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The map label for this gene is murC

Identifier: 13471548

GI number: 13471548

Start: 1292088

End: 1293488

Strand: Reverse

Name: murC

Synonym: mll1553

Alternate gene names: 13471548

Gene position: 1293488-1292088 (Counterclockwise)

Preceding gene: 13471549

Following gene: 13471547

Centisome position: 18.38

GC content: 64.88

Gene sequence:

>1401_bases
ATGAAGATGCCGCAGACCATCGGCCTTGTGCATTTCATCGGCATTGGCGGCATCGGCATGAGCGGCATCGCCGAGGTGCT
GCACAATCTCGGTTACAAGGTGCAAGGGTCCGACCAGGCCGACAGCGCCAATGTGCAGCGGCTGCGCGACAAGGGCATCG
AATGCTTCGTCGGCCACAAGGCCGAGAATCTCGGCGATGCCGAGGTGGTGGTCGTCTCGACGGCGATCAAGAAGACCAAT
CCGGAACTGAAGGCCGCGCGCGAAAAGCTGCTGCCGATCGTGCGCCGCGCCGAAATGCTGGCCGAGCTGATGCGCTTTCG
CCAGGCGGTGGCGATCGGCGGCACGCATGGCAAGACGACGACGACCTCGATGGTCGCGACCTTGCTCGAAGCCGGCGGGC
TCGATCCGACCGTCATCAATGGCGGCATCATCAATGCCTATGGCACCAATGCGCGCATGGGCGACGGCGAGTGGATGGTG
GTCGAGGCCGACGAGAGCGACGGCACCTTCCTCAAATTGCCGGCCGACATCGCCGTCGTCACCAACATCGATCCCGAACA
TCTCGACCACTATGGCAGTTTCGACAAGGTGCGCGAGGCGTTCCGCCAGTTCGTCGAGAACGTGCCGTTCTACGGCTTTG
GCGTGATGTGCACCGACCATCCTGAAGTGCAGGCGCTGGTCGGCCGCATCGAGGACCGCCGCGTCATCACCTACGGCGAG
AACGCGCAAGCCGATGTGCGCTTCACCAACCACCGCATGGCGGGCGCCACCTCCGAATTCGACGTGGTGATCCGCGACCG
CAAGACCGGCAGCCAGAGCACGATTTCAGGCCTGCGCCTGCCGATGCCCGGCCGCCACAATGTCTCCAACGCCACCGCCG
CGATCGCCGTCGCGCATGAGCTCGGCCTGTCCGGCGAGGCGATCAAGAAGGGCCTGTCGTCCTTCGCCGGCGTCAAGCGC
CGCTTCACCCATACCGGATCCTGGAACGGCGTCGATGTGTTCGACGATTACGGCCACCATCCGGTCGAGATCTCGGCGGT
GCTGAAGGCGGCGCGCAGCGCCACCAAGGGCCGCGTCATCGCCATTGCCCAACCGCACCGCTTCACCCGGCTCCACGATC
TGTTCAACGAGTTCTCCGCCTGCTTCAACGACGCCGACACGGTGATTGTCGCGCCGGTCTATGCTGCCGGCGAAGACCCG
ATCGACGGCGTCAGCTCGGACGAACTGGTGTCGCGCATCCGCGCCGGCGGTCATCGTGACGCGCGCTATATCGAGGGGCC
GACAGCGATCGCGCCGATCATTCGCGGCCTGGCCAAGCCCGGCGACTTCGTCGTCTTCCTCGGCGCCGGCAACATCACCC
AATGGGCCTATGCTCTGCCAAAGGAGCTTGCCGCCTCATGA

Upstream 100 bases:

>100_bases
AATCGGTCGGCAGGCCGGACGCGGCACGGTTGCTCGCCGATCTCACAGAGGCTATTGCGTCCCAAAAAACCGTTTCGGAT
TTCAAGAAAGGGACGCAAGC

Downstream 100 bases:

>100_bases
TGCACGGCCAGGCCCTGATCGACAGACTTGGTGACCGGCTTGCCGGCCTGCGCGGCCGTCTCACGCCAAATGCCGAGATG
GACAAGATCACCTGGTTCCG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKMPQTIGLVHFIGIGGIGMSGIAEVLHNLGYKVQGSDQADSANVQRLRDKGIECFVGHKAENLGDAEVVVVSTAIKKTN
PELKAAREKLLPIVRRAEMLAELMRFRQAVAIGGTHGKTTTTSMVATLLEAGGLDPTVINGGIINAYGTNARMGDGEWMV
VEADESDGTFLKLPADIAVVTNIDPEHLDHYGSFDKVREAFRQFVENVPFYGFGVMCTDHPEVQALVGRIEDRRVITYGE
NAQADVRFTNHRMAGATSEFDVVIRDRKTGSQSTISGLRLPMPGRHNVSNATAAIAVAHELGLSGEAIKKGLSSFAGVKR
RFTHTGSWNGVDVFDDYGHHPVEISAVLKAARSATKGRVIAIAQPHRFTRLHDLFNEFSACFNDADTVIVAPVYAAGEDP
IDGVSSDELVSRIRAGGHRDARYIEGPTAIAPIIRGLAKPGDFVVFLGAGNITQWAYALPKELAAS

Sequences:

>Translated_466_residues
MKMPQTIGLVHFIGIGGIGMSGIAEVLHNLGYKVQGSDQADSANVQRLRDKGIECFVGHKAENLGDAEVVVVSTAIKKTN
PELKAAREKLLPIVRRAEMLAELMRFRQAVAIGGTHGKTTTTSMVATLLEAGGLDPTVINGGIINAYGTNARMGDGEWMV
VEADESDGTFLKLPADIAVVTNIDPEHLDHYGSFDKVREAFRQFVENVPFYGFGVMCTDHPEVQALVGRIEDRRVITYGE
NAQADVRFTNHRMAGATSEFDVVIRDRKTGSQSTISGLRLPMPGRHNVSNATAAIAVAHELGLSGEAIKKGLSSFAGVKR
RFTHTGSWNGVDVFDDYGHHPVEISAVLKAARSATKGRVIAIAQPHRFTRLHDLFNEFSACFNDADTVIVAPVYAAGEDP
IDGVSSDELVSRIRAGGHRDARYIEGPTAIAPIIRGLAKPGDFVVFLGAGNITQWAYALPKELAAS
>Mature_466_residues
MKMPQTIGLVHFIGIGGIGMSGIAEVLHNLGYKVQGSDQADSANVQRLRDKGIECFVGHKAENLGDAEVVVVSTAIKKTN
PELKAAREKLLPIVRRAEMLAELMRFRQAVAIGGTHGKTTTTSMVATLLEAGGLDPTVINGGIINAYGTNARMGDGEWMV
VEADESDGTFLKLPADIAVVTNIDPEHLDHYGSFDKVREAFRQFVENVPFYGFGVMCTDHPEVQALVGRIEDRRVITYGE
NAQADVRFTNHRMAGATSEFDVVIRDRKTGSQSTISGLRLPMPGRHNVSNATAAIAVAHELGLSGEAIKKGLSSFAGVKR
RFTHTGSWNGVDVFDDYGHHPVEISAVLKAARSATKGRVIAIAQPHRFTRLHDLFNEFSACFNDADTVIVAPVYAAGEDP
IDGVSSDELVSRIRAGGHRDARYIEGPTAIAPIIRGLAKPGDFVVFLGAGNITQWAYALPKELAAS

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=461, Percent_Identity=44.468546637744, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI1790680, Length=460, Percent_Identity=26.304347826087, Blast_Score=161, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_RHILO (Q98KB4)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_103114.1
- ProteinModelPortal:   Q98KB4
- SMR:   Q98KB4
- GeneID:   1225777
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll1553
- NMPDR:   fig|266835.1.peg.1219
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BRENDA:   6.3.2.8
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50168; Mature: 50168

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMPQTIGLVHFIGIGGIGMSGIAEVLHNLGYKVQGSDQADSANVQRLRDKGIECFVGHK
CCCCCHHHHHHEEECCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCEEEECCC
AENLGDAEVVVVSTAIKKTNPELKAAREKLLPIVRRAEMLAELMRFRQAVAIGGTHGKTT
CCCCCCCEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
TTSMVATLLEAGGLDPTVINGGIINAYGTNARMGDGEWMVVEADESDGTFLKLPADIAVV
HHHHHHHHHHHCCCCCEEECCCEEEECCCCCEECCCCEEEEEECCCCCCEEEECCCEEEE
TNIDPEHLDHYGSFDKVREAFRQFVENVPFYGFGVMCTDHPEVQALVGRIEDRRVITYGE
ECCCHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCCCEEEEECC
NAQADVRFTNHRMAGATSEFDVVIRDRKTGSQSTISGLRLPMPGRHNVSNATAAIAVAHE
CCCEEEEEECCCCCCCCCCEEEEEECCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHH
LGLSGEAIKKGLSSFAGVKRRFTHTGSWNGVDVFDDYGHHPVEISAVLKAARSATKGRVI
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHCCCCCEE
AIAQPHRFTRLHDLFNEFSACFNDADTVIVAPVYAAGEDPIDGVSSDELVSRIRAGGHRD
EEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCC
ARYIEGPTAIAPIIRGLAKPGDFVVFLGAGNITQWAYALPKELAAS
CEEECCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCHHHHCC
>Mature Secondary Structure
MKMPQTIGLVHFIGIGGIGMSGIAEVLHNLGYKVQGSDQADSANVQRLRDKGIECFVGHK
CCCCCHHHHHHEEECCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCEEEECCC
AENLGDAEVVVVSTAIKKTNPELKAAREKLLPIVRRAEMLAELMRFRQAVAIGGTHGKTT
CCCCCCCEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
TTSMVATLLEAGGLDPTVINGGIINAYGTNARMGDGEWMVVEADESDGTFLKLPADIAVV
HHHHHHHHHHHCCCCCEEECCCEEEECCCCCEECCCCEEEEEECCCCCCEEEECCCEEEE
TNIDPEHLDHYGSFDKVREAFRQFVENVPFYGFGVMCTDHPEVQALVGRIEDRRVITYGE
ECCCHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCCCEEEEECC
NAQADVRFTNHRMAGATSEFDVVIRDRKTGSQSTISGLRLPMPGRHNVSNATAAIAVAHE
CCCEEEEEECCCCCCCCCCEEEEEECCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHH
LGLSGEAIKKGLSSFAGVKRRFTHTGSWNGVDVFDDYGHHPVEISAVLKAARSATKGRVI
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHCCCCCEE
AIAQPHRFTRLHDLFNEFSACFNDADTVIVAPVYAAGEDPIDGVSSDELVSRIRAGGHRD
EEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCC
ARYIEGPTAIAPIIRGLAKPGDFVVFLGAGNITQWAYALPKELAAS
CEEECCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968