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The map label for this gene is pyrH [H]

Identifier: 13470841

GI number: 13470841

Start: 508808

End: 509551

Strand: Reverse

Name: pyrH [H]

Synonym: mll0643

Alternate gene names: 13470841

Gene position: 509551-508808 (Counterclockwise)

Preceding gene: 13470842

Following gene: 13470840

Centisome position: 7.24

GC content: 60.62

Gene sequence:

>744_bases
ATGCAAAATGACGAGGACCAGATGACGGTGAAGCCCCTCTACCGACGTGTCTTGCTGAAAGCGTCGGGCGAAGCGTTGAT
GGGCGAACAACATTTCGGCATCGACGTTTCGGTCGTGGATCGCATCGCCGCCGACATCGCCGAGGCCCGCGGGCTGGGCA
TCGAGGTCGGCGTCGTCATCGGTGGCGGCAATATCTTTCGCGGCGTGGCCGTCGCCTCCAAGGGTGGAGACCGCGTCACC
GGCGACCACATGGGCATGCTTGCCACGGTCATCAACTCGCTGGCGCTGCGCACCTCGCTGCACAAGATCGGCGTCGATGC
CGTGGTGCTGTCCGCGATCGCCATGCCAGAACTCTGCGAGAGTTTTTCGCAACGCCAGGCAGACGCTTACATGAACCAGG
GCAGGGTGGTGATCTTTGCCGGCGGCACCGGCAACCCGTTCTTCACCACTGATTCGGCAGCGGCACTGCGCGCGGCCGAA
ATCGGTGCCGATGCGCTGTTCAAGGGCACGCAGGTCGATGGCGTCTATTCGGCCGATCCGAAAAAGGATCCGAATGCGAC
GCGTTTCGAGCGCATCAGCCATGCCGAAGTCATAAATCGAGGCCTTTCCATCATGGATACGGCTGCGATTGCACTTGCGC
GCGAAAACAACATTCCGATAATCGTCTATTCGATCCACGAAAAAGGTGGTTTCGGCGATATTCTGAGGGGCGGCGGCCGC
TGTACGGTCGTTGCGGACGATTGA

Upstream 100 bases:

>100_bases
CGCGTGACATCGCGGCGCCCTTCGTGTATCGGAACTCGGCATCGCGCCAATGTTCGGGGTGCGGCGCCTGCGCGAGGGCG
GCCGGCCCAGGCGTAACCAC

Downstream 100 bases:

>100_bases
TCCGGGGCCTGATCCCTAGAACGGGAAAACCGGCTTTTCGAAAATCAGGCTCGAACGGGGCCTTGCCCCGAGGCAGTGAA
CCCGCGGCAGACGGGTCGAG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MQNDEDQMTVKPLYRRVLLKASGEALMGEQHFGIDVSVVDRIAADIAEARGLGIEVGVVIGGGNIFRGVAVASKGGDRVT
GDHMGMLATVINSLALRTSLHKIGVDAVVLSAIAMPELCESFSQRQADAYMNQGRVVIFAGGTGNPFFTTDSAAALRAAE
IGADALFKGTQVDGVYSADPKKDPNATRFERISHAEVINRGLSIMDTAAIALARENNIPIIVYSIHEKGGFGDILRGGGR
CTVVADD

Sequences:

>Translated_247_residues
MQNDEDQMTVKPLYRRVLLKASGEALMGEQHFGIDVSVVDRIAADIAEARGLGIEVGVVIGGGNIFRGVAVASKGGDRVT
GDHMGMLATVINSLALRTSLHKIGVDAVVLSAIAMPELCESFSQRQADAYMNQGRVVIFAGGTGNPFFTTDSAAALRAAE
IGADALFKGTQVDGVYSADPKKDPNATRFERISHAEVINRGLSIMDTAAIALARENNIPIIVYSIHEKGGFGDILRGGGR
CTVVADD
>Mature_247_residues
MQNDEDQMTVKPLYRRVLLKASGEALMGEQHFGIDVSVVDRIAADIAEARGLGIEVGVVIGGGNIFRGVAVASKGGDRVT
GDHMGMLATVINSLALRTSLHKIGVDAVVLSAIAMPELCESFSQRQADAYMNQGRVVIFAGGTGNPFFTTDSAAALRAAE
IGADALFKGTQVDGVYSADPKKDPNATRFERISHAEVINRGLSIMDTAAIALARENNIPIIVYSIHEKGGFGDILRGGGR
CTVVADD

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=236, Percent_Identity=51.271186440678, Blast_Score=257, Evalue=6e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 26045; Mature: 26045

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNDEDQMTVKPLYRRVLLKASGEALMGEQHFGIDVSVVDRIAADIAEARGLGIEVGVVI
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEE
GGGNIFRGVAVASKGGDRVTGDHMGMLATVINSLALRTSLHKIGVDAVVLSAIAMPELCE
ECCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
SFSQRQADAYMNQGRVVIFAGGTGNPFFTTDSAAALRAAEIGADALFKGTQVDGVYSADP
HHHHHHHHHHHCCCCEEEEECCCCCCCEECCCHHHHHHHHCCHHHHCCCCCCCCEECCCC
KKDPNATRFERISHAEVINRGLSIMDTAAIALARENNIPIIVYSIHEKGGFGDILRGGGR
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCCEEEEEECCCCCCHHHHCCCCE
CTVVADD
EEEEECC
>Mature Secondary Structure
MQNDEDQMTVKPLYRRVLLKASGEALMGEQHFGIDVSVVDRIAADIAEARGLGIEVGVVI
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEE
GGGNIFRGVAVASKGGDRVTGDHMGMLATVINSLALRTSLHKIGVDAVVLSAIAMPELCE
ECCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
SFSQRQADAYMNQGRVVIFAGGTGNPFFTTDSAAALRAAEIGADALFKGTQVDGVYSADP
HHHHHHHHHHHCCCCEEEEECCCCCCCEECCCHHHHHHHHCCHHHHCCCCCCCCEECCCC
KKDPNATRFERISHAEVINRGLSIMDTAAIALARENNIPIIVYSIHEKGGFGDILRGGGR
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCCEEEEEECCCCCCHHHHCCCCE
CTVVADD
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]