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The map label for this gene is uhpA [H]

Identifier: 15603205

GI number: 15603205

Start: 1532694

End: 1533293

Strand: Reverse

Name: uhpA [H]

Synonym: PM1340

Alternate gene names: 15603205

Gene position: 1533293-1532694 (Counterclockwise)

Preceding gene: 15603206

Following gene: 15603204

Centisome position: 67.92

GC content: 42.0

Gene sequence:

>600_bases
ATGATTAAAGTAGCGTTGATCGATGATCATATCATTGTCCGCTCAGGCTTTGCTCAATTGCTTGCGTTAGAAAATGATCT
TCACGTTGTCGGTGAATTTAGTTCTGCTAAAGAAGCACGCCAACATCTGCCCAGTGTGCGTCCTGATGTGTGTATTATTG
ACATTTCAATGCCTGATGAAACCGGCTTAGCATTGCTCAAAGACATTCCCTCGGGTATCCACTGTATTATGCTCAGCGTG
AATGATTCCGATATCATGGTACGCAAAGCCTTGGAATTGGGTGCCAAAGGCTATTTAAGTAAACGTTGCCACCCTGATGA
ACTGATTCAAGCCGTACATGCCGTATTTGCTGGTGGGCTTTACTTAATGCCTGAACTGACTTCAAAACTGCTTAATCCTA
CCGCCTCTTATACCCAGCAGCTCACACGAAGAGAAATGGAAGTATGTGAATTATTAACAACCGGCTTAGATGCAAAAGAG
ATTGCTCAACAGCTGAATGTAAGCTTTAAAACAGTGCACGTGCATCGTGCTAATGCCATGAGTAAGCTCAACCTAAAAAA
TAATGTGGAACTCACGAATTTCTTTCATCAAACATATTAA

Upstream 100 bases:

>100_bases
ATCCGTAAAATAAAGGCTCAAGCCAGATAAACAGGTAAATAACATGACACAAAAGTGCGGTTAAATTGACCGCACTTTTT
CATTTTTGAGGATAATAAAG

Downstream 100 bases:

>100_bases
CTTGAACAAGTTGTTCACCTTCATTTACAGTTGGTTTCTGCTCACCTGTTCCTATTTCTGTTTATGGGGCGTGGCAGATT
ATTTGTTACATGACTCGCGC

Product: UhpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MIKVALIDDHIIVRSGFAQLLALENDLHVVGEFSSAKEARQHLPSVRPDVCIIDISMPDETGLALLKDIPSGIHCIMLSV
NDSDIMVRKALELGAKGYLSKRCHPDELIQAVHAVFAGGLYLMPELTSKLLNPTASYTQQLTRREMEVCELLTTGLDAKE
IAQQLNVSFKTVHVHRANAMSKLNLKNNVELTNFFHQTY

Sequences:

>Translated_199_residues
MIKVALIDDHIIVRSGFAQLLALENDLHVVGEFSSAKEARQHLPSVRPDVCIIDISMPDETGLALLKDIPSGIHCIMLSV
NDSDIMVRKALELGAKGYLSKRCHPDELIQAVHAVFAGGLYLMPELTSKLLNPTASYTQQLTRREMEVCELLTTGLDAKE
IAQQLNVSFKTVHVHRANAMSKLNLKNNVELTNFFHQTY
>Mature_199_residues
MIKVALIDDHIIVRSGFAQLLALENDLHVVGEFSSAKEARQHLPSVRPDVCIIDISMPDETGLALLKDIPSGIHCIMLSV
NDSDIMVRKALELGAKGYLSKRCHPDELIQAVHAVFAGGLYLMPELTSKLLNPTASYTQQLTRREMEVCELLTTGLDAKE
IAQQLNVSFKTVHVHRANAMSKLNLKNNVELTNFFHQTY

Specific function: Appears to be the positive activator of uhpT transcription [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=199, Percent_Identity=55.7788944723618, Blast_Score=213, Evalue=8e-57,
Organism=Escherichia coli, GI1788222, Length=203, Percent_Identity=34.4827586206897, Blast_Score=118, Evalue=2e-28,
Organism=Escherichia coli, GI1788521, Length=205, Percent_Identity=33.1707317073171, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1787473, Length=205, Percent_Identity=35.1219512195122, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788546, Length=204, Percent_Identity=31.8627450980392, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1786747, Length=198, Percent_Identity=28.7878787878788, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1788712, Length=196, Percent_Identity=27.5510204081633, Blast_Score=84, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 22133; Mature: 22133

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVALIDDHIIVRSGFAQLLALENDLHVVGEFSSAKEARQHLPSVRPDVCIIDISMPDE
CEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCCEEEEEECCCCC
TGLALLKDIPSGIHCIMLSVNDSDIMVRKALELGAKGYLSKRCHPDELIQAVHAVFAGGL
HHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHCCE
YLMPELTSKLLNPTASYTQQLTRREMEVCELLTTGLDAKEIAQQLNVSFKTVHVHRANAM
EEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEEEEECCCHH
SKLNLKNNVELTNFFHQTY
HHCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MIKVALIDDHIIVRSGFAQLLALENDLHVVGEFSSAKEARQHLPSVRPDVCIIDISMPDE
CEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCCEEEEEECCCCC
TGLALLKDIPSGIHCIMLSVNDSDIMVRKALELGAKGYLSKRCHPDELIQAVHAVFAGGL
HHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHCCE
YLMPELTSKLLNPTASYTQQLTRREMEVCELLTTGLDAKEIAQQLNVSFKTVHVHRANAM
EEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEEEEECCCHH
SKLNLKNNVELTNFFHQTY
HHCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]