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The map label for this gene is hemC [H]

Identifier: 15603677

GI number: 15603677

Start: 2041930

End: 2042868

Strand: Direct

Name: hemC [H]

Synonym: PM1812

Alternate gene names: 15603677

Gene position: 2041930-2042868 (Clockwise)

Preceding gene: 15603671

Following gene: 15603678

Centisome position: 90.45

GC content: 45.58

Gene sequence:

>939_bases
ATGGTTGTGATGATGACAAGAAAAAGCTTGAGAATCGCTACGCGTCAGAGCCCGCTTGCATTGTGGCAAGCGAACTATGT
GAAAGCCTGTTTAGAAAAAATCCATGCTGGATTAGTGGTCGAACTTGTCCCAATGGTGACAAAAGGGGATGTGATTTTAG
ATACGCCACTGGCTAAAATTGGAGGAAAAGGACTCTTTGTGAAAGAGTTAGAACAAGCTTTATTAAAGGGCGAAGCCGAT
ATTGCCGTACATTCGATGAAAGATGTCCCTATGCAGTTTCCAGCAGGATTAATGCTTAGCACCATTTGTCAACGTGAAGA
TCCGCGTGATGCATTTGTATCAAATTCATACCGCACTCTCATGGAATTACCTGCTGGTGCGGTGGTGGGTACCTCTAGCT
TACGTCGCCAATGTCAGTTAAAGCAGTTACGTCCTGATCTACACATTCATTCACTACGTGGCAATGTTGGGACTCGCTTA
GCAAAATTAGATAACGGCGATTATGATGCGATTATTCTGGCTGCCGCGGGGCTTATTCGTTTAGGGCAACAACAACGTAT
CACCTCTTTGATTGATGTCACACAATGTTTACCTGCCGTAGGGCAAGGTGCCGTTGGCATTGAATGTCGTCAAGAAGCAG
AAATTGAGCTGCTGTTAGCCCCTTTAGCCGATCCAGAAACGACTGCTTGTGTATTGGCTGAACGTGCGATGAATCGGCAT
TTACAAGGGGGATGTCAGGTGCCAATTGCAGGTTACGCGATTATCGAAGAGGGACAGCTCTTTTTGCGTGCTTTAGTGGG
CGAAGTAGACGGTTCCAGTATACTTCGTGCAGAAGGACGGAGTGCGGTTGCGGATGCCGAAACATTAGGTATTCAAGTGG
CAGAAAAACTTTTACAGCAAGGTGCGGATAAAATCTTGCAAACACTTTATTCAAACTAA

Upstream 100 bases:

>100_bases
AGTACTCTAACACTTGGTATAACTGAAAGCAAAAAATTTAAATGGAAACTGACATTTAAACCCAACAATGTTAGGATAGG
AGCAAATTATTCTGCCTAAA

Downstream 100 bases:

>100_bases
GGAAGGGAAGAATAAAATGGCGGTATTAGTCACTCGACCTGATGTGCGAGGCGCACAGTTAACAGAGATGTTGATTCAAG
CGGGGATTTTTGCAATCCAT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MVVMMTRKSLRIATRQSPLALWQANYVKACLEKIHAGLVVELVPMVTKGDVILDTPLAKIGGKGLFVKELEQALLKGEAD
IAVHSMKDVPMQFPAGLMLSTICQREDPRDAFVSNSYRTLMELPAGAVVGTSSLRRQCQLKQLRPDLHIHSLRGNVGTRL
AKLDNGDYDAIILAAAGLIRLGQQQRITSLIDVTQCLPAVGQGAVGIECRQEAEIELLLAPLADPETTACVLAERAMNRH
LQGGCQVPIAGYAIIEEGQLFLRALVGEVDGSSILRAEGRSAVADAETLGIQVAEKLLQQGADKILQTLYSN

Sequences:

>Translated_312_residues
MVVMMTRKSLRIATRQSPLALWQANYVKACLEKIHAGLVVELVPMVTKGDVILDTPLAKIGGKGLFVKELEQALLKGEAD
IAVHSMKDVPMQFPAGLMLSTICQREDPRDAFVSNSYRTLMELPAGAVVGTSSLRRQCQLKQLRPDLHIHSLRGNVGTRL
AKLDNGDYDAIILAAAGLIRLGQQQRITSLIDVTQCLPAVGQGAVGIECRQEAEIELLLAPLADPETTACVLAERAMNRH
LQGGCQVPIAGYAIIEEGQLFLRALVGEVDGSSILRAEGRSAVADAETLGIQVAEKLLQQGADKILQTLYSN
>Mature_312_residues
MVVMMTRKSLRIATRQSPLALWQANYVKACLEKIHAGLVVELVPMVTKGDVILDTPLAKIGGKGLFVKELEQALLKGEAD
IAVHSMKDVPMQFPAGLMLSTICQREDPRDAFVSNSYRTLMELPAGAVVGTSSLRRQCQLKQLRPDLHIHSLRGNVGTRL
AKLDNGDYDAIILAAAGLIRLGQQQRITSLIDVTQCLPAVGQGAVGIECRQEAEIELLLAPLADPETTACVLAERAMNRH
LQGGCQVPIAGYAIIEEGQLFLRALVGEVDGSSILRAEGRSAVADAETLGIQVAEKLLQQGADKILQTLYSN

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=331, Percent_Identity=42.9003021148036, Blast_Score=238, Evalue=4e-63,
Organism=Homo sapiens, GI66933009, Length=333, Percent_Identity=42.6426426426426, Blast_Score=238, Evalue=4e-63,
Organism=Escherichia coli, GI48994974, Length=308, Percent_Identity=67.2077922077922, Blast_Score=397, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=38.9408099688474, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI20130425, Length=284, Percent_Identity=40.1408450704225, Blast_Score=194, Evalue=7e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33666; Mature: 33666

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVMMTRKSLRIATRQSPLALWQANYVKACLEKIHAGLVVELVPMVTKGDVILDTPLAKI
CEEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHH
GGKGLFVKELEQALLKGEADIAVHSMKDVPMQFPAGLMLSTICQREDPRDAFVSNSYRTL
CCCCCCHHHHHHHHHCCCCCEEEEHHHCCCCCCCHHHHHHHHHCCCCCCHHHHCCHHHHH
MELPAGAVVGTSSLRRQCQLKQLRPDLHIHSLRGNVGTRLAKLDNGDYDAIILAAAGLIR
HHCCCCCEECCHHHHHHHHHHHCCCCCEEEECCCCHHHEEEECCCCCCCHHHHHHHHHHH
LGQQQRITSLIDVTQCLPAVGQGAVGIECRQEAEIELLLAPLADPETTACVLAERAMNRH
CCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
LQGGCQVPIAGYAIIEEGQLFLRALVGEVDGSSILRAEGRSAVADAETLGIQVAEKLLQQ
HCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GADKILQTLYSN
HHHHHHHHHHCC
>Mature Secondary Structure
MVVMMTRKSLRIATRQSPLALWQANYVKACLEKIHAGLVVELVPMVTKGDVILDTPLAKI
CEEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHH
GGKGLFVKELEQALLKGEADIAVHSMKDVPMQFPAGLMLSTICQREDPRDAFVSNSYRTL
CCCCCCHHHHHHHHHCCCCCEEEEHHHCCCCCCCHHHHHHHHHCCCCCCHHHHCCHHHHH
MELPAGAVVGTSSLRRQCQLKQLRPDLHIHSLRGNVGTRLAKLDNGDYDAIILAAAGLIR
HHCCCCCEECCHHHHHHHHHHHCCCCCEEEECCCCHHHEEEECCCCCCCHHHHHHHHHHH
LGQQQRITSLIDVTQCLPAVGQGAVGIECRQEAEIELLLAPLADPETTACVLAERAMNRH
CCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
LQGGCQVPIAGYAIIEEGQLFLRALVGEVDGSSILRAEGRSAVADAETLGIQVAEKLLQQ
HCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GADKILQTLYSN
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]