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The map label for this gene is hbd [H]

Identifier: 13474204

GI number: 13474204

Start: 3990534

End: 3991628

Strand: Direct

Name: hbd [H]

Synonym: mlr5041

Alternate gene names: 13474204

Gene position: 3990534-3991628 (Clockwise)

Preceding gene: 13474203

Following gene: 13474205

Centisome position: 56.72

GC content: 63.84

Gene sequence:

>1095_bases
ATGAGCATCATCAACAAGGCGGCCGCCATTGGCGGCGGTGTCATCGGCGCCGGCTGGGTGGCGCGGCTGCTGCTCAACGG
CATCGACGTGTCGATCTTCGATCCCGATCCGGAAGCCTCGCGCAAGGTCTCGGAAGTGATGAAAGGCGCGCGCCGCGCCT
ACAAGCAGATGGTCCCCGGCGGCCTGCCGAAAGAGGGCAAGCTGACCTTCGCCAAGACCATCGCCGAGGCGGTCGCGGAC
GCCGACTTCATCCAGGAAAGCGTGCCGGAACGCCTCGATCTCAAGCACAGGGTGCTGGCCGAGATCGATGCCCACGCGCC
GGCCAACGCCATTGTCGGCTCCTCGACCTCCGGCATCAAGCCGACCGACATGCAGGTGGCGATGAAGAAGCATCCGGAGC
GGCTGGTCGTCGGCCATCCATTCAACCCGGTCTACCTCCTGCCGCTGGTAGAGATCGTCGGCGGCGACCAGACCTTTCCC
GAGGCGATCGAAGTCGCCAAGGAGATCTATGCCTCGATCGGCATGAAGCCTGTCGTCATCCGCAAGGAGATCGAGGCCTT
CGTCGGCGACCGCCTGCTCGAAGCGGCATGGCGCGAGGCGCTGTGGCTGATCAAGGACGGCATCTGCACGGTCGAGGAAC
TCGACGACATCATGCGCTACGGCTTCGGCCTGCGCTGGGCGCAGATGGGCATGTTCCAGGTCTATCGCGTCGCTGGCGGC
GAGGCCGGCATGCGCCACTTCATGGCGCAGTTCGGGCCGTGCCTGAAATGGCCGTGGACCAAGCTGATGGACGTGCCGGA
ATTCAACGACGAGCTGGTCGACCTGATCGCCACCCAGTCGGACGACCAGGCGCATGGCCTGTCGATCCGCGAGCTGGAAA
AGATCCGCGACGACAATCTGGTCGCGATCATGGATGCGCTGTCGAAGCAGAACAAGGGCAAGGGTTGGGGCGCCGGCGCC
TTGCACAAGGATTATACGAAGCAATTGGCCAAGCTGGCGGCGAAGAAGCCGGCGGCTTCCACTGCGGCCGAGAAGGCCAA
GGCCTCCAAGCCGGTGAAGAAGGCGGAAAAACCGAAGAAAAAGAAGAAGGGCTGA

Upstream 100 bases:

>100_bases
TCTTCGCCCGCAAGGCCTACGACGCATCCGTGATCCGCGCCGGCGAGCGCGTGCCTCTCATCGATCCCGAAACAGCCAGG
ACAAGAACCGGAGCTTCCGC

Downstream 100 bases:

>100_bases
GGCCATGGATTTTGGTCTTTCGGAGGAACAAAAACTCATCGTCGAGACGACGCGCGCTTTCGTGGAGAACGAGCTTTACC
CGCATGAGCGCGAGGTCGAG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSIINKAAAIGGGVIGAGWVARLLLNGIDVSIFDPDPEASRKVSEVMKGARRAYKQMVPGGLPKEGKLTFAKTIAEAVAD
ADFIQESVPERLDLKHRVLAEIDAHAPANAIVGSSTSGIKPTDMQVAMKKHPERLVVGHPFNPVYLLPLVEIVGGDQTFP
EAIEVAKEIYASIGMKPVVIRKEIEAFVGDRLLEAAWREALWLIKDGICTVEELDDIMRYGFGLRWAQMGMFQVYRVAGG
EAGMRHFMAQFGPCLKWPWTKLMDVPEFNDELVDLIATQSDDQAHGLSIRELEKIRDDNLVAIMDALSKQNKGKGWGAGA
LHKDYTKQLAKLAAKKPAASTAAEKAKASKPVKKAEKPKKKKKG

Sequences:

>Translated_364_residues
MSIINKAAAIGGGVIGAGWVARLLLNGIDVSIFDPDPEASRKVSEVMKGARRAYKQMVPGGLPKEGKLTFAKTIAEAVAD
ADFIQESVPERLDLKHRVLAEIDAHAPANAIVGSSTSGIKPTDMQVAMKKHPERLVVGHPFNPVYLLPLVEIVGGDQTFP
EAIEVAKEIYASIGMKPVVIRKEIEAFVGDRLLEAAWREALWLIKDGICTVEELDDIMRYGFGLRWAQMGMFQVYRVAGG
EAGMRHFMAQFGPCLKWPWTKLMDVPEFNDELVDLIATQSDDQAHGLSIRELEKIRDDNLVAIMDALSKQNKGKGWGAGA
LHKDYTKQLAKLAAKKPAASTAAEKAKASKPVKKAEKPKKKKKG
>Mature_363_residues
SIINKAAAIGGGVIGAGWVARLLLNGIDVSIFDPDPEASRKVSEVMKGARRAYKQMVPGGLPKEGKLTFAKTIAEAVADA
DFIQESVPERLDLKHRVLAEIDAHAPANAIVGSSTSGIKPTDMQVAMKKHPERLVVGHPFNPVYLLPLVEIVGGDQTFPE
AIEVAKEIYASIGMKPVVIRKEIEAFVGDRLLEAAWREALWLIKDGICTVEELDDIMRYGFGLRWAQMGMFQVYRVAGGE
AGMRHFMAQFGPCLKWPWTKLMDVPEFNDELVDLIATQSDDQAHGLSIRELEKIRDDNLVAIMDALSKQNKGKGWGAGAL
HKDYTKQLAKLAAKKPAASTAAEKAKASKPVKKAEKPKKKKKG

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=274, Percent_Identity=30.2919708029197, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI296179429, Length=246, Percent_Identity=26.4227642276423, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI261878539, Length=259, Percent_Identity=24.7104247104247, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI68989263, Length=259, Percent_Identity=24.7104247104247, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI20127408, Length=228, Percent_Identity=26.7543859649123, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI296179427, Length=263, Percent_Identity=24.7148288973384, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787661, Length=239, Percent_Identity=28.0334728033473, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788682, Length=160, Percent_Identity=30.625, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790281, Length=142, Percent_Identity=29.5774647887324, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=241, Percent_Identity=28.6307053941909, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193203623, Length=241, Percent_Identity=28.6307053941909, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17549919, Length=253, Percent_Identity=26.4822134387352, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71985930, Length=245, Percent_Identity=26.1224489795918, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25144276, Length=237, Percent_Identity=27.4261603375527, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508953, Length=237, Percent_Identity=27.4261603375527, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508951, Length=237, Percent_Identity=27.4261603375527, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71985923, Length=223, Percent_Identity=26.457399103139, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17553560, Length=281, Percent_Identity=25.2669039145907, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17563036, Length=226, Percent_Identity=28.3185840707965, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17558304, Length=223, Percent_Identity=28.6995515695067, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45549573, Length=256, Percent_Identity=32.8125, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI20129993, Length=306, Percent_Identity=26.797385620915, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19921000, Length=223, Percent_Identity=27.8026905829596, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24583077, Length=230, Percent_Identity=27.3913043478261, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24583079, Length=230, Percent_Identity=27.3913043478261, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 39789; Mature: 39658

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIINKAAAIGGGVIGAGWVARLLLNGIDVSIFDPDPEASRKVSEVMKGARRAYKQMVPG
CCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
GLPKEGKLTFAKTIAEAVADADFIQESVPERLDLKHRVLAEIDAHAPANAIVGSSTSGIK
CCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
PTDMQVAMKKHPERLVVGHPFNPVYLLPLVEIVGGDQTFPEAIEVAKEIYASIGMKPVVI
CCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHH
RKEIEAFVGDRLLEAAWREALWLIKDGICTVEELDDIMRYGFGLRWAQMGMFQVYRVAGG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
EAGMRHFMAQFGPCLKWPWTKLMDVPEFNDELVDLIATQSDDQAHGLSIRELEKIRDDNL
HHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCHHCCCHHHHHHHCCCCH
VAIMDALSKQNKGKGWGAGALHKDYTKQLAKLAAKKPAASTAAEKAKASKPVKKAEKPKK
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCCHH
KKKG
HCCC
>Mature Secondary Structure 
SIINKAAAIGGGVIGAGWVARLLLNGIDVSIFDPDPEASRKVSEVMKGARRAYKQMVPG
CHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
GLPKEGKLTFAKTIAEAVADADFIQESVPERLDLKHRVLAEIDAHAPANAIVGSSTSGIK
CCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
PTDMQVAMKKHPERLVVGHPFNPVYLLPLVEIVGGDQTFPEAIEVAKEIYASIGMKPVVI
CCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHH
RKEIEAFVGDRLLEAAWREALWLIKDGICTVEELDDIMRYGFGLRWAQMGMFQVYRVAGG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
EAGMRHFMAQFGPCLKWPWTKLMDVPEFNDELVDLIATQSDDQAHGLSIRELEKIRDDNL
HHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCHHCCCHHHHHHHCCCCH
VAIMDALSKQNKGKGWGAGALHKDYTKQLAKLAAKKPAASTAAEKAKASKPVKKAEKPKK
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCCHH
KKKG
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA