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The map label for this gene is acoA [H]

Identifier: 13473131

GI number: 13473131

Start: 2926822

End: 2927850

Strand: Reverse

Name: acoA [H]

Synonym: mll3629

Alternate gene names: 13473131

Gene position: 2927850-2926822 (Counterclockwise)

Preceding gene: 13473132

Following gene: 13473130

Centisome position: 41.61

GC content: 62.78

Gene sequence:

>1029_bases
ATGGCTGGTGCCAGCAAAGCCGTCGCGGACAGTCGCGCCAACCTGCCTTTCGTCTATCGCCAGTACAGCGCCGAGCAGCT
CAGAGAGGTGCTCTACAAGATGTATCTTATCCGCCGCTTCGAGGAGGGCGCGGAGGAAAGCTACATGCGCGGCCTGATCC
ACGGCACCATGCATCTGTCGATCGGCCAGGAAGCCAGCGCCATGGGTATCTGCATGCCGCTTGGCGAGGATGACCAGATC
ACCTCGACCCATCGCGGCCATGGCCATTGCATCGCCAAGGGCGCCGAGGTCAAGCGCATGTTCGCCGAGTTCTTCGGCAA
GACCACGGGCTACTGCAAGGGCCGCGGCGGCTCGATGCACATTGCCGATGTCGCCAAGGGCAATCTCGGCGCCAACGGCA
TTGTCGGCGGCGGTATTCCGATCGCCGTCGGGGCGGCGCTCTCGTCCAAGATGATGAAGACCGGCAAGGTGGTCGTCTCC
TTCTTCGGCGACGGCGCCAACAATGAAGGCGCCTTCCACGAGGCGCTCAACATGGCGGCGGTCTGGAAGCTGCCGGTCAT
CTTCGTCTGCGAGAACAATGGCTATGGCATGTCGACCTCGACCGCCCGTTCGACCGCGGTGAAGAACATCGCCGACCGCG
CCGCCGCCTATTCGATGCCCGGCGTCATCGTCAACGGCAATATTTTTTCGGAAGTCGCCGAGGCGTCCTACAGGGCCGTC
GAGCGCGCCCGCGCCGGTGAAGGGCCGACGCTGATCGAATCCAAGACCTATCGCCATCGCGGCCATTCCAAGAGCGACCG
CAATCGCTATCGCACCAAGGAAGAGATCGAGGACTGGATGTCGAACCGCGACCCGATCACGCTGTTCGAGAACGAGCTGC
GCGAATTCGGCTTCATCGACGACAAGGGCATCGAGGCCATTCGCAGTGCGGTGTCGCAGGAGATCGCCGACGGCATCGAG
TTCGCCAAGGCGAGCCCGTCGCCTGACGTCAGCGAGACCGGAAATTACGTGTATACGGAGCAGGCGTGA

Upstream 100 bases:

>100_bases
TCATCACCTATGCCAATGCGGTGCCTGCCCCTGGCTCCAAGATCGCCGAACTGCGCGCCCGCCAGGACAAGCTCGTCTAC
GGAACCGTGGGAGCCTGATC

Downstream 100 bases:

>100_bases
TGGACGCGACGGTGCGTGAACTGAGCTACGCCCAGGCGATCCAGGAAGCCATGGCGATCGCCATGGACATGGACGAGCGC
GTCTTCCTGATGGGCGAGGA

Product: acetoin dehydrogenase (TPP-dependent) alpha chain

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-alpha; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit alpha [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MAGASKAVADSRANLPFVYRQYSAEQLREVLYKMYLIRRFEEGAEESYMRGLIHGTMHLSIGQEASAMGICMPLGEDDQI
TSTHRGHGHCIAKGAEVKRMFAEFFGKTTGYCKGRGGSMHIADVAKGNLGANGIVGGGIPIAVGAALSSKMMKTGKVVVS
FFGDGANNEGAFHEALNMAAVWKLPVIFVCENNGYGMSTSTARSTAVKNIADRAAAYSMPGVIVNGNIFSEVAEASYRAV
ERARAGEGPTLIESKTYRHRGHSKSDRNRYRTKEEIEDWMSNRDPITLFENELREFGFIDDKGIEAIRSAVSQEIADGIE
FAKASPSPDVSETGNYVYTEQA

Sequences:

>Translated_342_residues
MAGASKAVADSRANLPFVYRQYSAEQLREVLYKMYLIRRFEEGAEESYMRGLIHGTMHLSIGQEASAMGICMPLGEDDQI
TSTHRGHGHCIAKGAEVKRMFAEFFGKTTGYCKGRGGSMHIADVAKGNLGANGIVGGGIPIAVGAALSSKMMKTGKVVVS
FFGDGANNEGAFHEALNMAAVWKLPVIFVCENNGYGMSTSTARSTAVKNIADRAAAYSMPGVIVNGNIFSEVAEASYRAV
ERARAGEGPTLIESKTYRHRGHSKSDRNRYRTKEEIEDWMSNRDPITLFENELREFGFIDDKGIEAIRSAVSQEIADGIE
FAKASPSPDVSETGNYVYTEQA
>Mature_341_residues
AGASKAVADSRANLPFVYRQYSAEQLREVLYKMYLIRRFEEGAEESYMRGLIHGTMHLSIGQEASAMGICMPLGEDDQIT
STHRGHGHCIAKGAEVKRMFAEFFGKTTGYCKGRGGSMHIADVAKGNLGANGIVGGGIPIAVGAALSSKMMKTGKVVVSF
FGDGANNEGAFHEALNMAAVWKLPVIFVCENNGYGMSTSTARSTAVKNIADRAAAYSMPGVIVNGNIFSEVAEASYRAVE
RARAGEGPTLIESKTYRHRGHSKSDRNRYRTKEEIEDWMSNRDPITLFENELREFGFIDDKGIEAIRSAVSQEIADGIEF
AKASPSPDVSETGNYVYTEQA

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde. The alpha subunit is probably the catalytic subunit of the enzyme [H]

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=313, Percent_Identity=38.9776357827476, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI4505685, Length=307, Percent_Identity=39.7394136807818, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI291084742, Length=307, Percent_Identity=39.7394136807818, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI291084744, Length=314, Percent_Identity=38.8535031847134, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI291084757, Length=307, Percent_Identity=36.1563517915309, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI11386135, Length=312, Percent_Identity=30.7692307692308, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI258645172, Length=312, Percent_Identity=30.7692307692308, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17536047, Length=292, Percent_Identity=39.7260273972603, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI32564172, Length=292, Percent_Identity=39.7260273972603, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI86563357, Length=267, Percent_Identity=31.8352059925094, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI86563355, Length=267, Percent_Identity=31.8352059925094, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6321026, Length=315, Percent_Identity=36.8253968253968, Blast_Score=209, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24639740, Length=325, Percent_Identity=37.8461538461538, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24639744, Length=325, Percent_Identity=37.8461538461538, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI28571106, Length=325, Percent_Identity=37.8461538461538, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24639746, Length=307, Percent_Identity=39.413680781759, Blast_Score=204, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24639748, Length=328, Percent_Identity=34.4512195121951, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21355903, Length=300, Percent_Identity=29.6666666666667, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: 1.2.4.1

Molecular weight: Translated: 37156; Mature: 37025

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGASKAVADSRANLPFVYRQYSAEQLREVLYKMYLIRRFEEGAEESYMRGLIHGTMHLS
CCCCCHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
IGQEASAMGICMPLGEDDQITSTHRGHGHCIAKGAEVKRMFAEFFGKTTGYCKGRGGSMH
CCCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCEEECCCCCEE
IADVAKGNLGANGIVGGGIPIAVGAALSSKMMKTGKVVVSFFGDGANNEGAFHEALNMAA
EEECCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHH
VWKLPVIFVCENNGYGMSTSTARSTAVKNIADRAAAYSMPGVIVNGNIFSEVAEASYRAV
EECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHH
ERARAGEGPTLIESKTYRHRGHSKSDRNRYRTKEEIEDWMSNRDPITLFENELREFGFID
HHHHCCCCCCEECCCHHHHCCCCCCHHHHHCCHHHHHHHHCCCCCEEHHHHHHHHCCCCC
DKGIEAIRSAVSQEIADGIEFAKASPSPDVSETGNYVYTEQA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEECCC
>Mature Secondary Structure 
AGASKAVADSRANLPFVYRQYSAEQLREVLYKMYLIRRFEEGAEESYMRGLIHGTMHLS
CCCCHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
IGQEASAMGICMPLGEDDQITSTHRGHGHCIAKGAEVKRMFAEFFGKTTGYCKGRGGSMH
CCCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCEEECCCCCEE
IADVAKGNLGANGIVGGGIPIAVGAALSSKMMKTGKVVVSFFGDGANNEGAFHEALNMAA
EEECCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHH
VWKLPVIFVCENNGYGMSTSTARSTAVKNIADRAAAYSMPGVIVNGNIFSEVAEASYRAV
EECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHH
ERARAGEGPTLIESKTYRHRGHSKSDRNRYRTKEEIEDWMSNRDPITLFENELREFGFID
HHHHCCCCCCEECCCHHHHCCCCCCHHHHHCCHHHHHHHHCCCCCEEHHHHHHHHCCCCC
DKGIEAIRSAVSQEIADGIEFAKASPSPDVSETGNYVYTEQA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969503; 10368162; 9384377 [H]