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The map label for this gene is ddc [H]

Identifier: 13470894

GI number: 13470894

Start: 563210

End: 564622

Strand: Reverse

Name: ddc [H]

Synonym: mll0712

Alternate gene names: 13470894

Gene position: 564622-563210 (Counterclockwise)

Preceding gene: 13470895

Following gene: 13470893

Centisome position: 8.02

GC content: 63.62

Gene sequence:

>1413_bases
ATGAACAATGACGAGTTCCGGCAGTGGTCGCGACGTGCCGCCGACTGGGGCGCCGACTATCGCAATTCATTGCGCGAGCG
GCCGGTGCGGCCGCTGGTCGAACCGGGTGACATTTTCAGGAGCATTGACGCCTCGCCGCCGGAAGACGCCGAACCCATGG
ACAGGATCTTCGCCGACTTCGAAGAGAAGATCGTGCCGGGCATGACGCATTGGCAGCACCCGCGCTTCTTCGCCTATTTC
CCGGCCAATGCGGCGCCGGTTTCGGTGGTGGCTGAGTATCTCGTCTCCGCAATGGCCGCGCAGTGCATGCTTTGGCAGAC
CTCGCCGGCGGCGACCGAACTCGAGACCCGCACCGTCGACTGGATGCGCCAGGCACTTGGTCTTCCCGAGGGATTTTCCG
GCGTCATCCAGGATTCGGCTTCGTCGGCGACACTCAATGCCGTGCTGACCATGCGCGAGCGGGCGCTGGATTGGCAAGGC
AACAAAAAGGGGTTGGCCGGGCAGGGCCAGTTGCGCATCTATTCCTCGGATCAGGTGCACACGTCGATCGACCGGGCGAT
CTGGGTGTCGGGCATCGGCGAGGACAATCTGGTGCGCATTCCCGTCGGCGGCCGGTTCCGCTCCATGGATACAGCAGCTC
TGGAAGCGGCAATCGTCGCTGACCGCGCGGCTGGAATGCTGCCTGCCGGCATCATAGGCAGCGTCGGTGGAACCAGCATC
GGCGGCACGGACGACATCGCCGCGGTCGCCGGCGTGGCGCGCCGGCATGGGCTCTATTTTCATGTCGATGCCGCTTGGGC
CGGGTCGGCCATGATCTGCCCGGAGTATCGTCATTTCTGGGCCGGCGCCGAACAGGCTGATTCTGTCGTCTTCAACCCGC
ACAAATGGCTGGGCGCGCAGTTTGACTGCTCCATCCAGTTCTTGCGACAGCCGGAAGACCTGGTGCGTACGCTGGCGATC
AAGCCCGAATTCCTCAAGACGCACGGACGTGACGGCATCATCAACTATTCCGAATGGTCGGTACCGCTCGGCCGCCGGTT
TCGCGCCCTGAAATTGTGGTTCCTGCTGCGTGCCCACGGGCTGGAAAACCTGCGCGCCATGGTCCGCAACCATGTGACCT
GGAGCGAGGGCCTTGCCGCGCGGCTGGCAAAGGAGCCGGATTTCGAGATCGTCAGCGAACCGATGCTGTCGCTGTTTTCA
TTCCGGCACAGGGCGCCCTCAAGCGCCGATGCGGACGAGCACAATCTGCGGCTGGTCAATGCGATCAACGACGATGGCCG
CATCTACCTGACGCAAACGAGGGTCGACGGGCAGGTGGCGATCCGCTTCCAGGTCGGCCAGTTCGAGGCGACCGCAGGCG
ATGTCGATTCGGCTTTTGCCGTCATTACCGAAATCGCGCGCGGCATGGCCTGA

Upstream 100 bases:

>100_bases
CGTAGCTGCCGGCGCTTGCATCTATTTTACATGTTAATTATTGATGGATTTGAAAGCCGGGCGAAGAGTGCCGGCATTGC
ATTCGTGTCGGGAGGACAGG

Downstream 100 bases:

>100_bases
CCGGCCGATATAGGATTGCGCTGGAGTTTGCCTTTGCAATCAGGTGATTTCCGTTAGCCGGCTTATACCTTTTCATTGCT
TTCGTTTTCGGCTATAGAAA

Product: aromatic amino acid decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MNNDEFRQWSRRAADWGADYRNSLRERPVRPLVEPGDIFRSIDASPPEDAEPMDRIFADFEEKIVPGMTHWQHPRFFAYF
PANAAPVSVVAEYLVSAMAAQCMLWQTSPAATELETRTVDWMRQALGLPEGFSGVIQDSASSATLNAVLTMRERALDWQG
NKKGLAGQGQLRIYSSDQVHTSIDRAIWVSGIGEDNLVRIPVGGRFRSMDTAALEAAIVADRAAGMLPAGIIGSVGGTSI
GGTDDIAAVAGVARRHGLYFHVDAAWAGSAMICPEYRHFWAGAEQADSVVFNPHKWLGAQFDCSIQFLRQPEDLVRTLAI
KPEFLKTHGRDGIINYSEWSVPLGRRFRALKLWFLLRAHGLENLRAMVRNHVTWSEGLAARLAKEPDFEIVSEPMLSLFS
FRHRAPSSADADEHNLRLVNAINDDGRIYLTQTRVDGQVAIRFQVGQFEATAGDVDSAFAVITEIARGMA

Sequences:

>Translated_470_residues
MNNDEFRQWSRRAADWGADYRNSLRERPVRPLVEPGDIFRSIDASPPEDAEPMDRIFADFEEKIVPGMTHWQHPRFFAYF
PANAAPVSVVAEYLVSAMAAQCMLWQTSPAATELETRTVDWMRQALGLPEGFSGVIQDSASSATLNAVLTMRERALDWQG
NKKGLAGQGQLRIYSSDQVHTSIDRAIWVSGIGEDNLVRIPVGGRFRSMDTAALEAAIVADRAAGMLPAGIIGSVGGTSI
GGTDDIAAVAGVARRHGLYFHVDAAWAGSAMICPEYRHFWAGAEQADSVVFNPHKWLGAQFDCSIQFLRQPEDLVRTLAI
KPEFLKTHGRDGIINYSEWSVPLGRRFRALKLWFLLRAHGLENLRAMVRNHVTWSEGLAARLAKEPDFEIVSEPMLSLFS
FRHRAPSSADADEHNLRLVNAINDDGRIYLTQTRVDGQVAIRFQVGQFEATAGDVDSAFAVITEIARGMA
>Mature_470_residues
MNNDEFRQWSRRAADWGADYRNSLRERPVRPLVEPGDIFRSIDASPPEDAEPMDRIFADFEEKIVPGMTHWQHPRFFAYF
PANAAPVSVVAEYLVSAMAAQCMLWQTSPAATELETRTVDWMRQALGLPEGFSGVIQDSASSATLNAVLTMRERALDWQG
NKKGLAGQGQLRIYSSDQVHTSIDRAIWVSGIGEDNLVRIPVGGRFRSMDTAALEAAIVADRAAGMLPAGIIGSVGGTSI
GGTDDIAAVAGVARRHGLYFHVDAAWAGSAMICPEYRHFWAGAEQADSVVFNPHKWLGAQFDCSIQFLRQPEDLVRTLAI
KPEFLKTHGRDGIINYSEWSVPLGRRFRALKLWFLLRAHGLENLRAMVRNHVTWSEGLAARLAKEPDFEIVSEPMLSLFS
FRHRAPSSADADEHNLRLVNAINDDGRIYLTQTRVDGQVAIRFQVGQFEATAGDVDSAFAVITEIARGMA

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI4503281, Length=480, Percent_Identity=37.2916666666667, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI132814448, Length=480, Percent_Identity=37.2916666666667, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI92110055, Length=469, Percent_Identity=33.4754797441365, Blast_Score=291, Evalue=1e-78,
Organism=Homo sapiens, GI197383062, Length=382, Percent_Identity=26.1780104712042, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI194294551, Length=339, Percent_Identity=28.6135693215339, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI58331246, Length=344, Percent_Identity=24.7093023255814, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI197276620, Length=351, Percent_Identity=24.7863247863248, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4503875, Length=351, Percent_Identity=24.7863247863248, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17534819, Length=477, Percent_Identity=34.5911949685535, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17534817, Length=477, Percent_Identity=34.5911949685535, Blast_Score=302, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI71981211, Length=523, Percent_Identity=32.1223709369025, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI71981217, Length=532, Percent_Identity=31.015037593985, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17551992, Length=514, Percent_Identity=28.4046692607004, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI133931025, Length=483, Percent_Identity=27.536231884058, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI71993058, Length=373, Percent_Identity=28.1501340482574, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17555682, Length=373, Percent_Identity=28.1501340482574, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71993062, Length=325, Percent_Identity=29.5384615384615, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI221476190, Length=485, Percent_Identity=36.0824742268041, Blast_Score=294, Evalue=8e-80,
Organism=Drosophila melanogaster, GI24585143, Length=485, Percent_Identity=36.0824742268041, Blast_Score=294, Evalue=8e-80,
Organism=Drosophila melanogaster, GI24585139, Length=485, Percent_Identity=36.0824742268041, Blast_Score=294, Evalue=8e-80,
Organism=Drosophila melanogaster, GI24586044, Length=483, Percent_Identity=33.9544513457557, Blast_Score=291, Evalue=7e-79,
Organism=Drosophila melanogaster, GI28573972, Length=479, Percent_Identity=34.446764091858, Blast_Score=285, Evalue=7e-77,
Organism=Drosophila melanogaster, GI24652373, Length=485, Percent_Identity=32.7835051546392, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI17136190, Length=476, Percent_Identity=33.8235294117647, Blast_Score=262, Evalue=4e-70,
Organism=Drosophila melanogaster, GI24585135, Length=476, Percent_Identity=32.563025210084, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI17136594, Length=396, Percent_Identity=27.7777777777778, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24657193, Length=403, Percent_Identity=25.8064516129032, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24657185, Length=403, Percent_Identity=25.8064516129032, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24657188, Length=403, Percent_Identity=25.8064516129032, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI21356415, Length=365, Percent_Identity=25.2054794520548, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 52054; Mature: 52054

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00123 ALKALINE_PHOSPHATASE ; PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNDEFRQWSRRAADWGADYRNSLRERPVRPLVEPGDIFRSIDASPPEDAEPMDRIFADF
CCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHH
EEKIVPGMTHWQHPRFFAYFPANAAPVSVVAEYLVSAMAAQCMLWQTSPAATELETRTVD
HHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHH
WMRQALGLPEGFSGVIQDSASSATLNAVLTMRERALDWQGNKKGLAGQGQLRIYSSDQVH
HHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHH
TSIDRAIWVSGIGEDNLVRIPVGGRFRSMDTAALEAAIVADRAAGMLPAGIIGSVGGTSI
HHHHHEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCC
GGTDDIAAVAGVARRHGLYFHVDAAWAGSAMICPEYRHFWAGAEQADSVVFNPHKWLGAQ
CCCHHHHHHHHHHHHCCEEEEEECCCCCCEEECHHHHHHHCCCCCCCCEEECCHHHCCCC
FDCSIQFLRQPEDLVRTLAIKPEFLKTHGRDGIINYSEWSVPLGRRFRALKLWFLLRAHG
CCCHHHHHCCHHHHHHHHHCCCHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHC
LENLRAMVRNHVTWSEGLAARLAKEPDFEIVSEPMLSLFSFRHRAPSSADADEHNLRLVN
HHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
AINDDGRIYLTQTRVDGQVAIRFQVGQFEATAGDVDSAFAVITEIARGMA
EECCCCEEEEEEEECCCEEEEEEEECCEECCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNDEFRQWSRRAADWGADYRNSLRERPVRPLVEPGDIFRSIDASPPEDAEPMDRIFADF
CCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHH
EEKIVPGMTHWQHPRFFAYFPANAAPVSVVAEYLVSAMAAQCMLWQTSPAATELETRTVD
HHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHH
WMRQALGLPEGFSGVIQDSASSATLNAVLTMRERALDWQGNKKGLAGQGQLRIYSSDQVH
HHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHH
TSIDRAIWVSGIGEDNLVRIPVGGRFRSMDTAALEAAIVADRAAGMLPAGIIGSVGGTSI
HHHHHEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCC
GGTDDIAAVAGVARRHGLYFHVDAAWAGSAMICPEYRHFWAGAEQADSVVFNPHKWLGAQ
CCCHHHHHHHHHHHHCCEEEEEECCCCCCEEECHHHHHHHCCCCCCCCEEECCHHHCCCC
FDCSIQFLRQPEDLVRTLAIKPEFLKTHGRDGIINYSEWSVPLGRRFRALKLWFLLRAHG
CCCHHHHHCCHHHHHHHHHCCCHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHC
LENLRAMVRNHVTWSEGLAARLAKEPDFEIVSEPMLSLFSFRHRAPSSADADEHNLRLVN
HHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
AINDDGRIYLTQTRVDGQVAIRFQVGQFEATAGDVDSAFAVITEIARGMA
EECCCCEEEEEEEECCCEEEEEEEECCEECCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]