Click here to switch to the map view.

The map label for this gene is nqo13 [H]

Identifier: 13471394

GI number: 13471394

Start: 1133214

End: 1134719

Strand: Reverse

Name: nqo13 [H]

Synonym: mll1354

Alternate gene names: 13471394

Gene position: 1134719-1133214 (Counterclockwise)

Preceding gene: 13471395

Following gene: 13471393

Centisome position: 16.13

GC content: 61.16

Gene sequence:

>1506_bases
ATGACCGCCTGGCCAATCCTCTCGCTGGTCACCTTCCTGCCGCTGGTTGGTGTGCTGCTTATCCTGTTCATCCGGGATGA
TAGCGAAAACGCGCGCCGCAACATTCGCGCCATCGCGCTGTTGACGACGACATTTACCTTCATCATCTCGGTGTTCATCT
GGACCGGCTTCGACAATTCGCAGTCCGGCTTCCAGTTCGTCGAAAAGGCCGCCTGGCTCGACTCCGGCATTTCCTACCAC
ATGGGTGTCGACGGCATTTCCATGCTGTTCGTCATCCTGACGACGTTCCTGATGCCGCTCTGTATCCTGGCCTCGTGGGA
AGCGATCGAGAAGCGCGTCAAGGCCTACATGATCGCCTTCCTGCTGCTCGAAACGCTGATGATCGGCGTGTTCTGCGCGC
TGGATATCGTGCTGTTCTACGTTTTCTTCGAAGCCGGCCTGATCCCGATGTTCATCATCATCGGTGTCTGGGGCGGCAAG
CGGCGCGTCTACGCGTCGTTCAAGTTCTTCCTTTATACGCTTGCCGGCTCGGTGCTGATGCTGCTCGCCATTATGGCGAT
GTTCTATCAGTCGGGCACGACCGACATTCCAACGCTTCTGACGCACAGCTTCCCGGCCAACATGCAGACCTGGCTATGGC
TCGCCTTCTTTGCCTCCTTCGCGGTGAAGATGCCGATGTGGCCGGTGCACACCTGGCTGCCCGACGCGCACGTCGAGGCG
CCGACGGCGGGCTCGGTGATCCTGGCCGCAATTCTGCTTAAGATGGGTGGGTACGGCTTCCTGCGCTTCTCGCTGCCGAT
GTTCCCGCTGGCGTCGGAAATGTTCGCGCCGCTGGTGTTCACGCTGTCGGTCGTCGCCATCATCTACACCTCGCTGGTGG
CGCTGATGCAGGACGACATGAAGAAGCTGATCGCCTATTCGTCCGTCGCCCATATGGGTTTCGTCACCATGGGCATCTTC
GCCATGAACCAGGAAGGCGTGCAGGGCGCCATCTTCCAGATGCTCAGCCACGGCCTCGTTTCCGGCGCGCTGTTCCTGTG
CGTCGGCGTCATCTATGACCGCATGCACACGCGTGAGATCGCCGCCTATGGCGGCCTGGTCAACAACATGCCGAAATACG
CCACCGTGTTCATGGTCTTCACCATGGCCAATGTCGGCCTGCCCGGCACCAGTGGCTTCGTCGGCGAGTTCCTGACCATG
CTCGGCGTGTTCCGGGTCAACACCTGGGTGGCGTTCTTCGCCGCCACCGGCGTCATCCTGTCGGCGGCCTACGCGCTCTG
GCTCTACCGCCGGGTGATCTTCGGCGCGCTGACCAAGGACAGCCTGAAGGGGCTGCTCGACCTGTCGCTGCGCGAGAAGG
TGATCATCTACCCGCTGGTCGCGCTGGTCATCTTCTTCGGCGTCTATCCCGCTCCCGTCTTCGATGCGACGGCCCAATCG
GTCAAGTCGCTCGTCACCAATGTCACCGCATCCATCGGCGCCGCGCAAACCGCGGCGGCGAACTGA

Upstream 100 bases:

>100_bases
TCACCAACCGCGTCGTCAAGCTGCAAACCGGCTACCTCTACCACTATGCCTTCGCCATGCTGATCGGCGTTGCCGCACTC
GTCACCTGGATGATGCTCTG

Downstream 100 bases:

>100_bases
CCAGGGGTTTTGCGAACCATGACGCCGGACCTTCTCTCCAGCCTGTCGCTCTCGACGCCCGAGCTGATCCTTGCCATCGG
CGCGCTCGCGCTGCTGATGG

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MTAWPILSLVTFLPLVGVLLILFIRDDSENARRNIRAIALLTTTFTFIISVFIWTGFDNSQSGFQFVEKAAWLDSGISYH
MGVDGISMLFVILTTFLMPLCILASWEAIEKRVKAYMIAFLLLETLMIGVFCALDIVLFYVFFEAGLIPMFIIIGVWGGK
RRVYASFKFFLYTLAGSVLMLLAIMAMFYQSGTTDIPTLLTHSFPANMQTWLWLAFFASFAVKMPMWPVHTWLPDAHVEA
PTAGSVILAAILLKMGGYGFLRFSLPMFPLASEMFAPLVFTLSVVAIIYTSLVALMQDDMKKLIAYSSVAHMGFVTMGIF
AMNQEGVQGAIFQMLSHGLVSGALFLCVGVIYDRMHTREIAAYGGLVNNMPKYATVFMVFTMANVGLPGTSGFVGEFLTM
LGVFRVNTWVAFFAATGVILSAAYALWLYRRVIFGALTKDSLKGLLDLSLREKVIIYPLVALVIFFGVYPAPVFDATAQS
VKSLVTNVTASIGAAQTAAAN

Sequences:

>Translated_501_residues
MTAWPILSLVTFLPLVGVLLILFIRDDSENARRNIRAIALLTTTFTFIISVFIWTGFDNSQSGFQFVEKAAWLDSGISYH
MGVDGISMLFVILTTFLMPLCILASWEAIEKRVKAYMIAFLLLETLMIGVFCALDIVLFYVFFEAGLIPMFIIIGVWGGK
RRVYASFKFFLYTLAGSVLMLLAIMAMFYQSGTTDIPTLLTHSFPANMQTWLWLAFFASFAVKMPMWPVHTWLPDAHVEA
PTAGSVILAAILLKMGGYGFLRFSLPMFPLASEMFAPLVFTLSVVAIIYTSLVALMQDDMKKLIAYSSVAHMGFVTMGIF
AMNQEGVQGAIFQMLSHGLVSGALFLCVGVIYDRMHTREIAAYGGLVNNMPKYATVFMVFTMANVGLPGTSGFVGEFLTM
LGVFRVNTWVAFFAATGVILSAAYALWLYRRVIFGALTKDSLKGLLDLSLREKVIIYPLVALVIFFGVYPAPVFDATAQS
VKSLVTNVTASIGAAQTAAAN
>Mature_500_residues
TAWPILSLVTFLPLVGVLLILFIRDDSENARRNIRAIALLTTTFTFIISVFIWTGFDNSQSGFQFVEKAAWLDSGISYHM
GVDGISMLFVILTTFLMPLCILASWEAIEKRVKAYMIAFLLLETLMIGVFCALDIVLFYVFFEAGLIPMFIIIGVWGGKR
RVYASFKFFLYTLAGSVLMLLAIMAMFYQSGTTDIPTLLTHSFPANMQTWLWLAFFASFAVKMPMWPVHTWLPDAHVEAP
TAGSVILAAILLKMGGYGFLRFSLPMFPLASEMFAPLVFTLSVVAIIYTSLVALMQDDMKKLIAYSSVAHMGFVTMGIFA
MNQEGVQGAIFQMLSHGLVSGALFLCVGVIYDRMHTREIAAYGGLVNNMPKYATVFMVFTMANVGLPGTSGFVGEFLTML
GVFRVNTWVAFFAATGVILSAAYALWLYRRVIFGALTKDSLKGLLDLSLREKVIIYPLVALVIFFGVYPAPVFDATAQSV
KSLVTNVTASIGAAQTAAAN

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=367, Percent_Identity=34.0599455040872, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI251831117, Length=467, Percent_Identity=23.7687366167024, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1788613, Length=479, Percent_Identity=40.2922755741127, Blast_Score=322, Evalue=4e-89,
Organism=Escherichia coli, GI1788827, Length=285, Percent_Identity=28.7719298245614, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788831, Length=295, Percent_Identity=27.1186440677966, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788614, Length=408, Percent_Identity=26.2254901960784, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI145693160, Length=446, Percent_Identity=25.7847533632287, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788829, Length=267, Percent_Identity=26.9662921348315, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI2367154, Length=255, Percent_Identity=23.921568627451, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55180; Mature: 55048

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
TAWPILSLVTFLPLVGVLLILFIRDDSENARRNIRAIALLTTTFTFIISVFIWTGFDNS
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC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HHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]