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The map label for this gene is pgl

Identifier: 13475444

GI number: 13475444

Start: 5323855

End: 5324571

Strand: Reverse

Name: pgl

Synonym: mll6514

Alternate gene names: 13475444

Gene position: 5324571-5323855 (Counterclockwise)

Preceding gene: 13475445

Following gene: 13475443

Centisome position: 75.68

GC content: 69.32

Gene sequence:

>717_bases
ATGGCACGAGAGCAATTGAACGGCGCCAGCTACAACTGGAACGCTTTCCCCGACCGGCCGCAACTGGCCGTGGCGCTGGC
CGGCCGCGTGGCCGATCGGCTGACCAGGGCGATTGCGGAGCGCGGTACGGCAGTGCTGGCCGTCTCCGGCGGCACGACGC
CGACAAAATTCTTCGCCGCCCTCTCGGCGATGCCGATCGCCTGGGACAAGGTGATCGTGACGCTGGTCGACGAGCGTTTC
GTGCCCGCCTCCTCGCCGCGCTCCAACGCCGGGCTGGTGGCCGCCAATCTCTTGCAGAACGCCGCCAAAGCCGCGCGCTT
CGTACCGCTCTACCATGAGGCATCGGGCATCGAGGATGCAGCGGCATCCGACGATGCAGCACTGCGCTCCCTGCCCTGGC
CGCTCGATGTCGTGGTGCTCGGCATGGGGCCGGACGGCCACACCGCCTCCTTCTTTCCCGACGCCGACGATCTGGCAGAG
CTGCTCGACCCGGCCTCGGACCGGATCATCCTGCCGGTTCATGCGGCCAGCGCGGGCGAGCCGCGGCTGACCCTGACGCT
GGCGCGCATCATCGATGCCGGCTTCATCGCGCTGCACATAGAGGGCGAGGACAAGCGCACCGCCTTCGACGGCGCGGTCG
CGCCCGGGCCGCGAAAGCCTATCCGCGCCGTGCTCGACGCCGCACCCAGACCCGTAGAGGTTTTCTGGGCGCCCTGA

Upstream 100 bases:

>100_bases
AGAATGCCTGGGAAGGCGCCAAGCAGGAAGCGCAGGGCTATACGGCAGGCACATGGGGGCCATCTGCCTCGATAGCGCTG
ATCGAACGTGACGGGCGGAC

Downstream 100 bases:

>100_bases
TTTTGGATTTAGTGGTCCCGGCAACGGCGGGAGGATGTTTCCGGGACCTCGCCTGAAAGGACCGACCGCCATGACCGCAA
GACGCGATATCGAAGCCATC

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MAREQLNGASYNWNAFPDRPQLAVALAGRVADRLTRAIAERGTAVLAVSGGTTPTKFFAALSAMPIAWDKVIVTLVDERF
VPASSPRSNAGLVAANLLQNAAKAARFVPLYHEASGIEDAAASDDAALRSLPWPLDVVVLGMGPDGHTASFFPDADDLAE
LLDPASDRIILPVHAASAGEPRLTLTLARIIDAGFIALHIEGEDKRTAFDGAVAPGPRKPIRAVLDAAPRPVEVFWAP

Sequences:

>Translated_238_residues
MAREQLNGASYNWNAFPDRPQLAVALAGRVADRLTRAIAERGTAVLAVSGGTTPTKFFAALSAMPIAWDKVIVTLVDERF
VPASSPRSNAGLVAANLLQNAAKAARFVPLYHEASGIEDAAASDDAALRSLPWPLDVVVLGMGPDGHTASFFPDADDLAE
LLDPASDRIILPVHAASAGEPRLTLTLARIIDAGFIALHIEGEDKRTAFDGAVAPGPRKPIRAVLDAAPRPVEVFWAP
>Mature_237_residues
AREQLNGASYNWNAFPDRPQLAVALAGRVADRLTRAIAERGTAVLAVSGGTTPTKFFAALSAMPIAWDKVIVTLVDERFV
PASSPRSNAGLVAANLLQNAAKAARFVPLYHEASGIEDAAASDDAALRSLPWPLDVVVLGMGPDGHTASFFPDADDLAEL
LDPASDRIILPVHAASAGEPRLTLTLARIIDAGFIALHIEGEDKRTAFDGAVAPGPRKPIRAVLDAAPRPVEVFWAP

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily

Homologues:

Organism=Homo sapiens, GI52145310, Length=236, Percent_Identity=29.6610169491525, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115533058, Length=223, Percent_Identity=29.5964125560538, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115533060, Length=221, Percent_Identity=28.5067873303167, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321957, Length=202, Percent_Identity=27.2277227722772, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 6PGL_RHILO (Q989A3)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107008.1
- ProteinModelPortal:   Q989A3
- SMR:   Q989A3
- GeneID:   1229663
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll6514
- NMPDR:   fig|266835.1.peg.5109
- HOGENOM:   HBG725991
- OMA:   EDAPISA
- BRENDA:   3.1.1.31
- InterPro:   IPR005900
- PANTHER:   PTHR11054
- TIGRFAMs:   TIGR01198

Pfam domain/function: NA

EC number: =3.1.1.31

Molecular weight: Translated: 25100; Mature: 24969

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAREQLNGASYNWNAFPDRPQLAVALAGRVADRLTRAIAERGTAVLAVSGGTTPTKFFAA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHH
LSAMPIAWDKVIVTLVDERFVPASSPRSNAGLVAANLLQNAAKAARFVPLYHEASGIEDA
HHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEECCCCCCCCC
AASDDAALRSLPWPLDVVVLGMGPDGHTASFFPDADDLAELLDPASDRIILPVHAASAGE
CCCCCHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCC
PRLTLTLARIIDAGFIALHIEGEDKRTAFDGAVAPGPRKPIRAVLDAAPRPVEVFWAP
CEEEEHHHHHHCCCEEEEEEECCCCCEECCCCCCCCCCHHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure 
AREQLNGASYNWNAFPDRPQLAVALAGRVADRLTRAIAERGTAVLAVSGGTTPTKFFAA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHH
LSAMPIAWDKVIVTLVDERFVPASSPRSNAGLVAANLLQNAAKAARFVPLYHEASGIEDA
HHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEECCCCCCCCC
AASDDAALRSLPWPLDVVVLGMGPDGHTASFFPDADDLAELLDPASDRIILPVHAASAGE
CCCCCHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCC
PRLTLTLARIIDAGFIALHIEGEDKRTAFDGAVAPGPRKPIRAVLDAAPRPVEVFWAP
CEEEEHHHHHHCCCEEEEEEECCCCCEECCCCCCCCCCHHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968