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The map label for this gene is murQ

Identifier: 15603441

GI number: 15603441

Start: 1785250

End: 1786155

Strand: Reverse

Name: murQ

Synonym: PM1576

Alternate gene names: 15603441

Gene position: 1786155-1785250 (Counterclockwise)

Preceding gene: 15603446

Following gene: 15603440

Centisome position: 79.12

GC content: 44.59

Gene sequence:

>906_bases
ATGCCAAATGCCATACATGCGCTCGTCACCGAAAGTCGGAATCCATTTAGTACACATATCGACCAGCTTTCAACTTTAGA
CATGTTAGCAGTTATTAATCAGGAAGACCAAAAAGTTCCTTTTGCTATCGAAAACGTTTTACCAGAAATCGCCCAAGCGG
TCGATGCCATTGCTGAAACGTTCATGAAAAATGGGCGGTTAATCTATTTAGGCGCGGGCACATCAGGACGCTTAGGCATT
TTAGATGCGAGTGAATGCCCACCAACGTTTGGTACCCCCCATGAACAAGTTGTGGGACTCATCGCAGGTGGACAACAAGC
CATTTTAAAAGCAGTTGAAAATGCCGAAGATGACCGTAGCGCCGGTGAGCAAGATCTACGTAACTTAGCACTGAATGAAA
AAGATGTGGTTGTTGGTATTGCCGCCAGTGGTCGCACCCCCTATGTTCTTGCTGGCATCGAATATGCAAATCACGTTGGC
TGTGTCACTGTAGGCATTAGCTGTAATCCGGATTCCGCTTTAGCCGCGCTTGCTAACATTGCGATCACGCCTATTGTTGG
TCCTGAAGTGATTACGGGTTCTTCACGAATGAAAGCAGGTACCGCACAAAAATTGATTCTCAATATGCTCACGACAGGGG
CGATGATTAAAACAGGCAAAGTTTTTGGTAATTTAATGGTCGATGTAGTGGCAACCAACGAGAAATTAGTCGAGCGCCAA
AAAAACATTGTCATGGAAGTGACGCAATGTGATCGCCAACAAGCGGAACAAGCCTTATTACAATCAAACGGACAATGTAA
AGTGGCGATTGTCATGCTATTGCTGAATATGTCGGCAGAAGAAGCAAAAAACTGCTTGGCGCAAGCCAATGGTTTTATTC
ACCAAGCATTAACTTTGGTTAAATAA

Upstream 100 bases:

>100_bases
AATAAAAAGTGAGCAAGCTCACAGAATGAATAAATAATCTCCATTATTGAGGTATTTTGGAATAAAATAATCCAAAGTAA
AGTCATTGGAGGAATTTTTT

Downstream 100 bases:

>100_bases
AGGAGAACGTTATGGCAACAATTGATAATGCGATGATCCACTCGCTCATCCAGCACCTAGGTGGAAAAAGCAACATCCAA
AGTGTCACTAATTGTATGAC

Product: N-acetylmuramic acid-6-phosphate etherase

Products: NA

Alternate protein names: MurNAc-6-P etherase; N-acetylmuramic acid 6-phosphate hydrolase; N-acetylmuramic acid 6-phosphate lyase

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MPNAIHALVTESRNPFSTHIDQLSTLDMLAVINQEDQKVPFAIENVLPEIAQAVDAIAETFMKNGRLIYLGAGTSGRLGI
LDASECPPTFGTPHEQVVGLIAGGQQAILKAVENAEDDRSAGEQDLRNLALNEKDVVVGIAASGRTPYVLAGIEYANHVG
CVTVGISCNPDSALAALANIAITPIVGPEVITGSSRMKAGTAQKLILNMLTTGAMIKTGKVFGNLMVDVVATNEKLVERQ
KNIVMEVTQCDRQQAEQALLQSNGQCKVAIVMLLLNMSAEEAKNCLAQANGFIHQALTLVK

Sequences:

>Translated_301_residues
MPNAIHALVTESRNPFSTHIDQLSTLDMLAVINQEDQKVPFAIENVLPEIAQAVDAIAETFMKNGRLIYLGAGTSGRLGI
LDASECPPTFGTPHEQVVGLIAGGQQAILKAVENAEDDRSAGEQDLRNLALNEKDVVVGIAASGRTPYVLAGIEYANHVG
CVTVGISCNPDSALAALANIAITPIVGPEVITGSSRMKAGTAQKLILNMLTTGAMIKTGKVFGNLMVDVVATNEKLVERQ
KNIVMEVTQCDRQQAEQALLQSNGQCKVAIVMLLLNMSAEEAKNCLAQANGFIHQALTLVK
>Mature_300_residues
PNAIHALVTESRNPFSTHIDQLSTLDMLAVINQEDQKVPFAIENVLPEIAQAVDAIAETFMKNGRLIYLGAGTSGRLGIL
DASECPPTFGTPHEQVVGLIAGGQQAILKAVENAEDDRSAGEQDLRNLALNEKDVVVGIAASGRTPYVLAGIEYANHVGC
VTVGISCNPDSALAALANIAITPIVGPEVITGSSRMKAGTAQKLILNMLTTGAMIKTGKVFGNLMVDVVATNEKLVERQK
NIVMEVTQCDRQQAEQALLQSNGQCKVAIVMLLLNMSAEEAKNCLAQANGFIHQALTLVK

Specific function: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported

COG id: COG2103

COG function: function code R; Predicted sugar phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1788768, Length=290, Percent_Identity=64.8275862068965, Blast_Score=370, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURQ_PASMU (P57951)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246515.1
- ProteinModelPortal:   P57951
- SMR:   P57951
- GeneID:   1244923
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1576
- NMPDR:   fig|272843.1.peg.1577
- HOGENOM:   HBG703490
- OMA:   DMCRIIN
- ProtClustDB:   PRK05441
- BioCyc:   PMUL272843:PM1576-MONOMER
- HAMAP:   MF_00068
- InterPro:   IPR005486
- InterPro:   IPR005488
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00274

Pfam domain/function: PF01380 SIS

EC number: NA

Molecular weight: Translated: 31911; Mature: 31780

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS01272 GCKR; PS51464 SIS

Important sites: ACT_SITE 85-85 ACT_SITE 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNAIHALVTESRNPFSTHIDQLSTLDMLAVINQEDQKVPFAIENVLPEIAQAVDAIAET
CCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FMKNGRLIYLGAGTSGRLGILDASECPPTFGTPHEQVVGLIAGGQQAILKAVENAEDDRS
HHHCCCEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHC
AGEQDLRNLALNEKDVVVGIAASGRTPYVLAGIEYANHVGCVTVGISCNPDSALAALANI
CCHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCHHCCCEEEEEEEECCCHHHHHHHHHH
AITPIVGPEVITGSSRMKAGTAQKLILNMLTTGAMIKTGKVFGNLMVDVVATNEKLVERQ
HCCCCCCCCEECCCCHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEECCHHHHHHH
KNIVMEVTQCDRQQAEQALLQSNGQCKVAIVMLLLNMSAEEAKNCLAQANGFIHQALTLV
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHC
K
C
>Mature Secondary Structure 
PNAIHALVTESRNPFSTHIDQLSTLDMLAVINQEDQKVPFAIENVLPEIAQAVDAIAET
CCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FMKNGRLIYLGAGTSGRLGILDASECPPTFGTPHEQVVGLIAGGQQAILKAVENAEDDRS
HHHCCCEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHC
AGEQDLRNLALNEKDVVVGIAASGRTPYVLAGIEYANHVGCVTVGISCNPDSALAALANI
CCHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCHHCCCEEEEEEEECCCHHHHHHHHHH
AITPIVGPEVITGSSRMKAGTAQKLILNMLTTGAMIKTGKVFGNLMVDVVATNEKLVERQ
HCCCCCCCCEECCCCHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEECCHHHHHHH
KNIVMEVTQCDRQQAEQALLQSNGQCKVAIVMLLLNMSAEEAKNCLAQANGFIHQALTLV
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100