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The map label for this gene is fhs

Identifier: 13472459

GI number: 13472459

Start: 2218002

End: 2219681

Strand: Direct

Name: fhs

Synonym: mlr2763

Alternate gene names: 13472459

Gene position: 2218002-2219681 (Clockwise)

Preceding gene: 13472458

Following gene: 13472461

Centisome position: 31.52

GC content: 63.69

Gene sequence:

>1680_bases
ATGGCCGAAGTGAAGTCCGACATCGAGATCGCGCGCGCCGCCAAGAAAAAGCAGATCCAGGAGATCGGCCAGAAGATCGG
CATCCCGACCGAACATCTGCTGCCCTATGGCCACGACAAGGCCAAGATCTCGGCCGAATTCATCAAATCGGTGAAGGGCA
ACAAGGACGGCAAGCTGATCCTGGTCACCGCCATCAACCCGACGCCTGCCGGCGAAGGCAAGACCACCACCACGGTCGGC
CTCGGCGATGGCCTCAACCGCATCGGCAAGAAGGCGATCGTCTGCATCCGCGAAGCTTCGCTCGGCCCGAATTTCGGCGT
CAAGGGCGGTGCCGCCGGCGGCGGCTATGCACAAGTGGTGCCGATGGAGGACATGAACCTCCATTTCACCGGCGATTTTC
ACGCCATCACCACGGCGCACAACCTTCTGTCGGCGCTGATCGACAACCACATCTACTGGGGCAATGAGCTCGGCATCGAC
ACACGCCGCGTGGTGTGGCGCCGCGTCATGGACATGAACGATCGGGCACTGCGCGAAATGATCTGTTCGCTCGGCGGCGT
CGCCAACGGCTTTCCGCGCGAGGGCGGCTTCGACATCACCGTCGCCTCGGAAGTCATGGCCATCCTGTGCCTGTCCACCG
ACCTCAAGGACCTGGAAAAGCGCCTCGGCGACATCATCGTTGCCTACCGTCGCGACAAGTCGCCGGTCTATGCCCGCGAC
CTCAAGGCCGACGGCGCCATGGCCGTGCTTCTGAAGGACGCCATGCAGCCCAATTTGGTGCAGACGCTGGAGAACAACCC
GGCCTTCGTCCATGGCGGCCCGTTCGCCAACATCGCGCATGGCTGCAACTCGGTCGTCGCCACCACCACGGCGCTGAAGC
TCGCCGACTATGTCGTCACCGAAGCCGGTTTCGGCGCCGACCTTGGTGCCGAGAAATTCTTTGACATCAAGTGCCGCAAG
GCGGGCCTCAAGCCGGCGGCCGCCGTCATCGTCGCCACCGTGCGCGCCATGAAGATGAATGGCGGCGTCAAGAAGGAAGA
CCTCGGCAAGGAAAACATCGAGGCGGTGAAGAAGGGCTGCGCCAATCTCGGCCGCCACATCGAGAACATCAGGCAGTTCG
GCGTGCCGGCGGTGGTTGCCATCAACCACTTCTATTCCGACACCGACGCCGAAATCCAGGCGATGAAGGACTATGTCGCC
TCGATGGGCGAAGAGGCTGTCCTGTGCAAGCACTGGGCCAAGGGCTCGGCCGGCATCGAGGAACTCGCCAACAAGGTGGT
GGCGCTGGCCGAATCCGGCGCCTCGCAGTTCGCGCCGCTCTATCCCGACGCCATGCCGCTGTTCGAGAAGATCAACACCA
TTGTCCAGCGCATCTATCGCGGCTCGGAAGCGATCGCCGACAAGTCGGTGCGCGACCAGTTGCACGCCTGGGAGCAGGCC
GGCTACGGCAACCTGCCGGTCTGCATGGCCAAGACGCAGTACTCGTTCTCGACCGACCCGAACCTGCGCGGCGCGCCGAC
CGGCCACACCGTGCCGGTGCGCGAGGTCAGGCTTTCGGCGGGCGCCGGCTTCGTCGTCATCATCTGCGGCGAGGTCATGA
CCATGCCCGGCCTGCCCAAGGCGCCGTCCTCGGAAAAGATCTTCCTCAACGAGGCCGGCCAGATCGAAGGCCTGTTCTAG

Upstream 100 bases:

>100_bases
CAGCGACAGGGTTAGAACATGCCCGCGCGCCCGGTTCCAACCTGCTTGCTCTAGAAATCAACCCCGTCCCCTCCACCGTT
CAATCCAGAGGAAAGCCGTC

Downstream 100 bases:

>100_bases
AATCTTCAAATTCCAAACGGCAAAGGGCGCCGCAGCGATGCAGCGCCCTTTCTGTTTGCGGATATTCCTACGCCGCGTTG
CGCGCCAGCGCCCGCTGGTT

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 559; Mature: 558

Protein sequence:

>559_residues
MAEVKSDIEIARAAKKKQIQEIGQKIGIPTEHLLPYGHDKAKISAEFIKSVKGNKDGKLILVTAINPTPAGEGKTTTTVG
LGDGLNRIGKKAIVCIREASLGPNFGVKGGAAGGGYAQVVPMEDMNLHFTGDFHAITTAHNLLSALIDNHIYWGNELGID
TRRVVWRRVMDMNDRALREMICSLGGVANGFPREGGFDITVASEVMAILCLSTDLKDLEKRLGDIIVAYRRDKSPVYARD
LKADGAMAVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVVATTTALKLADYVVTEAGFGADLGAEKFFDIKCRK
AGLKPAAAVIVATVRAMKMNGGVKKEDLGKENIEAVKKGCANLGRHIENIRQFGVPAVVAINHFYSDTDAEIQAMKDYVA
SMGEEAVLCKHWAKGSAGIEELANKVVALAESGASQFAPLYPDAMPLFEKINTIVQRIYRGSEAIADKSVRDQLHAWEQA
GYGNLPVCMAKTQYSFSTDPNLRGAPTGHTVPVREVRLSAGAGFVVIICGEVMTMPGLPKAPSSEKIFLNEAGQIEGLF

Sequences:

>Translated_559_residues
MAEVKSDIEIARAAKKKQIQEIGQKIGIPTEHLLPYGHDKAKISAEFIKSVKGNKDGKLILVTAINPTPAGEGKTTTTVG
LGDGLNRIGKKAIVCIREASLGPNFGVKGGAAGGGYAQVVPMEDMNLHFTGDFHAITTAHNLLSALIDNHIYWGNELGID
TRRVVWRRVMDMNDRALREMICSLGGVANGFPREGGFDITVASEVMAILCLSTDLKDLEKRLGDIIVAYRRDKSPVYARD
LKADGAMAVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVVATTTALKLADYVVTEAGFGADLGAEKFFDIKCRK
AGLKPAAAVIVATVRAMKMNGGVKKEDLGKENIEAVKKGCANLGRHIENIRQFGVPAVVAINHFYSDTDAEIQAMKDYVA
SMGEEAVLCKHWAKGSAGIEELANKVVALAESGASQFAPLYPDAMPLFEKINTIVQRIYRGSEAIADKSVRDQLHAWEQA
GYGNLPVCMAKTQYSFSTDPNLRGAPTGHTVPVREVRLSAGAGFVVIICGEVMTMPGLPKAPSSEKIFLNEAGQIEGLF
>Mature_558_residues
AEVKSDIEIARAAKKKQIQEIGQKIGIPTEHLLPYGHDKAKISAEFIKSVKGNKDGKLILVTAINPTPAGEGKTTTTVGL
GDGLNRIGKKAIVCIREASLGPNFGVKGGAAGGGYAQVVPMEDMNLHFTGDFHAITTAHNLLSALIDNHIYWGNELGIDT
RRVVWRRVMDMNDRALREMICSLGGVANGFPREGGFDITVASEVMAILCLSTDLKDLEKRLGDIIVAYRRDKSPVYARDL
KADGAMAVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVVATTTALKLADYVVTEAGFGADLGAEKFFDIKCRKA
GLKPAAAVIVATVRAMKMNGGVKKEDLGKENIEAVKKGCANLGRHIENIRQFGVPAVVAINHFYSDTDAEIQAMKDYVAS
MGEEAVLCKHWAKGSAGIEELANKVVALAESGASQFAPLYPDAMPLFEKINTIVQRIYRGSEAIADKSVRDQLHAWEQAG
YGNLPVCMAKTQYSFSTDPNLRGAPTGHTVPVREVRLSAGAGFVVIICGEVMTMPGLPKAPSSEKIFLNEAGQIEGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=621, Percent_Identity=42.6731078904992, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI36796743, Length=625, Percent_Identity=43.2, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=37.2093023255814, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17568737, Length=628, Percent_Identity=42.515923566879, Blast_Score=454, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17568739, Length=628, Percent_Identity=42.515923566879, Blast_Score=454, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=43.4504792332268, Blast_Score=461, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6319558, Length=635, Percent_Identity=40.6299212598425, Blast_Score=448, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24645718, Length=621, Percent_Identity=43.4782608695652, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI17137370, Length=621, Percent_Identity=43.4782608695652, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI62472483, Length=621, Percent_Identity=43.4782608695652, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45551871, Length=621, Percent_Identity=43.4782608695652, Blast_Score=469, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_RHILO (Q98HQ4)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_104026.1
- ProteinModelPortal:   Q98HQ4
- SMR:   Q98HQ4
- GeneID:   1226687
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr2763
- NMPDR:   fig|266835.1.peg.2130
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- ProtClustDB:   PRK13505
- BRENDA:   6.3.4.3
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59972; Mature: 59841

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVKSDIEIARAAKKKQIQEIGQKIGIPTEHLLPYGHDKAKISAEFIKSVKGNKDGKLI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEE
LVTAINPTPAGEGKTTTTVGLGDGLNRIGKKAIVCIREASLGPNFGVKGGAAGGGYAQVV
EEEEECCCCCCCCCCEEEEECCCCHHHHCHHHEEEEEECCCCCCCCCCCCCCCCCCEEEE
PMEDMNLHFTGDFHAITTAHNLLSALIDNHIYWGNELGIDTRRVVWRRVMDMNDRALREM
ECCCCEEEEECCCHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCCHHHHHHH
ICSLGGVANGFPREGGFDITVASEVMAILCLSTDLKDLEKRLGDIIVAYRRDKSPVYARD
HHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHEEEEEECCCCCCCHHH
LKADGAMAVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVVATTTALKLADYVVT
CCCCCHHHHHHHHHCCCHHHHHHCCCCCEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHH
EAGFGADLGAEKFFDIKCRKAGLKPAAAVIVATVRAMKMNGGVKKEDLGKENIEAVKKGC
CCCCCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHH
ANLGRHIENIRQFGVPAVVAINHFYSDTDAEIQAMKDYVASMGEEAVLCKHWAKGSAGIE
HHHHHHHHHHHHHCCCEEEEEHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHH
ELANKVVALAESGASQFAPLYPDAMPLFEKINTIVQRIYRGSEAIADKSVRDQLHAWEQA
HHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
GYGNLPVCMAKTQYSFSTDPNLRGAPTGHTVPVREVRLSAGAGFVVIICGEVMTMPGLPK
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHEECCCCCEEEEEECHHHCCCCCCC
APSSEKIFLNEAGQIEGLF
CCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
AEVKSDIEIARAAKKKQIQEIGQKIGIPTEHLLPYGHDKAKISAEFIKSVKGNKDGKLI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEE
LVTAINPTPAGEGKTTTTVGLGDGLNRIGKKAIVCIREASLGPNFGVKGGAAGGGYAQVV
EEEEECCCCCCCCCCEEEEECCCCHHHHCHHHEEEEEECCCCCCCCCCCCCCCCCCEEEE
PMEDMNLHFTGDFHAITTAHNLLSALIDNHIYWGNELGIDTRRVVWRRVMDMNDRALREM
ECCCCEEEEECCCHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCCHHHHHHH
ICSLGGVANGFPREGGFDITVASEVMAILCLSTDLKDLEKRLGDIIVAYRRDKSPVYARD
HHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHEEEEEECCCCCCCHHH
LKADGAMAVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVVATTTALKLADYVVT
CCCCCHHHHHHHHHCCCHHHHHHCCCCCEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHH
EAGFGADLGAEKFFDIKCRKAGLKPAAAVIVATVRAMKMNGGVKKEDLGKENIEAVKKGC
CCCCCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHH
ANLGRHIENIRQFGVPAVVAINHFYSDTDAEIQAMKDYVASMGEEAVLCKHWAKGSAGIE
HHHHHHHHHHHHHCCCEEEEEHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHH
ELANKVVALAESGASQFAPLYPDAMPLFEKINTIVQRIYRGSEAIADKSVRDQLHAWEQA
HHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
GYGNLPVCMAKTQYSFSTDPNLRGAPTGHTVPVREVRLSAGAGFVVIICGEVMTMPGLPK
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHEECCCCCEEEEEECHHHCCCCCCC
APSSEKIFLNEAGQIEGLF
CCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968