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The map label for this gene is ilvD1

Identifier: 13474469

GI number: 13474469

Start: 4278927

End: 4280771

Strand: Direct

Name: ilvD1

Synonym: mlr5361

Alternate gene names: 13474469

Gene position: 4278927-4280771 (Clockwise)

Preceding gene: 13474465

Following gene: 13474471

Centisome position: 60.81

GC content: 66.23

Gene sequence:

>1845_bases
ATGCCCGCCTATCGCTCCCGCACCACCACCCATGGCCGCAACATGGCCGGCGCCCGCGGCCTGTGGCGCGCGACCGGCAT
GAAGGATTCGGATTTCGGCAAGCCGATCATCGCCGTGGTCAACTCCTTCACCCAGTTCGTGCCGGGCCATGTCCACTTGA
AGGACCTCGGCCAGCTGGTGGCGCGCGAGATCGAGAAGGCCGGCGGCGTCGCCAAGGAATTCAACACCATCGCGGTCGAC
GACGGCATCGCCATGGGCCACGACGGCATGCTCTATTCGCTGCCGTCGCGCGAGCTGATCGCCGATTCCGTCGAGTACAT
GGTCAACGCCCACTGCGCCGACGCCATGGTCTGCATCTCCAATTGCGACAAGATCACCCCCGGCATGCTGATGGCCTCGC
TGCGCCTCAACATCCCGACCGTCTTCGTCTCCGGCGGGCCGATGGAAGCCGGCAAGGTGGTGCTGGCCGGCAAGACTCAG
GCGCTCGACCTGGTCGACGCCATGGTCGCGGCCGCCGACGACAAGATCTCCGACGAGGACGTCAAGGTCATCGAGCGCTC
GGCTTGCCCGACCTGCGGTTCCTGCTCGGGCATGTTCACCGCCAATTCCATGAACTGCCTGACCGAGGCGCTCGGCCTGT
CGTTGCCGGGCAACGGCTCGACGCTGGCCACGCATGCCGACCGCAAGCGGCTGTTCGTCGAGGCCGGCCATCTCATCGTC
GATCTGGCCCAGCGCTATTACGAGCAGGATGACGAAACGGCACTGCCGCGCAGCATCGCCTCGAAAGGCGCCTTCGAAAA
CGCCATGACGCTCGACATCGCCATGGGCGGCTCGACCAACACCGTGCTGCACATCCTGGCCGCCGCACATGAGGGCGAGG
TCGACTTCACCATGGAGGATATCGACCGGCTGTCGCGGCGGGTTCCAGTGCTCTGCAAGGTGGCGCCGGCCAAGTCCGAC
GTCCACATGGAAGACGTCCACCGTGCCGGCGGCATCATGGCGATCCTCGGCCAGCTCGACAATGCCGGGCTGATCAACCG
CGACCTGCCGACAGTGCACACATCAAGCCTCGGCGAGGCGCTTGACCATTGGGATATTTCCCGCACCTCCAGCCAGAACG
TCCGCGACTTCTTCCTCGCCGCGCCCGGCGGCGTGCCGACCCAGGTCGCCTTCAGCCAGGACCGCCGCTGGGACGAGCTC
GATCTCGATCGTGAAAAGGGTGTCATCCGTTCGGCGGAAACGCCGTTCTCGAAAGATGGCGGTCTTGCCGTGCTGAAAGG
CAATCTGGCGCTCGACGGCTGCATCGTGAAGACGGCCGGTGTCGATGAGTCGATCCTGAAATTCACCGGCCCGGCGCGGG
TGTTCGAAAGCCAGGACGCTTCGGTCAAGGCAATCCTCTCCAACGAGATCAAGGCCGGCGACGTCGTTGTCATCCGCTAT
GAGGGCCCGCGCGGCGGCCCCGGCATGCAGGAAATGCTCTACCCGACCAGCTATCTGAAGTCGAAGGGCCTGGGCAAGGC
CTGCGCGCTGGTCACCGATGGCCGCTTCTCCGGCGGCACGTCGGGCCTGTCGATCGGCCATGCGTCGCCGGAAGCCGCCG
AAGGCGGCACGATCGGGCTGGTCCAAGAGGGCGACACGATCGAGATCGATATCCCCAACCGCACCATCCGCCTCGCTGTC
AGCGACGCCGAACTCGACAGCCGCCGGGCGGCGATGGAAGCCAAGGGCGCCCTGGCCTGGAAGCCCGAGGAAAAGCGCAA
GCGCAAGGTGACGACCGCGCTGCGCGCCTACGCCGCCTTCGCCACCAGCGCCGACAAGGGCGCGGTGCGGCACGTGCCGG
AGTGA

Upstream 100 bases:

>100_bases
AATGTGGCCAGACCATACTTGCGAGTCTATAAGGCCTGCGGTCCGAATTCAGCGCCGCCACGCTCCGCATCGAGCGCAGT
CAGCCAGCTAAGGAAAAGTC

Downstream 100 bases:

>100_bases
CGGACTTCTTCCTTCTCCCGCAAGGGGAGAAGGTGGAGGCCGCACTACGGCATCAGCTGATATTCATAAAGCTTCTGGTA
AAGCCCGCCCTGCGTGAGCA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 1

Number of amino acids: Translated: 614; Mature: 613

Protein sequence:

>614_residues
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPTVFVSGGPMEAGKVVLAGKTQ
ALDLVDAMVAAADDKISDEDVKVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
DLAQRYYEQDDETALPRSIASKGAFENAMTLDIAMGGSTNTVLHILAAAHEGEVDFTMEDIDRLSRRVPVLCKVAPAKSD
VHMEDVHRAGGIMAILGQLDNAGLINRDLPTVHTSSLGEALDHWDISRTSSQNVRDFFLAAPGGVPTQVAFSQDRRWDEL
DLDREKGVIRSAETPFSKDGGLAVLKGNLALDGCIVKTAGVDESILKFTGPARVFESQDASVKAILSNEIKAGDVVVIRY
EGPRGGPGMQEMLYPTSYLKSKGLGKACALVTDGRFSGGTSGLSIGHASPEAAEGGTIGLVQEGDTIEIDIPNRTIRLAV
SDAELDSRRAAMEAKGALAWKPEEKRKRKVTTALRAYAAFATSADKGAVRHVPE

Sequences:

>Translated_614_residues
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPTVFVSGGPMEAGKVVLAGKTQ
ALDLVDAMVAAADDKISDEDVKVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
DLAQRYYEQDDETALPRSIASKGAFENAMTLDIAMGGSTNTVLHILAAAHEGEVDFTMEDIDRLSRRVPVLCKVAPAKSD
VHMEDVHRAGGIMAILGQLDNAGLINRDLPTVHTSSLGEALDHWDISRTSSQNVRDFFLAAPGGVPTQVAFSQDRRWDEL
DLDREKGVIRSAETPFSKDGGLAVLKGNLALDGCIVKTAGVDESILKFTGPARVFESQDASVKAILSNEIKAGDVVVIRY
EGPRGGPGMQEMLYPTSYLKSKGLGKACALVTDGRFSGGTSGLSIGHASPEAAEGGTIGLVQEGDTIEIDIPNRTIRLAV
SDAELDSRRAAMEAKGALAWKPEEKRKRKVTTALRAYAAFATSADKGAVRHVPE
>Mature_613_residues
PAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPTVFVSGGPMEAGKVVLAGKTQA
LDLVDAMVAAADDKISDEDVKVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIVD
LAQRYYEQDDETALPRSIASKGAFENAMTLDIAMGGSTNTVLHILAAAHEGEVDFTMEDIDRLSRRVPVLCKVAPAKSDV
HMEDVHRAGGIMAILGQLDNAGLINRDLPTVHTSSLGEALDHWDISRTSSQNVRDFFLAAPGGVPTQVAFSQDRRWDELD
LDREKGVIRSAETPFSKDGGLAVLKGNLALDGCIVKTAGVDESILKFTGPARVFESQDASVKAILSNEIKAGDVVVIRYE
GPRGGPGMQEMLYPTSYLKSKGLGKACALVTDGRFSGGTSGLSIGHASPEAAEGGTIGLVQEGDTIEIDIPNRTIRLAVS
DAELDSRRAAMEAKGALAWKPEEKRKRKVTTALRAYAAFATSADKGAVRHVPE

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=610, Percent_Identity=74.9180327868852, Blast_Score=948, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=591, Percent_Identity=30.6260575296108, Blast_Score=192, Evalue=8e-50,
Organism=Escherichia coli, GI1786464, Length=529, Percent_Identity=31.5689981096408, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1788157, Length=537, Percent_Identity=28.6778398510242, Blast_Score=179, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6322476, Length=612, Percent_Identity=36.9281045751634, Blast_Score=342, Evalue=9e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD1_RHILO (Q98BZ8)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_106037.1
- GeneID:   1228698
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr5361
- NMPDR:   fig|266835.1.peg.4141
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- ProtClustDB:   PRK12448
- BRENDA:   4.2.1.9
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65368; Mature: 65237

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPTVFVSGGPMEAGKVVLAGKTQALDLVDAMVAAADDKISDED
CCCCCCHHHHHHHEEECCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCH
VKVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCCCEEEHHHHHHHH
DLAQRYYEQDDETALPRSIASKGAFENAMTLDIAMGGSTNTVLHILAAAHEGEVDFTMED
HHHHHHHCCCCCHHCCHHHHHCCCCCCCEEEEEEECCCCHHHHEEEECCCCCCCEEEHHH
IDRLSRRVPVLCKVAPAKSDVHMEDVHRAGGIMAILGQLDNAGLINRDLPTVHTSSLGEA
HHHHHCCCCEEEEECCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHH
LDHWDISRTSSQNVRDFFLAAPGGVPTQVAFSQDRRWDELDLDREKGVIRSAETPFSKDG
HHHCCCCCCCCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCHHCCCEECCCCCCCCCC
GLAVLKGNLALDGCIVKTAGVDESILKFTGPARVFESQDASVKAILSNEIKAGDVVVIRY
CEEEEECCEEECCEEEEECCCCHHHHHHCCCHHHHCCCCCCEEEEHHCCCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKSKGLGKACALVTDGRFSGGTSGLSIGHASPEAAEGGTIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEE
VQEGDTIEIDIPNRTIRLAVSDAELDSRRAAMEAKGALAWKPEEKRKRKVTTALRAYAAF
EECCCEEEEECCCCEEEEEEECCCHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHH
ATSADKGAVRHVPE
HCCCCCCCCCCCCC
>Mature Secondary Structure 
PAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPTVFVSGGPMEAGKVVLAGKTQALDLVDAMVAAADDKISDED
CCCCCCHHHHHHHEEECCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCH
VKVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCCCEEEHHHHHHHH
DLAQRYYEQDDETALPRSIASKGAFENAMTLDIAMGGSTNTVLHILAAAHEGEVDFTMED
HHHHHHHCCCCCHHCCHHHHHCCCCCCCEEEEEEECCCCHHHHEEEECCCCCCCEEEHHH
IDRLSRRVPVLCKVAPAKSDVHMEDVHRAGGIMAILGQLDNAGLINRDLPTVHTSSLGEA
HHHHHCCCCEEEEECCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHH
LDHWDISRTSSQNVRDFFLAAPGGVPTQVAFSQDRRWDELDLDREKGVIRSAETPFSKDG
HHHCCCCCCCCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCHHCCCEECCCCCCCCCC
GLAVLKGNLALDGCIVKTAGVDESILKFTGPARVFESQDASVKAILSNEIKAGDVVVIRY
CEEEEECCEEECCEEEEECCCCHHHHHHCCCHHHHCCCCCCEEEEHHCCCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKSKGLGKACALVTDGRFSGGTSGLSIGHASPEAAEGGTIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEE
VQEGDTIEIDIPNRTIRLAVSDAELDSRRAAMEAKGALAWKPEEKRKRKVTTALRAYAAF
EECCCEEEEECCCCEEEEEEECCCHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHH
ATSADKGAVRHVPE
HCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968