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The map label for this gene is pbp2 [H]

Identifier: 15603789

GI number: 15603789

Start: 2162643

End: 2164577

Strand: Direct

Name: pbp2 [H]

Synonym: PM1924

Alternate gene names: 15603789

Gene position: 2162643-2164577 (Clockwise)

Preceding gene: 15603788

Following gene: 15603790

Centisome position: 95.8

GC content: 41.19

Gene sequence:

>1935_bases
ATGAAAAAGTTAAAAAAATTGTTGGCTAAACCACAACAAGAATTGATTAGAGATAAAAAATCGGAGCGCAATTTATTTGC
CCGCCGAGCATTAGTTTCATTTATTTTTGTGTGGGTGCTGACGGCAATTTTGGCAACCAATTTATACCATTTACAAATCG
TCAATTACGACAGTTATCAGACTCGTTCAAATGGTAACCGCATTAAATTGTTACCTCTTCCGCCTACTCGTGGGCTTATC
TATGATCGTTATGGCAAATTGTTAGCGGAAAATTTAACCTTTTTTGGTCTCTATATTGTGCCTGAAAAAGTGGAAAATTT
AGAGCGCACTTTTGAAGAATTGAAAGCGATTGTGGGACTGACGGAAGAGGATATTGAAAATTTCAAAAAAGAGCGCCGTC
GCGCTTCGCGTTACACCTCTATTTTACTGAAACCACACTTAACTGAGGAGCAGATTGCCCGTTTTTCGGTCAATCAATAC
CGTTTTACCAGTTTAGAAGTGAAGCCGTATTTTAAACGCCATTATTTATACGGAGAACCCTTAACGCATATTCTGGGTTA
TGTCGCGAAAATTAATGATAAAGATGTTGAACGCCTAAAAAAAGAAGGGAAATTTGCAAATTACGCAGGCACACATGATA
TTGGTAAATTGGGCATTGAACGTTATTACGAAACACAATTACACGGGAGTACGGGCTTTGAAGAAGTAGAAGTCAATAAC
CGCGGTAAAGTGATCCGTAAATTACGCGAACAGCCAGCGATTGCAGGAAAAAGCATTCATTTGACTATTGATTTAGAATT
GCAACGTTATATTACTGATTTGCTTAGCGGGCAAAAAGGGGCAGTTGTGGTGCTAGATCCAAAAGATAACAGCATTCTCG
CGATGGTTTCCACACCAAGTTATGACAACAATTTATTTGTTGATGGTATATCCAGTGCGGATTATAAACGGTTATTAAAT
GATCCAAACCGTCCTTTATATAGTCGCGTAACACAAGGTGCTTATCCGCCAGCTTCGACTGTCAAACCGTTCATTGGTGT
TGCAGCATTACATGAAAATGTGATTACACAAAATATGACCATTTTTGATCCTGGCTATTGGGTTCTACCAAATACTACCA
AGCGTTTCCGGGATTGGAAAAAAACGGGGCATGGGCATACGGACTTGAATAAAGCGATTGTGGAATCGTCTGATACATAT
TTTTACCAAACCGCTTATAACATGGGCATTGATCGTTTATCCGATTGGATGAAACGCTTTGGTTTCGGTGTGCCGACAGG
TATTGATATTCAGGAAGAAACGGCAGGGATTATGCCAAGTCGTGAGTGGAAACAAAAGCGCCATAAACGCCCATGGGTAC
AAGGCGATACGATTTCCGTTGGGATTGGGCAGGGTTATTGGATTGCCACCCCCTTACAAGTGGCAAAAGCCACCAGTATT
TTAATCAATGAAGGGAAAGTTCATACACCACATTTAATGAAAAGTGTGGAGGGCAGTACAGTTGAACCTTATCAAGATCC
ACTGTTATATGAAGATATTACTGAGCCTAAAGCGGCTTACTGGGACGCGGCTAAGCGAGGTATGTATAACGTGGTCAATG
CTGCGAATGGCACGGGACGTAAAGCCTTCATTGGAACCAGTTATCGTGTTGCGGGCAAATCAGGGACCGCGCAAGTCTTT
AGTTTGAAAGAAAACCAAACTTATGATGCGAGTGGATTGAAAAAAGAATTGCATGATCATGCTTGGTTTACTGCTTATGC
GCCTTATGATGATCCTAAAATGGTGGTGGCGATTATTTTAGAAAATGCGGGAGGGGGATCCAGTGTGGCAGCGCCTGTGG
TGCGTCAAATTATGGATTATTATTTAACGCAACGATTGCCTCAAATATCGCGTTTATCTCCTGCTGACTCGTTAGCAACT
GAGGACTCAGAATAA

Upstream 100 bases:

>100_bases
ACCGCATCCGCTCGTGCGTGTTGTGGTCGCCGAGAGTTTGTATCGTGCTTGGTCTGTGACCATGAATCATCCATATCATC
GTGAATAATGCTGTGATTCA

Downstream 100 bases:

>100_bases
TGCATAAAAAGAATATTTGGCTGTCTTTATGGCGCAAATTGCACATTGATTTATGGCTGTTGATCGGATTGATTGTAATT
TCCGGTTATGGCTTACTGGT

Product: Pbp2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MKKLKKLLAKPQQELIRDKKSERNLFARRALVSFIFVWVLTAILATNLYHLQIVNYDSYQTRSNGNRIKLLPLPPTRGLI
YDRYGKLLAENLTFFGLYIVPEKVENLERTFEELKAIVGLTEEDIENFKKERRRASRYTSILLKPHLTEEQIARFSVNQY
RFTSLEVKPYFKRHYLYGEPLTHILGYVAKINDKDVERLKKEGKFANYAGTHDIGKLGIERYYETQLHGSTGFEEVEVNN
RGKVIRKLREQPAIAGKSIHLTIDLELQRYITDLLSGQKGAVVVLDPKDNSILAMVSTPSYDNNLFVDGISSADYKRLLN
DPNRPLYSRVTQGAYPPASTVKPFIGVAALHENVITQNMTIFDPGYWVLPNTTKRFRDWKKTGHGHTDLNKAIVESSDTY
FYQTAYNMGIDRLSDWMKRFGFGVPTGIDIQEETAGIMPSREWKQKRHKRPWVQGDTISVGIGQGYWIATPLQVAKATSI
LINEGKVHTPHLMKSVEGSTVEPYQDPLLYEDITEPKAAYWDAAKRGMYNVVNAANGTGRKAFIGTSYRVAGKSGTAQVF
SLKENQTYDASGLKKELHDHAWFTAYAPYDDPKMVVAIILENAGGGSSVAAPVVRQIMDYYLTQRLPQISRLSPADSLAT
EDSE

Sequences:

>Translated_644_residues
MKKLKKLLAKPQQELIRDKKSERNLFARRALVSFIFVWVLTAILATNLYHLQIVNYDSYQTRSNGNRIKLLPLPPTRGLI
YDRYGKLLAENLTFFGLYIVPEKVENLERTFEELKAIVGLTEEDIENFKKERRRASRYTSILLKPHLTEEQIARFSVNQY
RFTSLEVKPYFKRHYLYGEPLTHILGYVAKINDKDVERLKKEGKFANYAGTHDIGKLGIERYYETQLHGSTGFEEVEVNN
RGKVIRKLREQPAIAGKSIHLTIDLELQRYITDLLSGQKGAVVVLDPKDNSILAMVSTPSYDNNLFVDGISSADYKRLLN
DPNRPLYSRVTQGAYPPASTVKPFIGVAALHENVITQNMTIFDPGYWVLPNTTKRFRDWKKTGHGHTDLNKAIVESSDTY
FYQTAYNMGIDRLSDWMKRFGFGVPTGIDIQEETAGIMPSREWKQKRHKRPWVQGDTISVGIGQGYWIATPLQVAKATSI
LINEGKVHTPHLMKSVEGSTVEPYQDPLLYEDITEPKAAYWDAAKRGMYNVVNAANGTGRKAFIGTSYRVAGKSGTAQVF
SLKENQTYDASGLKKELHDHAWFTAYAPYDDPKMVVAIILENAGGGSSVAAPVVRQIMDYYLTQRLPQISRLSPADSLAT
EDSE
>Mature_644_residues
MKKLKKLLAKPQQELIRDKKSERNLFARRALVSFIFVWVLTAILATNLYHLQIVNYDSYQTRSNGNRIKLLPLPPTRGLI
YDRYGKLLAENLTFFGLYIVPEKVENLERTFEELKAIVGLTEEDIENFKKERRRASRYTSILLKPHLTEEQIARFSVNQY
RFTSLEVKPYFKRHYLYGEPLTHILGYVAKINDKDVERLKKEGKFANYAGTHDIGKLGIERYYETQLHGSTGFEEVEVNN
RGKVIRKLREQPAIAGKSIHLTIDLELQRYITDLLSGQKGAVVVLDPKDNSILAMVSTPSYDNNLFVDGISSADYKRLLN
DPNRPLYSRVTQGAYPPASTVKPFIGVAALHENVITQNMTIFDPGYWVLPNTTKRFRDWKKTGHGHTDLNKAIVESSDTY
FYQTAYNMGIDRLSDWMKRFGFGVPTGIDIQEETAGIMPSREWKQKRHKRPWVQGDTISVGIGQGYWIATPLQVAKATSI
LINEGKVHTPHLMKSVEGSTVEPYQDPLLYEDITEPKAAYWDAAKRGMYNVVNAANGTGRKAFIGTSYRVAGKSGTAQVF
SLKENQTYDASGLKKELHDHAWFTAYAPYDDPKMVVAIILENAGGGSSVAAPVVRQIMDYYLTQRLPQISRLSPADSLAT
EDSE

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=615, Percent_Identity=57.8861788617886, Blast_Score=745, Evalue=0.0,
Organism=Escherichia coli, GI1786272, Length=609, Percent_Identity=21.8390804597701, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 73112; Mature: 73112

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLKKLLAKPQQELIRDKKSERNLFARRALVSFIFVWVLTAILATNLYHLQIVNYDSYQ
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCE
TRSNGNRIKLLPLPPTRGLIYDRYGKLLAENLTFFGLYIVPEKVENLERTFEELKAIVGL
ECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEEEHHHHHHHHHHHHHHHHHHCC
TEEDIENFKKERRRASRYTSILLKPHLTEEQIARFSVNQYRFTSLEVKPYFKRHYLYGEP
CHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHCCCCEEEEEEEECHHHHHHEECCCC
LTHILGYVAKINDKDVERLKKEGKFANYAGTHDIGKLGIERYYETQLHGSTGFEEVEVNN
HHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECC
RGKVIRKLREQPAIAGKSIHLTIDLELQRYITDLLSGQKGAVVVLDPKDNSILAMVSTPS
CHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCC
YDNNLFVDGISSADYKRLLNDPNRPLYSRVTQGAYPPASTVKPFIGVAALHENVITQNMT
CCCCEEEECCCCHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCE
IFDPGYWVLPNTTKRFRDWKKTGHGHTDLNKAIVESSDTYFYQTAYNMGIDRLSDWMKRF
EECCCEEECCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEHHHCCHHHHHHHHHHH
GFGVPTGIDIQEETAGIMPSREWKQKRHKRPWVQGDTISVGIGQGYWIATPLQVAKATSI
CCCCCCCCCCCHHHCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCEEEECHHHHHHHHHE
LINEGKVHTPHLMKSVEGSTVEPYQDPLLYEDITEPKAAYWDAAKRGMYNVVNAANGTGR
EEECCCCCCHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHCCHHHHHCCCCCCCC
KAFIGTSYRVAGKSGTAQVFSLKENQTYDASGLKKELHDHAWFTAYAPYDDPKMVVAIIL
EEEEECCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEEEEE
ENAGGGSSVAAPVVRQIMDYYLTQRLPQISRLSPADSLATEDSE
ECCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHCCCCCCC
>Mature Secondary Structure
MKKLKKLLAKPQQELIRDKKSERNLFARRALVSFIFVWVLTAILATNLYHLQIVNYDSYQ
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCE
TRSNGNRIKLLPLPPTRGLIYDRYGKLLAENLTFFGLYIVPEKVENLERTFEELKAIVGL
ECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEEEHHHHHHHHHHHHHHHHHHCC
TEEDIENFKKERRRASRYTSILLKPHLTEEQIARFSVNQYRFTSLEVKPYFKRHYLYGEP
CHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHCCCCEEEEEEEECHHHHHHEECCCC
LTHILGYVAKINDKDVERLKKEGKFANYAGTHDIGKLGIERYYETQLHGSTGFEEVEVNN
HHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECC
RGKVIRKLREQPAIAGKSIHLTIDLELQRYITDLLSGQKGAVVVLDPKDNSILAMVSTPS
CHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCC
YDNNLFVDGISSADYKRLLNDPNRPLYSRVTQGAYPPASTVKPFIGVAALHENVITQNMT
CCCCEEEECCCCHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCE
IFDPGYWVLPNTTKRFRDWKKTGHGHTDLNKAIVESSDTYFYQTAYNMGIDRLSDWMKRF
EECCCEEECCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEHHHCCHHHHHHHHHHH
GFGVPTGIDIQEETAGIMPSREWKQKRHKRPWVQGDTISVGIGQGYWIATPLQVAKATSI
CCCCCCCCCCCHHHCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCEEEECHHHHHHHHHE
LINEGKVHTPHLMKSVEGSTVEPYQDPLLYEDITEPKAAYWDAAKRGMYNVVNAANGTGR
EEECCCCCCHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHCCHHHHHCCCCCCCC
KAFIGTSYRVAGKSGTAQVFSLKENQTYDASGLKKELHDHAWFTAYAPYDDPKMVVAIIL
EEEEECCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEEEEE
ENAGGGSSVAAPVVRQIMDYYLTQRLPQISRLSPADSLATEDSE
ECCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]