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The map label for this gene is norM

Identifier: 13474102

GI number: 13474102

Start: 3895108

End: 3896511

Strand: Reverse

Name: norM

Synonym: mll4906

Alternate gene names: 13474102

Gene position: 3896511-3895108 (Counterclockwise)

Preceding gene: 13474109

Following gene: 13474099

Centisome position: 55.38

GC content: 66.74

Gene sequence:

>1404_bases
ATGTCTGCGATCGATGCCGGCGCTCGCGCGCCGGAAAATCTTTGGCGTCAGGAAATCAGGGCGACGCTGGCGCTGGCCTG
GCCGATGGTGCTGACCAATCTCGGCCAGACCGCGATGACGGCCACCGACGTCATGATGATGGGCAGGCTTGGGCCGGACA
CGCTGGCCAGCGGCGCGCTTGGCGCCAACCTCTATTTCATGCCGCTGATCTTCGGCCTCGGCCTGATGCTGGCGACGTCG
CCGATGATCGCCACCGAGCTTGGCCGACGCCGTTATTCGGTGCGTGACCTGCGCCGCACCGTGCGCCAGGGCCTGTGGCT
GGCGATCCTGATTTCGATCCCGATCTGGATCGTGCTCTGGCACGGCGAAGCGATCCTGCTGGCCATGGGCCAGGAACCCG
CGCTGGCGCACCAGGCCGGCATCTATTTGCGCTGGCTGGAATGGGCGGTGCTGCCTTTCTACGGCTATATCGTGCTGCGC
TCGTTCATCTCGGCGCTGGAGCGGCCGGGCTGGGCGCTGATCATCGTTTTCGTCGCCGTCGCCTGCAACGCGCTGTTCAA
CTGGGTGTTCATGTTCGGCAATCTCGGCTTTCCGGCCATGGGCATTGCCGGCTCGGGTCTCGCCACCTCGCTGTCCAGCA
CGCTGATGTTCGCCGGCATGGCCGCTGTGGTAATGCTGGAGAAGAAGTTCCGGCGCTACCGGCTGTTCGGCCGCTTCTGG
CGGTCCGACTGGCCGCGCTTCAACGGGCTGCTGCGGCTTGGCCTGCCGATTGCCGGCATCCTCGCCTTCGAGGTGACGAT
CTTCAACGCCGCGGCCCTGCTGATGGGCCTGATCGACGCGGATTCGCTGGCCGCGCACGCCATCGCCATCCAGATCGCTT
CGATCTCGTTCATGGTGCCGCTCGGCCTCAACCAGGCGGTGACGGTGCGCGTCGGGCTTGCGCATGGCGCCGGCAATCCG
GAAGGCGTGTCGCGCGCCGGCTGGACCGCCTTCGTCATCGGCGTCTCGTTCATGGCGCTGATGGGGCTGGTGATGGTGCT
GTGGCCGCATCTCCTGATCAGCGCCTTCATCGATCTCGCCAACCCGGCCAATGCCCGGGTGATCGCGCTTGCCGTGTCGT
TCCTGGTGTTTGCCGCACTGTTCCAGGTCTTCGACGGCGCGCAGGCGGTCGCCGCCGGCATGCTGCGCGGCCTGCACGAC
ACCAAGGTGCCGATGATCTATGCCGCGATCGGCTATTGGGGCGTCGGCCTGCCGCTCGGCGTGCTGCTCGCCTTCCATTT
CGGCTTCCACGGCGTCGGTATCTGGATCGGCCTGTCATCAGGGCTGGCCGTGGTGGCGGCGCTGCTCCTGACGCGCTGGC
TGCGCCGCGACCGGATCGCACCACCGCTGGCGTTCGGGCATTGA

Upstream 100 bases:

>100_bases
TCAATACACGGCGCAAACGCCGCGAAACCTACGGTTTTGCCGTTTGTCATGCGGCTTCCGGCTCTTTTGCCGACGCGCCG
CGCCTGGAAAGAGCGGAACA

Downstream 100 bases:

>100_bases
GACGGGAAAGCCGTCGCGCGCTTCATTCGTCCTGTCCGGACGGATGAGATTTGAGATAGGCGATGATATCCGCGCGGATT
TGCTGATCTGCTATCGAGAT

Product: multidrug efflux protein (NorM)

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSAIDAGARAPENLWRQEIRATLALAWPMVLTNLGQTAMTATDVMMMGRLGPDTLASGALGANLYFMPLIFGLGLMLATS
PMIATELGRRRYSVRDLRRTVRQGLWLAILISIPIWIVLWHGEAILLAMGQEPALAHQAGIYLRWLEWAVLPFYGYIVLR
SFISALERPGWALIIVFVAVACNALFNWVFMFGNLGFPAMGIAGSGLATSLSSTLMFAGMAAVVMLEKKFRRYRLFGRFW
RSDWPRFNGLLRLGLPIAGILAFEVTIFNAAALLMGLIDADSLAAHAIAIQIASISFMVPLGLNQAVTVRVGLAHGAGNP
EGVSRAGWTAFVIGVSFMALMGLVMVLWPHLLISAFIDLANPANARVIALAVSFLVFAALFQVFDGAQAVAAGMLRGLHD
TKVPMIYAAIGYWGVGLPLGVLLAFHFGFHGVGIWIGLSSGLAVVAALLLTRWLRRDRIAPPLAFGH

Sequences:

>Translated_467_residues
MSAIDAGARAPENLWRQEIRATLALAWPMVLTNLGQTAMTATDVMMMGRLGPDTLASGALGANLYFMPLIFGLGLMLATS
PMIATELGRRRYSVRDLRRTVRQGLWLAILISIPIWIVLWHGEAILLAMGQEPALAHQAGIYLRWLEWAVLPFYGYIVLR
SFISALERPGWALIIVFVAVACNALFNWVFMFGNLGFPAMGIAGSGLATSLSSTLMFAGMAAVVMLEKKFRRYRLFGRFW
RSDWPRFNGLLRLGLPIAGILAFEVTIFNAAALLMGLIDADSLAAHAIAIQIASISFMVPLGLNQAVTVRVGLAHGAGNP
EGVSRAGWTAFVIGVSFMALMGLVMVLWPHLLISAFIDLANPANARVIALAVSFLVFAALFQVFDGAQAVAAGMLRGLHD
TKVPMIYAAIGYWGVGLPLGVLLAFHFGFHGVGIWIGLSSGLAVVAALLLTRWLRRDRIAPPLAFGH
>Mature_466_residues
SAIDAGARAPENLWRQEIRATLALAWPMVLTNLGQTAMTATDVMMMGRLGPDTLASGALGANLYFMPLIFGLGLMLATSP
MIATELGRRRYSVRDLRRTVRQGLWLAILISIPIWIVLWHGEAILLAMGQEPALAHQAGIYLRWLEWAVLPFYGYIVLRS
FISALERPGWALIIVFVAVACNALFNWVFMFGNLGFPAMGIAGSGLATSLSSTLMFAGMAAVVMLEKKFRRYRLFGRFWR
SDWPRFNGLLRLGLPIAGILAFEVTIFNAAALLMGLIDADSLAAHAIAIQIASISFMVPLGLNQAVTVRVGLAHGAGNPE
GVSRAGWTAFVIGVSFMALMGLVMVLWPHLLISAFIDLANPANARVIALAVSFLVFAALFQVFDGAQAVAAGMLRGLHDT
KVPMIYAAIGYWGVGLPLGVLLAFHFGFHGVGIWIGLSSGLAVVAALLLTRWLRRDRIAPPLAFGH

Specific function: Multidrug efflux pump

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family

Homologues:

Organism=Homo sapiens, GI22907060, Length=432, Percent_Identity=26.3888888888889, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI153792564, Length=453, Percent_Identity=23.6203090507726, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI38261960, Length=227, Percent_Identity=28.6343612334802, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI48994890, Length=449, Percent_Identity=32.739420935412, Blast_Score=199, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6321821, Length=453, Percent_Identity=23.6203090507726, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320545, Length=440, Percent_Identity=22.2727272727273, Blast_Score=63, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NORM_RHILO (Q98D15)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105670.1
- GeneID:   1228331
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll4906
- NMPDR:   fig|266835.1.peg.3774
- HOGENOM:   HBG479615
- OMA:   ISALERP
- ProtClustDB:   CLSK864142
- InterPro:   IPR002528
- PANTHER:   PTHR11206
- TIGRFAMs:   TIGR00797

Pfam domain/function: PF01554 MatE

EC number: NA

Molecular weight: Translated: 50529; Mature: 50398

Theoretical pI: Translated: 10.85; Mature: 10.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x13637fd0)-; HASH(0x1418d164)-; HASH(0x139b8784)-; HASH(0x1411c744)-; HASH(0x130361cc)-; HASH(0x1421fb6c)-; HASH(0x141f8a34)-; HASH(0x11b13d68)-; HASH(0x126b1ac4)-; HASH(0x1186adb8)-; HASH(0x142077fc)-; HASH(0x136e8a38)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIDAGARAPENLWRQEIRATLALAWPMVLTNLGQTAMTATDVMMMGRLGPDTLASGAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHCCCC
GANLYFMPLIFGLGLMLATSPMIATELGRRRYSVRDLRRTVRQGLWLAILISIPIWIVLW
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
HGEAILLAMGQEPALAHQAGIYLRWLEWAVLPFYGYIVLRSFISALERPGWALIIVFVAV
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ACNALFNWVFMFGNLGFPAMGIAGSGLATSLSSTLMFAGMAAVVMLEKKFRRYRLFGRFW
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSDWPRFNGLLRLGLPIAGILAFEVTIFNAAALLMGLIDADSLAAHAIAIQIASISFMVP
HCCCCHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEEEEE
LGLNQAVTVRVGLAHGAGNPEGVSRAGWTAFVIGVSFMALMGLVMVLWPHLLISAFIDLA
CCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NPANARVIALAVSFLVFAALFQVFDGAQAVAAGMLRGLHDTKVPMIYAAIGYWGVGLPLG
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
VLLAFHFGFHGVGIWIGLSSGLAVVAALLLTRWLRRDRIAPPLAFGH
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCH
>Mature Secondary Structure 
SAIDAGARAPENLWRQEIRATLALAWPMVLTNLGQTAMTATDVMMMGRLGPDTLASGAL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHCCCC
GANLYFMPLIFGLGLMLATSPMIATELGRRRYSVRDLRRTVRQGLWLAILISIPIWIVLW
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
HGEAILLAMGQEPALAHQAGIYLRWLEWAVLPFYGYIVLRSFISALERPGWALIIVFVAV
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ACNALFNWVFMFGNLGFPAMGIAGSGLATSLSSTLMFAGMAAVVMLEKKFRRYRLFGRFW
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSDWPRFNGLLRLGLPIAGILAFEVTIFNAAALLMGLIDADSLAAHAIAIQIASISFMVP
HCCCCHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEEEEE
LGLNQAVTVRVGLAHGAGNPEGVSRAGWTAFVIGVSFMALMGLVMVLWPHLLISAFIDLA
CCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NPANARVIALAVSFLVFAALFQVFDGAQAVAAGMLRGLHDTKVPMIYAAIGYWGVGLPLG
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
VLLAFHFGFHGVGIWIGLSSGLAVVAALLLTRWLRRDRIAPPLAFGH
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11214968