Click here to switch to the map view.

The map label for this gene is ilvG [H]

Identifier: 13471596

GI number: 13471596

Start: 1343641

End: 1345290

Strand: Direct

Name: ilvG [H]

Synonym: mlr1615

Alternate gene names: 13471596

Gene position: 1343641-1345290 (Clockwise)

Preceding gene: 13471595

Following gene: 13471599

Centisome position: 19.1

GC content: 66.18

Gene sequence:

>1650_bases
ATGAAGACCGGTGGACAACTGATCGTCGATGCGCTGGAAGCGAACGGCACCGACCGCATCTTCTGCGTGCCGGGCGAATC
CTATCTGGCGGTGCTCGACGCGCTGCACGATTCATCGATCCGCACCATCGTCTGCCGCCAGGAGGGGGGTGCCGCGATGA
TGGCCGACTGCCAGGGGCGGCTGACCGGCAAGCCCGGCATCTGCTTCGTCACCCGCGGCCCCGGCGCCACCAACGCATCC
GCCGGCATCCACATCGCCATGCAGGATTCGGTGCCGCTCATCCTGTTCATCGGCCAGGTCGCCAGCCACGCCAAGGAGCG
CGAGGCGTTCCAGGAGGTGGATTACAAGAGGTTCTTCGGCGACATCGCCAAATGGGTGGTCGAGATCGACGACGCCTCGC
GCATCCCCGAATTCGTCACCCGCGCCTTCGCGGTGGCAACGTCGGGCCGGCCTGGTCCAGTCGTCATCTCGCTGCCCGAA
GACATGCTGACCAGCGAGGTCGAGGCTCCGGAAGCGCTTCCCCATACTCCGGTCGAGACCTATCCCGGCGGGGCCGAACT
CGATGCGCTGGAAATGCTGCTCAACGGCGCCAAGCGACCATTCGTCATCCTGGGCGGCACACGCTGGAATGAGGAAGCCG
TCGCGCGCATGCGCACCATATCGGAGACATGGTCGCTTCCCGTCGGCTGCTCTTTCCGCCGCCAGATGCTGTTCGACCAT
CTTCACGCGAACTACGCAGGCGACGTCGGAATCGGCATCAACCCCAAGCTGGCGGCGCAGGTCAAGGCGGCCGACGTCGT
GCTGTTGATCGGCGGGCGCATGGGCGAGATGCCCTCTTCCGACTACACGCTGCTGAAAAGCCCCTACCCCGACCAGACGC
TGGTGCATGTCCACGCCGACGCCGGCGAACTCGGCCGCGTCTACCGGCCGACGCTGGCGATCAACGCCTCGCCCGCCGCC
TTCGTCGAGGCCTTTGCCAAGCGCAAGCCGGCCCGAACGCCATCCTGGGCAGGCGAGACGGCGAAAGCGCACAGCGCCTA
TCTCGAATGGTCGACGCCACCGCAGACGGGTCCGGGCGACGTGCAGATGGGCCCGATCATGACATATCTGGAACAGGAAC
TGCCCCACGACGCCATCTTCGCCAACGGCGCCGGCAATTACGCCACCTGGGTGCATCGTTTCCACCGCTTCCGCCGTTTC
GGCACGCAGGCGGCGCCGACCTCCGGCTCGATGGGCTACGGCACCCCGGCGGCGGTCGCCGCCAAGGCGCTTCATCCGGA
TCGCACCGTGATCGCCTTTGCCGGCGACGGCTGCTTCCTGATGAATGGCCAGGAGTTCGCCACCGCCGTGCAATATGACC
TGCCGATCATCGTGATCGTCGTCAACAACGGCATTTACGGCACCATCCGCATGCACCAGGAACGCGAATATCCCGGCCGC
GTCGTCGCCACCGATCTCAGGAATCCCGATTTCGCGTCGCTGGCACGCGCCTATGGCGGCCATGGCGAGACGGTCGAGAA
GACGGCCGACTTCGCGCCGGCCTTCGAGCGAGCGCGGGCCAGCGGCAAGCCGGCCATCGTCGAAATCAGGCTCGATCCCG
AAGCGATCACGCCGACCCGCACGATGACCCAGATCCGCGACAAGGCGTGA

Upstream 100 bases:

>100_bases
CGATGGTGATGTCGGGCACGCCGCTGGTCTACGAGCGCCCCTCGCCGCGCCTGGGCGAACACACCGACGAAATCCTTGCC
GAACTGGAGAGATCAGCGAC

Downstream 100 bases:

>100_bases
TCCAAACAAAAGGGGCGGCAGCCCGCCCCTTTTGTCCAAGCGGTTCCGCTATTTCGCCGCCTCGATCTGGCCGCGGATCT
CGCCATCCTTGTTGGCGGCG

Product: thiamine pyrophosphate protein

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MKTGGQLIVDALEANGTDRIFCVPGESYLAVLDALHDSSIRTIVCRQEGGAAMMADCQGRLTGKPGICFVTRGPGATNAS
AGIHIAMQDSVPLILFIGQVASHAKEREAFQEVDYKRFFGDIAKWVVEIDDASRIPEFVTRAFAVATSGRPGPVVISLPE
DMLTSEVEAPEALPHTPVETYPGGAELDALEMLLNGAKRPFVILGGTRWNEEAVARMRTISETWSLPVGCSFRRQMLFDH
LHANYAGDVGIGINPKLAAQVKAADVVLLIGGRMGEMPSSDYTLLKSPYPDQTLVHVHADAGELGRVYRPTLAINASPAA
FVEAFAKRKPARTPSWAGETAKAHSAYLEWSTPPQTGPGDVQMGPIMTYLEQELPHDAIFANGAGNYATWVHRFHRFRRF
GTQAAPTSGSMGYGTPAAVAAKALHPDRTVIAFAGDGCFLMNGQEFATAVQYDLPIIVIVVNNGIYGTIRMHQEREYPGR
VVATDLRNPDFASLARAYGGHGETVEKTADFAPAFERARASGKPAIVEIRLDPEAITPTRTMTQIRDKA

Sequences:

>Translated_549_residues
MKTGGQLIVDALEANGTDRIFCVPGESYLAVLDALHDSSIRTIVCRQEGGAAMMADCQGRLTGKPGICFVTRGPGATNAS
AGIHIAMQDSVPLILFIGQVASHAKEREAFQEVDYKRFFGDIAKWVVEIDDASRIPEFVTRAFAVATSGRPGPVVISLPE
DMLTSEVEAPEALPHTPVETYPGGAELDALEMLLNGAKRPFVILGGTRWNEEAVARMRTISETWSLPVGCSFRRQMLFDH
LHANYAGDVGIGINPKLAAQVKAADVVLLIGGRMGEMPSSDYTLLKSPYPDQTLVHVHADAGELGRVYRPTLAINASPAA
FVEAFAKRKPARTPSWAGETAKAHSAYLEWSTPPQTGPGDVQMGPIMTYLEQELPHDAIFANGAGNYATWVHRFHRFRRF
GTQAAPTSGSMGYGTPAAVAAKALHPDRTVIAFAGDGCFLMNGQEFATAVQYDLPIIVIVVNNGIYGTIRMHQEREYPGR
VVATDLRNPDFASLARAYGGHGETVEKTADFAPAFERARASGKPAIVEIRLDPEAITPTRTMTQIRDKA
>Mature_549_residues
MKTGGQLIVDALEANGTDRIFCVPGESYLAVLDALHDSSIRTIVCRQEGGAAMMADCQGRLTGKPGICFVTRGPGATNAS
AGIHIAMQDSVPLILFIGQVASHAKEREAFQEVDYKRFFGDIAKWVVEIDDASRIPEFVTRAFAVATSGRPGPVVISLPE
DMLTSEVEAPEALPHTPVETYPGGAELDALEMLLNGAKRPFVILGGTRWNEEAVARMRTISETWSLPVGCSFRRQMLFDH
LHANYAGDVGIGINPKLAAQVKAADVVLLIGGRMGEMPSSDYTLLKSPYPDQTLVHVHADAGELGRVYRPTLAINASPAA
FVEAFAKRKPARTPSWAGETAKAHSAYLEWSTPPQTGPGDVQMGPIMTYLEQELPHDAIFANGAGNYATWVHRFHRFRRF
GTQAAPTSGSMGYGTPAAVAAKALHPDRTVIAFAGDGCFLMNGQEFATAVQYDLPIIVIVVNNGIYGTIRMHQEREYPGR
VVATDLRNPDFASLARAYGGHGETVEKTADFAPAFERARASGKPAIVEIRLDPEAITPTRTMTQIRDKA

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=571, Percent_Identity=25.0437828371278, Blast_Score=136, Evalue=7e-32,
Organism=Homo sapiens, GI21361361, Length=580, Percent_Identity=24.4827586206897, Blast_Score=120, Evalue=5e-27,
Organism=Escherichia coli, GI87081685, Length=557, Percent_Identity=29.2639138240575, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1790104, Length=543, Percent_Identity=30.3867403314917, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1786717, Length=554, Percent_Identity=27.9783393501805, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI1787096, Length=571, Percent_Identity=25.3940455341506, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1788716, Length=575, Percent_Identity=25.5652173913043, Blast_Score=109, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17531301, Length=549, Percent_Identity=26.0473588342441, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17531299, Length=549, Percent_Identity=26.0473588342441, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17542570, Length=160, Percent_Identity=32.5, Blast_Score=83, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323755, Length=558, Percent_Identity=26.5232974910394, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6323163, Length=490, Percent_Identity=23.0612244897959, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323073, Length=491, Percent_Identity=22.1995926680244, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320816, Length=284, Percent_Identity=22.887323943662, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19922626, Length=505, Percent_Identity=27.5247524752475, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 59303; Mature: 59303

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTGGQLIVDALEANGTDRIFCVPGESYLAVLDALHDSSIRTIVCRQEGGAAMMADCQGR
CCCCCEEEEEEECCCCCCEEEEECCCHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCE
LTGKPGICFVTRGPGATNASAGIHIAMQDSVPLILFIGQVASHAKEREAFQEVDYKRFFG
ECCCCCEEEEECCCCCCCCCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
DIAKWVVEIDDASRIPEFVTRAFAVATSGRPGPVVISLPEDMLTSEVEAPEALPHTPVET
HHHHHEEEECCHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHCCCCCCCCCCCCCC
YPGGAELDALEMLLNGAKRPFVILGGTRWNEEAVARMRTISETWSLPVGCSFRRQMLFDH
CCCCCCHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LHANYAGDVGIGINPKLAAQVKAADVVLLIGGRMGEMPSSDYTLLKSPYPDQTLVHVHAD
HHCCCCCCCCCCCCCCHHEEEEECEEEEEECCCCCCCCCCCCEEEECCCCCCEEEEEECC
AGELGRVYRPTLAINASPAAFVEAFAKRKPARTPSWAGETAKAHSAYLEWSTPPQTGPGD
CCCCCCEECCEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
VQMGPIMTYLEQELPHDAIFANGAGNYATWVHRFHRFRRFGTQAAPTSGSMGYGTPAAVA
EEHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
AKALHPDRTVIAFAGDGCFLMNGQEFATAVQYDLPIIVIVVNNGIYGTIRMHQEREYPGR
HHHCCCCCEEEEEECCCEEEECCHHHHHEEEECCCEEEEEECCCEEEEEEEECCCCCCCC
VVATDLRNPDFASLARAYGGHGETVEKTADFAPAFERARASGKPAIVEIRLDPEAITPTR
EEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCH
TMTQIRDKA
HHHHHHCCC
>Mature Secondary Structure
MKTGGQLIVDALEANGTDRIFCVPGESYLAVLDALHDSSIRTIVCRQEGGAAMMADCQGR
CCCCCEEEEEEECCCCCCEEEEECCCHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCE
LTGKPGICFVTRGPGATNASAGIHIAMQDSVPLILFIGQVASHAKEREAFQEVDYKRFFG
ECCCCCEEEEECCCCCCCCCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
DIAKWVVEIDDASRIPEFVTRAFAVATSGRPGPVVISLPEDMLTSEVEAPEALPHTPVET
HHHHHEEEECCHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHCCCCCCCCCCCCCC
YPGGAELDALEMLLNGAKRPFVILGGTRWNEEAVARMRTISETWSLPVGCSFRRQMLFDH
CCCCCCHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LHANYAGDVGIGINPKLAAQVKAADVVLLIGGRMGEMPSSDYTLLKSPYPDQTLVHVHAD
HHCCCCCCCCCCCCCCHHEEEEECEEEEEECCCCCCCCCCCCEEEECCCCCCEEEEEECC
AGELGRVYRPTLAINASPAAFVEAFAKRKPARTPSWAGETAKAHSAYLEWSTPPQTGPGD
CCCCCCEECCEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
VQMGPIMTYLEQELPHDAIFANGAGNYATWVHRFHRFRRFGTQAAPTSGSMGYGTPAAVA
EEHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
AKALHPDRTVIAFAGDGCFLMNGQEFATAVQYDLPIIVIVVNNGIYGTIRMHQEREYPGR
HHHCCCCCEEEEEECCCEEEECCHHHHHEEEECCCEEEEEECCCEEEEEEEECCCCCCCC
VVATDLRNPDFASLARAYGGHGETVEKTADFAPAFERARASGKPAIVEIRLDPEAITPTR
EEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCH
TMTQIRDKA
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]