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The map label for this gene is pdhB [H]

Identifier: 13473130

GI number: 13473130

Start: 2925824

End: 2926822

Strand: Reverse

Name: pdhB [H]

Synonym: mll3628

Alternate gene names: 13473130

Gene position: 2926822-2925824 (Counterclockwise)

Preceding gene: 13473131

Following gene: 13473129

Centisome position: 41.6

GC content: 64.76

Gene sequence:

>999_bases
ATGGACGCGACGGTGCGTGAACTGAGCTACGCCCAGGCGATCCAGGAAGCCATGGCGATCGCCATGGACATGGACGAGCG
CGTCTTCCTGATGGGCGAGGATATCGGCGTCTATGGCGGCGCCTTCCAGGTGACCGGCGATCTGGTGGAGCGTTATGGCA
CTGAGCGCGTGATCGACACGCCGATCTCGGAACTGGGCGGCGCGGGGGTGGCGGTGGGTGCGGCGCTCACCGGCATGCGG
CCGATCTTCGAATTCCAGTTTTCCGATTTCGCCACGCTCGCCATGGAGCAGATCGTCAACCAGGCGGCCAAGATGCGATT
CATGCTGGGAGGCGAGGTTTCGGTTCCCGTGGTGATGCGCTTTCCCGCCGGTTCGGGTACGGGTGCGGCCGCGCAGCACA
GCCAAAGCCTCGAAGCCTGGCTTGGCCATGTGCCAGGCCTGAAGGTCATCCAGCCGGCGACGCCCTATGATGCCAAGGGC
ATGCTCCTGGCTGCGGTCGCCGATCCCGATCCGGTGATGATCTTCGAGCACAAGCTGCTCTACAAGATGAAGGGCCCGGT
GCCAGAGGGCTATTACACCGTGCCGATCGGCAAGGCCGACATCCGCCGCGAGGGCCGCGATCTCACCATCGTCGCCACCT
CGATCATGGTGCAGAAGGCGCTCGACGCCGCCGCCACGCTGGAAGCCGAAGGCATCGACGTCGAAGTCGTCGATCTGAGG
ACCATCCGGCCGATGGACAAGCAGACCGTCATCGACAGCGTCAAGAAGACGTCGCGGCTGATGTGCGTCTACGAAGCGGT
CAAGACGCTGGGCATCGGCGCCGAGGTCAGCGCCATGATCGCCGAGAGCGAGGCGTTCGACTATCTCGACGCGCCGATCG
TGCGGTTGGGCGGCGCGGAAACGCCGATCCCCTACAATCCGGAGCTCGAAAAGGCCACGGTGCCGCAGGTTCCCGACATC
ATCAGCGCCGCGCGCGACCTCGTGAAAGGGGTTCGCTGA

Upstream 100 bases:

>100_bases
CGGTGTCGCAGGAGATCGCCGACGGCATCGAGTTCGCCAAGGCGAGCCCGTCGCCTGACGTCAGCGAGACCGGAAATTAC
GTGTATACGGAGCAGGCGTG

Downstream 100 bases:

>100_bases
GACATGCCGACCGAAGTCATTCTCCCCAAGGTCGATATGGACATGGCGACCGGACAGATCTCGCGCTGGTTCGCCGAAGA
AGGTGCCCGGGTCAAGAAGG

Product: acetoin dehydrogenase (TPP-dependent) beta chain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MDATVRELSYAQAIQEAMAIAMDMDERVFLMGEDIGVYGGAFQVTGDLVERYGTERVIDTPISELGGAGVAVGAALTGMR
PIFEFQFSDFATLAMEQIVNQAAKMRFMLGGEVSVPVVMRFPAGSGTGAAAQHSQSLEAWLGHVPGLKVIQPATPYDAKG
MLLAAVADPDPVMIFEHKLLYKMKGPVPEGYYTVPIGKADIRREGRDLTIVATSIMVQKALDAAATLEAEGIDVEVVDLR
TIRPMDKQTVIDSVKKTSRLMCVYEAVKTLGIGAEVSAMIAESEAFDYLDAPIVRLGGAETPIPYNPELEKATVPQVPDI
ISAARDLVKGVR

Sequences:

>Translated_332_residues
MDATVRELSYAQAIQEAMAIAMDMDERVFLMGEDIGVYGGAFQVTGDLVERYGTERVIDTPISELGGAGVAVGAALTGMR
PIFEFQFSDFATLAMEQIVNQAAKMRFMLGGEVSVPVVMRFPAGSGTGAAAQHSQSLEAWLGHVPGLKVIQPATPYDAKG
MLLAAVADPDPVMIFEHKLLYKMKGPVPEGYYTVPIGKADIRREGRDLTIVATSIMVQKALDAAATLEAEGIDVEVVDLR
TIRPMDKQTVIDSVKKTSRLMCVYEAVKTLGIGAEVSAMIAESEAFDYLDAPIVRLGGAETPIPYNPELEKATVPQVPDI
ISAARDLVKGVR
>Mature_332_residues
MDATVRELSYAQAIQEAMAIAMDMDERVFLMGEDIGVYGGAFQVTGDLVERYGTERVIDTPISELGGAGVAVGAALTGMR
PIFEFQFSDFATLAMEQIVNQAAKMRFMLGGEVSVPVVMRFPAGSGTGAAAQHSQSLEAWLGHVPGLKVIQPATPYDAKG
MLLAAVADPDPVMIFEHKLLYKMKGPVPEGYYTVPIGKADIRREGRDLTIVATSIMVQKALDAAATLEAEGIDVEVVDLR
TIRPMDKQTVIDSVKKTSRLMCVYEAVKTLGIGAEVSAMIAESEAFDYLDAPIVRLGGAETPIPYNPELEKATVPQVPDI
ISAARDLVKGVR

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156564403, Length=333, Percent_Identity=45.3453453453453, Blast_Score=301, Evalue=4e-82,
Organism=Homo sapiens, GI291084858, Length=329, Percent_Identity=43.4650455927052, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI4557353, Length=327, Percent_Identity=37.0030581039755, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI34101272, Length=327, Percent_Identity=37.0030581039755, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17538422, Length=326, Percent_Identity=44.478527607362, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17506935, Length=322, Percent_Identity=40.6832298136646, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6319698, Length=331, Percent_Identity=43.5045317220544, Blast_Score=291, Evalue=1e-79,
Organism=Drosophila melanogaster, GI21358145, Length=329, Percent_Identity=43.4650455927052, Blast_Score=295, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24650940, Length=329, Percent_Identity=43.4650455927052, Blast_Score=295, Evalue=3e-80,
Organism=Drosophila melanogaster, GI160714828, Length=329, Percent_Identity=39.8176291793313, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI160714832, Length=329, Percent_Identity=39.8176291793313, Blast_Score=240, Evalue=7e-64,
Organism=Drosophila melanogaster, GI24650943, Length=92, Percent_Identity=41.304347826087, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24650945, Length=92, Percent_Identity=41.304347826087, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000089
- InterPro:   IPR011053
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35641; Mature: 35641

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDATVRELSYAQAIQEAMAIAMDMDERVFLMGEDIGVYGGAFQVTGDLVERYGTERVIDT
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEHHHHHHHCCCCCCCCC
PISELGGAGVAVGAALTGMRPIFEFQFSDFATLAMEQIVNQAAKMRFMLGGEVSVPVVMR
CHHHHCCCCHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEE
FPAGSGTGAAAQHSQSLEAWLGHVPGLKVIQPATPYDAKGMLLAAVADPDPVMIFEHKLL
ECCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEEEECCCCCEEEEHHHHH
YKMKGPVPEGYYTVPIGKADIRREGRDLTIVATSIMVQKALDAAATLEAEGIDVEVVDLR
HHCCCCCCCCEEEEECCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHEECCCCEEEEEEEE
TIRPMDKQTVIDSVKKTSRLMCVYEAVKTLGIGAEVSAMIAESEAFDYLDAPIVRLGGAE
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCC
TPIPYNPELEKATVPQVPDIISAARDLVKGVR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDATVRELSYAQAIQEAMAIAMDMDERVFLMGEDIGVYGGAFQVTGDLVERYGTERVIDT
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEHHHHHHHCCCCCCCCC
PISELGGAGVAVGAALTGMRPIFEFQFSDFATLAMEQIVNQAAKMRFMLGGEVSVPVVMR
CHHHHCCCCHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEE
FPAGSGTGAAAQHSQSLEAWLGHVPGLKVIQPATPYDAKGMLLAAVADPDPVMIFEHKLL
ECCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEEEECCCCCEEEEHHHHH
YKMKGPVPEGYYTVPIGKADIRREGRDLTIVATSIMVQKALDAAATLEAEGIDVEVVDLR
HHCCCCCCCCEEEEECCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHEECCCCEEEEEEEE
TIRPMDKQTVIDSVKKTSRLMCVYEAVKTLGIGAEVSAMIAESEAFDYLDAPIVRLGGAE
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCC
TPIPYNPELEKATVPQVPDIISAARDLVKGVR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]