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The map label for this gene is acdA [H]

Identifier: 13474205

GI number: 13474205

Start: 3991633

End: 3992796

Strand: Direct

Name: acdA [H]

Synonym: mlr5042

Alternate gene names: 13474205

Gene position: 3991633-3992796 (Clockwise)

Preceding gene: 13474204

Following gene: 13474206

Centisome position: 56.73

GC content: 63.66

Gene sequence:

>1164_bases
ATGGATTTTGGTCTTTCGGAGGAACAAAAACTCATCGTCGAGACGACGCGCGCTTTCGTGGAGAACGAGCTTTACCCGCA
TGAGCGCGAGGTCGAGCGCACCGGCGTGCTGCGCCGCGAGCTGATCGAAGAGCTCAAGGCCAAGGCGATCGAGGCAGGGC
TCTACGCAGCCAATATGCCGGCGGATGTCGGCGGCGCGGGCCTCGATACGGTGACCTGGCTGCTCTACGAAAAGGAACTC
GGCCGCGCCAATTACGCGCTGCACTGGACCTGCGTCGCACGCCCCTCCAACATCCTCTTGGCTGGCACGCCGGAGCAGCG
CGAAAAATATCTCTTCCCGTGCATCCGTGGCGAGAAATGGGACTGCCTGGCGATGACCGAGCCGGGCGCCGGCTCCGACC
TGCGCGGCATGAAGGCTTCAGCCGTGCAGGACGGCGACGACTGGGTGCTGAACGGCACCAAACATTTCATCAGCCACGCC
GATCTCGCCGATTTCGCCATCGTCTTCATGGCTTCGGGCGAAGAGGATTCGCCGCGCGGCAAGCGCAAGAAGATCACCGC
CTTCTTCGTCGACAAAGGCACCAAGGGTTTCACGGTTCGCGATGGCTATCGCAACGTCTCGCATCGCGGCTACACCAACG
CCATCCTCGAATTCGACGATTGCCGGCTGCCGGCGAGCCAGGTGCTCGGCGAAGTGCACAAGGGCTTCGACGTCGCCAAT
TCCTGGCTCGGCGCCACCCGTCTGCAGGTCGGCGCCACCTGTCTCGGCCGCGCCGAGCGGGCGCTTGGCCACGCGGTCGA
GTACGCCGCGCAGCGCCAGCAATTCGGCCAGCAGATCGGCAAGTTCCAGGGCGTGTCGTTCAAGCTCGCAGACATGGCGA
CCGAATTGAAGGCCGCCGACCTGATGGTGTTCGAAGCCGGCTGGAAGTACGATCAGGGCACCGTCACCGACCAGGACATG
GCCATGGCCAAGCTGAAAGCCACCGAAATGCTGGCTTTCGTTGCCGACGAAGCCATCCAGATCCATGGCGGCATGGGGCT
GATGGACGACCTGCCGCTGGAGCGCATCTGGCGCGACGCCCGCGTCGAGCGCATCTGGGAGGGCACGTCGGAGATTCAGC
GACATATTATTTCGCGGGCGCTGCTGCGTCCGTTCGGTGCTTAG

Upstream 100 bases:

>100_bases
GCGAAGAAGCCGGCGGCTTCCACTGCGGCCGAGAAGGCCAAGGCCTCCAAGCCGGTGAAGAAGGCGGAAAAACCGAAGAA
AAAGAAGAAGGGCTGAGGCC

Downstream 100 bases:

>100_bases
AGCATGATCGCCCAAAGCCGAGATTCGGTTTTGTCGGGCAAACGAGATCGTTTGTCCTGAGATGCTCAAACGAAAAGATG
ACCATGCATAAACTTGAACG

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MDFGLSEEQKLIVETTRAFVENELYPHEREVERTGVLRRELIEELKAKAIEAGLYAANMPADVGGAGLDTVTWLLYEKEL
GRANYALHWTCVARPSNILLAGTPEQREKYLFPCIRGEKWDCLAMTEPGAGSDLRGMKASAVQDGDDWVLNGTKHFISHA
DLADFAIVFMASGEEDSPRGKRKKITAFFVDKGTKGFTVRDGYRNVSHRGYTNAILEFDDCRLPASQVLGEVHKGFDVAN
SWLGATRLQVGATCLGRAERALGHAVEYAAQRQQFGQQIGKFQGVSFKLADMATELKAADLMVFEAGWKYDQGTVTDQDM
AMAKLKATEMLAFVADEAIQIHGGMGLMDDLPLERIWRDARVERIWEGTSEIQRHIISRALLRPFGA

Sequences:

>Translated_387_residues
MDFGLSEEQKLIVETTRAFVENELYPHEREVERTGVLRRELIEELKAKAIEAGLYAANMPADVGGAGLDTVTWLLYEKEL
GRANYALHWTCVARPSNILLAGTPEQREKYLFPCIRGEKWDCLAMTEPGAGSDLRGMKASAVQDGDDWVLNGTKHFISHA
DLADFAIVFMASGEEDSPRGKRKKITAFFVDKGTKGFTVRDGYRNVSHRGYTNAILEFDDCRLPASQVLGEVHKGFDVAN
SWLGATRLQVGATCLGRAERALGHAVEYAAQRQQFGQQIGKFQGVSFKLADMATELKAADLMVFEAGWKYDQGTVTDQDM
AMAKLKATEMLAFVADEAIQIHGGMGLMDDLPLERIWRDARVERIWEGTSEIQRHIISRALLRPFGA
>Mature_387_residues
MDFGLSEEQKLIVETTRAFVENELYPHEREVERTGVLRRELIEELKAKAIEAGLYAANMPADVGGAGLDTVTWLLYEKEL
GRANYALHWTCVARPSNILLAGTPEQREKYLFPCIRGEKWDCLAMTEPGAGSDLRGMKASAVQDGDDWVLNGTKHFISHA
DLADFAIVFMASGEEDSPRGKRKKITAFFVDKGTKGFTVRDGYRNVSHRGYTNAILEFDDCRLPASQVLGEVHKGFDVAN
SWLGATRLQVGATCLGRAERALGHAVEYAAQRQQFGQQIGKFQGVSFKLADMATELKAADLMVFEAGWKYDQGTVTDQDM
AMAKLKATEMLAFVADEAIQIHGGMGLMDDLPLERIWRDARVERIWEGTSEIQRHIISRALLRPFGA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=385, Percent_Identity=36.6233766233766, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI226958412, Length=385, Percent_Identity=35.5844155844156, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI226958414, Length=338, Percent_Identity=36.3905325443787, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4501857, Length=384, Percent_Identity=33.0729166666667, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=32.7272727272727, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=32.7272727272727, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI4557235, Length=387, Percent_Identity=33.5917312661499, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI76496475, Length=387, Percent_Identity=33.5917312661499, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI7656849, Length=389, Percent_Identity=31.3624678663239, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4501859, Length=381, Percent_Identity=28.8713910761155, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI21361497, Length=360, Percent_Identity=31.6666666666667, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI38505218, Length=399, Percent_Identity=27.0676691729323, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI4503943, Length=388, Percent_Identity=27.5773195876289, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI48976061, Length=404, Percent_Identity=27.4752475247525, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI211971008, Length=404, Percent_Identity=27.4752475247525, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI7669494, Length=357, Percent_Identity=27.7310924369748, Blast_Score=115, Evalue=8e-26,
Organism=Escherichia coli, GI1786223, Length=390, Percent_Identity=32.0512820512821, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI87081958, Length=392, Percent_Identity=30.1020408163265, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17538396, Length=390, Percent_Identity=35.1282051282051, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17570075, Length=385, Percent_Identity=33.7662337662338, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17534899, Length=390, Percent_Identity=33.5897435897436, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI17508101, Length=381, Percent_Identity=33.0708661417323, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17569725, Length=397, Percent_Identity=33.2493702770781, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17506239, Length=383, Percent_Identity=30.5483028720627, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17533517, Length=383, Percent_Identity=31.331592689295, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71985184, Length=335, Percent_Identity=30.7462686567164, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71990804, Length=286, Percent_Identity=34.6153846153846, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=26.3707571801567, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17551932, Length=373, Percent_Identity=26.8096514745308, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71982178, Length=284, Percent_Identity=29.2253521126761, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17505929, Length=376, Percent_Identity=25.531914893617, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71985192, Length=269, Percent_Identity=27.8810408921933, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17562446, Length=401, Percent_Identity=26.4339152119701, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32563615, Length=233, Percent_Identity=31.7596566523605, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17531909, Length=249, Percent_Identity=29.718875502008, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI86563383, Length=282, Percent_Identity=28.0141843971631, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI86563381, Length=282, Percent_Identity=28.0141843971631, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17531913, Length=175, Percent_Identity=28, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356377, Length=387, Percent_Identity=35.6589147286822, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24646207, Length=387, Percent_Identity=35.4005167958656, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24660351, Length=383, Percent_Identity=34.2036553524804, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI21355753, Length=388, Percent_Identity=35.0515463917526, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24666513, Length=389, Percent_Identity=30.0771208226221, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI281363737, Length=337, Percent_Identity=36.2017804154303, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI19920834, Length=386, Percent_Identity=26.9430051813472, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 43083; Mature: 43083

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFGLSEEQKLIVETTRAFVENELYPHEREVERTGVLRRELIEELKAKAIEAGLYAANMP
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCC
ADVGGAGLDTVTWLLYEKELGRANYALHWTCVARPSNILLAGTPEQREKYLFPCIRGEKW
CCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEECCCHHHHHEECCCCCCCCC
DCLAMTEPGAGSDLRGMKASAVQDGDDWVLNGTKHFISHADLADFAIVFMASGEEDSPRG
CEEEECCCCCCCCCCCCCHHCCCCCCCEEECCHHHHHHHCCHHHEEEEEEECCCCCCCCC
KRKKITAFFVDKGTKGFTVRDGYRNVSHRGYTNAILEFDDCRLPASQVLGEVHKGFDVAN
CCEEEEEEEEECCCCCCEEECCCCCCCCCCCCHHEEEECCCCCCHHHHHHHHHHHHHHHH
SWLGATRLQVGATCLGRAERALGHAVEYAAQRQQFGQQIGKFQGVSFKLADMATELKAAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHH
LMVFEAGWKYDQGTVTDQDMAMAKLKATEMLAFVADEAIQIHGGMGLMDDLPLERIWRDA
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHH
RVERIWEGTSEIQRHIISRALLRPFGA
HHHHHHCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDFGLSEEQKLIVETTRAFVENELYPHEREVERTGVLRRELIEELKAKAIEAGLYAANMP
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCC
ADVGGAGLDTVTWLLYEKELGRANYALHWTCVARPSNILLAGTPEQREKYLFPCIRGEKW
CCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEECCCHHHHHEECCCCCCCCC
DCLAMTEPGAGSDLRGMKASAVQDGDDWVLNGTKHFISHADLADFAIVFMASGEEDSPRG
CEEEECCCCCCCCCCCCCHHCCCCCCCEEECCHHHHHHHCCHHHEEEEEEECCCCCCCCC
KRKKITAFFVDKGTKGFTVRDGYRNVSHRGYTNAILEFDDCRLPASQVLGEVHKGFDVAN
CCEEEEEEEEECCCCCCEEECCCCCCCCCCCCHHEEEECCCCCCHHHHHHHHHHHHHHHH
SWLGATRLQVGATCLGRAERALGHAVEYAAQRQQFGQQIGKFQGVSFKLADMATELKAAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHH
LMVFEAGWKYDQGTVTDQDMAMAKLKATEMLAFVADEAIQIHGGMGLMDDLPLERIWRDA
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHH
RVERIWEGTSEIQRHIISRALLRPFGA
HHHHHHCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]