAELLEAESKSYHGPGTCTFYGTANSNQMLMEIMGL
HTPGASFVNPGTPLREALTREATKRALAITALGNAYTPVGRMIDERSIVNGVVGLHATGGSTNHTIHLIAMAAAAGIALT
WQDISDLSEAVPLLARVYPNGLADVNHFHAAGGLGFLIRELLDEGVLHEDVQTVWGEGLRPYAVEAKLGADGSVVREASP
QASGDEKVLAPFHKAFQPTGGLKVLAGNLGHAVIKTSAVKPERRIIEAPAKVFDSQQGLNDAFKAGTLTGDFIAVIRFQG
PKANGMPELHKLTTVLGILQDRGQRVALVTDGRMSGASGKVPAAIHVTPEAVEDGPIARLHDGDIIRLDADAGTLEVLVP
GTEFALRRTAEADLIGNEFGFGRELFAGFRQLVGRADHGASAFGTA

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=595, Percent_Identity=59.8319327731092, Blast_Score=728, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=542, Percent_Identity=30.2583025830258, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI2367371, Length=466, Percent_Identity=30.9012875536481, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1786464, Length=465, Percent_Identity=29.4623655913978, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322476, Length=525, Percent_Identity=28.5714285714286, Blast_Score=173, Evalue=7e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 63800; Mature: 63668

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARRDIEAITERIRQRSKAGRERYLGRIAEASNQTANRSVLSCGNLAHGFAVCSPSEKL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEECCCCCE
ALGADKVPNLGIITSYNDMLSAHQPFETYPALIKDAAREAGGIAQVAGGVPAMCDGVTQG
EECCCCCCCCEEEECCHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCHHHCCCCCC
QPGMELSLFSRDVIAMSAAVGLSHNMFDAAVFLGVCDKIVPGLVIAALTFGHLPAVFIPA
CCCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
GPMTTGLPNDEKAKVRQLYAEGKAGRAELLEAESKSYHGPGTCTFYGTANSNQMLMEIMG
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHH
LHTPGASFVNPGTPLREALTREATKRALAITALGNAYTPVGRMIDERSIVNGVVGLHATG
CCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEECC
GSTNHTIHLIAMAAAAGIALTWQDISDLSEAVPLLARVYPNGLADVNHFHAAGGLGFLIR
CCCCCEEEEEEEHHHCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHH
ELLDEGVLHEDVQTVWGEGLRPYAVEAKLGADGSVVREASPQASGDEKVLAPFHKAFQPT
HHHHCCCHHHHHHHHHCCCCCCEEEEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHCCC
GGLKVLAGNLGHAVIKTSAVKPERRIIEAPAKVFDSQQGLNDAFKAGTLTGDFIAVIRFQ
CCEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCEEEEEEEC
GPKANGMPELHKLTTVLGILQDRGQRVALVTDGRMSGASGKVPAAIHVTPEAVEDGPIAR
CCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECHHHCCCCCEEE
LHDGDIIRLDADAGTLEVLVPGTEFALRRTAEADLIGNEFGFGRELFAGFRQLVGRADHG
ECCCCEEEEECCCCEEEEEECCCHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
ASAFGTA
CCCCCCC
>Mature Secondary Structure 
TARRDIEAITERIRQRSKAGRERYLGRIAEASNQTANRSVLSCGNLAHGFAVCSPSEKL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEECCCCCE
ALGADKVPNLGIITSYNDMLSAHQPFETYPALIKDAAREAGGIAQVAGGVPAMCDGVTQG
EECCCCCCCCEEEECCHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCHHHCCCCCC
QPGMELSLFSRDVIAMSAAVGLSHNMFDAAVFLGVCDKIVPGLVIAALTFGHLPAVFIPA
CCCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
GPMTTGLPNDEKAKVRQLYAEGKAGRAELLEAESKSYHGPGTCTFYGTANSNQMLMEIMG
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHH
LHTPGASFVNPGTPLREALTREATKRALAITALGNAYTPVGRMIDERSIVNGVVGLHATG
CCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEECC
GSTNHTIHLIAMAAAAGIALTWQDISDLSEAVPLLARVYPNGLADVNHFHAAGGLGFLIR
CCCCCEEEEEEEHHHCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHH
ELLDEGVLHEDVQTVWGEGLRPYAVEAKLGADGSVVREASPQASGDEKVLAPFHKAFQPT
HHHHCCCHHHHHHHHHCCCCCCEEEEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHCCC
GGLKVLAGNLGHAVIKTSAVKPERRIIEAPAKVFDSQQGLNDAFKAGTLTGDFIAVIRFQ
CCEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCEEEEEEEC
GPKANGMPELHKLTTVLGILQDRGQRVALVTDGRMSGASGKVPAAIHVTPEAVEDGPIAR
CCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECHHHCCCCCEEE
LHDGDIIRLDADAGTLEVLVPGTEFALRRTAEADLIGNEFGFGRELFAGFRQLVGRADHG
ECCCCEEEEECCCCEEEEEECCCHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
ASAFGTA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]