Click here to switch to the map view.

The map label for this gene is frr

Identifier: 13470840

GI number: 13470840

Start: 508144

End: 508698

Strand: Reverse

Name: frr

Synonym: mll0642

Alternate gene names: 13470840

Gene position: 508698-508144 (Counterclockwise)

Preceding gene: 13470841

Following gene: 13470839

Centisome position: 7.23

GC content: 60.72

Gene sequence:

>555_bases
ATGAGTGGTGAGTACGACGATCTCAAGCGGCGCATGGATGGGGCAATCGCCGCGTTCAAGCATGACCTGGCTTCGCTGCG
GACCGGCCGCGCCTCCAGCAATCTGCTCGACGCCATCCAGGTGCAGGCCTATGGCACCACCATGCCGATCAACCAGGTTG
CCAACGTTACGGTACCGGAGCCGCGCATGATCTCGGTGTCGATCTGGGACAAGTCGATGGTCGGCGCGGTCGACCGCGCC
ATCCGAGAATCCAACCTGGGCTTCAACCCGATCGTCGACGGTACCAATCTGAGGATTCCGCTGCCGGAGCTCAACGAGCA
GCGCCGCAAGGAACTGGTCAAGATCTCGCACGGCTATGCAGAGAACGCTCGTGTCGCCGCGCGCCATGTGCGCCGCGACG
GCATGGACTTCCTGAAGAAGGCCGAGAAGGACGGCGTGATCAGCGAGGACGATCAGCGCAAGCGTTCGGACCAGGTCCAG
AAGCTTACCGACGAAACGATCAGCACCATCGATCATCTGCTTTCCGACAAGGAAGCTGAAATCATGCAGGTTTAG

Upstream 100 bases:

>100_bases
TGATCCCTAGAACGGGAAAACCGGCTTTTCGAAAATCAGGCTCGAACGGGGCCTTGCCCCGAGGCAGTGAACCCGCGGCA
GACGGGTCGAGGAGACTAAG

Downstream 100 bases:

>100_bases
GGTTGGCGGCCGGCTGACCCGAAAGCGAGATCATGACAACGCCCGCGCATGTCGCGATCATCATGGATGGGAATGGACGC
TGGGCCAAGGCGCGCGGCAT

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MSGEYDDLKRRMDGAIAAFKHDLASLRTGRASSNLLDAIQVQAYGTTMPINQVANVTVPEPRMISVSIWDKSMVGAVDRA
IRESNLGFNPIVDGTNLRIPLPELNEQRRKELVKISHGYAENARVAARHVRRDGMDFLKKAEKDGVISEDDQRKRSDQVQ
KLTDETISTIDHLLSDKEAEIMQV

Sequences:

>Translated_184_residues
MSGEYDDLKRRMDGAIAAFKHDLASLRTGRASSNLLDAIQVQAYGTTMPINQVANVTVPEPRMISVSIWDKSMVGAVDRA
IRESNLGFNPIVDGTNLRIPLPELNEQRRKELVKISHGYAENARVAARHVRRDGMDFLKKAEKDGVISEDDQRKRSDQVQ
KLTDETISTIDHLLSDKEAEIMQV
>Mature_183_residues
SGEYDDLKRRMDGAIAAFKHDLASLRTGRASSNLLDAIQVQAYGTTMPINQVANVTVPEPRMISVSIWDKSMVGAVDRAI
RESNLGFNPIVDGTNLRIPLPELNEQRRKELVKISHGYAENARVAARHVRRDGMDFLKKAEKDGVISEDDQRKRSDQVQK
LTDETISTIDHLLSDKEAEIMQV

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family

Homologues:

Organism=Homo sapiens, GI20270317, Length=178, Percent_Identity=30.8988764044944, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI291042689, Length=148, Percent_Identity=33.1081081081081, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI1786368, Length=177, Percent_Identity=51.9774011299435, Blast_Score=182, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24661488, Length=179, Percent_Identity=27.9329608938547, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): RRF_RHILO (Q98MB8)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102409.1
- ProteinModelPortal:   Q98MB8
- SMR:   Q98MB8
- GeneID:   1225072
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll0642
- NMPDR:   fig|266835.1.peg.514
- HOGENOM:   HBG533975
- OMA:   YYGAETP
- ProtClustDB:   PRK00083
- GO:   GO:0005737
- HAMAP:   MF_00040
- InterPro:   IPR002661
- InterPro:   IPR015998
- PANTHER:   PTHR20982
- PANTHER:   PTHR20982:SF3
- TIGRFAMs:   TIGR00496

Pfam domain/function: PF01765 RRF; SSF55194 Ribosome_recyc_fac

EC number: NA

Molecular weight: Translated: 20630; Mature: 20498

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGEYDDLKRRMDGAIAAFKHDLASLRTGRASSNLLDAIQVQAYGTTMPINQVANVTVPE
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCCC
PRMISVSIWDKSMVGAVDRAIRESNLGFNPIVDGTNLRIPLPELNEQRRKELVKISHGYA
CCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCC
ENARVAARHVRRDGMDFLKKAEKDGVISEDDQRKRSDQVQKLTDETISTIDHLLSDKEAE
HHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IMQV
HHCC
>Mature Secondary Structure 
SGEYDDLKRRMDGAIAAFKHDLASLRTGRASSNLLDAIQVQAYGTTMPINQVANVTVPE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCCC
PRMISVSIWDKSMVGAVDRAIRESNLGFNPIVDGTNLRIPLPELNEQRRKELVKISHGYA
CCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCC
ENARVAARHVRRDGMDFLKKAEKDGVISEDDQRKRSDQVQKLTDETISTIDHLLSDKEAE
HHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IMQV
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968