Click here to switch to the map view.

The map label for this gene is lrp [H]

Identifier: 13475094

GI number: 13475094

Start: 4938429

End: 4938926

Strand: Direct

Name: lrp [H]

Synonym: mlr6100

Alternate gene names: 13475094

Gene position: 4938429-4938926 (Clockwise)

Preceding gene: 13475093

Following gene: 13475095

Centisome position: 70.19

GC content: 55.22

Gene sequence:

>498_bases
ATGAAGTCGAAACCCAATCCTGCGCGCCTGGACGCTTGGGACTTCCGGATTCTCTCAGAGATTCAGTCAGACGGCCGGAT
TTCAAAAAGCGAGCTTGCAAAACGCGTTCATCTTTCGGCGTCGGCCTGCTCGGAGCGGCTCCGTGCACTCGAGGTCGCAG
GGATTATTGAGGGGTTCTACGCGCGGCTGAGTCCGGTCCTCATCAGCGGCATGGTCTTTGTCATGGTGGAGGTCGTGCTG
GAACGTCATCGCCTCGAGGACCAAAGACACTTTGAGACTGCGATCGGAGAATTTCCGGAAATCTTGGATTGCTGGGCTAT
CGGCGGGCGGATCGATTATCTGATGCGCATCGCATCTCCTTCTATGGCTGCGTATCAGGATTTCATGGAGCGACTGCTGC
AGGCAGGCTTGGGGATCGATCAATATTACAGTCTTGTCGTGACCAAACCTGTGAAATCCAATTCGCCGATCCCCTTGTCC
GCACTAAGGGAACGGTGA

Upstream 100 bases:

>100_bases
GCCGACAGCATCGCACGCAACATCGGCGTTTGAGCCTTCCGACTAAGCTCGGTTGGTGGGCGTCAATTCCGTTGTTGACA
ACGGCTAAGAGCAGAAGGTC

Downstream 100 bases:

>100_bases
ATGCCGAAGCCGTGGTTTCCACGGCGTTTGATGGCGATTCCGCCAATTCGTCGGCGAAAGACGTGCATTCCCGCGAAACT
CAAAAGGCTGTTGCGGTATG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MKSKPNPARLDAWDFRILSEIQSDGRISKSELAKRVHLSASACSERLRALEVAGIIEGFYARLSPVLISGMVFVMVEVVL
ERHRLEDQRHFETAIGEFPEILDCWAIGGRIDYLMRIASPSMAAYQDFMERLLQAGLGIDQYYSLVVTKPVKSNSPIPLS
ALRER

Sequences:

>Translated_165_residues
MKSKPNPARLDAWDFRILSEIQSDGRISKSELAKRVHLSASACSERLRALEVAGIIEGFYARLSPVLISGMVFVMVEVVL
ERHRLEDQRHFETAIGEFPEILDCWAIGGRIDYLMRIASPSMAAYQDFMERLLQAGLGIDQYYSLVVTKPVKSNSPIPLS
ALRER
>Mature_165_residues
MKSKPNPARLDAWDFRILSEIQSDGRISKSELAKRVHLSASACSERLRALEVAGIIEGFYARLSPVLISGMVFVMVEVVL
ERHRLEDQRHFETAIGEFPEILDCWAIGGRIDYLMRIASPSMAAYQDFMERLLQAGLGIDQYYSLVVTKPVKSNSPIPLS
ALRER

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=154, Percent_Identity=38.3116883116883, Blast_Score=107, Evalue=4e-25,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=32, Blast_Score=83, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18625; Mature: 18625

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKPNPARLDAWDFRILSEIQSDGRISKSELAKRVHLSASACSERLRALEVAGIIEGFY
CCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLSPVLISGMVFVMVEVVLERHRLEDQRHFETAIGEFPEILDCWAIGGRIDYLMRIASP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCC
SMAAYQDFMERLLQAGLGIDQYYSLVVTKPVKSNSPIPLSALRER
CHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHCCC
>Mature Secondary Structure
MKSKPNPARLDAWDFRILSEIQSDGRISKSELAKRVHLSASACSERLRALEVAGIIEGFY
CCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLSPVLISGMVFVMVEVVLERHRLEDQRHFETAIGEFPEILDCWAIGGRIDYLMRIASP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCC
SMAAYQDFMERLLQAGLGIDQYYSLVVTKPVKSNSPIPLSALRER
CHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]