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The map label for this gene is murP

Identifier: 15603440

GI number: 15603440

Start: 1783808

End: 1785238

Strand: Reverse

Name: murP

Synonym: PM1575

Alternate gene names: 15603440

Gene position: 1785238-1783808 (Counterclockwise)

Preceding gene: 15603441

Following gene: 15603438

Centisome position: 79.08

GC content: 44.3

Gene sequence:

>1431_bases
ATGGCAACAATTGATAATGCGATGATCCACTCGCTCATCCAGCACCTAGGTGGAAAAAGCAACATCCAAAGTGTCACTAA
TTGTATGACACGTTTGCGTGTCACCTTGCACGATTCGTCCGTTGTTGATAAAGACGAGTTAAAAAAAATCCAAGGTGTGC
TAGGTGTTGTCGAAGCGGATGAGCAACTCCAACTGATTCTTGGTCCGGGTAAAGCAACAAAAGCCGCGGAAATGATGAAA
GCCAGCTTAGGGGATAACATGAGTTCGCCTTCTCTCCAAGAGATTGCACGCACCCAAAAACAACAAATTAAGTCTGCTCA
AACGAGTAGTATCCATCAATTCTTTGCGAAGTTTGCTACTATTTTTACCCCGCTCATTCCGGGTTTTATTGGCGCAGGCT
TACTCCTAGGCTTAGCAACCGTATTGCAACAAGCCTTTGTGGCTGGGGTAGAAAATCCAAATGCGTTTTTAGTGGATTTG
ATTGCGTACATGAAAGTGTTCAGTAAAGGCTTATTTAGCTTTTTAAGTATTCTGATTGGTTATAATGCAGCAAAAGCCTT
TGGGGGTTCGGGTGTCAACGGCGCAATCCTTGCCTCTTTATTTATCTTGGGCTATAACCCAGAAGCGACCAAAGGGATTT
ATTCTGGATTAAGCAATTTCTTTGGCTTAACTATTGACCCACGCGGTAACATCATCGGGGTTTTAATCGCAGCAATTGTT
GGGGCAAAAGTCGAACGTTGGGTCAGAAAGTTCATTCCTGATAGCTTAGATATGGCATTAACTTCCACGGTTACGCTATT
AATTATGGGCTGTTTTACCTTCTTATTTATCATGCCAATTGGGGTGTATCTCTTTAATGGAATGTCTTGGTTATTCTCTA
ACTTAAATGGCAATCCATTGGGTACCGCAGTTCTAGCAGGCTTATTCCTTATCTCCGTTATGCTCGGTATTCACCAAGGT
TTTGTCCCGGTCTATTTTGCCTTAGTGGAAACACAAGGCTTTAACGCGCTCTTCCCAGTGCTTGCTATGGCAGGCGCAGG
ACAAGTGGGTGCCGCGTTAGCGCTTTACTTCAAAGCAAACAAAGGCGCCGTCTTGCGTGATCAAATCAAAGGGGCAATTA
TTCCGGGCTTTTTAGGTATCGGCGAACCGCTGATTTACGGGGTAACCTTACCGCGAGTAAAACCGTTTATTACAGCCTGT
ATCGGTGGTGCTGCGGGCGGCTTTACTATTGGGTTAATCGCCTACTTAGGTTTCCCAATGGGGTTAAATACAGTCTTTGG
TCCATCTGGATTACTCGCGATCCCATTAATGACCTCGCCGAATGGTGTATTACCGGCTATCGCTACCTATTTATTAGGTA
CCGTTGTCGCTTACGCAACAGGTTTTATCACAACCTATTTCTTTGCGACGAAAGATGTCGATTTAAGCTAA

Upstream 100 bases:

>100_bases
TATTGCTGAATATGTCGGCAGAAGAAGCAAAAAACTGCTTGGCGCAAGCCAATGGTTTTATTCACCAAGCATTAACTTTG
GTTAAATAAAGGAGAACGTT

Downstream 100 bases:

>100_bases
ACATTTTTGCTAAGCCGTACTTTTTCTCATAGGAACATTATGGATATCTAAATTTGGGTGGCGCAGTCCACCCTTTTTTT
ATTGCTTTACTTTCCTTTCA

Product: PTS system N-acetylmuramic acid transporter subunits EIIBC

Products: NA

Alternate protein names: EIIBC-MurNAc; N-acetylmuramic acid-specific phosphotransferase enzyme IIB component; PTS system N-acetylmuramic acid-specific EIIB component; N-acetylmuramic acid permease IIC component; PTS system N-acetylmuramic acid-specific EIIC component

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MATIDNAMIHSLIQHLGGKSNIQSVTNCMTRLRVTLHDSSVVDKDELKKIQGVLGVVEADEQLQLILGPGKATKAAEMMK
ASLGDNMSSPSLQEIARTQKQQIKSAQTSSIHQFFAKFATIFTPLIPGFIGAGLLLGLATVLQQAFVAGVENPNAFLVDL
IAYMKVFSKGLFSFLSILIGYNAAKAFGGSGVNGAILASLFILGYNPEATKGIYSGLSNFFGLTIDPRGNIIGVLIAAIV
GAKVERWVRKFIPDSLDMALTSTVTLLIMGCFTFLFIMPIGVYLFNGMSWLFSNLNGNPLGTAVLAGLFLISVMLGIHQG
FVPVYFALVETQGFNALFPVLAMAGAGQVGAALALYFKANKGAVLRDQIKGAIIPGFLGIGEPLIYGVTLPRVKPFITAC
IGGAAGGFTIGLIAYLGFPMGLNTVFGPSGLLAIPLMTSPNGVLPAIATYLLGTVVAYATGFITTYFFATKDVDLS

Sequences:

>Translated_476_residues
MATIDNAMIHSLIQHLGGKSNIQSVTNCMTRLRVTLHDSSVVDKDELKKIQGVLGVVEADEQLQLILGPGKATKAAEMMK
ASLGDNMSSPSLQEIARTQKQQIKSAQTSSIHQFFAKFATIFTPLIPGFIGAGLLLGLATVLQQAFVAGVENPNAFLVDL
IAYMKVFSKGLFSFLSILIGYNAAKAFGGSGVNGAILASLFILGYNPEATKGIYSGLSNFFGLTIDPRGNIIGVLIAAIV
GAKVERWVRKFIPDSLDMALTSTVTLLIMGCFTFLFIMPIGVYLFNGMSWLFSNLNGNPLGTAVLAGLFLISVMLGIHQG
FVPVYFALVETQGFNALFPVLAMAGAGQVGAALALYFKANKGAVLRDQIKGAIIPGFLGIGEPLIYGVTLPRVKPFITAC
IGGAAGGFTIGLIAYLGFPMGLNTVFGPSGLLAIPLMTSPNGVLPAIATYLLGTVVAYATGFITTYFFATKDVDLS
>Mature_475_residues
ATIDNAMIHSLIQHLGGKSNIQSVTNCMTRLRVTLHDSSVVDKDELKKIQGVLGVVEADEQLQLILGPGKATKAAEMMKA
SLGDNMSSPSLQEIARTQKQQIKSAQTSSIHQFFAKFATIFTPLIPGFIGAGLLLGLATVLQQAFVAGVENPNAFLVDLI
AYMKVFSKGLFSFLSILIGYNAAKAFGGSGVNGAILASLFILGYNPEATKGIYSGLSNFFGLTIDPRGNIIGVLIAAIVG
AKVERWVRKFIPDSLDMALTSTVTLLIMGCFTFLFIMPIGVYLFNGMSWLFSNLNGNPLGTAVLAGLFLISVMLGIHQGF
VPVYFALVETQGFNALFPVLAMAGAGQVGAALALYFKANKGAVLRDQIKGAIIPGFLGIGEPLIYGVTLPRVKPFITACI
GGAAGGFTIGLIAYLGFPMGLNTVFGPSGLLAIPLMTSPNGVLPAIATYLLGTVVAYATGFITTYFFATKDVDLS

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1263

COG function: function code G; Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-1 domain

Homologues:

Organism=Escherichia coli, GI1788769, Length=474, Percent_Identity=60.337552742616, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1790159, Length=472, Percent_Identity=29.0254237288136, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI2367362, Length=429, Percent_Identity=23.5431235431235, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI48994906, Length=429, Percent_Identity=26.3403263403263, Blast_Score=123, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTYBC_PASMU (Q9CKN5)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246514.1
- HSSP:   P69786
- ProteinModelPortal:   Q9CKN5
- SMR:   Q9CKN5
- GeneID:   1244922
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1575
- NMPDR:   fig|272843.1.peg.1576
- HOGENOM:   HBG673521
- OMA:   RTQIKGA
- ProtClustDB:   PRK09586
- BioCyc:   PMUL272843:PM1575-MONOMER
- BRENDA:   2.7.1.69
- InterPro:   IPR018113
- InterPro:   IPR001996
- InterPro:   IPR003352
- InterPro:   IPR013013
- Gene3D:   G3DSA:3.30.1360.60

Pfam domain/function: PF00367 PTS_EIIB; PF02378 PTS_EIIC; SSF55604 PTS_EIIB

EC number: =2.7.1.69

Molecular weight: Translated: 50205; Mature: 50074

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS51098 PTS_EIIB_TYPE_1; PS01035 PTS_EIIB_TYPE_1_CYS; PS51103 PTS_EIIC_TYPE_1

Important sites: ACT_SITE 28-28

Signals:

None

Transmembrane regions:

HASH(0xf0bda50)-; HASH(0xf0f13d8)-; HASH(0xec5cc98)-; HASH(0xefc5e0c)-; HASH(0xb29d77c)-; HASH(0xdfd8418)-; HASH(0xeba74b4)-; HASH(0xf0b376c)-; HASH(0xc2d61fc)-; HASH(0xebec52c)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIDNAMIHSLIQHLGGKSNIQSVTNCMTRLRVTLHDSSVVDKDELKKIQGVLGVVEAD
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHCCC
EQLQLILGPGKATKAAEMMKASLGDNMSSPSLQEIARTQKQQIKSAQTSSIHQFFAKFAT
CCEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFTPLIPGFIGAGLLLGLATVLQQAFVAGVENPNAFLVDLIAYMKVFSKGLFSFLSILIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
YNAAKAFGGSGVNGAILASLFILGYNPEATKGIYSGLSNFFGLTIDPRGNIIGVLIAAIV
CCHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHH
GAKVERWVRKFIPDSLDMALTSTVTLLIMGCFTFLFIMPIGVYLFNGMSWLFSNLNGNPL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
GTAVLAGLFLISVMLGIHQGFVPVYFALVETQGFNALFPVLAMAGAGQVGAALALYFKAN
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHEEEEECC
KGAVLRDQIKGAIIPGFLGIGEPLIYGVTLPRVKPFITACIGGAAGGFTIGLIAYLGFPM
CCCCHHHHHCCCCCCHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
GLNTVFGPSGLLAIPLMTSPNGVLPAIATYLLGTVVAYATGFITTYFFATKDVDLS
CCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCH
>Mature Secondary Structure 
ATIDNAMIHSLIQHLGGKSNIQSVTNCMTRLRVTLHDSSVVDKDELKKIQGVLGVVEAD
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHCCC
EQLQLILGPGKATKAAEMMKASLGDNMSSPSLQEIARTQKQQIKSAQTSSIHQFFAKFAT
CCEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFTPLIPGFIGAGLLLGLATVLQQAFVAGVENPNAFLVDLIAYMKVFSKGLFSFLSILIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
YNAAKAFGGSGVNGAILASLFILGYNPEATKGIYSGLSNFFGLTIDPRGNIIGVLIAAIV
CCHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHH
GAKVERWVRKFIPDSLDMALTSTVTLLIMGCFTFLFIMPIGVYLFNGMSWLFSNLNGNPL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
GTAVLAGLFLISVMLGIHQGFVPVYFALVETQGFNALFPVLAMAGAGQVGAALALYFKAN
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHEEEEECC
KGAVLRDQIKGAIIPGFLGIGEPLIYGVTLPRVKPFITACIGGAAGGFTIGLIAYLGFPM
CCCCHHHHHCCCCCCHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
GLNTVFGPSGLLAIPLMTSPNGVLPAIATYLLGTVVAYATGFITTYFFATKDVDLS
CCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11248100