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The map label for this gene is nuoN1 [H]

Identifier: 13471393

GI number: 13471393

Start: 1131759

End: 1133195

Strand: Reverse

Name: nuoN1 [H]

Synonym: mll1352

Alternate gene names: 13471393

Gene position: 1133195-1131759 (Counterclockwise)

Preceding gene: 13471394

Following gene: 13471392

Centisome position: 16.11

GC content: 63.19

Gene sequence:

>1437_bases
ATGACGCCGGACCTTCTCTCCAGCCTGTCGCTCTCGACGCCCGAGCTGATCCTTGCCATCGGCGCGCTCGCGCTGCTGAT
GGTCGGCGCCTATTCGCGCGCCAACACCGCCAATACGGTGACCGGCCTTGCCGTCGCCGTGCTGGTGGTCGCCGGCGTCT
GGCTGATCTTTTCCACGGGGCAGGGCAGCGCCTATGGCAATGCCTTCATCCAGGATCCCTTCTCCCGCTTCATGAAGGTG
CTGGCGCTGGTCGGCTCGGCGGTGACGCTCGTCATGTCGATGCGCTTTGCCAAGGCGGAGCGTTTCGACAAGTTCGAATA
TCCGGTGCTGATCCTGCTGTGCACGCTCGGCATGATGCTGATGATCTCGGCCAACGGCATGATCGGGCTCTATCTCGGCC
TCGAACTGCAGTCGCTGGCGATCTACGTGCTGGCGGCGATCAACCGCGACAATCTGCGTTCGACCGAGGCGGGCCTGAAG
TATTTCGTCCTTGGCGCGCTGTCGTCGGGCATGCTGCTCTACGGCATCAGCCTGGTCTACGGCTACACCGGCAACACCGG
TTTCCAGGAAATCGCCTCGGCGCTCGGCAGTGGCCAGCGCCAGCTCGGTCTCGTTTTCGGTCTGGTCTTCGTGCTTGCCG
GCCTTGCCTTCAAGATCTCGGCGGTGCCGTTCCATATGTGGACGCCCGACGTCTATGAAGGCGCACCGACGCCCGTGACC
GCCTTCCTGGCGGCAGCCCCCAAGATGGCGGCAATGGCATTGATCGTGCGCGTCACCATGGGCGCTTTCAAGCCGATCGC
CGCCGACTGGCAGCAGATCATCGTCTTCATCTCGATCGCCTCGATGGCGCTCGGCGCCTTCGCCGCCATCGGCCAGAGCA
ACATCAAGCGGCTGATGGCCTATTCCTCGATCGGCCATATGGGCTACGCGCTGGTCGGCCTTGCCGCCAACAGCCAGGCC
GGCGTGCGTGGCGTCGCCATCTACATGCTGATCTATCTGGTGATGACGCTGGGCACCTTCGCCTTCATCCTCGCCATGCG
GCGCAAGGAAGGCAATGTCGAACAGATCAGCGACCTGGCCGGGCTGTCTTCGACCAACCCGATCATGGCGACGATCCTCA
CCATCCTGATGTTCTCGCTGGCCGGCATTCCGCCGCTCGCCGGCTTCTGGGGGAAGTGGTATGTCTTCCTCGCCGCCATC
AACGCCAACCTCTACGCGCTGGCGATCATCGGCGTGCTGGCCTCGGTGGTGGGCGCCTATTACTATCTGCGCATCATCAA
GATCATGTGGTTCGACGAACCGGTCGGCGGCTTCGTGCCGATGGCCAGCGAATTGCGTGTCGTGCTCGGCGTCTGCGGCG
CCTTCGTGCTGTTCTATGTGCTGATCGGCGGACCGATCGGCACCTATGCCGAAGCCGCCGCCAAGACATTTTTCTGA

Upstream 100 bases:

>100_bases
TGCGACGGCCCAATCGGTCAAGTCGCTCGTCACCAATGTCACCGCATCCATCGGCGCCGCGCAAACCGCGGCGGCGAACT
GACCAGGGGTTTTGCGAACC

Downstream 100 bases:

>100_bases
CGGGATGGCATTTCGGCTGGCCCCAACCTCGTTGTCGGAAGGGTTCCGGCTCGAGGCCCATGACAGCGTCGGCTCCACCA
ACACGGTGGCGCTGGACCAC

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N 1; NDH-1 subunit N 1 [H]

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MTPDLLSSLSLSTPELILAIGALALLMVGAYSRANTANTVTGLAVAVLVVAGVWLIFSTGQGSAYGNAFIQDPFSRFMKV
LALVGSAVTLVMSMRFAKAERFDKFEYPVLILLCTLGMMLMISANGMIGLYLGLELQSLAIYVLAAINRDNLRSTEAGLK
YFVLGALSSGMLLYGISLVYGYTGNTGFQEIASALGSGQRQLGLVFGLVFVLAGLAFKISAVPFHMWTPDVYEGAPTPVT
AFLAAAPKMAAMALIVRVTMGAFKPIAADWQQIIVFISIASMALGAFAAIGQSNIKRLMAYSSIGHMGYALVGLAANSQA
GVRGVAIYMLIYLVMTLGTFAFILAMRRKEGNVEQISDLAGLSSTNPIMATILTILMFSLAGIPPLAGFWGKWYVFLAAI
NANLYALAIIGVLASVVGAYYYLRIIKIMWFDEPVGGFVPMASELRVVLGVCGAFVLFYVLIGGPIGTYAEAAAKTFF

Sequences:

>Translated_478_residues
MTPDLLSSLSLSTPELILAIGALALLMVGAYSRANTANTVTGLAVAVLVVAGVWLIFSTGQGSAYGNAFIQDPFSRFMKV
LALVGSAVTLVMSMRFAKAERFDKFEYPVLILLCTLGMMLMISANGMIGLYLGLELQSLAIYVLAAINRDNLRSTEAGLK
YFVLGALSSGMLLYGISLVYGYTGNTGFQEIASALGSGQRQLGLVFGLVFVLAGLAFKISAVPFHMWTPDVYEGAPTPVT
AFLAAAPKMAAMALIVRVTMGAFKPIAADWQQIIVFISIASMALGAFAAIGQSNIKRLMAYSSIGHMGYALVGLAANSQA
GVRGVAIYMLIYLVMTLGTFAFILAMRRKEGNVEQISDLAGLSSTNPIMATILTILMFSLAGIPPLAGFWGKWYVFLAAI
NANLYALAIIGVLASVVGAYYYLRIIKIMWFDEPVGGFVPMASELRVVLGVCGAFVLFYVLIGGPIGTYAEAAAKTFF
>Mature_477_residues
TPDLLSSLSLSTPELILAIGALALLMVGAYSRANTANTVTGLAVAVLVVAGVWLIFSTGQGSAYGNAFIQDPFSRFMKVL
ALVGSAVTLVMSMRFAKAERFDKFEYPVLILLCTLGMMLMISANGMIGLYLGLELQSLAIYVLAAINRDNLRSTEAGLKY
FVLGALSSGMLLYGISLVYGYTGNTGFQEIASALGSGQRQLGLVFGLVFVLAGLAFKISAVPFHMWTPDVYEGAPTPVTA
FLAAAPKMAAMALIVRVTMGAFKPIAADWQQIIVFISIASMALGAFAAIGQSNIKRLMAYSSIGHMGYALVGLAANSQAG
VRGVAIYMLIYLVMTLGTFAFILAMRRKEGNVEQISDLAGLSSTNPIMATILTILMFSLAGIPPLAGFWGKWYVFLAAIN
ANLYALAIIGVLASVVGAYYYLRIIKIMWFDEPVGGFVPMASELRVVLGVCGAFVLFYVLIGGPIGTYAEAAAKTFF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=300, Percent_Identity=22.6666666666667, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI251831117, Length=210, Percent_Identity=29.0476190476191, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI145693160, Length=446, Percent_Identity=34.7533632286996, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1788831, Length=298, Percent_Identity=27.1812080536913, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1788614, Length=318, Percent_Identity=23.2704402515723, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788613, Length=232, Percent_Identity=28.0172413793103, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788827, Length=284, Percent_Identity=25.7042253521127, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 50773; Mature: 50642

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPDLLSSLSLSTPELILAIGALALLMVGAYSRANTANTVTGLAVAVLVVAGVWLIFSTG
CCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEECC
QGSAYGNAFIQDPFSRFMKVLALVGSAVTLVMSMRFAKAERFDKFEYPVLILLCTLGMML
CCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
MISANGMIGLYLGLELQSLAIYVLAAINRDNLRSTEAGLKYFVLGALSSGMLLYGISLVY
HHCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
GYTGNTGFQEIASALGSGQRQLGLVFGLVFVLAGLAFKISAVPFHMWTPDVYEGAPTPVT
CCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHCCCCCCHHH
AFLAAAPKMAAMALIVRVTMGAFKPIAADWQQIIVFISIASMALGAFAAIGQSNIKRLMA
HHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSSIGHMGYALVGLAANSQAGVRGVAIYMLIYLVMTLGTFAFILAMRRKEGNVEQISDLA
HHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GLSSTNPIMATILTILMFSLAGIPPLAGFWGKWYVFLAAINANLYALAIIGVLASVVGAY
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
YYLRIIKIMWFDEPVGGFVPMASELRVVLGVCGAFVLFYVLIGGPIGTYAEAAAKTFF
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TPDLLSSLSLSTPELILAIGALALLMVGAYSRANTANTVTGLAVAVLVVAGVWLIFSTG
CCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEECC
QGSAYGNAFIQDPFSRFMKVLALVGSAVTLVMSMRFAKAERFDKFEYPVLILLCTLGMML
CCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
MISANGMIGLYLGLELQSLAIYVLAAINRDNLRSTEAGLKYFVLGALSSGMLLYGISLVY
HHCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
GYTGNTGFQEIASALGSGQRQLGLVFGLVFVLAGLAFKISAVPFHMWTPDVYEGAPTPVT
CCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHCCCCCCHHH
AFLAAAPKMAAMALIVRVTMGAFKPIAADWQQIIVFISIASMALGAFAAIGQSNIKRLMA
HHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSSIGHMGYALVGLAANSQAGVRGVAIYMLIYLVMTLGTFAFILAMRRKEGNVEQISDLA
HHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GLSSTNPIMATILTILMFSLAGIPPLAGFWGKWYVFLAAINANLYALAIIGVLASVVGAY
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
YYLRIIKIMWFDEPVGGFVPMASELRVVLGVCGAFVLFYVLIGGPIGTYAEAAAKTFF
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]