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The map label for this gene is hemX [H]

Identifier: 15603678

GI number: 15603678

Start: 2042885

End: 2043631

Strand: Direct

Name: hemX [H]

Synonym: PM1813

Alternate gene names: 15603678

Gene position: 2042885-2043631 (Clockwise)

Preceding gene: 15603677

Following gene: 15603679

Centisome position: 90.49

GC content: 43.37

Gene sequence:

>747_bases
ATGGCGGTATTAGTCACTCGACCTGATGTGCGAGGCGCACAGTTAACAGAGATGTTGATTCAAGCGGGGATTTTTGCAAT
CCATTTACCGCTCTTTACGATCGAAACAGGACGAGAATTGAATGACTTGCCGAATAAACTGTCGCAACTTAAAGCGGGTG
ATTATGTTTTTGCAGTTTCAAAACATGCTGTTCAGTATGCAGTCGATACGTTAAAGAATACAGGGTTTTCTTGGCGAACA
GATTTAGCCTATTTTGCGGTAGGACAGCGCAGTGCTGAATTTTTTGCCAGTCAAATCGAACGTGCGGTATTGTATCCTTA
TCGACAGGAAAGTAGCGAAGGATTATTAGCACTGGATGCCATGCAAGATTTGTCAGAAAAGCACATTTTAATTTTACGCG
GCAATGGGGGACGTGAGTATTTTTCTGAACAGGCACAATTGCGTGGTGCTAAAGTGGAGACGCTCGAATGTTACCAGCGT
GTACCGACTGCCTACAATAATGCAGAGCAGATCAGTATTTGTAAGCGTGCAGGAATTAATCGGCTTGTGATTAGCAGTGC
AGAAATTTTGCAGTATCTTGTGGATTTTGTTCCAGAAAGCGAACATAATTGGCTAAAAAGTTGTCAGCTGGTGACGGTAA
GTCAGCGTATTGCCAATTTAGCCAAACAATTGGGTTGGTGTGATGTGGTGGTTTCACCGCGAGCAGATAACGTGCATTTA
CTAAAAACATTGCTGTCTGCGGACTAA

Upstream 100 bases:

>100_bases
GCCGAAACATTAGGTATTCAAGTGGCAGAAAAACTTTTACAGCAAGGTGCGGATAAAATCTTGCAAACACTTTATTCAAA
CTAAGGAAGGGAAGAATAAA

Downstream 100 bases:

>100_bases
CTAGTGTTGAATTCTAATGATCATAAAGGAAATGGGTATTATGGCTGAAAATAAAATAACCTCTTCTGAAAGCAGTACTG
TACCAAAAAATGAGGGAAGT

Product: HemX

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MAVLVTRPDVRGAQLTEMLIQAGIFAIHLPLFTIETGRELNDLPNKLSQLKAGDYVFAVSKHAVQYAVDTLKNTGFSWRT
DLAYFAVGQRSAEFFASQIERAVLYPYRQESSEGLLALDAMQDLSEKHILILRGNGGREYFSEQAQLRGAKVETLECYQR
VPTAYNNAEQISICKRAGINRLVISSAEILQYLVDFVPESEHNWLKSCQLVTVSQRIANLAKQLGWCDVVVSPRADNVHL
LKTLLSAD

Sequences:

>Translated_248_residues
MAVLVTRPDVRGAQLTEMLIQAGIFAIHLPLFTIETGRELNDLPNKLSQLKAGDYVFAVSKHAVQYAVDTLKNTGFSWRT
DLAYFAVGQRSAEFFASQIERAVLYPYRQESSEGLLALDAMQDLSEKHILILRGNGGREYFSEQAQLRGAKVETLECYQR
VPTAYNNAEQISICKRAGINRLVISSAEILQYLVDFVPESEHNWLKSCQLVTVSQRIANLAKQLGWCDVVVSPRADNVHL
LKTLLSAD
>Mature_247_residues
AVLVTRPDVRGAQLTEMLIQAGIFAIHLPLFTIETGRELNDLPNKLSQLKAGDYVFAVSKHAVQYAVDTLKNTGFSWRTD
LAYFAVGQRSAEFFASQIERAVLYPYRQESSEGLLALDAMQDLSEKHILILRGNGGREYFSEQAQLRGAKVETLECYQRV
PTAYNNAEQISICKRAGINRLVISSAEILQYLVDFVPESEHNWLKSCQLVTVSQRIANLAKQLGWCDVVVSPRADNVHLL
KTLLSAD

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=246, Percent_Identity=39.4308943089431, Blast_Score=172, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 27762; Mature: 27631

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVLVTRPDVRGAQLTEMLIQAGIFAIHLPLFTIETGRELNDLPNKLSQLKAGDYVFAVS
CEEEEECCCCCHHHHHHHHHHHCHHHEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEHH
KHAVQYAVDTLKNTGFSWRTDLAYFAVGQRSAEFFASQIERAVLYPYRQESSEGLLALDA
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHH
MQDLSEKHILILRGNGGREYFSEQAQLRGAKVETLECYQRVPTAYNNAEQISICKRAGIN
HHCCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
RLVISSAEILQYLVDFVPESEHNWLKSCQLVTVSQRIANLAKQLGWCDVVVSPRADNVHL
CEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
LKTLLSAD
HHHHHHCC
>Mature Secondary Structure 
AVLVTRPDVRGAQLTEMLIQAGIFAIHLPLFTIETGRELNDLPNKLSQLKAGDYVFAVS
EEEEECCCCCHHHHHHHHHHHCHHHEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEHH
KHAVQYAVDTLKNTGFSWRTDLAYFAVGQRSAEFFASQIERAVLYPYRQESSEGLLALDA
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHH
MQDLSEKHILILRGNGGREYFSEQAQLRGAKVETLECYQRVPTAYNNAEQISICKRAGIN
HHCCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
RLVISSAEILQYLVDFVPESEHNWLKSCQLVTVSQRIANLAKQLGWCDVVVSPRADNVHL
CEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
LKTLLSAD
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]